• 275 results in Exploration of Targeted Anti-tumor Therapy
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    Original Article
    Predictive markers of response to immune checkpoint inhibitor rechallenge in metastatic non-small cell lung cancer
    Aim: The present study aims to evaluate the efficacy of rechallenge with immune checkpoint inhibitors (ICIs) compared to chemotherapy and the predictive role of clinical parameters in non-small c [...] Read more.
    Aram A. Musaelyan ... Sergey V. Orlov
    Published: October 18, 2024 Explor Target Antitumor Ther. 2024;5:1271–1288
    DOI: https://doi.org/10.37349/etat.2024.00275
    This article belongs to the special issue Immunotherapy Strategies for Non-small Cell Lung Cancer
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    Open Access
    Case Report
    Upper tract urothelial cancer (UTUC) genomic profiling and correlation regarding benefit of platinum-based chemotherapy
    Upper tract urothelial cancer (UTUC) are rare subsets of urothelial cancer, which typically present with more aggressive course. Molecular markers stratifying urothelial tumors as luminal subtype an [...] Read more.
    Min Woo Hwang ... Jeanny B. Aragon-Ching
    Published: October 17, 2024 Explor Target Antitumor Ther. 2024;5:1261–1270
    DOI: https://doi.org/10.37349/etat.2024.00274
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
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    Open Access
    Review
    Evidence for the evolving role of neoadjuvant and perioperative immunotherapy in resectable non-small cell lung cancer
    The treatment of early-stage non-small cell lung cancer (NSCLC) is becoming increasingly complex. Standard of care management for the past decade has been adjuvant chemotherapy following curative in [...] Read more.
    Thomas Hansen ... Udit Nindra
    Published: September 29, 2024 Explor Target Antitumor Ther. 2024;5:1247–1260
    DOI: https://doi.org/10.37349/etat.2024.00273
    This article belongs to the special issue Immunotherapy Strategies for Non-small Cell Lung Cancer
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    Open Access
    Review
    Exploring the therapeutic potential of lipid-based nanoparticles in the management of oral squamous cell carcinoma
    Oral squamous cell carcinoma (OSCC) is a highly malignant and invasive tumor with significant mortality and morbidity. Current treatment modalities such as surgery, radiotherapy, and chemotherapy en [...] Read more.
    Anis Ahmad Chaudhary ... Md. Rizwanullah
    Published: September 29, 2024 Explor Target Antitumor Ther. 2024;5:1223–1246
    DOI: https://doi.org/10.37349/etat.2024.00272
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    Open Access
    Review
    Blood-based circulating biomarkers for prediction of immune-checkpoint inhibitors efficacy in renal cell carcinoma
    Immune checkpoint inhibitors (ICI)-based combinations have become the standard first-line treatment for advanced clear cell renal cell carcinoma (ccRCC). Despite significant improvements in survival [...] Read more.
    Loubna Omri ... Lucía Carril-Ajuria
    Published: September 20, 2024 Explor Target Antitumor Ther. 2024;5:1199–1222
    DOI: https://doi.org/10.37349/etat.2024.00271
    This article belongs to the special issue Immune Checkpoint Therapy and Biomarkers in Cancer
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    Open Access
    Systematic Review
    Diagnostic and prognostic role of NLR in testicular cancer
    Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on [...] Read more.
    Shirin Sarejloo ... Brandon Lucke-Wold
    Published: September 19, 2024 Explor Target Antitumor Ther. 2024;5:1177–1198
    DOI: https://doi.org/10.37349/etat.2024.00270
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
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    Open Access
    Original Article
    Diagnostic utility of prostate health index density prior to MRI-ultrasound fusion targeted biopsy
    Aim: Prostate biopsy can be prone to complications and thus should be avoided when unnecessary. Although the combination of magnetic resonance imaging (MRI), the prostate health index (PHI), and  [...] Read more.
    Benjamin H. Press ... Preston C. Sprenkle
    Published: September 13, 2024 Explor Target Antitumor Ther. 2024;5:1168–1176
    DOI: https://doi.org/10.37349/etat.2024.00269
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    Open Access
    Review
    GPCRs as targets for flavonoids in cancer cells: new options for intervention
    For a long time, the family of receptor tyrosine kinases, including epidermal growth factor receptor and insulin-like growth factor 1 receptor, was regarded as the main players stimulating cell prol [...] Read more.
    Katrin Sak
    Published: August 30, 2024 Explor Target Antitumor Ther. 2024;5:1155–1167
    DOI: https://doi.org/10.37349/etat.2024.00268
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    Open Access
    Review
    Emerging molecular therapies in the treatment of bladder cancer
    Bladder cancer is a leading cancer type in men. The complexity of treatment in late-stage bladder cancer after systemic spread through the lymphatic system highlights the importance of modulating di [...] Read more.
    Scott D. Bell ... Yujiang Fang
    Published: August 29, 2024 Explor Target Antitumor Ther. 2024;5:1135–1154
    DOI: https://doi.org/10.37349/etat.2024.00267
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
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    Times Cited: 0
    Open Access
    Review
    Therapy resistance in prostate cancer: mechanism, signaling and reversal strategies
    Prostate cancer (PC) depicts a major health challenge all over the globe due to its complexities in the treatment and diverse clinical trajectories. Even in the advances in the modern treatment stra [...] Read more.
    Neha Thakur ... Sunny Dholpuria
    Published: August 29, 2024 Explor Target Antitumor Ther. 2024;5:1110–1134
    DOI: https://doi.org/10.37349/etat.2024.00266
    This article belongs to the special issue Mechanisms of Targeted Therapy Resistance and Reversal Strategies
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