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  • 318 results in Exploration of Targeted Anti-tumor Therapy
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    Open Access
    Original Article
    Prognostic impact of biomarkers in PMBCL: rationale for early integration of immune checkpoint inhibitors
    Aim: This research aims to guide future strategies for personalized treatment of primary mediastinal large B-cell lymphoma (PMBCL), particularly to identify high-risk patients who may benefit fro [...] Read more.
    Yana K. Mangasarova ... Andrey B. Sudarikov
    Published: May 20, 2025 Explor Target Antitumor Ther. 2025;6:1002318
    DOI: https://doi.org/10.37349/etat.2025.1002318
    This article belongs to the special issue Immune Checkpoint Therapy and Biomarkers in Cancer
    View:46
    Download:3
    Times Cited: 0
    Open Access
    Commentary
    The role of circulating tumor DNA (ctDNA) in urothelial cancers
    The role of circulating tumor DNA (ctDNA) in urothelial cancers is a rapidly evolving area of research. Urothelial cancer is the most common subtype of bladder cancer, and biomarkers that predict re [...] Read more.
    Jeanny B. Aragon-Ching
    Published: May 19, 2025 Explor Target Antitumor Ther. 2025;6:1002317
    DOI: https://doi.org/10.37349/etat.2025.1002317
    This article belongs to the special issue ​Liquid Biopsy: Has Already Changed the Clinical Decision-Making in Solid Tumors Treatment?​​
    View:59
    Download:5
    Times Cited: 0
    Open Access
    Systematic Review
    Utility of CA-125 for diagnosis and prognosis of breast cancer: a systematic review
    Background: Different tumor markers are utilized in the assessment of breast cancer. The function of these markers in assessing, tracking, and following up on breast cancer has drawn the interest [...] Read more.
    Zohre Momenimovahed ... Ibrahim Alkatout
    Published: May 15, 2025 Explor Target Antitumor Ther. 2025;6:1002316
    DOI: https://doi.org/10.37349/etat.2025.1002316
    View:150
    Download:5
    Times Cited: 0
    Open Access
    Review
    Harnessing the power of tumor-draining lymph nodes: unveiling predictive biomarkers for immune checkpoint inhibitor
    With the escalating application of immune checkpoint inhibitors (ICIs) in solid tumors, these therapies have demonstrated clinical benefits but remain hampered by relatively low response rates. Reli [...] Read more.
    Zihan Chen ... Lei Wang
    Published: May 13, 2025 Explor Target Antitumor Ther. 2025;6:1002315
    DOI: https://doi.org/10.37349/etat.2025.1002315
    This article belongs to the special issue Novel Biomarkers in the Immunotherapy Era
    View:169
    Download:10
    Times Cited: 0
    Open Access
    Review
    The development and applications of circulating tumour cells, circulating tumour DNA and other emerging biomarkers for early cancer detection
    Despite major improvements in cancer treatment, detection, and health promotion, the mortality rates of late-stage cancer remain high. This is a critical issue because a large proportion of cancer m [...] Read more.
    David Sinclair Thomas Junior ... Yong-Jie Lu
    Published: May 13, 2025 Explor Target Antitumor Ther. 2025;6:1002314
    DOI: https://doi.org/10.37349/etat.2025.1002314
    View:173
    Download:5
    Times Cited: 0
    Open Access
    Review
    Neoantigen-based immunotherapy: advancing precision medicine in cancer and glioblastoma treatment through discovery and innovation
    Neoantigen-based immunotherapy has emerged as a transformative approach in cancer treatment, offering precision medicine strategies that target tumor-specific antigens derived from genetic, transcri [...] Read more.
    Moawiah M Naffaa ... Valiko Begiashvili
    Published: April 27, 2025 Explor Target Antitumor Ther. 2025;6:1002313
    DOI: https://doi.org/10.37349/etat.2025.1002313
    View:649
    Download:18
    Times Cited: 0
    Open Access
    Review
    Cytokine-based immunotherapy for gastric cancer: targeting inflammation for tumor control
    Emerging cancer immunotherapy methods, notably cytokine-based ones that modify immune systems’ inflammatory reactions to tumor cells, may help slow gastric cancer progression. Cytokines, tiny sign [...] Read more.
    Mathan Muthu Chinakannu Marimuthu ... Hitesh Chopra
    Published: April 26, 2025 Explor Target Antitumor Ther. 2025;6:1002312
    DOI: https://doi.org/10.37349/etat.2025.1002312
    View:418
    Download:8
    Times Cited: 0
    Open Access
    Review
    Viral infections and immune modulation in bladder cancer: implications for immunotherapy
    This review explores the intricate relationship between viral infections and Bacillus Calmette-Guerin (BCG) efficacy, emphasizing immune modulation mechanisms that may influence treatment outcomes.  [...] Read more.
    Lívia Bitencourt Pascoal ... Leonardo O. Reis
    Published: April 24, 2025 Explor Target Antitumor Ther. 2025;6:1002311
    DOI: https://doi.org/10.37349/etat.2025.1002311
    This article belongs to the special issue Comprehensive Immunotherapy of Solid Tumors
    View:373
    Download:8
    Times Cited: 0
    Open Access
    Review
    Modulation of anti-tumour immunity by XPO1 inhibitors
    Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients. As such,  [...] Read more.
    Jack G. Fisher ... Matthew D. Blunt
    Published: April 23, 2025 Explor Target Antitumor Ther. 2025;6:1002310
    DOI: https://doi.org/10.37349/etat.2025.1002310
    This article belongs to the special issue Immune Checkpoint Therapy and Biomarkers in Cancer
    View:698
    Download:22
    Times Cited: 0
    Open Access
    Case Report
    Eosinophil cytolysis with or without ETosis in four cases of human gastric cancer: a comparative ultrastructural study
    The ultrastructural morphology of eosinophil cytolysis and extracellular trap cell death (ETosis) has predominantly been examined in non-neoplastic eosinophil-associated diseases, with a limited inv [...] Read more.
    Rosario Caruso ... Luciana Rigoli
    Published: April 21, 2025 Explor Target Antitumor Ther. 2025;6:1002309
    DOI: https://doi.org/10.37349/etat.2025.1002309
    View:265
    Download:9
    Times Cited: 0
    Open Access
    Review
    Nanoimmunotherapy: the smart trooper for cancer therapy
    Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body’s immune system to fight cancer. Despite initial successes, its broader clinical appli [...] Read more.
    Suphiya Parveen ... Fahima Dilnawaz
    Published: April 10, 2025 Explor Target Antitumor Ther. 2025;6:1002308
    DOI: https://doi.org/10.37349/etat.2025.1002308
    This article belongs to the special issue Comprehensive Immunotherapy of Solid Tumors
    View:535
    Download:16
    Times Cited: 0
    Open Access
    Review
    Strategies to overcome resistance to enfortumab vedotin and pembrolizumab for patients with urothelial carcinoma: harnessing present knowledge for future advances
    The combination of enfortumab vedotin and pembrolizumab (EVP) has been recently approved for patients with locally advanced and metastatic urothelial carcinoma. This combination showed a higher obje [...] Read more.
    Albert Jang, Jason R. Brown
    Published: April 07, 2025 Explor Target Antitumor Ther. 2025;6:1002307
    DOI: https://doi.org/10.37349/etat.2025.1002307
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
    View:565
    Download:23
    Times Cited: 0
    Open Access
    Review
    Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review
    The purpose of this review was to provide a comprehensive review of the latest insights on the pathogenesis of uveal melanoma (UM) and its intracellular pathways. This article covers the epidemiolog [...] Read more.
    Majid Banimohammad ... Hamidreza Pazoki-Toroudi
    Published: April 02, 2025 Explor Target Antitumor Ther. 2025;6:1002306
    DOI: https://doi.org/10.37349/etat.2025.1002306
    This article belongs to the special issue Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era
    View:812
    Download:19
    Times Cited: 0
    Open Access
    Short Communication
    Real-world outcomes of lenvatinib plus pembrolizumab in intermediate- and poor-risk metastatic renal cell carcinoma
    The combination of lenvatinib and pembrolizumab (Len + Pembro) demonstrated significant efficacy in the phase 3 CLEAR study for metastatic renal cell carcinoma (RCC). However, poor-risk patients rep [...] Read more.
    Ilya Tsimafeyeu ... Mark Gluzman
    Published: April 01, 2025 Explor Target Antitumor Ther. 2025;6:1002305
    DOI: https://doi.org/10.37349/etat.2025.1002305
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
    View:2651
    Download:68
    Times Cited: 0
    Open Access
    Review
    Key immune cells and their crosstalk in the tumor microenvironment of bladder cancer: insights for innovative therapies
    Bladder cancer (BC) is a heterogeneous disease associated with high mortality if not diagnosed early. BC is classified into non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC), with MIBC li [...] Read more.
    Anna Di Spirito ... Lorenzo Mortara
    Published: March 31, 2025 Explor Target Antitumor Ther. 2025;6:1002304
    DOI: https://doi.org/10.37349/etat.2025.1002304
    This article belongs to the special issue Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
    View:849
    Download:15
    Times Cited: 0
    Open Access
    Review
    State-of-the-art photodynamic therapy for malignant gliomas: innovations in photosensitizers and combined therapeutic approaches
    Glioblastoma (GBM), the most aggressive and lethal primary brain tumor, poses a significant therapeutic challenge due to its highly invasive nature and resistance to conventional therapies, includin [...] Read more.
    Bruno A. Cesca ... Luis E. Ibarra
    Published: March 28, 2025 Explor Target Antitumor Ther. 2025;6:1002303
    DOI: https://doi.org/10.37349/etat.2025.1002303
    Open Access
    Review
    Advances in adoptive cell therapies in small cell lung cancer
    Small cell lung cancer (SCLC) is an aggressive tumor characterized by early metastasis and resistance to treatment making it a prime target for therapeutic investigation. The current standard of car [...] Read more.
    Eljie Isaak Bragasin ... Robert Hsu
    Published: March 26, 2025 Explor Target Antitumor Ther. 2025;6:1002302
    DOI: https://doi.org/10.37349/etat.2025.1002302
    This article belongs to the special issue Comprehensive Immunotherapy of Solid Tumors
    View:955
    Download:22
    Times Cited: 0
    Open Access
    Review
    Bladder cancer biomarkers
    Bladder cancer (BCa) is among the most frequently diagnosed urinary tract cancers, characterized by a high recurrence rate and significant clinical heterogeneity. Effective diagnosis and treatment o [...] Read more.
    Dominik Godlewski ... David Aebisher
    Published: March 25, 2025 Explor Target Antitumor Ther. 2025;6:1002301
    DOI: https://doi.org/10.37349/etat.2025.1002301
    View:666
    Download:9
    Times Cited: 0
    Open Access
    Meta-Analysis
    A systematic review and meta-analysis of phase III randomized controlled trials to assess the risk of pneumonia, URTIs, and VTE in multiple myeloma patients treated with isatuximab
    Background: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of malignant plasma cells in the bone marrow, constituting approximately 13% of all hematol [...] Read more.
    Daniel Thomas Jones ... Thura Win Htut
    Published: March 19, 2025 Explor Target Antitumor Ther. 2025;6:1002300
    DOI: https://doi.org/10.37349/etat.2025.1002300
    View:706
    Download:23
    Times Cited: 0
    Open Access
    Review
    Pancreatic cancer: failures and hopes—a review of new promising treatment approaches
    Pancreatic cancer is a challenging disease with limited treatment options and a high mortality rate. Just few therapy advances have been made in recent years. Tumor microenvironment, immunosuppressi [...] Read more.
    Vittore Cereda, Mario Rosario D’Andrea
    Published: March 18, 2025 Explor Target Antitumor Ther. 2025;6:1002299
    DOI: https://doi.org/10.37349/etat.2025.1002299
    View:1103
    Download:18
    Times Cited: 0