• 12 results in Exploration of Digestive Diseases
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    Hypoxia signaling and cholesterol/steroidogenic acute regulatory protein 1 axis: interplay and role in alcohol and non-alcohol-related liver diseases
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Sandra Torres ... Carmen Garcia-Ruiz
    Published: December 30, 2022 Explor Dig Dis. 2022;1:170–186
    DOI: https://doi.org/10.37349/edd.2022.00012
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    Review
    The bile acid receptor TGR5 and cholestasis
    Metabolic zonation in the liver carries out the maintenance of organ and body homeostasis. Hypoxia is an inherent physiological feature of the liver and contributes to the zonal properties of the he [...] Read more.
    Grégory Merlen ... Thierry Tordjmann
    Published: December 30, 2022 Explor Dig Dis. 2022;1:154–169
    DOI: https://doi.org/10.37349/edd.2022.00011
    This article belongs to the special issue CHOLESTASIS
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    Review
    Cholestasis associated to inborn errors in bile acid synthesis
    Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or tauri [...] Read more.
    Ricardo Espinosa-Escudero ... Maria J. Monte
    Published: December 7, 2022 Explor Dig Dis. 2022;1:137–153
    DOI: https://doi.org/10.37349/edd.2022.00010
    This article belongs to the special issue CHOLESTASIS
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    Original Article
    Probiotic human alcohol dehydrogenase-4 expressing bacteria protects from diet-induced obesity and metabolic impairment: a new concept of disease prevention
    Aim: Probiotic bacteria consumption for improving human health and for disease prevention is still controversial. There is a need to develop functional probiotic bacteria with proven efficacy for [...] Read more.
    Rajnish Prakash Singh ... Zvi Hayouka
    Published: October 31, 2022 Explor Dig Dis. 2022;1:118–136
    DOI: https://doi.org/10.37349/edd.2022.00009
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    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
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    Caspase-2 in liver disease and hepatocellular carcinoma
    Caspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit f [...] Read more.
    Amaya Lopez-Pascual ... Maite G. Fernández-Barrena
    Published: October 31, 2022 Explor Dig Dis. 2022;1:80–96
    DOI: https://doi.org/10.37349/edd.2022.00007
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    Perspective
    The intermicrovillar adhesion complex in gut barrier function and inflammation
    The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.
    Bernadette Mödl ... Robert Eferl
    Published: October 11, 2022 Explor Dig Dis. 2022;1:72–79
    DOI: https://doi.org/10.37349/edd.2022.00006
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    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
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    Original Article
    The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damage
    Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such [...] Read more.
    Jocelyn López-Ramirez ... Leticia Bucio-Ortiz
    Published: August 11, 2022 Explor Dig Dis. 2022;1:40–50
    DOI: https://doi.org/10.37349/edd.2022.00004
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    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
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    Editorial
    Exploration of Digestive Diseases, where discovery and communication meet
    Jose C. Fernandez-Checa
    Published: July 01, 2022 Explor Dig Dis. 2022;1:1–3
    DOI: https://doi.org/10.37349/edd.2022.00001
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    Times Cited: 0