• 57 results in Exploration of Neuroprotective Therapy
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    Meta-Analysis
    Efficacy and safety of CDP-choline, cerebrolysin, MLC601, and edaravone in recovery of patients with acute ischemic strokes: a meta-analysis
    Aim: Stroke is the second most common cause of mortality and disability worldwide with ischemic strokes being the predominant type. The advent of neuroprotectants brought hope of improved outcome [...] Read more.
    Shafiq Dexter B. Abou Zaki, Johnny K. Lokin
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:398–408
    DOI: https://doi.org/10.37349/ent.2023.00057
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
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    Review
    Exploration of transcutaneous vagus nerve stimulation as a treatment option for adjuvant cancer and heart failure therapy
    Vagus nerve stimulation (VNS) has gained prominence in the treatment of various clinical disorders such as migraine, depression, and tinnitus. Based on increased scientific knowledge of the VNS and  [...] Read more.
    Niklas Frank ... Carola Y. Förster
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:363–397
    DOI: https://doi.org/10.37349/ent.2023.00056
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:247
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    Review
    Stem cell therapy in neurological disorders: promises and concerns
    Self-neuronal regeneration is often limited or nonexistent after neuronal cell damage, making new technologies necessary for treating neurological damage. Although the brain can partially compensate [...] Read more.
    Said Hachimi-Idrissi
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:346–362
    DOI: https://doi.org/10.37349/ent.2023.00055
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
    View:206
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    Review
    Neuroprotective astroglial response to neural damage and its relevance to affective disorders
    Astrocytes not only support neuronal function with essential roles in synaptic neurotransmission, action potential propagation, metabolic support, or neuroplastic and developmental adaptations. They [...] Read more.
    José Javier Miguel-Hidalgo
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:328–345
    DOI: https://doi.org/10.37349/ent.2023.00054
    This article belongs to the special issue Glia and Neuroprotection
    View:259
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    Original Article
    Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models of neurodegenerative disease
    Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)]. The correlation between αSyn patho [...] Read more.
    Bianca Vlcek ... Åsa Wallén-Mackenzie
    Published: October 30, 2023 Explor Neuroprot Ther. 2023;3:299–327
    DOI: https://doi.org/10.37349/ent.2023.00053
    This article belongs to the special issue Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinsons Disease
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    Review
    The effects of post-translational modifications on alpha-synuclein aggregation and immune cell activation in Parkinson’s disease
    Post-translational modifications (PTMs) of alpha-synuclein (α-syn) can alter protein aggregation propensity to affect α-syn oligomer and fibril formation. The inflammatory response in Parkinson’ [...] Read more.
    Zaina Khan, Yoo Jin Jung
    Published: October 26, 2023 Explor Neuroprot Ther. 2023;3:281–298
    DOI: https://doi.org/10.37349/ent.2023.00052
    This article belongs to the special issue Parkinson’s Disease: Principal Targets and Interventional Mechanisms
    View:239
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    Original Article
    Cognitive recovery in psychiatric disorders: transdiagnostic interdisciplinary intervention in a high intensity partial psychiatric in-patient unit
    Aim: The present study aims to analyze the impact on cognitive recovery of an interdisciplinary treatment for acute and severe psychiatric patients. Methods: The present research is a natur [...] Read more.
    Ana Isabel De Santiago-Díaz ... Elsa Gómez-Ruiz
    Published: October 26, 2023 Explor Neuroprot Ther. 2023;3:268–280
    DOI: https://doi.org/10.37349/ent.2023.00051
    This article belongs to the special issue Cognitive Alterations in Psychiatry
    View:206
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    Original Article
    Cannabinoid CB2 receptor ligands disrupt the sequential regulation of p-MEK1/2 to p-ERK1/2 in mouse brain cortex
    Aim The sequential phosphorylation of mitogen-activated protein (MAP) kinases MEK-ERK is the most relevant cellular signaling pathway. This study quantified the parallel in vivo regulation of bra [...] Read more.
    Glòria Salort ... Jesús A. García-Sevilla
    Published: October 24, 2023 Explor Neuroprot Ther. 2023;3:258–267
    DOI: https://doi.org/10.37349/ent.2023.00050
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:293
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    Review
    Rehabilitation for non-motor symptoms for patients with Parkinson’s disease from an α-synuclein perspective: a narrative review
    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbr [...] Read more.
    Zhaoyang Liu ... Wen Liu
    Published: August 27, 2023 Explor Neuroprot Ther. 2023;3:235–257
    DOI: https://doi.org/10.37349/ent.2023.00049
    This article belongs to the special issue Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
    View:413
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    Review
    Targeting α-synuclein aggregation with immunotherapy: a promising therapeutic approach for Parkinson’s disease
    Parkinson’s disease (PD) is a prevalent neurodegenerative disease (NDD) affecting millions of individuals. The pathogenesis of PD centers around α-synuclein (α-Syn), a pivotal protein whose aggr [...] Read more.
    Gabriela Henriquez, Mahesh Narayan
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:207–234
    DOI: https://doi.org/10.37349/ent.2023.00048
    This article belongs to the special issue Parkinsons Disease: Principal Targets and Interventional Mechanisms
    View:442
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    Review
    Diffusion magnetic resonance imaging-based surrogate marker in amyotrophic lateral sclerosis
    Amyotrophic lateral sclerosis (ALS) is the most prevalent type of motor neuron disease (MND) and is diagnosed with a delay from the first appearance of symptoms. Surrogate markers that may be used t [...] Read more.
    Yuya Saito
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:186–206
    DOI: https://doi.org/10.37349/ent.2023.00047
    This article belongs to the special issue Biomarkers in Amyotrophic Lateral Sclerosis
    Open Access
    Case Report
    Tension pneumocephalus as a complication of surgical evacuation of chronic subdural hematoma: case report and literature review
    The management of symptomatic chronic subdural hematoma (CSDH) is surgical evacuation and prognosis in most cases is good. Tension pneumocephalus is the presence of air under pressure in the intracr [...] Read more.
    Mohammed A. Azab ... Brandon Lucke-Wold
    Published: August 23, 2023 Explor Neuroprot Ther. 2023;3:177–185
    DOI: https://doi.org/10.37349/ent.2023.00046
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:338
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    Review
    Muscle fatigue and exercise-related biomarkers in amyotrophic lateral sclerosis
    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder affecting motor neurons. The complex etiopathogenetic mechanism of ALS can lead to extensive alterations, including co [...] Read more.
    Francesca Bianchi ... Gabriele Siciliano
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:164–176
    DOI: https://doi.org/10.37349/ent.2023.00045
    This article belongs to the special issue Biomarkers in Amyotrophic Lateral Sclerosis
    View:416
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    Review
    Looking at the periphery—new hypothesis to look for new targets for Alzheimer’s disease therapy
    Currently, the predominant targets for the treatment of Alzheimer’s disease (AD) are the main components of the two pathological structures: senile plaques (composed of amyloid beta peptide aggreg [...] Read more.
    Jesús Avila ... Félix Hernández
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:151–163
    DOI: https://doi.org/10.37349/ent.2023.00044
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
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    Original Article
    Alzheimer’s disease detection from magnetic resonance imaging: a deep learning perspective
    Aim: Up to date many successful attempts to identify various types of lesions with machine learning (ML) were made, however, the recognition of Alzheimer’s disease (AD) from brain images and inter [...] Read more.
    Karolina Armonaite ... Luigi Laura
    Published: June 30, 2023 Explor Neuroprot Ther. 2023;3:139–150
    DOI: https://doi.org/10.37349/ent.2023.00043
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
    View:496
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    Original Article
    Efficacy of memantine compared with sodium valproate as prophylactic treatment for migraine: a controlled randomized pilot study
    Aim: To compare the efficacy of memantine with that of valproate as a prophylactic treatment for episodic migraine within three months. The efficacy, safety, and response rate were evaluated.  [...] Read more.
    Damaris Vazquez-Guevara ... Ildefonso Rodriguez-Leyva
    Published: April 28, 2023 Explor Neuroprot Ther. 2023;3:131–138
    DOI: https://doi.org/10.37349/ent.2023.00042
    View:431
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    Review
    Reversible cerebral vasoconstriction syndrome: a clinical and therapeutic challenge
    Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by thunderclap headache and intracranial segmental vasoconstriction with or without signs of neurological deficit with a variabl [...] Read more.
    Andrés Ricaurte-Fajardo ... Nathalia Melo Gonzalez
    Published: April 28, 2023 Explor Neuroprot Ther. 2023;3:120–130
    DOI: https://doi.org/10.37349/ent.2023.00041
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:582
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    Review
    Epigenetic and non-epigenetic mechanisms in the accelerated cellular aging in late-onset Alzheimer’s disease
    Late-onset Alzheimer's disease (LOAD) is the most common form of Alzheimer's disease (AD) and its risk increases exponentially with aging. The incidence of LOAD is reported to  [...] Read more.
    Kajal Rawat, Prathiba Garlapally
    Published: April 28, 2023 Explor Neuroprot Ther. 2023;3:105–119
    DOI: https://doi.org/10.37349/ent.2023.00040
    This article belongs to the special issue Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
    View:556
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    Review
    Innate and adaptive glial cell responses in Alzheimer’s disease
    Alzheimer’s disease (AD), which affects around twenty-seven million people globally, is an aging-related neurodegenerative condition characterized by the extracellular deposition of misfolded amyl [...] Read more.
    Ankita Singh, Tiratha Raj Singh
    Published: April 03, 2023 Explor Neuroprot Ther. 2023;3:90–104
    DOI: https://doi.org/10.37349/ent.2023.00039
    This article belongs to the special issue Glia and Neuroprotection
    View:633
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    Review
    The role of microbiota-gut-brain axis in neurodegenerative diseases: biochemical and therapeutic aspects
    The enteric nervous system (ENS) is considered by some authors as the second human brain, given its fundamental role in the regulation process of the central nervous system (CNS). Recent data from s [...] Read more.
    Januário T. Ernesto ... Cláudio Viegas Jr.
    Published: March 29, 2023 Explor Neuroprot Ther. 2023;3:71–89
    DOI: https://doi.org/10.37349/ent.2023.00038
    View:785
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    Review
    Neuroprotective agents in acute ischemic stroke
    Acute ischemic stroke (AIS) is the leading cause of disability and one of the top causes of mortality worldwide. The current standard of care is reperfusion therapy including intravenous thrombolysi [...] Read more.
    Grace YY Chia ... Benjamin YQ Tan
    Published: February 28, 2023 Explor Neuroprot Ther. 2023;3:47–70
    DOI: https://doi.org/10.37349/ent.2023.00037
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:945
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    Review
    Pathophysiology of non-motor signs in Parkinson’s disease: some recent updating with brief presentation
    Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting 1% of the population above sixty years. It is caused by an interaction between genetic and envi [...] Read more.
    Khaled Radad ... Wolf-Dieter Rausch
    Published: February 27, 2023 Explor Neuroprot Ther. 2023;3:24–46
    DOI: https://doi.org/10.37349/ent.2023.00036
    This article belongs to the special issue Parkinsons Disease: Principal Targets and Interventional Mechanisms
    View:567
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    Review
    Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?
    There is no approved drug capable of halting the progression of the most prevalent neurodegenerative disorders, namely Alzheimer's disease (AD) and Parkinson's disease (PD).  [...] Read more.
    Rafael Franco, Joan Serrano-Marín
    Published: February 27, 2023 Explor Neuroprot Ther 2023;3:8–23
    DOI: https://doi.org/10.37349/ent.2023.00035
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimers Disease
    Open Access
    Perspective
    Machine learning as a new tool in neurological disease prevention, diagnosis, and treatment
    More than 600 different neurological diseases affect the human population. Some of these are genetic and can emerge even before birth, and some are caused by defects, infections, trauma, degeneratio [...] Read more.
    Cinzia Volonté
    Published: February 21, 2023 Explor Neuroprot Ther. 2023;3:1–7
    DOI: https://doi.org/10.37349/ent.2023.00034
    View:616
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    Review
    Biomarkers in small fiber neuropathy
    Small fiber neuropathy (SFN) is a relatively common, but largely understudied neurological syndrome which has affected the lives of many globally. The common symptoms of SFN include pain, dysesthesi [...] Read more.
    Amanda C. Y. Chan ... Joy Vijayan
    Published: December 30, 2022 Explor Neuroprot Ther. 2022;2:264–283
    DOI: https://doi.org/10.37349/ent.2022.00033
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:1706
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    Case Report
    Catatonia in two women with Parkinson’s disease treated with electroconvulsive therapy
    Catatonia is a neuropsychiatric syndrome characterized by a broad range of motor, behavioral and cognitive abnormalities. Catatonia and Parkinson’s disease (PD) may show partially overlapping symptomatology. For this reason, cat [...] Read more.
    Camilla Elefante ... Giulio Perugi
    Published: December 28, 2022 Explor Neuroprot Ther. 2022;2:256–263
    DOI: https://doi.org/10.37349/ent.2022.00032
    This article belongs to the special issue Cognitive Alterations in Psychiatry
    View:935
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    Case Report
    Dry needling with electrical stimulation for the treatment of a pediatric patient with spastic cerebral palsy: a case report
    The patient was a 6-year-old child with spastic quadriplegic cerebral palsy (CP) categorized with the gross motor function classification system (GMFCS) as a level IV and a Modified Modified Ashwort [...] Read more.
    Temrah Okonski, Jan Dommerholt
    Published: November 16, 2022 Explor Neuroprot Ther. 2022;2:242–255
    DOI: https://doi.org/10.37349/ent.2022.00031
    This article belongs to the special issue Dry Needling for Neurological Disorders
    View:824
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    Review
    Blockage of thrombospondin 4 secreted by spinal astrocytes may be a promising therapeutic target in the treatment of neuropathic pain
    Neuropathic pain (NP), which is difficult to treat, remains a heavy burden for both individuals and society. The efficacy of current treatments is insufficient. The pathophysiology of NP is still no [...] Read more.
    Neslihan Düzenli ... Aytül Önal
    Published: October 31, 2022 Explor Neuroprot Ther. 2022;2:226–241
    DOI: https://doi.org/10.37349/ent.2022.00030
    This article belongs to the special issue Glia and Neuroprotection
    View:949
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    Review
    Overview of biomarkers in myasthenia gravis
    Myasthenia gravis (MG) is a rare auto-immune neuromuscular junction (NMJ) disorder which is caused by formation of autoantibodies and destruction of NMJ components. The MG diagnosis is based on the  [...] Read more.
    Fatemeh Afrashteh, Rayan Rajabi
    Published: October 31, 2022 Explor Neuroprot Ther. 2022;2:210–225
    DOI: https://doi.org/10.37349/ent.2022.00029
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:1007
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    Review
    Toll-like receptor 4 in the interface between neuroimmune response and behavioral alterations caused by stress
    Different stressors can elicit neuroinflammatory responses modulated by innate immunity receptors, such as the family of Toll-like receptors (TLRs). The TLR4, a pattern recognition receptor (PRR), i [...] Read more.
    Fábio José Coelho Souza-Junior ... Sabrina Francesca Lisboa
    Published: October 31, 2022 Explor Neuroprot Ther. 2022;2:182–209
    DOI: https://doi.org/10.37349/ent.2022.00028
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:1172
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    Case Report
    Paraclinoid unruptured giant aneurysm with therapeutic success
    The global prevalence of intracranial aneurysms (IA) ranges from 5–10%, with a demographic variation. Large and giant aneurysms typically involve cavernous and paraclinoid se [...] Read more.
    Gonçalo Januário
    Published: August 30, 2022 Explor Neuroprot Ther. 2022;2:174–181
    DOI: https://doi.org/10.37349/ent.2022.00027
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:839
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    Review
    Delayed cerebral ischemia and therapeutic approaches after subarachnoid hemorrhage
    Delayed cerebral ischemia after subarachnoid hemorrhage is one of the most important causes of mortality and poor functional outcome in patients. Initially, the etiology and treatment of delayed cer [...] Read more.
    Fettah Eren ... Sueda Ecem Yilmaz
    Published: August 22, 2022 Explor Neuroprot Ther. 2022;2:162–173
    DOI: https://doi.org/10.37349/ent.2022.00026
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:867
    Download:51
    Times Cited: 0
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    Review
    Autism: genetics, environmental stressors, maternal immune activation, and the male bias in autism
    Autism spectrum disorder (ASD) is a class of neurodevelopmental disorders (NDD) characterized by deficits in three domains: impairments in social interactions, language, and communication, and increased stereotyped restrictive/rep [...] Read more.
    Sarah Otaru, David A. Lawrence
    Published: August 11, 2022 Explor Neuroprot Ther. 2022;2:141–161
    DOI: https://doi.org/10.37349/ent.2022.00025
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:1173
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    Review
    Economics of dry needling and botulinum toxin type A for treatment of post-stroke spasticity: a review
    Stroke is one of the most common causes of disability and exerts a high burden of direct and indirect costs. Stroke may cause spasticity, which limits patients’ abilities and affects the [...] Read more.
    Daniel Fernández ... Eva María Gómez-Trullén
    Published: June 30, 2022 Explor Neuroprot Ther. 2022;2:131–140
    DOI: https://doi.org/10.37349/ent.2022.00024
    This article belongs to the special issue Dry Needling for Neurological Disorders
    View:1027
    Download:62
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:1421
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    Open Access
    Perspective
    Can meditation-based approaches improve the cleansing power of the glymphatic system?
    The glymphatic system, first described in 2012, is a brain-wide perivascular network that plays an important role in promoting interstitial metabolic waste removal from the brain. Glymphatic pathway [...] Read more.
    Peter Wostyn, Piet Goddaer
    Published: June 20, 2022 Explor Neuroprot Ther. 2022;2:110–117
    DOI: https://doi.org/10.37349/ent.2022.00022
    View:1683
    Download:67
    Open Access
    Original Article
    Combined effects of dry needling and exercises therapy on muscle spasticity and motor function in chronic stroke: a pretest-posttest pilot study
    Aim: Spasticity is one of the most common symptoms in post-stroke patients. Dry needling (DN) is a relatively new method for the management of muscle spasticity. A multimodal treatment may be mor [...] Read more.
    Seyedeh Saeideh Babazadeh-Zavieh ... Korosh Mansoori
    Published: June 20, 2022 Explor Neuroprot Ther. 2022;2:100–109
    DOI: https://doi.org/10.37349/ent.2022.00021
    This article belongs to the special issue Dry Needling for Neurological Disorders
    Open Access
    Review
    The role of physical activity against chemotherapy-induced peripheral neuropathy: a narrative review
    Several studies investigated the side effect of adjuvant cancer treatments, and different types of preventive techniques or treatments have been assessed. Chemotherapy-induced peripheral neuropathy  [...] Read more.
    Daniele Diotti ... Lucio Marinelli
    Published: April 28, 2022 Explor Neuroprot Ther. 2022;2:87–99
    DOI: https://doi.org/10.37349/ent.2022.00020
    View:1363
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    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:4505
    Download:1363
    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    View:2015
    Download:54
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:2745
    Download:130
    Open Access
    Review
    Dry needling in stroke
    Stroke causes acute neurological deficit which is an important cause of morbidity and mortality. Neurorehabilitation is an important dimension in the management of post-stroke deficits. Spasticity,  [...] Read more.
    Nirmal Surya, Guhan Ramamurthy
    Published: February 17, 2022 Explor Neuroprot Ther. 2022;2:28–35
    DOI: https://doi.org/10.37349/ent.2022.00016
    This article belongs to the special issue Dry Needling for Neurological Disorders
    View:2155
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    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
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    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr [...] Read more.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    Open Access
    Review
    Targeting cytochrome P450 46A1 and brain cholesterol 24-hydroxylation to treat neurodegenerative diseases
    The brain cholesterol content is determined by the balance between the pathways of in situ biosynthesis and cholesterol elimination via 24-hydroxylation catalyzed by cytochrome P450 46A1 (CYP46A1).  [...] Read more.
    Irina A. Pikuleva
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:159–172
    DOI: https://doi.org/10.37349/ent.2021.00013
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1726
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    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het [...] Read more.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:1504
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    Open Access
    Review
    Peroxisomes in intracellular cholesterol transport: from basic physiology to brain pathology
    Peroxisomes are actively involved in the metabolism of various lipids including fatty acids, ether phospholipids, bile acids as well as the processing of reactive oxygen and nitrogen species. Recent [...] Read more.
    Jian Xiao ... Jie Luo
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:127–145
    DOI: https://doi.org/10.37349/ent.2021.00011
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2206
    Download:115
    Open Access
    Perspective
    Maternal imprinting, mitochondrial DNA, nuclear DNA and Alzheimer’s disease
    Familial early-onset Alzheimer’s disease (AD) is more probable in individuals coming from mothers diagnosed with AD than from fathers diagnosed with AD. Studies in animal models have show [...] Read more.
    Alberto Pérez-Mediavilla, Marta Zamarbide
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:121–126
    DOI: https://doi.org/10.37349/ent.2021.00010
    View:923
    Download:34
    Times Cited: 0
    Open Access
    Review
    Immunization with neural-derived peptides as a neuroprotective therapy for spinal cord injury
    Spinal cord injury (SCI) induces several destructive events that develop immediately after the primary insult. These phenomena increase tissue damage; that is why, numerous therapeutic approaches ar [...] Read more.
    Andrea Paola Ibarra-García, Antonio Ibarra
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:111–120
    DOI: https://doi.org/10.37349/ent.2021.00009
    View:1009
    Download:48
    Times Cited: 0
    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:4357
    Download:248
    Open Access
    Review
    T-cell based immunotherapies for Parkinson’s disease
    Current evidence indicates that neurodegeneration of dopaminergic neurons of the substantia nigra associated to Parkinson's disease is a consequence of a neuroinflammatory process in whic [...] Read more.
    Rodrigo Pacheco
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:72–85
    DOI: https://doi.org/10.37349/ent.2021.00007
    View:1787
    Download:101
    Open Access
    Review
    Therapeutic potential of the cannabinoid receptor 2 in neuropsychiatry
    Since the identification and cloning of the cannabinoid receptor 2 (CB2R), several studies focused on the characterization of its physiological and pathological role. Initially, CB2R was considered  [...] Read more.
    María S. García-Gutiérrez ... Jorge Manzanares
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:55–71
    DOI: https://doi.org/10.37349/ent.2021.00006
    View:3500
    Download:208
    Open Access
    Review
    Gut microbial imbalance and neurodegenerative proteinopathies: from molecular mechanisms to prospects of clinical applications
    The pathogenic basis behind some of the most prevalent neurodegenerative diseases in advanced societies, known as proteinopathies, deals with alterations in protein homeostasis. Despite the broad di [...] Read more.
    Paula Alonso-García ... Eva Martínez-Pinilla
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:33–54
    DOI: https://doi.org/10.37349/ent.2021.00005
    View:1996
    Download:85
    Times Cited: 0
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:3374
    Download:202
    Open Access
    Review
    Cholesterol in autism spectrum disorders
    The autism spectrum disorder (ASD) comprises a series of neurological diseases that share serious alterations of the development of the central nervous system. The degree of disability may vary so t [...] Read more.
    Rafael Franco ... Irene Reyes-Resina
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:10–18
    DOI: https://doi.org/10.37349/ent.2021.00003
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:2858
    Download:94
    Times Cited: 0
    Open Access
    Letter to the Editor
    P2X7 receptor involvement in COVID-19 disease
    Peter Illes
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:7–9
    DOI: https://doi.org/10.37349/ent.2021.00002
    View:987
    Download:39
    Times Cited: 0
    Open Access
    Editorial
    Science plus technology to address challenges in determining the efficacy of neuroprotective/neurorestorative therapies
    Rafael Franco
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:1–6
    DOI: https://doi.org/10.37349/ent.2021.00001
    View:1544
    Download:31