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  • Special Issue Topic

    Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease

    Submission Deadline: May 31, 2023

    Guest Editor

    Dr. Abdelhamid Benazzouz E-Mail

    Research Director, Team Leader, Neurochemistry, Deep brain stimulation & Parkinson’s disease, Neurodegenerative Diseases Institute, Bordeaux University, Bordeaux, France

    Research Keywords: Deep brain stimulation; monoaminergic systems; Basal ganglia; animal models


    About the Special Issue

    Parkinson's disease (PD) is a neurological condition representing the second most common neurodegenerative disorder after Alzheimer's disease. Although the cause of neuronal degeneration is not known, it is accepted that the motor symptoms of PD are due to the degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. In addition, PD is also characterized by the manifestation of non-motor symptoms that may occur even before the motor symptoms and that these disorders may be due to impaired function in the noradrenergic and/or serotonergic system. However, the exact role and mechanisms of involvement of these systems in the pathogenesis and pathophysiology of the disease remain to be determined.

    The proposed issue invites papers across, but not limited to, the following themes:

    (1) Is there a role of the noradrenergic and/or serotonergic system in the pathophysiology of motor symptoms
    (2) Is there a role of the noradrenergic and/or serotonergic system in the pathophysiology of non-motor symptoms
    (3) Is there any novel drugs targeting these monoaminergic systems in the treatment of PD
    (4) Is there any potential role of noradrenaline in neuroprotection against dopaminergic neurodegeneration
    (5) Are the noradrenergic and serotonergic systems involved in the mechanism of L-Dopa-induced dyskinesia in PD

    Keywords: Parkinson’s disease; dopamine; noradrenaline; serotonin; cell death; neuroprotection; motor symptoms; non-motor symptoms; risk-factors in PD

    Call for Papers

    Published Articles

    Open Access
    Review
    Rehabilitation for non-motor symptoms for patients with Parkinson’s disease from an α-synuclein perspective: a narrative review
    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbr [...] Read more.

    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbrain and the loss of dopaminergic neurons with various motor and non-motor symptoms associated with the disease. The protein α-synuclein has been extensively studied for its contribution to PD pathology, as α-synuclein aggregates form the major component of Lewy bodies, a hallmark of PD. In this narrative review, the authors first focus on a brief explanation of α-synuclein aggregation and circumstances under which aggregation can occur, then present a hypothesis for PD pathogenesis in the peripheral nervous system (PNS) and how PD can spread to the central nervous system from the PNS via the transport of α-synuclein aggregates. This article presents arguments both for and against this hypothesis. It also presents various non-pharmacological rehabilitation approaches and management techniques for both motor and non-motor symptoms of PD and the related pathology. This review seeks to examine a possible hypothesis of PD pathogenesis and points to a new research direction focus on rehabilitation therapy for patients with PD. As various non-motor symptoms of PD appear to occur earlier than motor symptoms, more focus on the treatment of non-motor symptoms as well as a better understanding of the biochemical mechanisms behind those non-motor symptoms may lead to better long-term outcomes for patients with PD.

    Zhaoyang Liu ... Wen Liu
    Published: August 27, 2023 Explor Neuroprot Ther. 2023;3:235–257
    DOI: https://doi.org/10.37349/ent.2023.00049
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    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbrain and the loss of dopaminergic neurons with various motor and non-motor symptoms associated with the disease. The protein α-synuclein has been extensively studied for its contribution to PD pathology, as α-synuclein aggregates form the major component of Lewy bodies, a hallmark of PD. In this narrative review, the authors first focus on a brief explanation of α-synuclein aggregation and circumstances under which aggregation can occur, then present a hypothesis for PD pathogenesis in the peripheral nervous system (PNS) and how PD can spread to the central nervous system from the PNS via the transport of α-synuclein aggregates. This article presents arguments both for and against this hypothesis. It also presents various non-pharmacological rehabilitation approaches and management techniques for both motor and non-motor symptoms of PD and the related pathology. This review seeks to examine a possible hypothesis of PD pathogenesis and points to a new research direction focus on rehabilitation therapy for patients with PD. As various non-motor symptoms of PD appear to occur earlier than motor symptoms, more focus on the treatment of non-motor symptoms as well as a better understanding of the biochemical mechanisms behind those non-motor symptoms may lead to better long-term outcomes for patients with PD.

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    • Ongoing Special Issues
      Neuroprotective Nitric Oxide and Its Metabolites (Nitrite and Nitrate)
      Cognitive Alterations in Psychiatry
      Glia and Neuroprotection
      The Future of Biomarkers in CNS Diseases
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      Molecular Mechanisms of Ischemic Tolerance in the Brain
      Recent Advances in Neurochemistry and Genetics of Late-onset Alzheimer's Disease
      The Search for Biomarkers: from Diagnosis to Progression Assessment
      Parkinson's Disease: Principal Targets and Interventional Mechanisms
      Intervention of Neuroimmune Responses
      Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease
      The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimer's Disease
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      Natural Products in Neurotherapeutic Applications
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