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  • 323 results in Exploration of Targeted Anti-tumor Therapy
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    Open Access
    Original Article
    Mutational landscape of epidermoid carcinoma of the penis in a Brazilian cohort
    Aim: Penile cancer (PeCa) is a rare malignancy strongly associated with poor genital hygiene and is more prevalent in regions with low socioeconomic status. PeCa accounts for approximately 2% to  [...] Read more.
    Renato Mendes Rossi De Lucca ... Rodolfo Borges dos Reis
    Published: June 06, 2025 Explor Target Antitumor Ther. 2025;6:1002323
    DOI: https://doi.org/10.37349/etat.2025.1002323
    This article belongs to the special issue Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era
    View:130
    Download:7
    Times Cited: 0
    Open Access
    Review
    Role of exosomes in transforming growth factor-β-mediated cancer cell plasticity and drug resistance
    Transforming growth factor-β (TGF-β) is a multifunctional molecule with a dual role in carcinogenesis. Recent studies have demonstrated its various effects on cancer-related processes. However, th [...] Read more.
    Tatiana Ruksha, Nadezhda Palkina
    Published: June 05, 2025 Explor Target Antitumor Ther. 2025;6:1002322
    DOI: https://doi.org/10.37349/etat.2025.1002322
    View:101
    Download:5
    Times Cited: 0
    Open Access
    Review
    Circulating tumor cells: overcoming challenges of detecting a needle in a haystack
    Circulating tumor cells (CTCs) are cancer cells that are detached from the primary and metastatic tumor site and invade the bloodstream. Most importantly, CTCs are the key players in the development [...] Read more.
    Zhuldyz Myrkhiyeva ... Aliya Bekmurzayeva
    Published: May 29, 2025 Explor Target Antitumor Ther. 2025;6:1002321
    DOI: https://doi.org/10.37349/etat.2025.1002321
    This article belongs to the special issue ​Liquid Biopsy: Has Already Changed the Clinical Decision-Making in Solid Tumors Treatment?​​
    View:320
    Download:13
    Times Cited: 0
    Open Access
    Original Article
    A viral circular RNA in Kaposi’s sarcoma-associated herpesvirus modulates viral and host gene expression during latent and lytic replication
    Aim: Circular RNA (circRNA) is a class of noncoding, single-stranded RNA generated by backsplicing, a process where the 5’ and 3’ ends of an RNA are covalently joined. Virally encoded circRNA [...] Read more.
    Soleil Torres ... Rolf Renne
    Published: May 29, 2025 Explor Target Antitumor Ther. 2025;6:1002320
    DOI: https://doi.org/10.37349/etat.2025.1002320
    This article belongs to the special issue Potential of Non-Coding RNAs in Cancer Research and Treatment
    View:282
    Download:8
    Times Cited: 0
    Open Access
    Review
    The DNA methylation landscape of musculoskeletal sarcomas
    Musculoskeletal sarcomas represent heterogeneous and rare malignant bone and soft tissue tumors, affecting children and adults. Patients exhibiting poor clinical outcomes are often described, being  [...] Read more.
    Mariana Chantre-Justino, Walter Meohas
    Published: May 26, 2025 Explor Target Antitumor Ther. 2025;6:1002319
    DOI: https://doi.org/10.37349/etat.2025.1002319
    View:242
    Download:12
    Times Cited: 0
    Open Access
    Original Article
    Prognostic impact of biomarkers in PMBCL: rationale for early integration of immune checkpoint inhibitors
    Aim: This research aims to guide future strategies for personalized treatment of primary mediastinal large B-cell lymphoma (PMBCL), particularly to identify high-risk patients who may benefit fro [...] Read more.
    Yana K. Mangasarova ... Andrey B. Sudarikov
    Published: May 20, 2025 Explor Target Antitumor Ther. 2025;6:1002318
    DOI: https://doi.org/10.37349/etat.2025.1002318
    This article belongs to the special issue Immune Checkpoint Therapy and Biomarkers in Cancer
    View:376
    Download:13
    Times Cited: 0
    Open Access
    Commentary
    The role of circulating tumor DNA (ctDNA) in urothelial cancers
    The role of circulating tumor DNA (ctDNA) in urothelial cancers is a rapidly evolving area of research. Urothelial cancer is the most common subtype of bladder cancer, and biomarkers that predict re [...] Read more.
    Jeanny B. Aragon-Ching
    Published: May 19, 2025 Explor Target Antitumor Ther. 2025;6:1002317
    DOI: https://doi.org/10.37349/etat.2025.1002317
    This article belongs to the special issue ​Liquid Biopsy: Has Already Changed the Clinical Decision-Making in Solid Tumors Treatment?​​
    View:286
    Download:18
    Times Cited: 0
    Open Access
    Systematic Review
    Utility of CA-125 for diagnosis and prognosis of breast cancer: a systematic review
    Background: Different tumor markers are utilized in the assessment of breast cancer. The function of these markers in assessing, tracking, and following up on breast cancer has drawn the interest [...] Read more.
    Zohre Momenimovahed ... Ibrahim Alkatout
    Published: May 15, 2025 Explor Target Antitumor Ther. 2025;6:1002316
    DOI: https://doi.org/10.37349/etat.2025.1002316
    View:427
    Download:9
    Times Cited: 0
    Open Access
    Review
    Harnessing the power of tumor-draining lymph nodes: unveiling predictive biomarkers for immune checkpoint inhibitor
    With the escalating application of immune checkpoint inhibitors (ICIs) in solid tumors, these therapies have demonstrated clinical benefits but remain hampered by relatively low response rates. Reli [...] Read more.
    Zihan Chen ... Lei Wang
    Published: May 13, 2025 Explor Target Antitumor Ther. 2025;6:1002315
    DOI: https://doi.org/10.37349/etat.2025.1002315
    This article belongs to the special issue Novel Biomarkers in the Immunotherapy Era
    View:439
    Download:15
    Times Cited: 0
    Open Access
    Review
    The development and applications of circulating tumour cells, circulating tumour DNA and other emerging biomarkers for early cancer detection
    Despite major improvements in cancer treatment, detection, and health promotion, the mortality rates of late-stage cancer remain high. This is a critical issue because a large proportion of cancer m [...] Read more.
    David Sinclair Thomas Junior ... Yong-Jie Lu
    Published: May 13, 2025 Explor Target Antitumor Ther. 2025;6:1002314
    DOI: https://doi.org/10.37349/etat.2025.1002314
    View:456
    Download:15
    Times Cited: 0
    Open Access
    Review
    Neoantigen-based immunotherapy: advancing precision medicine in cancer and glioblastoma treatment through discovery and innovation
    Neoantigen-based immunotherapy has emerged as a transformative approach in cancer treatment, offering precision medicine strategies that target tumor-specific antigens derived from genetic, transcri [...] Read more.
    Moawiah M Naffaa ... Valiko Begiashvili
    Published: April 27, 2025 Explor Target Antitumor Ther. 2025;6:1002313
    DOI: https://doi.org/10.37349/etat.2025.1002313
    View:1026
    Download:24
    Times Cited: 0
    Open Access
    Review
    Cytokine-based immunotherapy for gastric cancer: targeting inflammation for tumor control
    Emerging cancer immunotherapy methods, notably cytokine-based ones that modify immune systems’ inflammatory reactions to tumor cells, may help slow gastric cancer progression. Cytokines, tiny sign [...] Read more.
    Mathan Muthu Chinakannu Marimuthu ... Hitesh Chopra
    Published: April 26, 2025 Explor Target Antitumor Ther. 2025;6:1002312
    DOI: https://doi.org/10.37349/etat.2025.1002312
    View:595
    Download:12
    Times Cited: 0
    Open Access
    Review
    Viral infections and immune modulation in bladder cancer: implications for immunotherapy
    This review explores the intricate relationship between viral infections and Bacillus Calmette-Guerin (BCG) efficacy, emphasizing immune modulation mechanisms that may influence treatment outcomes.  [...] Read more.
    Lívia Bitencourt Pascoal ... Leonardo O. Reis
    Published: April 24, 2025 Explor Target Antitumor Ther. 2025;6:1002311
    DOI: https://doi.org/10.37349/etat.2025.1002311
    This article belongs to the special issue Comprehensive Immunotherapy of Solid Tumors
    View:497
    Download:10
    Times Cited: 0
    Open Access
    Review
    Modulation of anti-tumour immunity by XPO1 inhibitors
    Exportin-1 (XPO1) is a nuclear export protein that, when overexpressed, can facilitate cancer cell proliferation and survival and is frequently overexpressed or mutated in cancer patients. As such,  [...] Read more.
    Jack G. Fisher ... Matthew D. Blunt
    Published: April 23, 2025 Explor Target Antitumor Ther. 2025;6:1002310
    DOI: https://doi.org/10.37349/etat.2025.1002310
    This article belongs to the special issue Immune Checkpoint Therapy and Biomarkers in Cancer
    View:921
    Download:25
    Times Cited: 0
    Open Access
    Case Report
    Eosinophil cytolysis with or without ETosis in four cases of human gastric cancer: a comparative ultrastructural study
    The ultrastructural morphology of eosinophil cytolysis and extracellular trap cell death (ETosis) has predominantly been examined in non-neoplastic eosinophil-associated diseases, with a limited inv [...] Read more.
    Rosario Caruso ... Luciana Rigoli
    Published: April 21, 2025 Explor Target Antitumor Ther. 2025;6:1002309
    DOI: https://doi.org/10.37349/etat.2025.1002309
    View:338
    Download:10
    Times Cited: 0
    Open Access
    Review
    Nanoimmunotherapy: the smart trooper for cancer therapy
    Immunotherapy has gathered significant attention and is now a widely used cancer treatment that uses the body’s immune system to fight cancer. Despite initial successes, its broader clinical appli [...] Read more.
    Suphiya Parveen ... Fahima Dilnawaz
    Published: April 10, 2025 Explor Target Antitumor Ther. 2025;6:1002308
    DOI: https://doi.org/10.37349/etat.2025.1002308
    This article belongs to the special issue Comprehensive Immunotherapy of Solid Tumors
    View:665
    Download:18
    Times Cited: 0
    Open Access
    Review
    Strategies to overcome resistance to enfortumab vedotin and pembrolizumab for patients with urothelial carcinoma: harnessing present knowledge for future advances
    The combination of enfortumab vedotin and pembrolizumab (EVP) has been recently approved for patients with locally advanced and metastatic urothelial carcinoma. This combination showed a higher obje [...] Read more.
    Albert Jang, Jason R. Brown
    Published: April 07, 2025 Explor Target Antitumor Ther. 2025;6:1002307
    DOI: https://doi.org/10.37349/etat.2025.1002307
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
    View:740
    Download:26
    Times Cited: 0
    Open Access
    Review
    Exploring recent advances in signaling pathways and hallmarks of uveal melanoma: a comprehensive review
    The purpose of this review was to provide a comprehensive review of the latest insights on the pathogenesis of uveal melanoma (UM) and its intracellular pathways. This article covers the epidemiolog [...] Read more.
    Majid Banimohammad ... Hamidreza Pazoki-Toroudi
    Published: April 02, 2025 Explor Target Antitumor Ther. 2025;6:1002306
    DOI: https://doi.org/10.37349/etat.2025.1002306
    This article belongs to the special issue Predictive and Prognostic Biomarkers in Cancer: Towards the Precision Medicine Era
    View:1047
    Download:21
    Times Cited: 0
    Open Access
    Short Communication
    Real-world outcomes of lenvatinib plus pembrolizumab in intermediate- and poor-risk metastatic renal cell carcinoma
    The combination of lenvatinib and pembrolizumab (Len + Pembro) demonstrated significant efficacy in the phase 3 CLEAR study for metastatic renal cell carcinoma (RCC). However, poor-risk patients rep [...] Read more.
    Ilya Tsimafeyeu ... Mark Gluzman
    Published: April 01, 2025 Explor Target Antitumor Ther. 2025;6:1002305
    DOI: https://doi.org/10.37349/etat.2025.1002305
    This article belongs to the special issue Emerging Molecular Targets and Therapies of Genitourinary Tumors
    View:2823
    Download:88
    Times Cited: 0
    Open Access
    Review
    Key immune cells and their crosstalk in the tumor microenvironment of bladder cancer: insights for innovative therapies
    Bladder cancer (BC) is a heterogeneous disease associated with high mortality if not diagnosed early. BC is classified into non-muscle-invasive BC (NMIBC) and muscle-invasive BC (MIBC), with MIBC li [...] Read more.
    Anna Di Spirito ... Lorenzo Mortara
    Published: March 31, 2025 Explor Target Antitumor Ther. 2025;6:1002304
    DOI: https://doi.org/10.37349/etat.2025.1002304
    This article belongs to the special issue Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
    View:1050
    Download:15
    Times Cited: 0