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  • 108 results in Exploration of Neuroprotective Therapy
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    Open Access
    Review
    Balancing cholesterol in the brain: from synthesis to disposal
    The cholesterol is a vital component of cell membranes and myelin sheaths, and a precursor for essential molecules such as steroid hormones. In humans, cholesterol is partially obtained through the  [...] Read more.
    Lydia Qian ... Andrew J. Brown
    Published: January 05, 2022 Explor Neuroprot Ther. 2022;2:1–27
    DOI: https://doi.org/10.37349/ent.2022.00015
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:14488
    Download:471
    Open Access
    Review
    Biomarkers in small fiber neuropathy
    Small fiber neuropathy (SFN) is a relatively common, but largely understudied neurological syndrome which has affected the lives of many globally. The common symptoms of SFN include pain, dysesthesi [...] Read more.
    Amanda C. Y. Chan ... Joy Vijayan
    Published: December 30, 2022 Explor Neuroprot Ther. 2022;2:264–283
    DOI: https://doi.org/10.37349/ent.2022.00033
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:12765
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    Open Access
    Review
    Resolving a paradox: antidepressants, neuroinflammation, and neurodegeneration
    Depression is a known risk factor for dementia. Antidepressants are the most commonly used treatment for this condition, and are effective in at least half to two-thirds of cases. Extensive evidence [...] Read more.
    Ravi Philip Rajkumar
    Published: February 23, 2024 Explor Neuroprot Ther. 2024;4:11–37
    DOI: https://doi.org/10.37349/ent.2024.00068
    This article belongs to the special issue Neuro-Inflammation as a Target in the Design of Multifunctional Drug Candidates for Neurodegenerative Diseases
    View:12594
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    Open Access
    Review
    Pathophysiology of non-motor signs in Parkinson’s disease: some recent updating with brief presentation
    Parkinson’s disease (PD) is a progressive neurodegenerative disorder affecting 1% of the population above sixty years. It is caused by an interaction between genetic and envi [...] Read more.
    Khaled Radad ... Wolf-Dieter Rausch
    Published: February 27, 2023 Explor Neuroprot Ther. 2023;3:24–46
    DOI: https://doi.org/10.37349/ent.2023.00036
    This article belongs to the special issue Parkinsons Disease: Principal Targets and Interventional Mechanisms
    View:12393
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    Open Access
    Review
    Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease
    Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeo [...] Read more.
    Kamran Tariq, Bryan W. Luikart
    Published: October 29, 2021 Explor Neuroprot Ther. 2021;1:86–110
    DOI: https://doi.org/10.37349/ent.2021.00008
    This article belongs to the special issue Cholesterol Dyshomeostasis in Neurological Diseases
    View:11133
    Download:337
    Open Access
    Case Report
    Hyperbaric oxygen therapy—a new hope for Alzheimer’s patients: a case report and literature review
    The currently available pharmacological anti-dementia treatments provide only temporary and limited benefits. Not surprisingly, patients and professionals increasingly explore non-pharmacological in [...] Read more.
    Elizabeta B. Mukaetova-Ladinska ... Qadeer Arshad
    Published: December 22, 2023 Explor Neuroprot Ther. 2023;3:457–469
    DOI: https://doi.org/10.37349/ent.2023.00062
    This article belongs to the special issue Defending the Brain and the Mind: Exploring Neuroprotective Therapies for Mental Health Disorders
    View:10565
    Download:96
    Open Access
    Systematic Review
    Various facets of excitotoxicity
    Aim: Excitotoxicity results from unusually increased activation of excitatory amino acid receptors leading to neuronal death. Since glutamate is the main excitatory neurotransmitter in the centra [...] Read more.
    Talita Glaser ... Henning Ulrich
    Published: February 23, 2022 Explor Neuroprot Ther. 2022;2:36–64
    DOI: https://doi.org/10.37349/ent.2022.00017
    View:10071
    Download:202
    Open Access
    Review
    Biomarkers in neurodegenerative diseases: a broad overview
    Degeneration and dysfunction of neurons in the brain are hallmarks of neurodegenerative diseases. Over the past decades, significant efforts have been devoted to the development and validation of bi [...] Read more.
    Sathish Selvam, Velpandi Ayyavoo
    Published: April 16, 2024 Explor Neuroprot Ther. 2024;4:119–147
    DOI: https://doi.org/10.37349/ent.2024.00075
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:9218
    Download:228
    Open Access
    Perspective
    Gut microbiota could modulate the effects of neuro-immune responses and memory traces via the gut-brain-immune axis in schizophrenia
    Altered immunity may have destructive consequences for the integrated central nervous system. This immune response often affects progressive neurodegenerative diseases such as Parkinson’s disease and/or psychiatric disorders suc [...] Read more.
    Haruka Sawamura ... Satoru Matsuda
    Published: April 24, 2022 Explor Neuroprot Ther. 2022;2:74–86
    DOI: https://doi.org/10.37349/ent.2022.00019
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:8577
    Download:2201
    Open Access
    Review
    The potential positive effects of coenzyme Q10 on the regeneration of peripheral nerve injury
    Peripheral nerve injuries (PNIs) constitute a significant concern as they predominantly affect young and productive age groups of the population, causing social and economic pressure on patients. PN [...] Read more.
    Ahmed Mead ... Süleyman Kaplan
    Published: June 21, 2024 Explor Neuroprot Ther. 2024;4:288–299
    DOI: https://doi.org/10.37349/ent.2024.00083
    View:8582
    Download:95
    Open Access
    Review
    Neuroprotective agents in acute ischemic stroke
    Acute ischemic stroke (AIS) is the leading cause of disability and one of the top causes of mortality worldwide. The current standard of care is reperfusion therapy including intravenous thrombolysi [...] Read more.
    Grace YY Chia ... Benjamin YQ Tan
    Published: February 28, 2023 Explor Neuroprot Ther. 2023;3:47–70
    DOI: https://doi.org/10.37349/ent.2023.00037
    This article belongs to the special issue The Future of Biomarkers in CNS Diseases
    View:8462
    Download:206
    Open Access
    Review
    Advances in neuroprotective therapy for acute ischemic stroke
    Acute ischemic stroke (AIS) is the leading cause of disability worldwide, and recanalization therapy is primary in the hyperacute phase of AIS. However, reperfusion injury and hemorrhagic transforma [...] Read more.
    Yang Yang ... Yi Li
    Published: February 27, 2024 Explor Neuroprot Ther. 2024;4:55–71
    DOI: https://doi.org/10.37349/ent.2024.00070
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
    View:8420
    Download:204
    Open Access
    Review
    Neurological complications during HIV infection
    Early in the course of infection, human immunodeficiency virus (HIV) is able to enter the central nervous system where it stablishes a permanent reservoir. Current antiretroviral therapies do not ef [...] Read more.
    Jose M. Martinez-Navio
    Published: August 05, 2021 Explor Neuroprot Ther. 2021;1:19–32
    DOI: https://doi.org/10.37349/ent.2021.00004
    View:8406
    Download:282
    Open Access
    Perspective
    Can meditation-based approaches improve the cleansing power of the glymphatic system?
    The glymphatic system, first described in 2012, is a brain-wide perivascular network that plays an important role in promoting interstitial metabolic waste removal from the brain. Glymphatic pathway [...] Read more.
    Peter Wostyn, Piet Goddaer
    Published: June 20, 2022 Explor Neuroprot Ther. 2022;2:110–117
    DOI: https://doi.org/10.37349/ent.2022.00022
    View:8026
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    Open Access
    Review
    Targeting α-synuclein aggregation with immunotherapy: a promising therapeutic approach for Parkinson’s disease
    Parkinson’s disease (PD) is a prevalent neurodegenerative disease (NDD) affecting millions of individuals. The pathogenesis of PD centers around α-synuclein (α-Syn), a pivotal protein whose aggr [...] Read more.
    Gabriela Henriquez, Mahesh Narayan
    Published: August 25, 2023 Explor Neuroprot Ther. 2023;3:207–234
    DOI: https://doi.org/10.37349/ent.2023.00048
    This article belongs to the special issue Parkinsons Disease: Principal Targets and Interventional Mechanisms
    View:7284
    Download:169
    Open Access
    Review
    Exploration of transcutaneous vagus nerve stimulation as a treatment option for adjuvant cancer and heart failure therapy
    Vagus nerve stimulation (VNS) has gained prominence in the treatment of various clinical disorders such as migraine, depression, and tinnitus. Based on increased scientific knowledge of the VNS and  [...] Read more.
    Niklas Frank ... Carola Y. Förster
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:363–397
    DOI: https://doi.org/10.37349/ent.2023.00056
    This article belongs to the special issue Intervention of Neuroimmune Responses
    View:6780
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    Open Access
    Review
    Dry needling in stroke
    Stroke causes acute neurological deficit which is an important cause of morbidity and mortality. Neurorehabilitation is an important dimension in the management of post-stroke deficits. Spasticity,  [...] Read more.
    Nirmal Surya, Guhan Ramamurthy
    Published: February 17, 2022 Explor Neuroprot Ther. 2022;2:28–35
    DOI: https://doi.org/10.37349/ent.2022.00016
    This article belongs to the special issue Dry Needling for Neurological Disorders
    View:6692
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    Open Access
    Systematic Review
    Effect of gardening physical activity on neuroplasticity and cognitive function
    Background: The beneficial effects of gardening as a form of physical activity have garnered growing interest in recent years. This research aimed to evaluate the effect of gardening as a physica [...] Read more.
    Antonio G. Lentoor
    Published: June 05, 2024 Explor Neuroprot Ther. 2024;4:251–272
    DOI: https://doi.org/10.37349/ent.2024.00081
    This article belongs to the special issue Empower Yourself - Physical Activity as Prevention and Rehabilitation of Neurological and Psychiatric Diseases
    View:6618
    Download:139
    Open Access
    Review
    From the ocean to the brain: harnessing the power of marine algae for neuroprotection and therapeutic advances
    Recent investigations have shed light on the potential of seaweed, an abundant source of bioactive compounds, to mitigate and combat neurodegenerative diseases. In this comprehensive review, the acc [...] Read more.
    Leonel Pereira, Ana Valado
    Published: November 17, 2023 Explor Neuroprot Ther. 2023;3:409–428
    DOI: https://doi.org/10.37349/ent.2023.00058
    This article belongs to the special issue Natural Products in Neurotherapeutic Applications
    View:6597
    Download:146
    Open Access
    Review
    Stem cell therapy in neurological disorders: promises and concerns
    Self-neuronal regeneration is often limited or nonexistent after neuronal cell damage, making new technologies necessary for treating neurological damage. Although the brain can partially compensate [...] Read more.
    Said Hachimi-Idrissi
    Published: October 31, 2023 Explor Neuroprot Ther. 2023;3:346–362
    DOI: https://doi.org/10.37349/ent.2023.00055
    This article belongs to the special issue Therapeutic Targets for Neuroprotection in Ischemic Stroke
    View:6314
    Download:85