• 30 results in Exploration of Digestive Diseases
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    Original Article
    Familial achalasia isolated or syndromic: about 18 families
    Aim: Familial achalasia (FA) is a very rare condition. This work aims to evaluate its prevalence, characterize its clinical profile in a large series, and assess the efficacy and safety of pneuma [...] Read more.
    Amar Tebaibia ... Nadia Oumnia
    Published: October 26, 2023 Explor Dig Dis. 2023;2:276–281
    DOI: https://doi.org/10.37349/edd.2023.00030
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
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    Review
    Molecular mechanisms of metabolic disease-associated hepatic inflammation in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide, with a progressive form of non-alcoholic steatohepatitis (NASH). It may progress to advanced liver diseases, [...] Read more.
    Chunye Zhang ... Ming Yang
    Published: October 25, 2023 Explor Dig Dis. 2023;2:246–275
    DOI: https://doi.org/10.37349/edd.2023.00029
    This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
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    Review
    Interplay of autophagy, apoptosis, and senescence in primary biliary cholangitis
    The pathogenesis of primary biliary cholangitis (PBC) is particularly complicated as both intrinsic and extrinsic factors are implicated. Several forms of cellular death, both programmable and non-p [...] Read more.
    Elias Kouroumalis ... Argyro Voumvouraki
    Published: October 16, 2023 Explor Dig Dis. 2023;2:223–245
    DOI: https://doi.org/10.37349/edd.2023.00028
    This article belongs to the special issue CHOLESTASIS
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    Review
    Drug-induced cholestasis: causative agents and challenges in diagnosis and management
    Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominan [...] Read more.
    Jose M. Pinazo-Bandera ... Miren García-Cortés
    Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222
    DOI: https://doi.org/10.37349/edd.2023.00027
    This article belongs to the special issue CHOLESTASIS
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    Review
    Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategies
    Nonalcoholic fatty liver disease (NAFLD) is an umbrella definition that describes the ectopic deposition of fat within the liver that occurs in the absence of inciting factors other than the metabol [...] Read more.
    Amedeo Lonardo
    Published: August 30, 2023 Explor Dig Dis. 2023;2:188–201
    DOI: https://doi.org/10.37349/edd.2023.00026
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
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    Original Article
    Human liver stem cell-derived extracellular vesicles modulate long non-coding RNA expression profile in an in vivo model of non-alcoholic steatohepatitis
    Aim: Modifications in long non-coding RNA (lncRNA) expression are associated with inflammation and fibrosis in chronic liver diseases. It has been recently demonstrated that human liver stem cell [...] Read more.
    Giulia Chiabotto ... Stefania Bruno
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    Review
    Pathophysiology of biochemical signs of primary biliary cholangitis
    Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is a rare chronic autoimmune cholestatic liver disease, affecting mostly females. With PBС develops chronic cholang [...] Read more.
    Vasiliy Ivanovich Reshetnyak, Igor Veniaminovich Maev
    Published: August 27, 2023 Explor Dig Dis. 2023;2:149–171
    DOI: https://doi.org/10.37349/edd.2023.00024
    This article belongs to the special issue CHOLESTASIS
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    Review
    Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms?
    A high consumption of ultra-processed food (UPF) is a hallmark of Western diets that has been related to increased risk of non-communicable diseases. As an underlying mechanism, UPF may promote non- [...] Read more.
    Franziska A. Hägele ... Anja Bosy-Westphal
    Published: August 24, 2023 Explor Dig Dis. 2023;2:133–148
    DOI: https://doi.org/10.37349/edd.2023.00023
    This article belongs to the special issue Nutrition, Intestinal Barrier and Metabolic Liver Disease
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    Review
    Alcohol-related liver disease: also a question of what you drink?
    Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer [...] Read more.
    Finn Jung ... Ina Bergheim
    Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132
    DOI: https://doi.org/10.37349/edd.2023.00022
    This article belongs to the special issue Nutrition, Intestinal Barrier and Metabolic Liver Disease
    View:478
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    Times Cited: 0
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    Original Article
    An analysis on the clinical features and risk factors associated with the prognosis of patients with drug-induced liver injury
    Aim: This is a Chinese population-based study aimed to determine the causes and clinical features of drug-induced liver injury (DILI) from traditional Chinese medicines (TCMs) and current Western m [...] Read more.
    Qian Wei ... Jinsheng Guo
    Published: June 30, 2023 Explor Dig Dis. 2023;2:100–117
    DOI: https://doi.org/10.37349/edd.2023.00021
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:351
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    Times Cited: 0
    Open Access
    Review
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a [...] Read more.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:585
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    Review
    Liver injury related to Japanese herbal medicines: clinical features and diagnosis
    The word “Kampo medicine” means the traditional Japanese herbal medicine. Even “natural herb” can cause drug-induced liver injury (DILI). In this review, the characteristics of Kampo medicin [...] Read more.
    Naoki Mantani
    Published: June 27, 2023 Explor Dig Dis. 2023;2:77–82
    DOI: https://doi.org/10.37349/edd.2023.00019
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:297
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    Times Cited: 0
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    Review
    Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
    The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) a [...] Read more.
    Alejandro Cueto-Sánchez ... Marina Villanueva-Paz
    Published: April 26, 2023 Explor Dig Dis. 2023;2:56–76
    DOI: https://doi.org/10.37349/edd.2023.00018
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:672
    Download:51
    Times Cited: 0
    Open Access
    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:712
    Download:57
    Times Cited: 0
    Open Access
    Case Report
    Diagnostic workup of suspected hereditary cholestasis in adults: a case report
    Hereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with di [...] Read more.
    Carola Dröge ... Verena Keitel
    Published: April 21, 2023 Explor Dig Dis. 2023;2:34–43
    DOI: https://doi.org/10.37349/edd.2023.00016
    This article belongs to the special issue CHOLESTASIS
    Open Access
    Review
    Monitoring the hepatobiliary function using image techniques and labeled cholephilic compounds
    Evaluation of the hepatobiliary function is critical for the clinicians, not only for the diagnosis of a large variety of liver diseases but also in the follow-up and management of some patients, for instance, those with different [...] Read more.
    Beatriz Sanchez de Blas ... Marta R. Romero
    Published: February 28, 2023 Explor Dig Dis. 2023;2:18–33
    DOI: https://doi.org/10.37349/edd.2023.00015
    This article belongs to the special issue CHOLESTASIS
    View:484
    Download:31
    Times Cited: 0
    Open Access
    Editorial
    Extra-hepatic cancers in metabolic fatty liver syndromes
    Amedeo Lonardo
    Published: February 24, 2023 Explor Dig Dis. 2023;2:11–17
    DOI: https://doi.org/10.37349/edd.2023.00014
    Open Access
    Review
    Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis
    Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modul [...] Read more.
    María Fernández-Fernández ... Anna Moles
    Published: February 22, 2023 Explor Dig Dis. 2023;2:1–10
    DOI: https://doi.org/10.37349/edd.2023.00013
    View:426
    Download:22
    Times Cited: 0
    Open Access
    Perspective
    Hypoxia signaling and cholesterol/steroidogenic acute regulatory protein 1 axis: interplay and role in alcohol and non-alcohol-related liver diseases
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Sandra Torres ... Carmen Garcia-Ruiz
    Published: December 30, 2022 Explor Dig Dis. 2022;1:170–186
    DOI: https://doi.org/10.37349/edd.2022.00012
    View:493
    Download:39
    Times Cited: 0
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    Review
    The bile acid receptor TGR5 and cholestasis
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Grégory Merlen ... Thierry Tordjmann
    Published: December 30, 2022 Explor Dig Dis. 2022;1:154–169
    DOI: https://doi.org/10.37349/edd.2022.00011
    This article belongs to the special issue CHOLESTASIS
    View:541
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    Times Cited: 0
    Open Access
    Review
    Cholestasis associated to inborn errors in bile acid synthesis
    Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or tauri [...] Read more.
    Ricardo Espinosa-Escudero ... Maria J. Monte
    Published: December 7, 2022 Explor Dig Dis. 2022;1:137–153
    DOI: https://doi.org/10.37349/edd.2022.00010
    This article belongs to the special issue CHOLESTASIS
    View:647
    Download:31
    Times Cited: 0
    Open Access
    Original Article
    Probiotic human alcohol dehydrogenase-4 expressing bacteria protects from diet-induced obesity and metabolic impairment: a new concept of disease prevention
    Aim: Probiotic bacteria consumption for improving human health and for disease prevention is still controversial. There is a need to develop functional probiotic bacteria with proven efficacy for [...] Read more.
    Rajnish Prakash Singh ... Zvi Hayouka
    Published: October 31, 2022 Explor Dig Dis. 2022;1:118–136
    DOI: https://doi.org/10.37349/edd.2022.00009
    View:712
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    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
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    Times Cited: 0
    Open Access
    Review
    Caspase-2 in liver disease and hepatocellular carcinoma
    Caspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit f [...] Read more.
    Amaya Lopez-Pascual ... Maite G. Fernández-Barrena
    Published: October 31, 2022 Explor Dig Dis. 2022;1:80–96
    DOI: https://doi.org/10.37349/edd.2022.00007
    View:679
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    Perspective
    The intermicrovillar adhesion complex in gut barrier function and inflammation
    The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.
    Bernadette Mödl ... Robert Eferl
    Published: October 11, 2022 Explor Dig Dis. 2022;1:72–79
    DOI: https://doi.org/10.37349/edd.2022.00006
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:2028
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    Original Article
    The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damage
    Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such [...] Read more.
    Jocelyn López-Ramirez ... Leticia Bucio-Ortiz
    Published: August 11, 2022 Explor Dig Dis. 2022;1:40–50
    DOI: https://doi.org/10.37349/edd.2022.00004
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    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:2039
    Download:67
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:1606
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    Open Access
    Editorial
    Exploration of Digestive Diseases, where discovery and communication meet
    Jose C. Fernandez-Checa
    Published: July 01, 2022 Explor Dig Dis. 2022;1:1–3
    DOI: https://doi.org/10.37349/edd.2022.00001
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