• Special Issue Topic

    Role of the Monoaminergic Systems in the Pathogenesis and the Pathophysiology of Parkinson's Disease

    Submission Deadline: May 31, 2023

    Guest Editor

    Dr. Abdelhamid Benazzouz E-Mail

    Research Director, Team Leader, Neurochemistry, Deep brain stimulation & Parkinson’s disease, Neurodegenerative Diseases Institute, Bordeaux University, Bordeaux, France

    Research Keywords: deep brain stimulation; monoaminergic systems; basal ganglia; animal models

    About the Special Issue

    Parkinson's disease (PD) is a neurological condition representing the second most common neurodegenerative disorder after Alzheimer's disease. Although the cause of neuronal degeneration is not known, it is accepted that the motor symptoms of PD are due to the degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. In addition, PD is also characterized by the manifestation of non-motor symptoms that may occur even before the motor symptoms and that these disorders may be due to impaired function in the noradrenergic and/or serotonergic system. However, the exact role and mechanisms of involvement of these systems in the pathogenesis and pathophysiology of the disease remain to be determined.

    The proposed issue invites papers across, but not limited to, the following themes:

    (1) Is there a role of the noradrenergic and/or serotonergic system in the pathophysiology of motor symptoms
    (2) Is there a role of the noradrenergic and/or serotonergic system in the pathophysiology of non-motor symptoms
    (3) Is there any novel drugs targeting these monoaminergic systems in the treatment of PD
    (4) Is there any potential role of noradrenaline in neuroprotection against dopaminergic neurodegeneration
    (5) Are the noradrenergic and serotonergic systems involved in the mechanism of L-Dopa-induced dyskinesia in PD

    Keywords: Parkinson’s disease; dopamine; noradrenaline; serotonin; cell death; neuroprotection; motor symptoms; non-motor symptoms; risk-factors in PD

    Call for Papers

    Published Articles

    Open Access
    An overview of the role of monoamine oxidase-B in Parkinson’s disease: implications for neurodegeneration and therapy
    Parkinson’s disease (PD) is a neurodegenerative disorder characterized by both non-motor and motor symptoms, due to the loss of dopamine-producing neurons in the brain. Monoamine oxidase-B (MAO-B) [...] Read more.
    Praveen Kumar Chandra Sekar ... Ramakrishnan Veerabathiran
    Published: July 14, 2024 Explor Neuroprot Ther. 2024;4:308–318
    DOI: https://doi.org/10.37349/ent.2024.00085
    Times Cited: 0
    Open Access
    Original Article
    Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models of neurodegenerative disease
    Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)]. The correlation between αSyn patho [...] Read more.
    Bianca Vlcek ... Åsa Wallén-Mackenzie
    Published: October 30, 2023 Explor Neuroprot Ther. 2023;3:299–327
    DOI: https://doi.org/10.37349/ent.2023.00053
    Times Cited: 0
    Open Access
    Rehabilitation for non-motor symptoms for patients with Parkinson’s disease from an α-synuclein perspective: a narrative review
    Parkinson’s disease (PD) is a common neurodegenerative disorder affecting aged population around the world. PD is characterized by neuronal Lewy bodies present in the substantia nigra of the midbr [...] Read more.
    Zhaoyang Liu ... Wen Liu
    Published: August 27, 2023 Explor Neuroprot Ther. 2023;3:235–257
    DOI: https://doi.org/10.37349/ent.2023.00049
    Times Cited: 0