• 25 results in Exploration of Neuroscience
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    Mini Review
    Nutritional treatment with the ketogenic diet in children with refractory epilepsy: a narrative review
    The two mainstays of therapy for refractory epilepsy are medication and surgery. Child behavioral and cognitive aspects of epilepsy can be improved by using a specialized dietary regimen such as the [...] Read more.
    Srilaxmi Vityala ... Swathi Nenavath
    Published: October 30, 2023 Explor Neurosci. 2023;2:245–250
    DOI: https://doi.org/10.37349/en.2023.00025
    This article belongs to the special issue Epilepsy
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    Times Cited: 0
    Open Access
    Original Article
    Estimation of the allelic status of apolipoprotein E4 isoforms with fully automated LUMIPULSE® assays
    Aim: Apolipoprotein E (ApoE) isoforms, especially the ApoE4 isoform, are genetic risk factors for Alzheimer’s disease (AD). Moreover, the APOE ε4 haplotype has a dose-dependent association wit [...] Read more.
    Tatsushi Yuri ... Hisashi Nojima
    Published: October 16, 2023 Explor Neurosci. 2023;2:238–244
    DOI: https://doi.org/10.37349/en.2023.00024
    This article belongs to the special issue Alzheimer’s Disease
    View:295
    Download:20
    Times Cited: 0
    Open Access
    Review
    Investigation into the vascular contributors to dementia and the associated treatments
    As the average lifespan has increased, memory disorders have become a more pressing public health concern. However, dementia in the elderly population is often neglected in light of other health pri [...] Read more.
    Caroline Grace Davidson ... Brandon Lucke-Wold
    Published: October 15, 2023 Explor Neurosci. 2023;2:224–237
    DOI: https://doi.org/10.37349/en.2023.00023
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:303
    Download:19
    Times Cited: 0
    Open Access
    Review
    Sleep disorders contribute to the development of dementia and Alzheimer’s disease
    Life is the highest form of adaptation to the environment which is based on energy metabolism. To maintain life, the neuromuscular system must constantly interact with the environment. The striatal  [...] Read more.
    Janusz Wiesław Błaszczyk
    Published: October 08, 2023 Explor Neurosci. 2023;2:212–223
    DOI: https://doi.org/10.37349/en.2023.00022
    This article belongs to the special issue Alzheimer’s Disease
    View:307
    Download:11
    Times Cited: 0
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    Review
    Negative environmental influences on the developing brain mediated by epigenetic modifications
    Brain development, a complex process, consisting of several phases, starting as early as two weeks after conception, and continuing through childhood till early adolescence, is crucial for the devel [...] Read more.
    Maya Komar-Fletcher ... Joanna Michalina Jurek
    Published: September 28, 2023 Explor Neurosci. 2023;2:193–211
    DOI: https://doi.org/10.37349/en.2023.00021
    View:343
    Download:18
    Times Cited: 0
    Open Access
    Review
    Multiple sclerosis with comorbidity depression and its association with vitamin D deficiency in a narrative review of the current literature
    Over the past decade, knowledge of the pathophysiology and immunology of multiple sclerosis (MS) and depression, and the complex links to vitamin D (VitD) balance, has increased rapidly. Both diseas [...] Read more.
    Hans-Klaus Goischke
    Published: August 31, 2023 Explor Neurosci. 2023;2:160–192
    DOI: https://doi.org/10.37349/en.2023.00020
    This article belongs to the special issue Novel Therapeutic Approaches for the Treatment of Depression
    View:335
    Download:19
    Times Cited: 0
    Open Access
    Case Report
    Covered stent graft for treatment of carotid artery stenosis with post-stenotic aneurysm
    Several bare metals, self-expanding stents have been approved by the Food and Drug Administration (FDA) to treat carotid stenosis, but no covered stents have been particularly examined or approved f [...] Read more.
    Mosaad Soliman ... Reem Soliman
    Published: August 31, 2023 Explor Neurosci. 2023;2:153–159
    DOI: https://doi.org/10.37349/en.2023.00019
    View:269
    Download:14
    Times Cited: 0
    Open Access
    Review
    Modify gut microbiome in autism: a promising strategy?
    The gut microbiota and dysbiosis have been implicated in various metabolic diseases and gastrointestinal disorders. Recently, there has been growing evidence suggesting the influence of gut microbio [...] Read more.
    Jean Demarquoy ... Caroline Demarquoy
    Published: August 31, 2023 Explor Neurosci. 2023;2:140–152
    DOI: https://doi.org/10.37349/en.2023.00018
    View:251
    Download:10
    Times Cited: 0
    Open Access
    Review
    Circadian regulation of the immune-hematopoietic system
    Earth’s rotation generates the basic circadian rhythm of day and night to which all living organisms must adapt to survive. In mammals, this happens thanks to a central clock located in the suprac [...] Read more.
    Georges Maestroni
    Published: June 30, 2023 Explor Neurosci. 2023;2:123–139
    DOI: https://doi.org/10.37349/en.2023.00017
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:528
    Download:31
    Times Cited: 0
    Open Access
    Review
    Therapeutic potential of extracellular vesicles in Parkinson’s disease
    Globally, the incidence of Parkinson’s disease (PD) is increasing faster than other neurodegenerative disorders. Neuropathologically, PD is characterized by the loss of dopaminergic neurons in the [...] Read more.
    Michelli Ramires Teixeira ... Rodrigo Pinheiro Araldi
    Published: June 29, 2023 Explor Neurosci. 2023;2:106–122
    DOI: https://doi.org/10.37349/en.2023.00016
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:517
    Download:32
    Times Cited: 0
    Open Access
    Perspective
    Mesenchymal stem cell stroke therapy: current limitations in its clinical translation
    For more than a decade now, research studies, proof of concept work, and clinical trials have endeavored to understand how mesenchymal stem cells might be used to help protect, repair, and/or regene [...] Read more.
    Ylenia Pastorello, Mark Slevin
    Published: June 28, 2023 Explor Neurosci. 2023;2:98–105
    DOI: https://doi.org/10.37349/en.2023.00015
    This article belongs to the special issue Neuroinflammation in the Ageing and the Injured Brain
    View:439
    Download:21
    Times Cited: 0
    Open Access
    Review
    Inflammatory responses involved in post-cardiac arrest brain injury: mechanisms, regulation, and therapeutic potential
    Neuroinflammation plays a key role in the pathogenesis of post-cardiac arrest (CA) brain injury. Innate immune cells sense a variety of danger signals through pattern-recognition receptors and evoke [...] Read more.
    Yuzhen Zhang ... Kaibin Huang
    Published: April 26, 2023 Explor Neurosci. 2023;2:82–97
    DOI: https://doi.org/10.37349/en.2023.00014
    View:578
    Download:40
    Times Cited: 0
    Open Access
    Review
    Metabolic correction of neurodegenerative pathologies: the role of macronutrients and timing
    Despite decades of intensive research, effective treatment and prevention strategies for neurodegenerative diseases (NDDs) remain elusive. This review focuses on Alzheimer’s and Parkinson’s dise [...] Read more.
    Yuri Zilberter, Tanya Zilberter
    Published: April 21, 2023 Explor Neurosci. 2023;2:67–81
    DOI: https://doi.org/10.37349/en.2023.00013
    View:462
    Download:36
    Times Cited: 0
    Open Access
    Original Article
    The effect of the tumour necrosis factor-alpha-inhibitor etanercept on microglial activation patients with mild cognitive impairment—a PET study
    Aim: Microglial activation is increasingly recognised as a factor in the progression of Alzheimer’s disease (AD) and may be modified by systemic inflammatory signals including serum tumour necrosis factor (TNF)-α. The aim was t [...] Read more.
    Alexander Gerhard ... Clive Holmes
    Published: March 26, 2023 Explor Neurosci. 2023;2:52–66
    DOI: https://doi.org/10.37349/en.2023.00012
    View:620
    Download:33
    Times Cited: 0
    Open Access
    Editorial
    Treatment concept successfully translated into human patients
    Dirk M. Hermann
    Published: February 28, 2023 Explor Neurosci. 2023;2:48–51
    DOI: https://doi.org/10.37349/en.2023.00011
    View:505
    Download:17
    Times Cited: 0
    Open Access
    Systematic Review
    Genetic plasma biomarkers associated with ischemic stroke
    Aim: Stroke is one of the leading causes of death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes and to make predictions about [...] Read more.
    Mihai Andrei Ruscu ... Aurel Popa-Wagner
    Published: February 26, 2023 Explor Neurosci. 2023;2:27–47
    DOI: https://doi.org/10.37349/en.2023.00010
    This article belongs to the special issue Cerebral Ischemia, Genetics, Comorbidities, Risk Factors and New Therapeutic Options for Neurorestoration
    View:525
    Download:23
    Times Cited: 0
    Open Access
    Review
    Update for astrocytomas: medical and surgical management considerations
    Astrocytomas include a wide range of tumors with unique mutations and varying grades of malignancy. These tumors all originate from the astrocyte, a star-shaped glial cell that plays a major role in [...] Read more.
    Matthew Willman ... Brandon Lucke-Wold
    Published: February 23, 2023 Explor Neurosci. 2023;2:1–26
    DOI: https://doi.org/10.37349/en.2023.00009
    This article belongs to the special issue Emerging Trends in Endovascular Management
    View:656
    Download:28
    Times Cited: 0
    Open Access
    Review
    Cellular and molecular mechanisms of stress-induced memory impairment
    Exposure to stressful conditions plays a critical role in brain processes, including neural plasticity, synaptic transmission, and cognitive functions. Since memory-related brain regions, the hippocampus (Hip), the amygdala, and t [...] Read more.
    Ameneh Rezayof ... Shiva Hashemizadeh
    Published: December 30, 2022 Explor Neurosci. 2022;1:100–119
    DOI: https://doi.org/10.37349/en.2022.00008
    This article belongs to the special issue Neuroinflammation in the Ageing and the Injured Brain
    View:541
    Download:37
    Times Cited: 0
    Open Access
    Review
    Updates in mechanical thrombectomy
    Stroke is a leading cause of morbidity and mortality. The advent of mechanical thrombectomy has largely improved patient outcomes. This article reviews the features and outcomes associated with aspi [...] Read more.
    Kevin Pierre ... Brandon Lucke-Wold
    Published: December 30, 2022 Explor Neurosci. 2022;1:83–99
    DOI: https://doi.org/10.37349/en.2022.00007
    This article belongs to the special issue Emerging Trends in Endovascular Management
    Open Access
    Perspective
    Should we rethink neurodegeneration?
    The therapy of many neurological disorders has advanced markedly during recent decades. Not so for neurodegenerative disorders. Early detection, deep individual genotyping and phenotyping, and perso [...] Read more.
    Jussi O. T. Sipilä
    Published: December 26, 2022 Explor Neurosci. 2022;1:75–82
    DOI: https://doi.org/10.37349/en.2022.00006
    View:459
    Download:20
    Times Cited: 0
    Open Access
    Review
    Neuroprotective and neurorestorative actions of mesenchymal stromal cell-derived small extracellular vesicles in the ischemic brain
    Ischemic stroke is a highly prevalent condition that frequently results in life-long disability and death. Considerable efforts have been made to establish treatments that prevent secondary ischemic [...] Read more.
    Chen Wang ... Dirk M. Hermann
    Published: October 09, 2022 Explor Neurosci. 2022;1:61–74
    DOI: https://doi.org/10.37349/en.2022.00005
    This article belongs to the special issue Extracellular Vesicles as Cell-based Therapeutics
    View:1083
    Download:42
    Times Cited: 0
    Open Access
    Perspective
    Recent developments and future perspectives of neuropathology
    This brief statement describes some recent achievements of neuropathological research, with the focus on Alzheimer’s and other age-related diseases, neurodegenerative disorders (tauopathies, synucleinopathies), multimorbidity of [...] Read more.
    Kurt A. Jellinger
    Published: September 30, 2022 Explor Neurosci. 2022;1:54–60
    DOI: https://doi.org/10.37349/en.2022.00004
    Open Access
    Review
    Neuregulins: subcellular localization, signaling pathways and their relationship with neuroplasticity and neurological diseases
    Neuregulins (NRGs) and their cognate ErbB receptors (ErbB2–ErbB4) constitute a vast group of proteins encoded by six different genes (NRG16) and many isoforms with critical  [...] Read more.
    Marines Longart ... Juan Carlos Martínez
    Published: September 29, 2022 Explor Neurosci. 2022;1:31–53
    DOI: https://doi.org/10.37349/en.2022.00003
    Open Access
    Review
    Impact of circadian clock dysfunction on human health
    All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic act [...] Read more.
    Saptadip Samanta, Sk Asif Ali
    Published: September 29, 2022 Explor Neurosci. 2022;1:4–30
    DOI: https://doi.org/10.37349/en.2022.00002
    This article belongs to the special issue Circadian Rhythm and Melatonin
    View:1311
    Download:52
    Times Cited: 0
    Open Access
    Editorial
    Cutting edges in neuroscience to exceed borders
    Dirk M. Hermann
    Published: September 01, 2022 Explor Neurosci. 2022;1:1–3
    DOI: https://doi.org/10.37349/en.2022.00001