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    Case Report
    A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy
    C1q nephropathy is a rare glomerular disease. Clinical presentation is diverse and ranges from asymptomatic hematuria or proteinuria to symptoms and signs of nephrotic/nephritic syndrome. On light microscopy, it can be classified into two subtypes: minimal change disease (MCD)/focal segmental glomerulosclerosis (FSGS) group and immune complex mediated proliferative glomerulonephritis group. ...
    Randa Choueiri ... Vanessa Nseir
    Published: August 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00101
    Viewed:195
    Downloaded:24
    Open Access
    Review
    Paradoxical role of reactive oxygen species in bone remodelling: implications in osteoporosis and possible nanotherapeutic interventions
    Osteoporosis is a metabolic bone disorder that affects both sexes and is the most common cause of fractures. Osteoporosis therapies primarily inhibit osteoclast activity, and are seldom designed to ...
    Largee Biswas ... Anita Kamra Verma
    Published: August 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00102
    Viewed:188
    Downloaded:33
    Open Access
    Systematic Review
    Signaling pathways and targets of natural products in psoriasis treatment
    Aim: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with...
    Ly Thi Huong Nguyen
    Published: August 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00098
    Viewed:164
    Downloaded:10
    Open Access
    Original Article
    Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?
    Aim: Lactate dehydrogenase (LDH) is an enzyme that acts as a catalyst in the conversion of lactate to pyruvate which is abundantly found in liver, kidney, heart and muscles. Previous studies have all shown a strong positive correlation between muscle fatigue and increased serum LDH levels with type 2 diabetes mellitus but no study has actually assessed the same for prediabetes. ...
    Charu Mishra ... Ranjan Kumar Dixit
    Published: August 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00099
    Viewed:114
    Downloaded:8
    Open Access
    Original Article
    Mathematical model for transmission of Chlamydia due to sexual activity and unhygienic environment
    Aim: Sexually transmitted diseases (STDs) need to be studied systematically to better understand their global spread. Transmission of Chlamydia trachomatis is a severe public health issue, with r...
    Nita H. Shah ... Yash N. Shah
    Published: August 30, 2022 Explor Med. DOI: 10.37349/emed.2022.00100
    Viewed:120
    Downloaded:14
    Open Access
    Review
    Feed your microbiome and improve sleep, stress resilience, and cognition
    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagu...
    Maciej Chichlowski ... Neeraj Pandey
    Published: August 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00097
    Viewed:408
    Downloaded:38
    Open Access
    Systematic Review
    Downhill esophageal varices: a systematic review of the case reports
    Aim: The etiologies, presentation, and management of downhill varices in the era of modern medicine are relatively under-explored and mostly limited to case reports or case series. Methods: P...
    Hassam Ali ... Devika Kapuria
    Published: August 11, 2022 Explor Med. DOI: 10.37349/emed.2022.00096
    Viewed:313
    Downloaded:33
    Open Access
    Letter to the Editor
    Adenine-rich diet: a potential mechanism for renal fibrosis progression
    Chronic kidney disease (CKD) is a major health problem but there are many modalities to prevent and manage CKD progression. Diet is one of these factors, which needs to be evaluated more. Adenine is a water-soluble nucleoprotein that exists in both vegetables and animal foods, which triggers and aggravates fibrosis process besides other metabolic derangements such as diabetes mellitus affection that accelerates glomerular filtration rate decline rapidly....
    Majid Malaki
    Published: July 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00095
    Viewed:287
    Downloaded:48
    Open Access
    Original Article
    Construction and validation of gastric cancer diagnosis model based on machine learning
    Aim: To screen differentially expressed genes related to gastric cancer based on The Cancer Genome Atlas (TCGA) database and construct a gastric cancer diagnosis model by machine learning. Methods:...
    Fei Kong ... Wenzhen Yuan
    Published: June 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00094
    Viewed:312
    Downloaded:85
    Open Access
    Original Article
    Pyogenic liver abscess: contrast-enhanced ultrasound allows morpho-evolutive classification and guides personalized management
    Aim: The aim of this study is to propose a contrast-enhanced ultrasound (CEUS)-based morphologic classification of pyogenic liver abscess (PLA) reflecting different evolutive stages and to assess th...
    Giampiero Francica
    Published: June 28, 2022 Explor Med. DOI: 10.37349/emed.2022.00093
    Viewed:249
    Downloaded:41
    Open Access
    Editorial
    Does our microbiota eat with or without gluten?
    Giuseppe Merra ... Marco Marchetti
    Published: June 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00091
    Viewed:289
    Downloaded:15
    Open Access
    Review
    Involvement of retroelements in the autoimmune response in humans
    Retroelements are mobile genomic components requiring reverse transcription into an RNA intermediate and then synthesis of complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotransposons and endogenous retroviruses. ...
    Sezer Okay
    Published: June 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00092
    Viewed:276
    Downloaded:26
    Open Access
    Meta-Analysis
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem...
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00089
    Viewed:370
    Downloaded:21
    Open Access
    Review
    Recent advances of gut microbiota in chronic kidney disease patients
    Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of these pathological development and progression remains to be fully understood. ...
    Ying-Yong Zhao
    Published: June 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00090
    Viewed:350
    Downloaded:22
    Open Access
    Review
    Early taurine administration as a means for halting the cytokine storm progression in COVID-19 patients
    Around the world, more than 6.2 million individuals have died as a result of COVID-19. According to a recent survey conducted among immunologists, epidemiologists, and virologists, this disease is expected to become endemic. This implies that the disease could have a continuous presence and/or normal frequency in the population. ...
    Alberto Rubio-Casillas ... Raied Badierah
    Published: June 08, 2022 Explor Med. DOI: 10.37349/emed.2022.00088
    Viewed:416
    Downloaded:35
    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects ...
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00087
    Viewed:424
    Downloaded:43
    Open Access
    Review
    Reactive oxygen species in cardiovascular diseases: an update
    Cardiovascular diseases are among the leading causes of death worldwide, imposing major health threats. Reactive oxygen species (ROS) are one of the most important products from the process of redox...
    Juanjuan Fei ... Jun Ren
    Published: April 26, 2022 Explor Med. DOI: 10.37349/emed.2022.00085
    Viewed:321
    Downloaded:38
    Open Access
    Original Article
    High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney
    Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism ...
    Dewan S. A. Majid ... L. Gabriel Navar
    Published: April 26, 2022 Explor Med. DOI: 10.37349/emed.2022.00086
    Viewed:400
    Downloaded:49
    Open Access
    Case Report
    Complex liver injury induced by combined Aloe Vera and vitamin A oral supplements, as assessed by histology and the updated RUCAM
    A case of combined acute and chronic liver injury related to consumption of multi-ingredient nutritional oral supplements containing Aloe Vera gel and vitamin A among other vitamins, minerals and di...
    Katerina Delladetsima ... Stratigoula Sakellariou
    Published: April 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00084
    Viewed:288
    Downloaded:28
    Open Access
    Commentary
    Semaglutide: a game changer for metabolic diseases?
    Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1 RA) molecule approved for the treatment of both type 2 diabetes (T2D) and obesity. Semaglutide has a greater impact on glycated haemo...
    Agostino Milluzzo ... Laura Sciacca
    Published: April 19, 2022 Explor Med. DOI: 10.37349/emed.2022.00083
    Viewed:458
    Downloaded:39
    Open Access
    Original Article
    Development of systolic dysfunction unrelated to myocardial infarction in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: While it is commonly thought that left ventricular (LV) systolic function may insidiously deteriorate in hypertensive patients, few prospective data are available to support this notion. ...
    Marcello Chinali ... Richard B. Devereux
    Published: April 02, 2022 Explor Med. DOI: 10.37349/emed.2022.00082
    Viewed:367
    Downloaded:28
    Open Access
    Original Article
    Incident left bundle branch block predicts cardiovascular events and death in hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: Whether incident left bundle branch block (LBBB) is associated with increased cardiovascular (CV) morbidity and mortality in treated hypertensive patients with left ventricular hypertrophy (...
    Casper N. Bang ... Peter M. Okin
    Published: March 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00081
    Viewed:335
    Downloaded:22
    Open Access
    Original Article
    Incident atrial fibrillation and heart failure in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: The present study investigated the appearance and severity of atrial fibrillation (AF) and heart failure (HF) in 8,702 hypertensive patients with left ventricular hypertrophy (LVH) receiving...
    Casper N. Bang ... Peter M. Okin
    Published: March 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00080
    Viewed:339
    Downloaded:20
    Open Access
    Original Article
    Time-varying serum uric acid predicts new-onset atrial fibrillation in treated hypertensive patients. The LIFE Study
    Aim: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study showed less new-onset atrial fibrillation (AF) in hypertensive patients receiving losartan- vs. atenolol-based t...
    Eran S. Zacks ... Richard B. Devereux
    Published: March 17, 2022 Explor Med. DOI: 10.37349/emed.2022.00079
    Viewed:373
    Downloaded:29
    Open Access
    Editorial
    Elimination of hepatitis C virus infection in Europe: targeting the obstacles
    Dante Romagnoli
    Published: February 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00075
    Viewed:279
    Downloaded:12
    Open Access
    Review
    Multi-faced roles of reactive oxygen species in anti-tumor T cell immune responses and combination immunotherapy
    T cells play a central role in anti-tumor immunity, and reactive oxygen species (ROS) lie at the crossroad on the anti-tumor T cell responses. To activate efficient T cell immunity, a moderate level...
    Tao Wang, Haiyan Xu
    Published: February 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00076
    Viewed:757
    Downloaded:32
    Open Access
    Original Article
    Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia
    Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously...
    Kristin E. Reeve ... Babbette LaMarca
    Published: February 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00077
    Viewed:464
    Downloaded:39
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, ...
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00078
    Viewed:2005
    Downloaded:79
    Open Access
    Review
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite...
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00074
    Viewed:772
    Downloaded:40
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole...
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. DOI: 10.37349/emed.2022.00073
    Viewed:942
    Downloaded:51
    Open Access
    Review
    Nano-immunotherapeutics: targeting approach as strategic regulation at tumor microenvironment for cancer treatment
    Cancer is the leading cause of mortality worldwide, which necessitates our consideration related to novel treatment approach. Tumor cells at the tumor microenvironment (TME), regulate a plethora of ...
    Priyanka Singh ... Anita Kamra Verma
    Published: February 16, 2022 Explor Med. DOI: 10.37349/emed.2022.00072
    Viewed:425
    Downloaded:37
    Open Access
    Original Article
    Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data)
    Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested...
    Gürer G. Budak ... Orkun Tarkun
    Published: January 18, 2022 Explor Med. DOI: 10.37349/emed.2022.00071
    Viewed:516
    Downloaded:41
    Open Access
    Review
    A global genetic epidemiological review of pseudoexfoliation syndrome
    Pseudoexfoliation (PXF) syndrome is an important public health concern requiring individual population level analysis. Disease prevalence differs by geographic location and ethnicity, and has environmental, demographic, genetic, and molecular risk factors have been demonstrated. Epidemiological factors that have been associated with PXF include age, sex, environmental factors, and diet. Genetic and molecular components have also been identified that are associated with PXF....
    Patrice M. Hicks ... Margaret M. DeAngelis
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00069
    Viewed:581
    Downloaded:46
    Open Access
    Review
    Antioxidant enzymes and vascular diseases
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has detrimental effects on human health, and numerous studies confirmed that high ROS/RNS production contributes to the initiation and progression of cardiovascular diseases. The antioxidant defense has an essential role in the homeostatic functioning of the vascular endothelial system. Endogenous antioxidative defense includes various molecules and enzymes such as superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase. ...
    Jelena Radovanovic ... Esma R. Isenovic
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00070
    Viewed:720
    Downloaded:53
    Open Access
    Review
    Key roles of CCCTC-binding factor in cancer evolution and development
    The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of cancer and are often responsible for the pivotal developmental processes such as cell survival, expansion, senescence, and differentiation. As an evolutionary conserved and ubiquitously expression protein, CCCTC-binding factor (CTCF) has diverse regulatory functions, including gene regulation, imprinting, insulation, X chromosome inactivation, and the establishment of three-dimensional (3D) chromatin structure during human embryogenesis. ...
    Zishuai Li ... Guangwen Cao
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00068
    Viewed:476
    Downloaded:30
    Open Access
    Commentary
    Functions of two distinct Kupffer cells in the liver
    Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation. Recently, two research studies accomplished by a collaborated group of researchers showed that there are two populations of liver resident Kupffer cells (KCs), including a major cluster of differentiation 206 low expression (CD206low)endothelial cell-selective adhesion molecule negative (ESAM−) population (KC1) and a minor CD206highESAM+ population (KC2). ...
    Chunye Zhang ... Ming Yang
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00067
    Viewed:794
    Downloaded:68
    Open Access
    Review
    Molecular targets regulating endoplasmic reticulum-mitochondria crosstalk for NAFLD treatment
    Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease poses a significant impact on public healthcare and economic risk worldwide. As a multifactorial disease, NAFLD is usually associated with many comorbidities such as obesity, insulin resistance, hypertension, hyperlipidemia, diabetes, and cardiovascular disease. Without effectively preventive intervention, the advanced stage of NAFLD, non-alcoholic steatohepatitis (NASH), can progress to cirrhosis and hepatocellular carcinoma (HCC). ...
    Chunye Zhang, Ming Yang
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00066
    Viewed:536
    Downloaded:48
    Open Access
    Original Article
    Cross-cultural adaptation of Delphi definitions of low back pain prevalence in French (Delphi DOLBaPP-F)
    Aim: The high heterogeneity in the definitions of low back pain encountered in the literature has led to the development of standardized definitions of this condition called “Delphi definitions of low back pain prevalence (Delphi DOLBaPP)” by a group of international researchers. In order to be widely used, these definitions need to be adapted according to the cultural and linguistic context. The aim of this work was to perform the cross-cultural adaptation of the Delphi DOLBaPP definitions in Quebec French and to pre-test them among French-speaking adults. ...
    Antarou Ly ... Clermont E. Dionne
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00065
    Viewed:422
    Downloaded:34
    Open Access
    Review
    Obstetric implications of maternal chronic hepatitis B virus infection
    Antenatal screening for hepatitis B surface antigen seropositivity is widely adopted to identify pregnant women with chronic hepatitis B virus (HBV) infection in order to target their newborn infants for combined passive-active neonatal immunization to prevent the maternal-to-child transmission of HBV. It is less certain whether the presence of chronic HBV infection in these largely asymptomatic women could impact their pregnancy outcome. There is now gathering ...
    Terence T. Lao
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00064
    Viewed:412
    Downloaded:24
    Open Access
    Review
    Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures
    According to the Global Cancer Observatory (GLOBOCAN) 2020, colorectal carcinoma (CRC) was the second leading cause of cancer death globally. Current literature utilizes reported databases such as Surveillance, Epidemiology, and End Results (SEER) to better understand the epidemiology of CRC. The global cancer observatory’s “Cancer Tomorrow” data visualization tools were used to predict the future incidence and mortality of colorectal cancers until 2030 as a guided tool to look over ways to reduce incidence by controlling risk factors of CRC. The total number of CRC is expected to rise by 2030, with a percent change of 17.3%. ...
    Hassam Ali
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00063
    Viewed:471
    Downloaded:24
    Open Access
    Review
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathies. AD was found to occur in 0.0004% of all pregnancies, and it is more pronounced in patients with underlying connective tissue disorders. The normal hemodynamic changes on a weak aorta will lead to AD and/or rupture, more so with increase in the period of gestation....
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00060
    Viewed:475
    Downloaded:43
    Open Access
    Commentary
    Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
    Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone publication clearly and exhaustively explains the multitude of pathogenic pathways involved in the development and progression of disease eventually conducive to heterogeneous clinical phenotypes and different disease outcomes. ...
    Amedeo Lonardo
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00061
    Viewed:552
    Downloaded:59
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. ...
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00062
    Viewed:1583
    Downloaded:402
    Open Access
    Meta-Analysis
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients with COVID-19 infection. Aortic thrombus is a rare thrombotic event with a wide spectrum of clinical manifestations and potential catastrophic complications. This study aimed to elucidate the clinical manifestations, diagnosis and treatment dilemmas of aortic thrombus with COVID-19 infection and raise awareness among frontline medical providers. Aortic thrombosis is rare, but if not considered early in the course of COVID-19 infection, the data suggest that the diagnosis will probably not be made until potentially serious complications arise. ...
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00059
    Viewed:772
    Downloaded:20
    Open Access
    Review
    Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical
    With the advent of various vaccines and antimicrobial agents during the 20th century, the control and containment of infectious diseases appeared to be a matter of time. However, studies unveiled the diverse natures of microbes, their lifestyle, and pathogenetic potentials. Since the ground-breaking discovery of the hepatitis B virus (HBV) by Baruch Blumberg and the subsequent development of a vaccine in the early 1980s, the main task of the scientific community has been to develop a proper management strategy for HBV-induced chronic liver diseases. In the early 1980’s, standard interferon (IFN) induced a reduction of HBV DNA levels, followed by the normalization of serum transaminases (alanine aminotransferase, ALT), in some chronic hepatitis B (CHB) patients. ...
    Sheikh Mohammad Fazle Akbar ... Yoichi Hiasa
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00058
    Viewed:549
    Downloaded:18
    Open Access
    Original Article
    Objective measurement of sleep by smartphone application: comparison with actigraphy and relation to self-reported sleep
    Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable to actigraphy in objectively monitoring sleep. The clinical utility of smartphone apps should be investigated further to increase access to convenient means of monitoring sleep....
    Taylor Maynard ... Sandy Neargarder
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00057
    Viewed:766
    Downloaded:29
    Open Access
    Commentary
    Breastfeeding duration and reduced risk of NAFLD in midlife of parous women
    Alessandro Mantovani ... Andrea Dalbeni
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00056
    Viewed:530
    Downloaded:10
    Open Access
    Review
    Role of angiotensin II in the development of subcellular remodeling in heart failure
    The development of heart failure under various pathological conditions such as myocardial infarction (MI), hypertension and diabetes are accompanied by adverse cardiac remodeling and cardiac dysfunction. Since heart function is mainly determined by coordinated activities of different subcellular organelles including sarcolemma, sarcoplasmic reticulum, mitochondria and myofibrils for regulating the intracellular concentration of Ca2+, it has been suggested that the occurrence of heart failure is a consequence of subcellular remodeling, metabolic alterations and Ca2+-handling abnormalities in cardiomyocytes. ...
    Sukhwinder K. Bhullar ... Naranjan S. Dhalla
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00054
    Viewed:803
    Downloaded:36
    Open Access
    Original Article
    High prevalence of false positive SARS-CoV2 serology in a cohort of patients with liver autoimmune diseases
    Aim: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) immunization in patients with autoimmune diseases is of particular concern to understand their response to the infection and to the vaccine. In fact, the immunological disorder and the immunosuppressive therapies could affect the serological response....
    Maria Giulia Cornacchia ... Gaetano Serviddio
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00055
    Viewed:1156
    Downloaded:36
    Open Access
    Perspective
    Why the aortic dissection detection risk score is problematic in emergency departments
    Acute aortic syndromes, including aortic dissection (AD), are rare. The AD detection risk score (ADDRS) and associated investigation pathway were developed to reduce missed diagnosis of AD. The methodology for its development was sub-optimal and it has not been robustly validated in the emergency department chest pain population....
    Anne-Maree Kelly
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00053
    Viewed:832
    Downloaded:16
    Open Access
    Case Report
    Submucosal esophageal hematomas in a critically ill patient on anticoagulation
    Submucosal esophageal hematoma is an uncommon clinical complication of anticoagulation. Current literature is scarce regarding presentation and management in acute submucosal hematomas in critically ill patients. Patients often present with retrosternal chest pain, making the diagnosis challenging due to overlap with common presentations of cardiopulmonary disorders. ...
    Hassam Ali, Maliha Naseer
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00052
    Viewed:519
    Downloaded:19
    Open Access
    Case Report
    Central pontine myelinolysis secondary to glycemic variability in type 1 diabetes: a case report and a systematic review of the literature
    Central pontine myelinolysis (CPM) is a rare manifestation of osmotic demyelination syndrome (ODS) which involves the pons and causes significant morbidity and mortality. CPM usually occurs in the setting of rapid correction of severe chronic hyponatremia. A rare case of CPM due to hyperglycemia in a 27-year-old man with type 1 diabetes is reported....
    Stefania Di Agostino ... Mauro Maurantonio
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00050
    Viewed:711
    Downloaded:32
    Open Access
    Review
    Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path
    The term non-alcoholic fatty liver disease (NAFLD) appears unfitting both in adults and in children. As obesity and metabolic syndrome play a relevant pathogenic role, an international group of adults’ liver disease experts has proposed to rename this condition metabolic (dysfunction)-associated fatty liver disease (MAFLD). While this new more appropriate and useful definition has mostly been met with good reactions in adults, it may present a tangled path in pediatrics. ...
    Angelo Colucci ... Claudia Mandato
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00051
    Viewed:900
    Downloaded:49
    Open Access
    Review
    Sex hormones abnormalities in non-alcoholic fatty liver disease: pathophysiological and clinical implications
    Obesity and metabolic syndrome are conditions at high risk for the development of complications such as type 2 diabetes mellitus, atherosclerotic cardiovascular disease, and non-alcoholic fatty liver disease (NAFLD). The growing prevalence of NAFLD has recently raised attention in the clinical practice, due to the worsening prognosis observed in the affected patients. Sex hormones abnormalities, commonly found in subjects suffering from obesity and metabolic syndrome, have been recently hypothesized to be directly involved in the physiopathology of obesity-related comorbidites;...
    Angelo Di Vincenzo ... Marco Rossato
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00049
    Viewed:789
    Downloaded:53
    Open Access
    Commentary
    An engineered mayhem: YAP/TAZ mechanosignaling and hepatocarcinogenesis in NAFLD
    Gyorgy Baffy
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00048
    Viewed:902
    Downloaded:37
    Open Access
    Review
    Wave propagation and reflection in the aorta and implications of the aortic Windkessel
    Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domain “impedance analysis” in which it was assumed that all variations in aortic pressure and flow were caused only by forward- and backward-going waves. ...
    John V. Tyberg
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00042
    Viewed:642
    Downloaded:35
    Open Access
    Review
    Emerging nanomaterials for cancer immunotherapy
    Immunotherapy is a unique approach to treat cancer that targets tumours besides triggering the immune cells. It attempts to harness the supremacy and specificity of immune cells for the regression of malignancy. The key strategy of immunotherapy is that it boosts the natural defence and manipulates the immune system at both cellular and molecular levels. ...
    Sureshbabu Ram Kumar Pandian ... Krishnan Sundar
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00043
    Viewed:754
    Downloaded:55
    Open Access
    Original Article
    Neuropsychological test validation of speech markers of cognitive impairment in the Framingham Cognitive Aging Cohort
    Aim: Although clinicians primarily diagnose dementia based on a combination of metrics such as medical history and formal neuropsychological tests, recent work using linguistic analysis of narrative speech to identify dementia has shown promising results. We aim to build upon research by Thomas JA & Burkardt HA et al. (J Alzheimers Dis. 2020;76:905–2) and Alhanai et al. (arXiv:1710.07551v1. 2020) on the Framingham Heart Study (FHS) Cognitive Aging Cohort by 1) demonstrating the predictive capability of linguistic analysis in differentiating cognitively normal from cognitively impaired participants and 2) comparing the performance of the original linguistic features with the performance of expanded features....
    Larry Zhang ... Reza Hosseini Ghomi
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00044
    Viewed:983
    Downloaded:47
    Open Access
    Original Article
    Digital sleep measures and white matter health in the Framingham Heart Study
    Aim: Impaired sleep quality and sleep oxygenation are common sleep pathologies. This study assessed the impact of these abnormalities on white matter (WM) integrity in an epidemiological cohort. Methods: The target population was the Framingham Heart Study Generation-2/Omni-1 Cohorts. Magnetic resonance imaging (diffusion tensor imaging) was used to assess WM integrity. Wearable digital devices were used to assess sleep quality: the (M1-SleepImageTM system) and the Nonin WristOx for nocturnal oxygenation. The M1 device collects trunk actigraphy and the electrocardiogram (ECG); sleep stability indices were computed using cardiopulmonary coupling using the ECG. Two nights of recording were averaged....
    Robert Joseph Thomas ... Rhoda Au
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00045
    Viewed:966
    Downloaded:32
    Open Access
    Review
    Angiotensin-(1-7) and Mas receptor in the brain
    The renin-angiotensin system (RAS) is a key regulator of blood pressure and electrolyte homeostasis. Besides its importance as regulator of the cardiovascular function, the RAS has also been associated to the modulation of higher brain functions, including cognition, memory, depression and anxiety. For many years, angiotensin II (Ang II) has been considered the major bioactive component of the RAS. However, the existence of many other biologically active RAS components has currently been recognized, with similar, opposite, or distinct effects to those exerted by Ang II. ...
    Natalia L. Rukavina Mikusic ... Mariela M. Gironacci
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00046
    Viewed:1893
    Downloaded:150
    Open Access
    Review
    Angiotensin peptides in the regulation of adrenal cortical function
    The adrenal cortex plays a key role in the regulation of metabolism, salt and water homeostasis and sex differentiation by synthesizing glucocorticoid, mineralocorticoid and androgen hormones. Evidence exists that angiotensin II regulates adrenocortical function and it has been contended that angiotensin peptides of the non-canonical branch of the renin angiotensin system (RAS) might also modulate steroidogenesis in adrenals. Thus, the aim of this review is to examine the role of the RAS, and particularly of the angiotensin peptides and their receptors, in the regulation of adrenocortical hormones with particular focus on aldosterone production....
    Gian Paolo Rossi ... Teresa Maria Seccia
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00047
    Viewed:1291
    Downloaded:99
    Open Access
    Perspective
    Vascular aging, the vascular cytoskeleton and aortic stiffness
    Vascular aging, aortic stiffness and hypertension are mechanistically interrelated. The perspective presented here will focus mainly on the molecular mechanisms of age-associated increases in the stiffness of the vascular smooth muscle cell (VSMC). This review will highlight the mechanisms by which the VSMC contributes to disorders of vascular aging. Distinct functional sub-components of the vascular cell and the molecular mechanisms of the protein-protein interactions, signaling mechanisms and intracellular trafficking processes in the setting of the aging aorta will be detailed....
    Lova Prasadareddy Kajuluri ... Kathleen G Morgan
    Published: June 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00041
    Viewed:974
    Downloaded:48
    Open Access
    Review
    AS1411-functionalized delivery nanosystems for targeted cancer therapy
    Nucleolin (NCL) is a multifunctional nucleolar phosphoprotein harboring critical roles in cells such as cell proliferation, survival, and growth. The dysregulation and overexpression of NCL are related to various pathologic and oncological indications. These characteristics of NCL make it an ideal target for the treatment of various cancers. AS1411 is a synthetic quadruplex-forming nuclease-resistant DNA oligonucleotide aptamer which shows a considerably high affinity for NCL, therefore, being capable of inducing growth inhibition in a variety of tumor cells. ...
    Pooria Safarzadeh Kozani ... Mohammad Tariq Malik
    Published: April 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00039
    Viewed:1241
    Downloaded:53
    Open Access
    Review
    Nanomedicine in cancer therapy: promises and hurdles of polymeric nanoparticles
    The limitations of current cancer treatments have stimulated the application of nanotechnology to develop more effective and safer cancer therapies. Remarkable progress has been made in the development of nanomedicine to overcome issues associated with conventional cancer treatment, including low drug solubility, insufficient targeting, and drug resistance. ...
    Carmen Paus ... Alessandra Cambi
    Published: April 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00040
    Viewed:1136
    Downloaded:40
    Open Access
    Case Report
    Hepatic manifestations of drug reaction with eosinophilia and systemic symptoms syndrome
    Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening drug reaction, which can affect multiple organs. Patients with DRESS syndrome and hepatic manifestations may present alterations ranging from mild hepatitis to acute liver failure. The diagnosis might be difficult, and the management of these patients is challenging. This report analyzes a series of five cases reporting the clinical presentation, which ranged from acute hepatitis to liver failure, and discussed their treatment....
    Maria Gabriela Delgado ... Jean François Dufour
    Published: April 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00037
    Viewed:1648
    Downloaded:29
    Open Access
    Original Article
    Angiotensin-(3-4) modulates the overweight- and undernutrition-induced ACE2 downregulation in renal proximal tubule cells: implications for COVID-19?
    Aim: The renal lesions–including severe acute kidney injury–are severe outcomes in severe acute respiratory syndrome coronavirus 2 infections. There are no reports regarding the influence of the nutritional status on the severity and progress of these lesions. Ageing is also an important risk factor. Methods: In the present study we compared the influence of overweight and undernutrition on the levels of renal angiotensin converting enzymes 1 and 2 (ACE and ACE2), which were evaluated by Western blotting. Since the renin-angiotensin-aldosterone system (RAAS) has been implicated in the progress of kidney failure during coronavirus disease 2019, the influence of Angiotensin-(3-4) [Ang-(3-4)] was investigated. Ang-(3-4) is the shortest angiotensin-derived peptide, which is considered the physiological antagonist of several Ang II effects....
    Rafael Luzes ... Adalberto Vieyra
    Published: April 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00038
    Viewed:1302
    Downloaded:94
    Open Access
    Original Article
    Proof of concept: digital clock drawing behaviors prior to transcatheter aortic valve replacement may predict length of hospital stay and cost of care
    Aims: Reduced pre-operative cognitive functioning in older adults is a risk factor for postoperative complications, but it is unknown if preoperative digitally-acquired clock drawing test (CDT) cognitive screening variables, which allow for more nuanced examination of patient performance, may predict lengthier hospital stay and greater cost of hospital care. ...
    Margaret Ellenora Wiggins ... Catherine C. Price
    Published: April 30, 2021 Explor Med. DOI: 10.37349/emed.2021.00036
    Viewed:1704
    Downloaded:28
    Open Access
    Review
    Cell-derived vesicles for delivery of cancer immunotherapy
    In recent years, cancer immunotherapy has received unprecedented attention due to the clinical achievements. The applications of biomedical engineering and materials science to cancer immunotherapy have solved the challenges caused by immunotherapy to a certain extent. Among them, cell-derived vesicles are natural biomaterials chosen as carriers or immune-engineering in view of their many unique advantages. This review will briefly introduce the recent applications of cell-derived vesicles for cancer immunotherapy....
    Jialu Xu, Chao Wang
    Published: February 28, 2021 Explor Med. DOI: 10.37349/emed.2021.00031
    Viewed:1406
    Downloaded:55
    Open Access
    Original Article
    Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes
    Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability, few genetic risk loci have been identified for either opioid or cocaine dependence (OD or CD, respectively). A genome-wide association study of OD and CD related phenotypes reflecting the time between first self-reported use of these substances and a first DSM-IV dependence diagnosis was conducted. ...
    Richard Sherva ... Lindsay A. Farrer
    Published: February 28, 2021 Explor Med. DOI: 10.37349/emed.2021.00032
    Viewed:1779
    Downloaded:28
    Open Access
    Original Article
    A machine learning approach to identify correlates of current e-cigarette use in Canada
    Aim: Popularity of electronic cigarettes (i.e. e-cigarettes) is soaring in Canada. Understanding person-level correlates of current e-cigarette use (vaping) is crucial to guide tobacco policy, but prior studies have not fully identified these correlates due to model overfitting caused by multicollinearity. This study addressed this issue by using classification tree, a machine learning algorithm. ...
    Rui Fu ... Michael Chaiton
    Published: February 28, 2021 Explor Med. DOI: 10.37349/emed.2021.00033
    Viewed:1522
    Downloaded:27
    Open Access
    Original Article
    Assessing the capacity for mental manipulation in patients with statically-determined mild cognitive impairment using digital technology
    Aims: Prior research employing a standard backward digit span test has been successful in operationally defining neurocognitive constructs associated with the Fuster’s model of executive attention. The current research sought to test if similar behavior could be obtained using a cross-modal mental manipulation test. ...
    Sheina Emrani ... David J. Libon
    Published: February 28, 2021 Explor Med. DOI: 10.37349/emed.2021.00034
    Viewed:1410
    Downloaded:20
    Open Access
    Original Article
    Risk factors in acute diabetic foot syndrome: analysis of 75 consecutive patients referred to a tertiary center in Modena, Italy
    Aim: Diabetic foot syndrome (DFS) is a complication of diabetes in which the presence of infections, ulceration and/or destruction of deep tissue associated with neuropathy, peripheral atherosclerosis and comorbidity affect the prognosis, the need for limb amputation and quality of life. Purpose of the present study is to report the features of patients with acute DFS admitted to our Diabetic Foot Unit tertiary Center in 2019. ...
    Mauro Maurantonio ... Luca Roncucci
    Published: February 28, 2021 Explor Med. DOI: 10.37349/emed.2021.00035
    Viewed:1299
    Downloaded:21
    Open Access
    Review
    Cardiovascular involvement after liver transplantation: role of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Patients submitted to liver transplantation (LT) are exposed to high risk of cardiovascular (CV) complications which are the main determinants of both short-term and long-term morbidity and mortality in LT. Non-alcoholic fatty liver disease (NAFLD) is a very frequent condition in general population and is associated with a high risk of cardiovascular disease (CVD) which represents the first cause of death of these patients. NAFLD is predicted to become the first indication to LT and nowadays is also frequently detected in patients submitted to LT for other indications....
    Rosa Lombardi ... Anna Ludovica Fracanzani
    Published: February 28, 2021 Explor Med DOI: 10.37349/emed.2021.00030
    Viewed:1070
    Downloaded:26
    Open Access
    Review
    Silent coronary artery disease in type 2 diabetes: a narrative review on epidemiology, risk factors, and clinical studies
    Silent coronary artery disease (CAD) is one of the manifestations of heart disease that particularly affects subjects with type 2 diabetes mellitus (T2DM). From a clinical point of view, silent CAD represents a constant challenge for the diabetologist, who has to decide whether a patient could or could not be screened for this disease. In the present narrative review, several aspects of silent CAD are considered: the epidemiology of the disease, the associated risk factors, and main studies conducted, in the last 20 years, especially aimed to demonstrate the usefulness of the screening of silent CAD, to improve cardiovascular outcomes in type 2 diabetes....
    Saula Vigili de Kreutzenberg
    Published: February 28, 2021 Explor Med. DOI: 10.37349/emed.2021.00029
    Viewed:1381
    Downloaded:31
    Open Access
    Original Article
    Detection of mild traumatic brain injury in pediatric populations using BrainCheck, a tablet-based cognitive testing software: a preliminary study
    Aim: Despite its high frequency of occurrence, mild traumatic brain injury (mTBI), or concussion, is difficult to recognize and diagnose, particularly in pediatric populations. Conventional methods to diagnose mTBI primarily rely on clinical questionnaires and sometimes include neuroimaging or pencil and paper neuropsychological testing. However, these methods are time consuming, require administration/interpretation from health professionals, and lack adequate test sensitivity and specificity. ...
    Siao Ye ... Reza Hosseini Ghomi
    Published: December 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00027
    Viewed:1495
    Downloaded:56
    Open Access
    Original Article
    Identification of digital voice biomarkers for cognitive health
    Aim: Human voice contains rich information. Few longitudinal studies have been conducted to investigate the potential of voice to monitor cognitive health. The objective of this study is to identify voice biomarkers that are predictive of future dementia. Methods: Participants were recruited from the Framingham Heart Study. The vocal responses to neuropsychological tests were recorded,...
    Honghuang Lin ... Rhoda Au
    Published: December 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00028
    Viewed:1632
    Downloaded:52
    Open Access
    Original Article
    Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity
    Aim: Research suggests that Alzheimer’s disease (AD) is heterogeneous with numerous subtypes. Through a proprietary interactive ML system, several underlying biological mechanisms associated with AD pathology were uncovered. This paper is an introduction to emerging analytic efforts that can more precisely elucidate the heterogeneity of AD. Methods: A public AD data set (GSE84422) consisting of transcriptomic data of postmortem brain samples from healthy controls (n = 121) and AD (n = 380) subjects was analyzed. ...
    Bessi Qorri ... Joseph Geraci
    Published: December 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00026
    Viewed:1917
    Downloaded:48
    Open Access
    Review
    The entero-insular axis: a journey in the physiopathology of diabetes
    Glycemic homeostasis is an essential mechanism for the proper working of an organism. However, balance in blood lipid and protein levels also plays an important role. The discovery of the hormone insulin and the description of its function for glycemic control made fundamental scientific progress in this field. However, since then our view of the problem has been deeply influenced only in terms of glucose and insulin (in an insulin-centric and glucose-centric way). ...
    Roberta Malaguarnera ... Salvatore Piro
    Published: December 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00025
    Viewed:1476
    Downloaded:39
    Open Access
    Commentary
    The need for a harmonized speech dataset for Alzheimer’s disease biomarker development
    This commentary is the product of a concerted effort to understand the needs, barriers, and gaps in the field of speech and language biomarkers for Alzheimer’s disease (AD). It distills interviews, surveys, and extensive correspondence with global leaders in the areas of dementia research, clinical trials, linguistics, and data analytics into an idealized clinical-study design for the harmonized collection of voice recordings....
    Nicole L. Bjorklund ... Lampros Kourtis
    Published: December 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00024
    Viewed:2036
    Downloaded:81
    Open Access
    Review
    Insulin pump therapy and continuous glucose monitoring in adults with type 2 diabetes: where are we now?
    Technology in diabetes is rapidly evolving, with the aim of helping affected people to safely optimize their blood glucose control. New technologies are now considered as an essential tool for managing glycemia predominantly in people with type 1 diabetes, and clinical trials have demonstrated that in these subjects the use of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) systems are associated with improved glycemic control along with a better quality of life. ...
    Erika Pedone ... Amelia Caretto
    Published: October 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00021
    Viewed:2201
    Downloaded:39
    Open Access
    Perspective
    High-performance computing will assist experiments in recovery from COVID-19
    Bhushan Dharmadhikari ... Prabir Patra
    Published: October 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00023
    Viewed:1320
    Downloaded:17
    Open Access
    Original Article
    Going against the norm: validation of a novel alternative to brain SPECT normative datasets
    Aim: Quantitative analysis of brain single photon emission computed tomography (SPECT) perfusion imaging is dependent on normative datasets that are challenging to produce. This study investigated the combination of SPECT neuroimaging from a large clinical population rather than small numbers of controls. The authors hypothesized this “population template” would demonstrate noninferiority to a control dataset, providing a viable alternative for quantifying perfusion abnormalities in SPECT neuroimaging. Methods: A total of 2, 068 clinical SPECT scans were averaged to form the “population template”. Validation was three-fold. First, the template was imported into SPECT brain analysis software, MIMneuro®, and compared against its control dataset of 90 individuals through its region and cluster analysis tools. ...
    Lindsay M. Quandt, Cyrus A. Raji
    Published: October 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00022
    Viewed:2001
    Downloaded:39
    Open Access
    Commentary
    Country rankings on the scientific production in endocrinology and diabetology
    Alessandro Mantovani ... Chiara Zusi
    Published: October 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00020
    Viewed:1236
    Downloaded:14
    Open Access
    Review
    The diagnostic conundrum in non-alcoholic fatty liver disease
    Non-alcoholic fatty liver disease (NAFLD) has become the most common liver alteration worldwide. It encompasses a spectrum of disorders that range from simple steatosis to a progressive form, defined non-alcoholic steatohepatitis (NASH), that can lead to advanced fibrosis and eventually cirrhosis and hepatocellular carcinoma. On liver histology, NASH is characterized by the concomitant presence of significant fat accumulation and inflammatory reaction with hepatocellular injury. ...
    Valerio Rosato ... Marcello Persico
    Published: October 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00018
    Viewed:2999
    Downloaded:105
    Open Access
    Review
    Nonalcoholic fatty liver disease and type 2 diabetes: pathophysiological mechanisms shared between the two faces of the same coin
    The pathophysiological mechanisms underlying the close relationship between nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are multiple, complex and only partially known. The purpose of this paper was to review the current knowledge of these mechanisms in a unified manner. Subjects with NAFLD and T2DM have established insulin resistance (IR), which exacerbates the two comorbidities....
    Carlo Acierno ... Ferdinando Carlo Sasso
    Published: October 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00019
    Viewed:3140
    Downloaded:122
    Open Access
    Review
    Non-alcoholic fatty liver disease and transient elastography
    Nonalcoholic fatty liver disease (NAFLD) is a serious condition that can lead to fibrosis, cirrhosis, and hepatocellular carcinoma. NAFLD is associated with metabolic syndrome (MetS) and all of its components. According to data, around 25–30% of population has NAFLD. Giving the growing incidence of MetS, obesity and diabetes mellitus type 2, NAFLD related terminal-stage liver disease is becoming prevailing indication for liver transplantation. In order to prevent terminal stage of this disease, it is crucial to determine those that are in risk group, to modify their risk factors and monitor their potential progression. ...
    Ivana Mikolasevic ... Sandra Milic
    Published: August 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00014
    Viewed:3567
    Downloaded:49
    Open Access
    Review
    Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
    Nonalcoholic fatty liver disease (NAFLD) has become the most prevalent liver chronic disease worldwide. The pathogenesis of NAFLD is complex and involves many metabolic enzymes and multiple pathways. Posttranslational modifications of proteins (PMPs) added another layer of complexity to the pathogenesis of NAFLD. PMPs change protein properties and regulate many biological functions, including cellular localization, stability, intracellular signaling, and protein function....
    Fatiha Nassir
    Published: August 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00017
    Viewed:2691
    Downloaded:70
    Open Access
    Review
    Type 2 diabetes and cancer: problems and suggestions for best patient management
    Diabetes and cancer are widespread worldwide and the number of subjects presenting both diseases increased over the years. The management of cancer patients having diabetes represents a challenge not only because of the complexity and heterogeneity of these pathologies but also for the lack of standardised clinical guidelines. The diagnosis of cancer is traumatizing and monopolizes the attention of both patients and caregivers. Thus, pre-existent or new-onset diabetes can be overshadowed thus increasing the risk for short- and long-term adverse events. ...
    Agostino Milluzzo ... Laura Sciacca
    Published: August 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00013
    Viewed:4318
    Downloaded:98
    Open Access
    Review
    Genetic and metabolic factors: the perfect combination to treat metabolic associated fatty liver disease
    The prevalence of nonalcoholic or more recently re-defined metabolic associated fatty liver disease (MAFLD) is rapidly growing worldwide. It is characterized by hepatic fat accumulation exceeding 5% of liver weight not attributable to alcohol consumption. MAFLD refers to an umbrella of conditions ranging from simple steatosis to nonalcoholic steatohepatitis which may finally progress to cirrhosis and hepatocellular carcinoma. MAFLD is closely related to components of the metabolic syndrome and to environmental factors. ...
    Marica Meroni ... Paola Dongiovanni
    Published: August 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00015
    Viewed:2935
    Downloaded:77
    Open Access
    Perspective
    Visual communication and learning from COVID-19 to advance preparedness for pandemics
    The currently ongoing coronavirus disease 19 (COVID-19) pandemic has affected globally human health and economy. Research in progress has shown facts associated with this disease and raised questions relevant for disease control and prevention. In this perspective, the collaboration between science and art in visual communication using the artwork “Enseñanza” (“Teaching”) contributes to the representation of the lessons ...
    José de la Fuente ... Christian Gortázar
    Published: August 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00016
    Viewed:2963
    Downloaded:53
    Open Access
    Review
    The therapeutic potential of C-C chemokine receptor antagonists in nonalcoholic steatohepatitis
    Pooled prevalence of nonalcoholic fatty liver disease (NAFLD) globally is about 25%. Nonalcoholic steatohepatitis (NASH) with advanced fibrosis has been linked with substantial morbidity and mortality, without having to-date any licensed treatment. C-C chemokine receptor (CCR) antagonists have been investigated as candidates for the treatment of NASH. Inhibition of CCR2 is expected to mitigate hepatic inflammation, through reducing the activation of Kupffer cells, as well as the infiltration of monocytes and macrophages into the liver. ...
    Michael Doulberis ... Stergios A. Polyzos
    Published: August 31, 2020 Explor Med. DOI: 10.37349/emed.2020.00012
    Viewed:2680
    Downloaded:42
    Open Access
    Review
    Perspectives of nonalcoholic fatty liver disease research: a personal point of view
    Rational government of patient fluxes from primary care to hepatology clinic is a priority of nonalcoholic fatty liver disease (NAFLD) research. Estimating pre-test probability of disease, risk of fibrosis progression, and exclusion of competing causes of liver disease must be addressed. Here we propose a novel taxonomic classification of NAFLD based on hepatic, pathogenic and systemic features of disease in the individual patient. The variable course of disease in any given patient remains a clinical enigma. ...
    Amedeo Lonardo, Stefano Ballestri
    Published: June 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00007
    Viewed:3626
    Downloaded:94
    Open Access
    Original Article
    Reduction of endoglin receptor impairs mononuclear cell-migration
    Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell surface and oxidative stress. Methods: MNCs of HHT patients and normal controls were subjected to migration assay. Fractions of MNCs were pre-incubated with antibodies specific to HHT causative genes ENG [hereditary hemorrhagic telangiectasia type 1 (HHT1)] or activin receptor-like kinase 1 [ALK1, hereditary hemorrhagic telangiectasia type 2 (HHT2)], AMD3100 or Diprotin-A to block ENG, ALK1 C-X-C chemokine receptor 4 (CXCR4) or CD26 (increased in HHT1 MNCs) before migration assay. ...
    Zhenying Han ... Hua Su
    Published: June 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00010
    Viewed:1595
    Downloaded:23
    Open Access
    Original Article
    Placental OPRM1 DNA methylation and associations with neonatal opioid withdrawal syndrome, a pilot study
    Aim: Epigenetic variation of DNA methylation of the mu-opioid receptor gene (OPRM1) has been identified in the blood and saliva of individuals with opioid use disorder (OUD) and infants with neonatal opioid withdrawal syndrome (NOWS). It is unknown whether epigenetic variation in OPRM1 exists within placental tissue in women with OUD and whether it is associated with NOWS outcomes. ...
    Elisha M. Wachman ... Huiping Zhang
    Published: June 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00009
    Viewed:2241
    Downloaded:32
    Open Access
    Meta-Analysis
    GLP-1 receptor agonists for NAFLD treatment in patients with and without type 2 diabetes: an updated meta-analysis
    Aim: Recent randomized controlled trials (RCTs) have tested the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1 RA) to specifically treat non-alcoholic fatty liver disease (NAFLD). We performed a meta-analysis of RCTs to investigate the efficacy of GLP-1 RAs for treatment of NAFLD or non-alcoholic steatohepatitis (NASH). Methods: We systematically searched PubMed and ClinicalTrials.Gov databases utilizing specific terms to identify placebo-controlled or head-to-head RCTs (last research on March 1, 2020) involving NAFLD patients with the aim of evaluating the efficacy of GLP-1 RAs to treat NAFLD/NASH....
    Alessandro Mantovani ... Giovanni Targher
    Published: June 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00008
    Viewed:1745
    Downloaded:65
    Open Access
    Review
    Nonalcoholic fatty liver disease and portal hypertension
    Nonalcoholic fatty liver disease (NAFLD) is a substantial and growing problem worldwide and has become the second most common indication for liver transplantation as it may progress to cirrhosis and develop complications from portal hypertension primarily caused by advanced fibrosis and erratic tissue remodeling. However, elevated portal venous pressure has also been detected in experimental models of fatty liver and in human NAFLD when fibrosis is far less advanced and cirrhosis is absent. ...
    Marvin Ryou ... Gyorgy Baffy
    Published: June 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00011
    Viewed:3337
    Downloaded:65
    Open Access
    Review
    Sex differences in non-alcoholic fatty liver disease: hints for future management of the disease
    Non-alcoholic fatty liver disease (NAFLD) remains a major cause of chronic liver disease worldwide. Despite extensive studies, the heterogeneity of the risk factors as well as different disease mechanisms complicate the goals toward effective diagnosis and management. Recently, it has been shown that sex differences play a role in the prevalence and progression of NAFLD....
    Noel C. Salvoza ... Natalia Rosso
    Published: April 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00005
    Viewed:6801
    Downloaded:155
    Open Access
    Review
    Understanding cardiac systolic performance beyond left ventricular ejection fraction
    Left ventricular ejection fraction is the critical parameter used for heart failure classification, decision making and assessing prognosis. It is defined as a volumetric ratio and is essentially a composite of arterial and ventricular elastances, but not intrinsic contractility. The clinician should be aware of its numerous limitations when measuring and reporting it. ...
    Elena-Laura Antohi, Ovidiu Chioncel
    Published: April 30, 2020 Explor Med. DOI: 10.37349/emed.2020.00006
    Viewed:4057
    Downloaded:107
    Open Access
    Review
    Current evidence and outcomes for retinopathy of prematurity prevention: insight into novel maternal and placental contributions
    Retinopathy of prematurity (ROP) is a blinding morbidity of preterm infants, which represents a significant clinical problem, accounting for up to 40% of all childhood blindness. ROP displays a range of severity, though even mild disease may result in life-long visual impairment. ...
    Lara Carroll, Leah A. Owen
    Published: February 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00002
    Viewed:2478
    Downloaded:89
    Open Access
    Original Article
    Identifying factors associated with opioid cessation in a biracial sample using machine learning
    Aim: Racial disparities in opioid use disorder (OUD) management exist, however, and there is limited research on factors that influence opioid cessation in different population groups. Methods: We employed multiple machine learning prediction algorithms least absolute shrinkage and selection operator, random forest, deep neural network, and support vector machine to assess factors associated with ceasing opioid use in a sample of 1,192 African Americans (AAs) and 2,557 individuals of European ancestry (EAs) who met Diagnostic and Statistical Manual of Mental Disorders, 5th Edition criteria for OUD. ...
    Jiayi W. Cox ... Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00003
    Viewed:3112
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    Open Access
    Review
    PNPLA3 gene and kidney disease
    Chronic kidney disease (CKD) is a disease regularly seen in clinical practice. At present, CKD is described as a change of kidney structure and/or function and it is classified in relation to cause, values of glomerular filtration rate and albuminuria category. Seeing that CKD is closely linked to the development of end-stage renal disease and other comorbidities, the determination of additional independent predictors for CKD is clinically necessary. ...
    Alessandro Mantovani, Chiara Zusi
    Published: February 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00004
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    Downloaded:35
    Open Access
    Editorial
    Welcome message from the Editor-in-Chief
    Lindsay A. Farrer
    Published: February 29, 2020 Explor Med. DOI: 10.37349/emed.2020.00001
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