• 92 results in Exploration of Neuroprotective Therapy
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    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
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    Review
    Advancing diagnosis and treatment of Niemann-Pick C disease through biomarker discovery
    Niemann-Pick C disease is a rare neurodegenerative, lysosomal storage disease caused by accumulation of unesterified cholesterol. Diagnosis of the disease is often delayed due to its rarity, the het [...] Read more.
    Xuntian Jiang, Daniel S. Ory
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:146–158
    DOI: https://doi.org/10.37349/ent.2021.00012
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    Open Access
    Review
    Blocking cholesterol storage to treat Alzheimer’s disease
    Cholesterol serves as an essential lipid molecule in various membrane organelles of mammalian cells. The metabolites of cholesterol also play important functions. Acyl-coenzyme A: cholesterol acyltr [...] Read more.
    Ta Yuan Chang ... James G. Gow
    Published: December 30, 2021 Explor Neuroprot Ther. 2021;1:173–184
    DOI: https://doi.org/10.37349/ent.2021.00014
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
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    Open Access
    Review
    Subarachnoid hemorrhage: management considerations for COVID-19
    Subarachnoid hemorrhage (SAH) has deleterious outcomes for patients, and during the hospital stay, patients are susceptible to vasospasm and delayed cerebral ischemia. Coronavirus disease 2019 (COVI [...] Read more.
    Eric J. Panther, Brandon Lucke-Wold
    Published: March 02, 2022 Explor Neuroprot Ther. 2022;2:65–73
    DOI: https://doi.org/10.37349/ent.2022.00018
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
    Open Access
    Review
    The glymphatic system and subarachnoid hemorrhage: disruption and recovery
    The glymphatic system, or glial-lymphatic system, is a waste clearance system composed of perivascular channels formed by astrocytes that mediate the clearance of proteins and metabolites from the b [...] Read more.
    Stephan Quintin ... Brandon Lucke-Wold
    Published: June 21, 2022 Explor Neuroprot Ther. 2022;2:118–130
    DOI: https://doi.org/10.37349/ent.2022.00023
    This article belongs to the special issue Emerging Concepts in Subarachnoid Hemorrhage
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    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
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    Review
    Economics of dry needling and botulinum toxin type A for treatment of post-stroke spasticity: a review
    Stroke is one of the most common causes of disability and exerts a high burden of direct and indirect costs. Stroke may cause spasticity, which limits patients’ abilities and affects the [...] Read more.
    Daniel Fernández ... Eva María Gómez-Trullén
    Published: June 30, 2022 Explor Neuroprot Ther. 2022;2:131–140
    DOI: https://doi.org/10.37349/ent.2022.00024
    This article belongs to the special issue Dry Needling for Neurological Disorders
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    Review
    T-cell based immunotherapies for Parkinson’s disease
    Current evidence indicates that neurodegeneration of dopaminergic neurons of the substantia nigra associated to Parkinson's disease is a consequence of a neuroinflammatory process in whic [...] Read more.
    Rodrigo Pacheco
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:72–85
    DOI: https://doi.org/10.37349/ent.2021.00007
    View:3372
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    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:6409
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    Review
    Can chronic therapeutic drug use by the elderly affect Alzheimer’s disease risk and rate of progression?
    There is no approved drug capable of halting the progression of the most prevalent neurodegenerative disorders, namely Alzheimer's disease (AD) and Parkinson's disease (PD).  [...] Read more.
    Rafael Franco, Joan Serrano-Marín
    Published: February 27, 2023 Explor Neuroprot Ther 2023;3:8–23
    DOI: https://doi.org/10.37349/ent.2023.00035
    This article belongs to the special issue The Urgent Need for New Hypotheses to Develop Effective Therapeutic Tools Against Alzheimers Disease
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