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    Original Article
    Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesions: findings from K14-HPV16 mice
    Aim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. ci...
    Beatriz Medeiros-Fonseca ... Paula A. Oliveira
    Published: June 18, 2024 Explor Med. DOI: 10.37349/emed.2024.00228
    Viewed:94
    Downloaded:8
    Open Access
    Original Article
    Screening tools for dementia assessment in UK based ethnic minorities
    Aim: The present study investigated whether commonly used screening tools and assessments for dementia were culturally appropriate for older adults from ethnic minorities (EM) groups living in th...
    Clara Calia, Mario A. Parra
    Published: June 06, 2024 Explor Med. DOI: 10.37349/emed.2024.00227
    Viewed:173
    Downloaded:14
    Open Access
    Review
    The future of cervical cancer prevention: advances in research and technology
    This article provides an informative overview of the current situation and future trends in cervical cancer prevention. Cervical cancer remains a significant public health concern worldwide and is c...
    Praveen Kumar Chandra Sekar ... Ramakrishnan Veerabathiran
    Published: May 22, 2024 Explor Med. DOI: 10.37349/emed.2024.00226
    Viewed:554
    Downloaded:11
    Open Access
    Review
    Impact of vitamin D on ultraviolet-induced photoaging and skin diseases
    Excessive exposure to ultraviolet (UV) radiation causes premature aging of the skin, known as photoaging. UV radiation induces DNA damage, oxidative stress, inflammatory reactions, and degradation o...
    Sankalya S. Ambagaspitiya ... Rohan S. Dassanayake
    Published: May 20, 2024 Explor Med. DOI: 10.37349/emed.2024.00225
    Viewed:359
    Downloaded:16
    Open Access
    Review
    Can magnetic nanoparticles enhance adoptive cell therapy via driving migration of lymphocytes into tumors?
    Therapy of malignant tumors still represents a huge problem for healthcare, since these diseases lead to a high rate of disability and premature death of the population. The main problems of adoptiv...
    Irina Chikileva ... Mikhail Kiselevskiy
    Published: May 16, 2024 Explor Med. DOI: 10.37349/emed.2024.00224
    Viewed:281
    Downloaded:9
    Open Access
    Review
    Dysregulation of BCL-2 family proteins in blood neoplasm: therapeutic relevance of antineoplastic agent venetoclax
    During cellular stress, the master regulators of intrinsic self-death (apoptosis) are BCL-2 family proteins. The BCL-2 family proteins play a key role in apoptosis and are tightly regulated via othe...
    Faris Tayeb
    Published: May 10, 2024 Explor Med. DOI: 10.37349/emed.2024.00223
    Viewed:284
    Downloaded:12
    Open Access
    Review
    A review on mushrooms as a versatile therapeutic agent with emphasis on its bioactive constituents for anticancer and antioxidant potential
    Mushrooms, due to their many medical, preventive, and nutraceutical purposes, as well as their reputation as a folk remedy, have long been an integral part of traditional cuisines. The therapeutic a...
    Mohd Javed Naim
    Published: May 06, 2024 Explor Med. DOI: 10.37349/emed.2024.00222
    Viewed:289
    Downloaded:12
    Open Access
    Review
    Physiologically driven nanodrug delivery system for targeted lung cancer treatment
    Lung cancer remains a leading cause of cancer-related deaths globally, and a significant number of patients are ineligible for surgery, while chemoradiotherapy often shows limited efficacy, a system...
    Shiying Zhang ... Zhiyue Zhang
    Published: April 25, 2024 Explor Med. DOI: 10.37349/emed.2024.00221
    Viewed:459
    Downloaded:29
    Open Access
    Review
    Effects of alimentary-derived bacterial metabolites on energy metabolism in colonic epithelial cells and inflammatory bowel diseases
    In this review, we present the main luminal fuels that are responsible for energy production in colonocytes, namely the bacterial metabolites short-chain fatty acids and lactate, which are produced ...
    Mireille Andriamihaja, François Blachier
    Published: April 24, 2024 Explor Med. DOI: 10.37349/emed.2024.00220
    Viewed:727
    Downloaded:24
    Open Access
    Review
    Medicinal and immunological aspects of bacteriophage therapy to combat antibiotic resistance
    Bacteriophages are viruses that infect bacterial cells and use their machinery to reproduce. This unique characteristic holds immense promise for combating antibiotic-resistant bacterial infections,...
    Isra Noor ... Ahmad Syibli Othman
    Published: April 22, 2024 Explor Med. DOI: 10.37349/emed.2024.00217
    Viewed:591
    Downloaded:26
    Open Access
    Original Article
    Cellular adenylate energy charge and adenine nucleotides in brain tissue during hypoglycemia in newly born BALB/c mice pups
    Aim: Hypoglycemia occurs in the neonatal period but the exact pathophysiology of the resulting brain injury at the cellular level is not well known. Therefore, a neonatal murine model was develop...
    Hassib Narchi ... Radhakrishnan Subramanian
    Published: April 22, 2024 Explor Med. DOI: 10.37349/emed.2024.00218
    Viewed:305
    Downloaded:12
    Open Access
    Original Article
    Relationship between gingival and peri-implant sulcular fluid active matrix metalloproteinase-8 concentration and clinical indices in healthy and diseased conditions
    Aim: The study was to evaluate the active matrix metalloproteinase-8 (aMMP-8) concentration in gingival crevicular fluid (GCF) and in peri-implant sulcular fluid (PISF) in healthy and diseased co...
    Renzo Guarnieri ... Luca Testarelli
    Published: April 22, 2024 Explor Med. DOI: 10.37349/emed.2024.00219
    Viewed:520
    Downloaded:15
    Open Access
    Original Article
    The influence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) family history on patients with ME/CFS
    Aim: It is unclear if individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) with family histories of ME/CFS differ from those with ME/CFS without this family history. To ex...
    Leonard A. Jason, Sarah Ngonmedje
    Published: April 11, 2024 Explor Med. DOI: 10.37349/emed.2024.00215
    Viewed:3727
    Downloaded:37
    Open Access
    Original Article
    The association between circulating CD34+CD133+ endothelial progenitor cells and reduced risk of Alzheimer’s disease in the Framingham Heart Study
    Aim: Endothelial dysfunction has been associated with both cerebrovascular pathology and Alzheimer’s disease (AD). However, the connection between circulating endothelial cells and the risk of ...
    Yixuan Wang ... Wei Qiao Qiu
    Published: April 12, 2024 Explor Med. DOI: 10.37349/emed.2024.00216
    Viewed:556
    Downloaded:17
    Open Access
    Review
    The coevolution of Covid-19 and host immunity
    The dynamic of the virus-host interaction is subject to constant evolution, which makes it difficult to predict when the SARS-CoV-2 pandemic will become endemic. Vaccines in conjunction with efforts...
    Azizul Haque, Anudeep B. Pant
    Published: April 08, 2024 Explor Med. DOI: 10.37349/emed.2024.00214
    Viewed:768
    Downloaded:13
    Open Access
    Review
    The low expression of matrix metalloproteinases: a key to longevity?
    Over the past few decades, it has become clear that an excessive activity of matrix metalloproteinases (MMPs) can accelerate the progression and fatal outcomes of several serious age-related disease...
    Katrin Sak
    Published: April 08, 2024 Explor Med. DOI: 10.37349/emed.2024.00213
    Viewed:454
    Downloaded:15
    Open Access
    Original Article
    Association of TGFBR2 gene polymorphisms (rs6785358 and rs764522) with congenital heart disease susceptibility in Egyptians
    Aim: Transforming growth factor beta (TGF-β) receptor II (TGFBR2) is a basic constituent of TGF-β signalling pathway and is important in heart development. This study investigates the relations...
    Nahed Dawood ... Rizk Elbaz
    Published: March 29, 2024 Explor Med. DOI: 10.37349/emed.2024.00212
    Viewed:399
    Downloaded:13
    Open Access
    Review
    Insights on aspects of apoptosis in neurodegenerative disorders: a comprehensive review
    Nerve cell death is the central aspect of human neurodegenerative disorders. Neuronal death in results leads to the onset of various human neurological disorders such as Alzheimer’s disease, Parki...
    Rajat Goyal ... Mohammad Amjad Kamal
    Published: February 28, 2024 Explor Med. DOI: 10.37349/emed.2024.00208
    Viewed:527
    Downloaded:16
    Open Access
    Original Article
    The severity of chronic heart failure and the parameters of daily blood pressure profile in patients with coronary heart disease
    Aim: Although the prevalence of coronary heart disease (CHD) and hypertension which are the most common causes of the development and progression of chronic heart failure (CHF) is high, 24-hour a...
    Natalia S. Akimova ... Oksana V. Bugaeva
    Published: February 28, 2024 Explor Med. DOI: 10.37349/emed.2024.00209
    Viewed:409
    Downloaded:13
    Open Access
    Original Article
    Role of chest radiographs and electrocardiograms in predicting the hemodynamics of congenital heart disease
    Aim: This study aimed to evaluate the role of chest radiographs and electrocardiograms in predicting the hemodynamics of congenital heart disease (CHD). Methods: This retrospective study in...
    Romila Chimoriya ... Neeraj Awasthy
    Published: February 29, 2024 Explor Med. DOI: 10.37349/emed.2024.00210
    Viewed:451
    Downloaded:23
    Open Access
    Review
    Effects of dietary imbalances of micro- and macronutrients on the ocular microbiome and its implications in dry eye disease
    Dry eye disease (DED) is a complex and multifactorial ocular surface disease affecting a large proportion of the population. There is emerging evidence of the impact of the microbiomes of the ocular...
    Madeline Pilkington ... Kenneth Gek-Jin Ooi
    Published: February 29, 2024 Explor Med. DOI: 10.37349/emed.2024.00211
    Viewed:741
    Downloaded:22
    Open Access
    Original Article
    Prevalence of specific human papillomavirus genotypes among Moroccan women with invasive cervical cancer
    Aim: The aim of this study is to investigate the prevalence of human papillomavirus (HPV) genotypes in Moroccan women diagnosed with invasive cervical cancer and to assess the association between...
    Kaoutar Anouar Tadlaoui ... Moulay Mustapha Ennaji
    Published: February 28, 2024 Explor Med. DOI: 10.37349/emed.2024.00207
    Viewed:668
    Downloaded:21
    Open Access
    Review
    Cell culture models for epilepsy research and treatment
    Acquired or hereditary epilepsy affects millions of people. Today, the disease is pharmacoresistant in about 30 percent of cases, meaning that the seizures do not come under acceptable control in re...
    Ilya Oblasov ... Evgeny Nikitin
    Published: February 25, 2024 Explor Med. DOI: 10.37349/emed.2024.00206
    Viewed:703
    Downloaded:29
    Open Access
    Original Article
    The most suitable system to grind the whole tooth to use it as graft material
    Aim: In regenerative dentistry, the success is influenced by the graft material, which should act as an osteoconductive scaffold. It provides a mineral substrate during resorption and induces the...
    Elio Minetti ... Francesco Inchingolo
    Published: February 06, 2024 Explor Med. DOI: 10.37349/emed.2024.00202
    Viewed:814
    Downloaded:17
    Open Access
    Review
    3D and 4D printing of biomedical materials: current trends, challenges, and future outlook
    Three-dimensional (3D) and four-dimensional (4D) printing have emerged as the next-generation fabrication technologies, covering a broad spectrum of areas, including construction, medicine, transpor...
    Gayan A. Appuhamillage ... Achintha Wijenayake
    Published: February 06, 2024 Explor Med. DOI: 10.37349/emed.2024.00203
    Viewed:1500
    Downloaded:52
    Open Access
    Review
    Cannabidiol, cognition and schizophrenia: a narrative review
    Schizophrenia is a serious mental disorder affecting about 1% of the population. It is characterised by multiple symptoms which are mostly responsive to treatment with antipsychotic medications. Cog...
    Trevor R. Norman
    Published: February 07, 2024 Explor Med. DOI: 10.37349/emed.2024.00204
    Viewed:927
    Downloaded:29
    Open Access
    Mini Review
    Navigating breast health: a comprehensive approach to atypical ductal hyperplasia of the breast management and surveillance
    Atypical ductal hyperplasia (ADH) is a benign lesion of the breast that is associated with an increased risk of invasive breast cancer. This review explores the pathophysiology, risk factors for pro...
    Nadia Islam, Suneela Vegunta
    Published: February 07, 2024 Explor Med. DOI: 10.37349/emed.2024.00205
    Viewed:1104
    Downloaded:25
    Open Access
    Commentary
    Group A streptococcal infection in the United Kingdom: an emerging threat
    Within group A Streptococcus (GAS), only Streptococcus pyogenes exhibits clinical significance. GAS is typed serologically based on unique surface proteins and critical virulence factors, such as a ...
    Kamran Zaman ... Ranjit Sah
    Published: December 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00192
    Viewed:1272
    Downloaded:28
    Open Access
    Original Article
    Development of patient-specific 3D printed implants for total knee arthroplasty
    Aim: Arthritis is a degenerative condition characterized by the progressive deterioration of the knee joint, leading to aches, rigidity, and decreased mobility. Total knee arthroplasty (TKA) surg...
    Dasharath Ramavath ... Sudheer Reddy Devana
    Published: December 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00193
    Viewed:915
    Downloaded:29
    Open Access
    Review
    Current roles of artificial intelligence in ophthalmology
    Artificial intelligence (AI) studies are increasingly reporting successful results in the diagnosis and prognosis prediction of ophthalmological diseases as well as systemic disorders. The goal of t...
    Kadircan H. Keskinbora
    Published: December 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00194
    Viewed:519
    Downloaded:25
    Open Access
    Original Article
    Risk factors associated with postoperative respiratory failure after esophagectomy for esophageal cancer
    Aim: Respiratory failure is common after esophagectomy for esophageal cancer (EC). This study aimed to identify the risk factors associated with postoperative respiratory failure following esopha...
    Zhanglan Fang ... Ling Luo
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00195
    Viewed:488
    Downloaded:15
    Open Access
    Original Article
    Cholesterol de novo biosynthesis: a promising target to overcome the resistance to aromatase inhibitors in postmenopausal patients with estrogen receptor-positive breast cancer
    Aim: Cholesterol is an essential component of cell membranes and serves as a precursor for several bioactive molecules, including steroid hormones and isoprenoids. Generally supplied by the blood...
    Danila Coradini, Federico Ambrogi
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00196
    Viewed:1177
    Downloaded:20
    Open Access
    Review
    The differential effect of the immune system in breast cancer
    Cancer cure with immunotherapy is an innovative step towards cancer treatment with better survivability, but it is mostly dependent on the response of the patient’s immune system to the immunother...
    Banashree Bondhopadhyay ... Vishakha Kasherwal
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00197
    Viewed:1282
    Downloaded:21
    Open Access
    Commentary
    From positive psychology to positive biology: laughter and longevity
    Gelotology (the study of laughter) has it seems mainly evaded the attention of longevity scientists, positive biologists, and geroscientists. However, the potential of laughter to result in immediat...
    Freda Gonot-Schoupinsky
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00198
    Viewed:1661
    Downloaded:43
    Open Access
    Review
    The role of pulmonary vascular endothelium in chronic obstructive pulmonary disease (COPD): Does endothelium play a role in the onset and progression of COPD?
    Chronic obstructive pulmonary disease (COPD) is an inflammatory lung pathology characterized by persistent airflow limitation and is the third leading cause of death globally. COPD pathophysiology i...
    Silvia Siragusa ... Silvia Pontis
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00199
    Viewed:927
    Downloaded:45
    Open Access
    Review
    3D printing in biomedicine: advancing personalized care through additive manufacturing
    The integration of three-dimensional (3D) printing techniques into the domains of biomedical research and personalized medicine highlights the evolving paradigm shifts within contemporary healthcare...
    Kalyani Pathak ... Barbie Borthakur
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00200
    Viewed:2068
    Downloaded:72
    Open Access
    Review
    Risk factors for the development of lung cancer around the world: a review
    According to recent data reported, it is noted that lung cancer is the leading cause of cancer death internationally followed by cardiovascular diseases and diabetes. This disease is observed in bot...
    Hervé Agonsanou ... Maurice Bergeron
    Published: December 29, 2023 Explor Med. DOI: 10.37349/emed.2023.00201
    Viewed:1170
    Downloaded:42
    Open Access
    Original Article
    Comparison of biochemical and anthropometric parameters in complicated and uncomplicated severe acute malnutrition among children aged 6 to 59 months: a cross-sectional study
    Aim: The frequency of severe acute malnutrition (SAM) is the highest in India. Although it should receive more attention, severe anemia is one of the comorbidities that increases mortality in chi...
    Malvika Mishra ... Desh Deepak Singh
    Published: December 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00188
    Viewed:397
    Downloaded:18
    Open Access
    Review
    Improving treatment of women with schizophrenia: a review of the recent literature
    Effective clinical management of women with schizophrenia is therapeutically challenging. While there have been recent advances in the understanding of neurobiological, hormonal, and female reproduc...
    Alexandre González-Rodríguez ... Mary V. Seeman
    Published: December 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00189
    Viewed:389
    Downloaded:14
    Open Access
    Review
    The role of microbiome in uveitis
    The gut microbiota comprises a complex bacterial community that resides in the intestine. Imbalances in the gut microbiota can disrupt immune homeostasis, triggering autoimmune diseases including no...
    Hind Amin, Samir Shoughy
    Published: December 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00190
    Viewed:330
    Downloaded:12
    Open Access
    Review
    Sleep disruption due to nocturnal heartburn: a review of the evidence and clinical implications
    Nocturnal heartburn (NHB) is a symptom that affects up to 25% of the general population and has been shown to cause sleep disruption that adversely affects quality of life and psychomotor performanc...
    David A. Johnson ... Nathaniel F. Watson
    Published: December 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00191
    Viewed:685
    Downloaded:30
    Open Access
    Review
    Mechanism of lungs fibrosis in mycobacterial infection
    Lung tuberculosis (TB) remains a heavy burden on public health worldwide. This review discusses mainly the mechanisms of the development of pulmonary fibrosis in an experimental TB model in mice. Th...
    Lena B. Kim, Anna N. Putyatina
    Published: December 12, 2023 Explor Med. DOI: 10.37349/emed.2023.00187
    Viewed:484
    Downloaded:16
    Open Access
    Original Article
    Analysis of microbiocenosis of a gingival sulcus and periodontal pockets of patients with periodontal diseases associated with systemic pathology
    Aim: The aim is to analyze the microbiome of gingival sulcus and periodontal pockets of patients with periodontal disease associated with systemic diseases. Methods: A microbiological study...
    Olha Denefil ... Khrystyna Loza
    Published: December 11, 2023 Explor Med. DOI: 10.37349/emed.2023.00186
    Viewed:670
    Downloaded:19
    Open Access
    Review
    Involvement of protein kinases associated signal transduction mechanisms in cardiac diseases
    Protein kinases, a family of enzymes responsible for regulating various cellular processes, have been implicated in the development and progression of various heart diseases, making them attractive ...
    Jaykrishan Prasad ... Naranjan S. Dhalla
    Published: December 08, 2023 Explor Med. DOI: 10.37349/emed.2023.00185
    Viewed:533
    Downloaded:9
    Open Access
    Review
    Recent advances in the development of bioartificial pancreas using 3D bioprinting for the treatment of type 1 diabetes: a review
    Type 1 diabetes is a chronic condition that results from the destruction of insulin-producing β-cells in the pancreas. Current treatments for type 1 diabetes, such as insulin therapy and pancreatic...
    Anushikha Ghosh ... Abhik Mallick
    Published: December 06, 2023 Explor Med. DOI: 10.37349/emed.2023.00184
    Viewed:983
    Downloaded:40
    Open Access
    Review
    Treatment of malignant diseases with phytocannabinoids: promising observations in animal models and patients
    Amazingly, almost 50 years after the first demonstration of anticancer effects of cannabinoids in vitro and in vivo, well-designed clinical trials that definitively prove tumour-inhibiting effects i...
    Gerhard Nahler
    Published: December 06, 2023 Explor Med. DOI: 10.37349/emed.2023.00182
    Viewed:821
    Downloaded:23
    Open Access
    Original Article
    Impact of the type of breast cancer on the biodiversity of the vaginal Candida represented by estrogen receptor and its levels
    Aim: Estrogen has an important role in the colonization of Candida through the presence of estrogen receptors (ERs). These ERs are usually used to categorize breast cancer into two types, positiv...
    Ali Abdul Hussein S. AL-Janabi ... Abdul Razzak Kalaf Hassan
    Published: December 06, 2023 Explor Med. DOI: 10.37349/emed.2023.00183
    Viewed:1042
    Downloaded:11
    Open Access
    Original Article
    Figuring the characteristics of the Delta variant SARS-CoV-2 gene mutations in an Indonesian hospital: a descriptive study
    Aim: Coronavirus disease 2019 (COVID-19) is a respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 has undergone several mutations, and ult...
    Phey Liana ... Tungki Pratama Umar
    Published: October 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00181
    Viewed:1383
    Downloaded:35
    Open Access
    Review
    Recent advancements in skin cancer treatment: a critical review
    The prevalence of skin cancer has increased hastily in the recent decade for both kinds of melanoma and non-melanoma skin cancer. Skin cancers mostly encompass keratinocyte cancers: cutaneous squamo...
    Rajat Goyal ... Rohit Sharma
    Published: October 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00178
    Viewed:1255
    Downloaded:41
    Open Access
    Perspective
    A U.S. Food and Drug Administration perspective on cannabis research and drug development
    Since the early 1970s, the U.S. Food and Drug Administration (FDA) has received over 800 investigational new drug applications (INDs) for, and pre-INDs pertaining to, research of cannabis or cannabi...
    Cassandra L. Taylor, Schuyler A. Pruyn
    Published: October 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00179
    Viewed:5111
    Downloaded:274
    Open Access
    Review
    Roles of poly(ADP-ribose) polymerase 1 and mitophagy in progeroid syndromes as well as physiological ageing
    Progeroid syndromes are characterized by clinical signs of premature ageing, which may contain several diseases such as Werner syndrome, Bloom syndrome, Rothmund-Thomson syndrome, Hutchinson-Gilford...
    Naoko Suga ... Satoru Matsuda
    Published: October 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00180
    Viewed:1607
    Downloaded:574
    Open Access
    Review
    Determinants of human longevity: input of environment, nutrition, physical activity, eustress, heredity, health care, motivation, and mental state
    The paper aims to review the possibilities of a complex transdisciplinary approach to forming health and longevity. Determinants of productive longevity (DPL) and health culture are reviewed; defini...
    Renad I. Zhdanov ... Alexey S. Sozinov
    Published: October 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00176
    Viewed:917
    Downloaded:49
    Open Access
    Review
    Contemporary review: recognition, management, and screening for radiation-induced heart disease
    Radiation is a primary therapy in the treatment of thoracic malignancies with clear survival benefits. Consequently, patients with cancer are living longer but may be subject to a wide array of card...
    Chirag Mehta ... Jess Brar
    Published: October 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00177
    Viewed:707
    Downloaded:42
    Open Access
    Review
    Association of oral bacteriome and oral squamous cell carcinoma
    Oral cancer is the most common carcinoma of head and neck cancers. The majority of oral cancers are oral squamous cell carcinoma (OSCC). Among the various etiological factors, oral microbes—bacter...
    Karthika Panneerselvam ... Mathan Mohan
    Published: October 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00172
    Viewed:641
    Downloaded:22
    Open Access
    Case Report
    A successful case of maturogenesis by stepwise excavation using calcium-enriched mixture cement
    This case report demonstrates the successful induction of apexogenesis in an extensively carious lower right first molar with immature roots through the use of stepwise excavation and calcium-enrich...
    Saeed Asgary, Laleh Alim Marvasti
    Published: October 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00173
    Viewed:876
    Downloaded:21
    Open Access
    Case Report
    Cheiro-oral-pedal syndrome of the pons and the role of imaging in diagnosis and management
    The patient is a 58-year-old male who presented with chief complaints of right-sided numbness, tingling, and loss of temperature sensation in the upper and lower extremities. The patient’s symptom...
    Zachary I. Merhavy ... Thomas C. Varkey
    Published: October 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00174
    Viewed:1094
    Downloaded:13
    Open Access
    Perspective
    Antiseptic pyolytics and warming wet compresses improve the prospect of healing chronic wounds
    Infection and suppuration of chronic wounds reduce the effectiveness of their treatment with a course of antibiotics and antiseptics combined with frequently renewed dressings. Therefore, daily shor...
    Aleksandr Urakov ... Marina Zavarzina
    Published: October 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00175
    Viewed:419
    Downloaded:18
    Open Access
    Original Article
    Modelling α-synuclein processing in primary patient cells for pharmacological intervention
    Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the di...
    Jessica K. Smith ... Alex M. Sykes
    Published: October 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00170
    Viewed:623
    Downloaded:22
    Open Access
    Original Article
    A large-scale survey of cannabis use for sleep: preferred products and perceived effects in comparison to over-the-counter and prescription sleep aids
    Aim: Cannabis use for sleep-related problems is on the rise; however, little is known about the cannabis products people are using for sleep or the perceived effects of cannabis in comparison to ...
    Amanda Stueber, Carrie Cuttler
    Published: October 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00171
    Viewed:8903
    Downloaded:133
    Open Access
    Case Report
    Cranial nerve VII on gadolinium contrast-enhanced magnetic resonance imaging in the case of Bell’s palsy
    Bell’s palsy is a rapid unilateral peripheral paralysis of cranial nerve VII whose etiology is varied, most commonly associated with an acute infectious or inflammatory demyelinating process. Nerv...
    Alvaro Alvarez ... Avtar Singh
    Published: October 23, 2023 Explor Med. DOI: 10.37349/emed.2023.00169
    Viewed:488
    Downloaded:19
    Open Access
    Review
    Self-replicating RNA viruses in vaccine development
    Self-replicating RNA viruses such as alphaviruses, flaviviruses, paramyxoviruses, and rhabdoviruses have been engineered as expression vectors for vaccine development. The prominent feature of self-...
    Kenneth Lundstrom
    Published: October 10, 2023 Explor Med. DOI: 10.37349/emed.2023.00168
    Viewed:672
    Downloaded:25
    Open Access
    Perspective
    Diabetes and substance use: a perspective within drug rehabilitation
    Diabetes mellitus has become increasingly more common and diagnosed within the global population. Coupled with the continued prevalence of substance use, there are some distinct considerations for u...
    Abuelgasim Elrasheed A. Alhassan ... Simon Elliott
    Published: October 08, 2023 Explor Med. DOI: 10.37349/emed.2023.00167
    Viewed:474
    Downloaded:13
    Open Access
    Original Article
    Body mass, blood pressure, and cognitive functioning among octogenarians and centenarians
    Aim: The purpose of this study was to examine the association among body mass, blood pressure (BP), and cognitive functioning for octogenarians and centenarians. Methods: A total of 300 par...
    Peter Martin ... Leonard W. Poon
    Published: September 15, 2023 Explor Med. DOI: 10.37349/emed.2023.00165
    Viewed:785
    Downloaded:27
    Open Access
    Review
    Mechanistic insights on anticancer drugs with specific biological targets and signalling pathways
    Complex enzyme interactions play a role in the spread of cancer, a process fueled by unregulated cell proliferation. DNA topoisomerases, which are important for fixing DNA topological problems, have...
    Mohsina Patwekar ... Rohit Sharma
    Published: September 15, 2023 Explor Med. DOI: 10.37349/emed.2023.00166
    Viewed:989
    Downloaded:34
    Open Access
    Original Article
    Comparison of eating habits and gut microbiota of preschool children with obesity
    Aim: Childhood obesity is a global health concern that affects the daily life of children. It has a complex pathogenesis that involves genetic and nutritional factors among others. Moreover, the ...
    Shymaa M. Al-Jabri ... Awatif A. Al-Judaibi
    Published: September 04, 2023 Explor Med. DOI: 10.37349/emed.2023.00164
    Viewed:648
    Downloaded:32
    Open Access
    Review
    An overview of current advances and pharmaceutical uses of 3D and 4D printing
    The development of patient-specific prosthetics, medication administration, the manufacture of tissues and organs, and surgical planning have all benefited significantly from the use of three-dimens...
    Pankaj Sharma, Vinay Jain
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00161
    Viewed:784
    Downloaded:21
    Open Access
    Review
    Autophagy and diabetes
    The current literature findings on autophagy’s beneficial and detrimental roles in diabetes mellitus (DM) and diabetes-related comorbidities were reviewed. The effects of oral hypoglycaemic medici...
    Milan Obradovic ... Esma R. Isenovic
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00162
    Viewed:754
    Downloaded:12
    Open Access
    Review
    Unveiling the role of artificial intelligence for wound assessment and wound healing prediction
    Wound healing is a very dynamic and complex process as it involves the patient, wound-level parameters, as well as biological, environmental, and socioeconomic factors. Its process includes hemostas...
    Dinh T. P. Le, Tuan D. Pham
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00163
    Viewed:1209
    Downloaded:37
    Open Access
    Original Article
    The brain activities of individuals with or without motivation to change: a preliminary study among cigarette smokers
    Aim: Cigarette smoking is an addictive behavior that requires high motivation to change, a phenotype related to the functional activity of the brain. The study aims to examine motiv...
    Rasmon Kalayasiri ... Witaya Sungkarat
    Published: August 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00154
    Viewed:536
    Downloaded:9
    Open Access
    Review
    RNA-RNA competitive interactions: a molecular civil war ruling cell physiology and diseases
    The idea that proteins are the main determining factors in the functioning of cells and organisms, and their dysfunctions are the first cause of pathologies, has been predominant in biology and biom...
    Cristina Barbagallo ... Marco Ragusa
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00159
    Viewed:766
    Downloaded:20
    Open Access
    Review
    Lactate metabolic pathway regulates tumor cell metastasis and its use as a new therapeutic target
    Abnormal energy metabolism is one of the ten hallmarks of tumors, and tumor cell metabolism provides energy and a suitable microenvironment for tumorigenesis and metastasis. Tumor cells can consume ...
    Weimei Xing ... Mingyue Zhu
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00160
    Viewed:696
    Downloaded:27
    Open Access
    Original Article
    An easy and safe method of subconjunctival injection of antimetabolites in glaucoma surgery
    Aim: The use of 5-fluorouracil in glaucoma surgery is associated with a high risk of corneal complications, as even minimal doses of the drug at the ocular surface inhibit corneal epithelial cell...
    Sergey N. Svetozarskiy ... Anna N. Sporysheva
    Published: August 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00155
    Viewed:618
    Downloaded:14
    Open Access
    Review
    Autophagy in ischemic stroke: role of circular RNAs
    Stroke, a central nervous system (CNS) injury, is responsible for the second leading cause of death in the world, bringing a great burden on the world. Stroke is normally divided into ischemic and h...
    Yiting Hong ... Honghong Yao
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00157
    Viewed:786
    Downloaded:15
    Open Access
    Perspective
    Utility of fibroblasts derived from broncho-alveolar lavage of patients with idiopathic pulmonary fibrosis or related disorders to develop in vitro models
    Broncho-alveolar lavage (BAL) represents a safe tool for the differential diagnosis of various pulmonary fibrotic diseases. Idiopathic pulmonary fibrosis (IPF) belongs to a heterogeneous group of di...
    Paolo Giannoni ... Daniela de Totero
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00156
    Viewed:629
    Downloaded:17
    Open Access
    Review
    Cannabis-based medicinal products (CBMPs) for the treatment of Long COVID symptoms: current and potential applications
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection can result in a range of persistent symptoms impacting everyday functioning for a considerable proportion of patients, a condit...
    Hannah Thurgur ... David J. Nutt
    Published: August 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00158
    Viewed:5242
    Downloaded:56
    Open Access
    Original Article
    Small patient datasets reveal genetic drivers of non-small cell lung cancer subtypes using machine learning for hypothesis generation
    Aim: Many small datasets of significant value exist in the medical space that are being underutilized. Due to the heterogeneity of complex disorders found in oncology, systems capable of discover...
    Moses Cook ... Joseph Geraci
    Published: July 26, 2023 Explor Med. DOI: 10.37349/emed.2023.00153
    Viewed:1637
    Downloaded:55
    Open Access
    Case Report
    Conservative approach in adult right-sided Bochdalek hernia with an intrathoracic ectopic kidney
    Bochdalek hernia (BH) is a congenital diaphragmatic defect primarily diagnosed in neonates and is usually left-sided. Adult diagnosis, especially of right-sided BH is exceedingly rare and usually pr...
    Husam El Sharu ... Ahmed Hebishy
    Published: July 12, 2023 Explor Med. DOI: 10.37349/emed.2023.00152
    Viewed:940
    Downloaded:36
    Open Access
    Original Article
    Cannabinoid-based medicines in clinical care of chronic non-cancer pain: an analysis of pain mechanism and cannabinoid profile
    Aim: Among treatments for chronic non-cancer pain (CNCP), cannabinoid-based medicines (CBMs) have become extremely popular. Evidence remains modest and limited primarily to delta-9-tetrahydrocann...
    Lucile Rapin ... Michael Dworkind
    Published: June 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00148
    Viewed:1318
    Downloaded:33
    Open Access
    Review
    Molecular mechanism of electroacupuncture for improving perioperative complications with the guidance of enhanced recovery after surgery
    Enhanced recovery after surgery (ERAS) is a recommended surgical strategy at present, the core content is to reduce perioperative stress response and postoperative complications through perioperativ...
    Yu Mao, Lifang Yang
    Published: June 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00149
    Viewed:626
    Downloaded:26
    Open Access
    Original Article
    Exploring medical cannabis use in individuals with a traumatic brain injury
    Aim: Traumatic brain injury (TBI) is a common neurological condition, which can present with a wide range of neuropsychological symptoms. Treating this broad spectrum of symptoms represents a sig...
    Elizabeth N. R. Schjelderup ... Alasdair M. Barr
    Published: June 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00150
    Viewed:1222
    Downloaded:44
    Open Access
    Original Article
    Associations between methamphetamine and alcohol use disorder, suicidal ideation, and lowered quality of life in methamphetamine users
    Aim: There is a strong comorbidity between methamphetamine (MA) and alcohol use whereby MA use may contribute to increased alcohol consumption. This study aims to determine the associations betwe...
    Ketsupar Jirakran ... Rasmon Kalayasiri
    Published: June 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00151
    Viewed:697
    Downloaded:36
    Open Access
    Original Article
    Association between coronavirus 2019 disease and pseudoneurological complaints: analysis of case-control data
    Aim: Pseudoneurological complaints (PNCs) are highly prevalent among the general population. Coronavirus disease 2019 (COVID-19) adversely influences such complaints in individuals who recovered ...
    Mohammad Ali ... Tajnuva Mehjabin
    Published: June 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00146
    Viewed:505
    Downloaded:16
    Open Access
    Original Article
    Type 2 diabetes mellitus and coronary artery stenosis: a risk pattern association study
    Aim: Cardiovascular diseases (CVD) are the leading cause of death globally. In the condition of type 2 diabetes mellitus (T2DM), the prevalence of CVD increase parallel with the rise of metabolic...
    Dharmsheel Shrivastav ... Vimal Mehta
    Published: June 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00145
    Viewed:673
    Downloaded:16
    Open Access
    Review
    The impact of COVID-19 pandemic on diagnosis and management of gastrointestinal cancers
    Gastrointestinal (GI) cancer is one of the leading causes of death that affect many patients around the world. The coronavirus disease 2019 (COVID-19) pandemic significantly impacted our healthcare ...
    Byung Soo Yoo ... David A. Johnson
    Published: June 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00147
    Viewed:766
    Downloaded:9
    Open Access
    Letter to the Editor
    Vascular accesses: Which choice? Less is more, more or less
    In the context of in-hospital care management, the need for infusion therapies involves the choice of appropriate devices. Historically, there is no consensus about the preference for vascular acces...
    Regina Frontera, Mirko Barone
    Published: May 31, 2023 Explor Med. DOI: 10.37349/emed.2023.00144
    Viewed:633
    Downloaded:30
    Open Access
    Original Article
    Effect of overweight and obesity on spirometric parameters in children and adolescent with asthma
    Aim: Being overweight and obesity are factors in the negative modification of bronchial asthma (BA). The mechanisms of the aggravating effect of obesity on the course of BA have not yet been fully determined, but include changes in external respiration. The aim of the study was to study the effect of being overweight/obesity on spirometric parameters and on the occurrence of dysanapsis in children and adolescents with BA. Methods: It was a cross-sectional, open, single-center study. The data were obtained from 428 patients with atopic BA aged 7 years to 17 years, 12.0 [9.0; 14.0], and 72.9% (312/428) of them were boys. The children were divided into 3 groups: group 1—normal body weight; group 2—overweight; and group 3—obesity. All participants underwent spirometry, the ratio of forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) was calculated and the diagnosis of dysanapsis was performed. Results: As body weight increases, a progressive decrease in FEV1/FVC is revealed—group 1: 79.55% [71.37; 85.43]; group 2: 76.82% [70.12; 82.03]; and group 3: 76.28% [67.04; 79.89] P = 0.004; as well as a decrease in Z FEV1/FVC: group 1—1.23 [–2.18; –0.28]; group 2—1.54 [–2.19; –0.68]; and group 3—1.75 [–2.63; –0.90] P = 0.02. Dysanapsis was detected in 37.7% (159/428) of patients. The incidence of dysanapsis increased statistically significantly with increasing body mass index (BMI) and amounted to: with normal body weight—31.7% (77/243), with overweight—42.0% (55/131), and with obesity—50% (27/54) P = 0.016. Conclusions: In children and adolescents with BA, as BMI increases, there is a statistically significant decrease in the ratio of FEV1/FVC, and, consequently, bronchial patency; the incidence of dysanapsis also increases statistically significantly. Taken together, this indicates the formation of an obstructive pattern of external respiration under the influence of being overweight and obesity in children and adolescents with BA....
    Regina N. Khramova ... Olga V. Khaletskaya
    Published: May 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00143
    Viewed:722
    Downloaded:38
    Open Access
    Original Article
    Effect of number of dissected lymph nodes on prognosis of patients with stage II and III colorectal cancer
    Aim: There is a correlation between the number of resected lymph nodes (LNs) and survival as well as staging in patients with colorectal cancer (CRC). This cohort discussed the effect of the numb...
    Reihane Mokarian Rajabi ... Sayyideh Forough Hosseini
    Published: May 30, 2023 Explor Med. DOI: 10.37349/emed.2023.00142
    Viewed:592
    Downloaded:20
    Open Access
    Original Article
    Prognostic importance of neutrophil-lymphocyte ratio in non-dialysis chronic kidney disease patients—a hospital-based prospective cohort
    Aim: In patients with cancer, ischemic heart disease, and peripheral vascular disease, the neutrophil-lymphocyte ratio (NLR), a measure of systemic inflammation, has been demonstrated to predict ...
    Ishfaq Rashid ... Shivani Jaswal
    Published: May 17, 2023 Explor Med. DOI: 10.37349/emed.2023.00141
    Viewed:1144
    Downloaded:41
    Open Access
    Original Article
    Serum levels of ceruloplasmin and magnesium in polycystic ovarian syndrome: a cross sectional study
    Aim: Polycystic ovarian syndrome (PCOS) is the most common endocrine condition, affecting 5–7% of reproductive-age women worldwide. It is associated with low-grade chronic inflammation, insulin...
    Pratibha Misra ... Yaongamphi Vashum
    Published: April 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00140
    Viewed:875
    Downloaded:31
    Open Access
    Original Article
    Cannabis use in cancer patients: acute and sustained associations with pain, cognition, and quality of life
    Aim: Given the myriad of negative sequalae associated with cancer and its treatment, the palliative use of cannabis by cancer patients is increasingly of special interest. This research sought to e...
    Gregory Giordano ... Angela D. Bryan
    Published: April 26, 2023 Explor Med. DOI: 10.37349/emed.2023.00138
    Viewed:8796
    Downloaded:243
    Open Access
    Original Article
    Can we estimate the causal effects of diet and sedentary behavior on schoolchildren’s overweight/obesity from observational studies?
    Aim: To investigate the causal impact of diet and sedentary behavior on Brazilian schoolchildren’s overweight/obesity using the data from observational studies. Methods: Annual cros...
    Emil Kupek
    Published: April 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00139
    Viewed:875
    Downloaded:35
    Open Access
    Review
    Gastrointestinal microbiome and coronavirus disease: evidence of a bidirectional association
    The gastrointestinal (GI) microbiome remains an emerging topic of study and the characterization and impact on human health and disease continue to be an area of great interest. Similarly, the coron...
    Kevin V. Houston ... David A. Johnson
    Published: April 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00130
    Viewed:840
    Downloaded:20
    Open Access
    Original Article
    Forward head posture and neck disability: what is the effect on lung function?
    Aim: Forward head posture (FHP) is a very common pathological neck posture among people who frequently use multimedia devices, and it could be related to some musculoskeletal disorders. However, it...
    Giada Annarumma ... Felice Sirico
    Published: April 26, 2023 Explor Med. DOI: 10.37349/emed.2023.00134
    Viewed:1112
    Downloaded:41
    Open Access
    Review
    Low copy repeats in the genome: from neglected to respected
    DNA paralogs that have a length of at least 1 kilobase (kb) and are duplicated with a sequence identity of over 90% are classified as low copy repeats (LCRs) or segmental duplications (SDs). They co...
    Lisanne Vervoort, Joris R. Vermeesch
    Published: April 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00131
    Viewed:1197
    Downloaded:56
    Open Access
    Original Article
    Development of solid lipid nanoparticle gel for transdermal delivery system of chaulmoogra oil
    Aim: The main objective of the study was to formulate, evaluate and perform an optimization study of chaulmoogra oil-loaded solid lipid nanoparticles (SLNs) based gel. Methods: The study involves isolation, identification, and quantification of hydnocarpic acid (HA), using high-performance thin-layer chromatography (HPTLC) and characterization using ultraviolet (UV), nuclear magnetic resonance (NMR), and mass spectroscopy (MS), and differential scanning calorimetry (DSC). Different concentration of assorted solid lipids and surfactants was used for the preparation of SLN gel with the improved transdermal application....
    Rabea Parveen ... Sayeed Ahmad
    Published: April 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00132
    Viewed:636
    Downloaded:33
    Open Access
    Review
    Immunomodulation strategies against COVID-19 evidence: key nutrients and dietary approaches
    The novel coronavirus disease-2019 (COVID-19) has created a major public health crisis. Various dietary factors may enhance immunological activity against COVID-19 and serve as a method to combat se...
    Lindsey B. Cundra ... David A. Johnson
    Published: April 25, 2023 Explor Med. DOI: 10.37349/emed.2023.00133
    Viewed:888
    Downloaded:22
    Open Access
    Review
    Impact exerted by scaffolds and biomaterials in periodontal bone and tissue regeneration engineering: new challenges and perspectives for disease treatment
    The periodontium is an appropriate target for regeneration, as it cannot restore its function following disease. Significantly, the periodontium’s limited regenerative capacity could be enhanced through the development of novel biomaterials and therapeutic approaches. Notably, the regenerative potential of the periodontium depends not only on its tissue-specific architecture and function but also on its ability ...
    Simona Santonocito ... Gaetano Isola
    Published: April 26, 2023 Explor Med. DOI: 10.37349/emed.2023.00135
    Viewed:1479
    Downloaded:40
    Open Access
    Original Article
    Abnormal glucose tolerance in children: oral glucose tolerance test is fit-for-purpose
    Aim: Childhood obesity is accompanied by an increased prevalence of abnormal glucose tolerance (AGT) including the prediabetes states. This study aims to investigate and evaluate the use of oral gl...
    Vivian Yuet Ho Law ... Louis Tsz Wang Chan
    Published: April 26, 2023 Explor Med. DOI: 10.37349/emed.2023.00136
    Viewed:715
    Downloaded:14
    Open Access
    Original Article
    Mechanistic approaching study in COVID-19 patients treated with high doses of vitamin D
    Aim: To evaluate angiotensin II (Ang II) and Ang-(1-7) levels and the cytokine profile in patients hospitalized with mild coronavirus disease 2019 (COVID-19) and contrast them with patients with identical clinical conditions but treated with high doses of vitamin D (vitD). Methods: From the 218 patients recruited (ClinicalTrials.gov NCT04411446), 16 participated in this sub-study and were randomized to a single oral dose of 500,000 IU vitD (n = 10) or placebo (n = 6). Plasmatic Ang II and Ang-(1-7) levels were determined by radioimmunoassay and interleukins (ILs) 1, 6, 8, and 10 and tumor necrosis factor alpha (TNF-α) by enzyme-linked immunosorbent assay before and after treatment. Parallel, serum 25-hydroxyvitamin D3 (25-OH vitD) concentrations as vitD status was measured by a chemiluminescence immunoassay. Results: A trend towards an increase in Ang-(1-7) and a decrease in Ang II levels were observed in placebo- and vitD-treated COVID-19 patients compared to baseline values. There was no difference in Ang II and Ang-(1-7) levels between placebo- and vitD-treated COVID-19 patients. Similar results were obtained with ILs profile. COVID-19 patients showed an increase in the protective component of the RAS which was not improved by vitD treatment. Conclusions: VitD did not improve RAS disbalance in COVID-19. Notwithstanding, the authors visualize that acute treatment with high doses of vitD may show a trend to a decline in inflammatory ILs and an increase in protective markers. Finally, the authors would like to highlight the limitations of this preliminary study, namely the small number of patients and the use of a large single bolus dose of vitD rather than lower daily doses for extended periods with prolonged follow-up times. All these factors need special consideration in the designs of new vitD supplementation trials. All these factors need special consideration in the designs of new vitD supplementation trials (ClinicalTrials.gov identifier: NCT04411446)....
    Mauro G. Silva ... Walter Manucha
    Published: April 26, 2023 Explor Med. DOI: 10.37349/emed.2023.00137
    Viewed:805
    Downloaded:22
    Open Access
    Review
    Oxidative stress and inflammation: the root causes of aging
    Oxygen free radicals [reactive oxygen species (ROS)] and nitrogen free radicals [reactive nitrogen species (RNS)] are generated by mitochondria during adenosine triphosphate synthesis, and catalytic...
    Prasert Sobhon ... Sawaek Weerakiet
    Published: April 17, 2023 Explor Med. DOI: 10.37349/emed.2023.00129
    Viewed:1139
    Downloaded:59
    Open Access
    Meta-Analysis
    Assessing cardiac contractility in hypertension with heart failure with preserved ejection fraction: the value of left ventricular strain
    Aim: Hypertension (HTN) is a major cause of heart failure but the precise pathways by which HTN leads to heart failure are not resolved. Newer echocardiographic techniques permit assessment of my...
    Simon W. Rabkin
    Published: April 10, 2023 Explor Med. DOI: 10.37349/emed.2023.00128
    Viewed:954
    Downloaded:24
    Open Access
    Review
    N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain
    Neuropathic pain (NP) remains maltreated for a wide number of patients by the currently available treatments and little research has been done in finding new drugs for treating NP. Ziconotide (Prial...
    Shikha Choudhary ... Md Sabir Alam
    Published: February 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00126
    Viewed:1035
    Downloaded:41
    Open Access
    Commentary
    m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection
    m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs....
    Hiromichi Sato ... Hideshi Ishii
    Published: February 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00127
    Viewed:1263
    Downloaded:44
    Open Access
    Review
    Oxidative stress, inflammation, dysfunctional redox homeostasis and autophagy cause age-associated diseases
    Aging and age-associated diseases (AADs) are growing risk factors in societies worldwide. During aging, there is an accumulation of excessive oxygen free radicals [reactive oxygen species (ROS)] and nitrogen free radicals [reactive nitrogen species (RNS)] due to dysfunctional mitochondria, dysregulated catalytic activities of cytochrome P450 (CYP), nicotinamide adenine dinucleotide (NAD) phosphate [NADP(H)] oxidase (NOX), cyclooxygenases, and nitric oxide synthases (NOS) over the threshold of physiological levels, creating oxidative stress (OS). ...
    Prasert Sobhon ... Sawaek Weerakiet
    Published: February 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00124
    Viewed:1057
    Downloaded:30
    Open Access
    Review
    An overview of current strategies and future prospects in drug repurposing in tuberculosis
    A large number of the population faces mortality as an effect of tuberculosis (TB). The line of treatment in the management of TB faces a jolt with ever-increasing multi-drug resistance (DR) cases. ...
    Dilpreet Singh ... Pooja A. Chawla
    Published: February 28, 2023 Explor Med. DOI: 10.37349/emed.2023.00125
    Viewed:1069
    Downloaded:33
    Open Access
    Original Article
    Molecular docking analysis of peptide-based antiviral agents against SARS-CoV-2 main protease: an approach towards drug repurposing
    Aim: Utilizing the therapeutic potentials of previously approved medications against a new target or pharmacological response is known as drug repurposing. The health and scientific communities a...
    Abhishek Chaurasiya ... Pooja A. Chawla
    Published: February 27, 2023 Explor Med. DOI: 10.37349/emed.2023.00123
    Viewed:1145
    Downloaded:33
    Open Access
    Original Article
    Disparities and trends in suicidal ideations for inflammatory bowel disease hospitalizations: a decade-long national database analysis
    Aim: Patients with inflammatory bowel disease (IBD) are more likely to develop anxiety or depression. The study aimed to describe the trends and disparities of suicidal ideation (SI) in hospitali...
    Hassam Ali ... Ramona Rajapakse
    Published: February 24, 2023 Explor Med. DOI: 10.37349/emed.2023.00122
    Viewed:819
    Downloaded:25
    Open Access
    Original Article
    An association study of the PNPLA3 I148M polymorphism (rs738409) with serum lipids in patients with dyslipidemia
    Aim: One single nucleotide polymorphism (SNP) rs738409 in the patatin-like phospholipase domain- containing protein 3 (PNPLA3) gene has been considered a major genetic risk factor of nonalcoholic...
    Despoina Ioannidou ... Antonis Goulas
    Published: February 22, 2023 Explor Med. DOI: 10.37349/emed.2023.00121
    Viewed:701
    Downloaded:31
    Open Access
    Original Article
    Alterations in metabolic status of healthy individuals with and without obesity during transition from adolescence to young adulthood
    Aim: Extensive research is carried out throughout the world in healthy persons with obesity phenotype in concern with prevalence, metabolic profiling, etc. To the best of the authors’ knowledge, not many studies have investigated the status of adiponectin, specific inflammatory changes, oxidative damage in healthy adolescents and young adults with obesity. Present study was undertaken in adolescents and young adults of urban population in a district of North Karnataka, India, in a view to understand relationship between hormone adiponectin, oxidative stress markers like C3, C4, high sensitivity C-reactive protein (hs-CRP) in non-hypertensive, non-diabetic, euthyroid individuals with and without obesity....
    Smita S. Sonoli ... Reshma D. Channashetti
    Published: February 21, 2023 Explor Med. DOI: 10.37349/emed.2023.00120
    Viewed:728
    Downloaded:26
    Open Access
    Letter to the Editor
    Ultra-widefield imaging technologies in the peripheral retinal pathologies
    Lokman Balyen
    Published: February 16, 2023 Explor Med. DOI: 10.37349/emed.2023.00119
    Viewed:566
    Downloaded:28
    Open Access
    Review
    Quality by design based development of nanostructured lipid carrier: a risk based approach
    The aim of this review is to discuss the development of nanostructured lipid carrier (NLC) by the application of quality by design (QbD). QbD started with the evolution of the quality concept and sl...
    Tausif Alam
    Published: December 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00118
    Viewed:969
    Downloaded:59
    Open Access
    Review
    The journey of dostarlimab: a successful weapon for cancer treatment
    In a number of malignancies, new immuno-oncology therapies that focus on the programmed cell death 1 (PD-1) have improvised the patient condition along with a positive aftereffect. Monoclonal antibo...
    Rouchan Ali ... Pooja A. Chawla
    Published: December 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00116
    Viewed:1215
    Downloaded:30
    Open Access
    Review
    Antioxidant and photoprotective potential of Polypodium leucotomos
    In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and...
    Rosy Yesela Mancilla Santa Cruz ... María Segunda Aurora Prado
    Published: December 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00117
    Viewed:921
    Downloaded:51
    Open Access
    Case Report
    Right atrial thrombus, junctional tachycardia, and critical lower limb ischemia: three rare complications of severe acute respiratory syndrome coronavirus 2 infection
    In recent years, Polypodium leucotomos has emerged with a great interest for having medicinal and therapeutic potential. It is producing very promising results due to the presence of antioxidant and...
    Said Makani ... Youssef Tijani
    Published: December 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00115
    Viewed:990
    Downloaded:20
    Open Access
    Case Report
    An unusual presentation of Whipple’s disease: adenopathies, polyarthralgia and dermatomyositis-like symptoms
    Whipple’s disease (WD) is a rare systemic disease caused by gram-positive bacillus bacteria that invades multiple organs mainly the intestinal epithelium. Its manifestation is not only l...
    Randa Choueiry ... Joseph Amara
    Published: December 27, 2022 Explor Med. DOI: 10.37349/emed.2022.00113
    Viewed:709
    Downloaded:16
    Open Access
    Original Article
    Predictive value of SII and sd-LDL for contrast-induced acute kidney injury in STEMI patients undergoing percutaneous coronary intervention
    Aim: To investigate the relationship between the incidence of contrast-induced acute kidney injury (CI-AKI) and the level of small dense low-density lipoprotein (sd-LDL) and systemic immune-infla...
    Guoqi Shen ... Wenhua Li
    Published: December 28, 2022 Explor Med. DOI: 10.37349/emed.2022.00114
    Viewed:835
    Downloaded:25
    Open Access
    Review
    Let’s review the gut microbiota in systemic lupus erythematosus
    Systemic lupus erythematosus (SLE) is a chronic, immune-mediated disease associated with significant morbidity and mortality. New evidence suggests that diet, gut microbiota, intestinal permeability...
    Inês Almada-Correia ... João Eurico Fonseca
    Published: December 26, 2022 Explor Med. DOI: 10.37349/emed.2022.00112
    Viewed:763
    Downloaded:21
    Open Access
    Review
    Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system
    Fernandoa adenophylla (FA, Heterophragma adenophyllum) is a plant, cultivated throughout Africa and Southeast Asia. It contains potent phytochemicals such as novel naphthoquinones, their derivatives...
    Sangeet Kumar Mall ... Md Sabir Alam
    Published: November 14, 2022 Explor Med. DOI: 10.37349/emed.2022.00111
    Viewed:1596
    Downloaded:76
    Open Access
    Review
    Role of mitochondria in brain functions and related disorders
    Mitochondria are important organelles for high energy synthesis, reactive oxygen species balancing, antiapoptotic molecule production, membrane stability, intracellular calcium buffering, neuroplast...
    Monu Yadav ... Anil Kumar
    Published: October 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00110
    Viewed:1423
    Downloaded:81
    Open Access
    Review
    Development of nanobiosensors for human immunodeficiency virus detection—a mini review
    Acquired immunodeficiency syndrome (AIDS) is a global disease caused by human immunodeficiency virus (HIV). About 50 million people have died worldwide due to HIV-1 infection alone. HIV is a primary...
    Shurfa Mudenkattil ... Koyeli Girigoswami
    Published: October 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00109
    Viewed:784
    Downloaded:32
    Open Access
    Meta-Analysis
    Efficacy of low-level laser therapy in oral mucosal surgical wound healing: a systematic review and meta-analysis
    Aim: Wound healing is a complex phenomenon with various biological changes in tissue integrity, low-level laser therapy (LLLT) has acquired several unique components to help into accelerating tis...
    Seyyed Amir Seyyedi ... Rohollah Valizadeh
    Published: October 27, 2022 Explor Med. DOI: 10.37349/emed.2022.00106
    Viewed:719
    Downloaded:36
    Open Access
    Commentary
    Update on trials examining effects of night-time blood pressure lowering drug treatment on prevention of cardiovascular disease
    Current evidence on benefits of night-time blood pressure (BP) lowering drug treatment on cardiovascular disease (CVD) prevention attributable to the Ambulatory Blood Pressure Monitoring in the Pred...
    Chau Le Bao Ho, Christopher M. Reid
    Published: October 27, 2022 Explor Med. DOI: 10.37349/emed.2022.00107
    Viewed:1110
    Downloaded:36
    Open Access
    Perspective
    A budding concept with certain microbiota, anti-proliferative family proteins, and engram theory for the innovative treatment of colon cancer
    Inflammatory bowel disease (IBD) is a multifactorial chronic disease. Patients with IBD have an increased risk of developing colorectal cancer which has become a major health concern. IBD might exer...
    Yuka Ikeda ... Satoru Matsuda
    Published: October 27, 2022 Explor Med. DOI: 10.37349/emed.2022.00108
    Viewed:3161
    Downloaded:1512
    Open Access
    Original Article
    Seminal fructose and citric acid concentrations relative to sperm parameters among men for fertility evaluation in Yaoundé, Cameroon
    Aim: Given the male infertility’s pluri-etiological nature, thorough examinations are needed for its evaluation. Fructose and citric acid are simple biomolecules, easy to assay, which provide reliable information on the seminal...
    Bih Tanni ... Christopher Odianosen Aimakhu
    Published: October 27, 2022 Explor Med. DOI: 10.37349/emed.2022.00105
    Viewed:2102
    Downloaded:48
    Open Access
    Review
    Nutritional prospects of wheatgrass (Triticum aestivum) and its effects in treatment and chemoprevention
    Nutraceuticals are organic and traditional foods consumed nowadays to maintain a healthy lifestyle and get rid of lifestyle diseases like obesity, cancer, diabetes, hypertension, etc. Globally, herb...
    Neha Minocha ... Parijat Pandey
    Published: October 12, 2022 Explor Med. DOI: 10.37349/emed.2022.00104
    Viewed:1175
    Downloaded:47
    Open Access
    Review
    Vasopressin: a possible link between hypoxia and hypertension
    Cardiovascular and respiratory diseases are frequently associated with transient and prolonged hypoxia, whereas hypoxia exerts pro-hypertensive effects, through stimulation of the sympathetic system...
    Ewa Szczepańska-Sadowska, Tymoteusz Żera
    Published: October 11, 2022 Explor Med. DOI: 10.37349/emed.2022.00103
    Viewed:1285
    Downloaded:40
    Open Access
    Case Report
    A case report: 19-year-old male diagnosed with C1q nephropathy requiring renal replacement therapy
    C1q nephropathy is a rare glomerular disease. Clinical presentation is diverse and ranges from asymptomatic hematuria or proteinuria to symptoms and signs of nephrotic/nephritic syndrome. On light microscopy, it can be classified into two subtypes: minimal change disease (MCD)/focal segmental glomerulosclerosis (FSGS) group and immune complex mediated proliferative glomerulonephritis group. ...
    Randa Choueiri ... Vanessa Nseir
    Published: August 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00101
    Viewed:1503
    Downloaded:42
    Open Access
    Review
    Paradoxical role of reactive oxygen species in bone remodelling: implications in osteoporosis and possible nanotherapeutic interventions
    Osteoporosis is a metabolic bone disorder that affects both sexes and is the most common cause of fractures. Osteoporosis therapies primarily inhibit osteoclast activity, and are seldom designed to ...
    Largee Biswas ... Anita Kamra Verma
    Published: August 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00102
    Viewed:1469
    Downloaded:74
    Open Access
    Systematic Review
    Signaling pathways and targets of natural products in psoriasis treatment
    Aim: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with...
    Ly Thi Huong Nguyen
    Published: August 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00098
    Viewed:1754
    Downloaded:77
    Open Access
    Original Article
    Is there any correlation between muscle fatigue and serum lactate dehydrogenase levels in prediabetic individuals?
    Aim: Lactate dehydrogenase (LDH) is an enzyme that acts as a catalyst in the conversion of lactate to pyruvate which is abundantly found in liver, kidney, heart and muscles. Previous studies have all shown a strong positive correlation between muscle fatigue and increased serum LDH levels with type 2 diabetes mellitus but no study has actually assessed the same for prediabetes. ...
    Charu Mishra ... Ranjan Kumar Dixit
    Published: August 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00099
    Viewed:1219
    Downloaded:22
    Open Access
    Original Article
    Mathematical model for transmission of Chlamydia due to sexual activity and unhygienic environment
    Aim: Sexually transmitted diseases (STDs) need to be studied systematically to better understand their global spread. Transmission of Chlamydia trachomatis is a severe public health issue, with r...
    Nita H. Shah ... Yash N. Shah
    Published: August 30, 2022 Explor Med. DOI: 10.37349/emed.2022.00100
    Viewed:1139
    Downloaded:45
    Open Access
    Review
    Feed your microbiome and improve sleep, stress resilience, and cognition
    The brain and gut are connected both physically and biochemically. The gut-brain axis includes the central nervous system, neuroendocrine and neuroimmune systems, the enteric nervous system and vagu...
    Maciej Chichlowski ... Neeraj Pandey
    Published: August 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00097
    Viewed:1830
    Downloaded:88
    Open Access
    Systematic Review
    Downhill esophageal varices: a systematic review of the case reports
    Aim: The etiologies, presentation, and management of downhill varices in the era of modern medicine are relatively under-explored and mostly limited to case reports or case series. Methods: P...
    Hassam Ali ... Devika Kapuria
    Published: August 11, 2022 Explor Med. DOI: 10.37349/emed.2022.00096
    Viewed:1970
    Downloaded:67
    Open Access
    Letter to the Editor
    Adenine-rich diet: a potential mechanism for renal fibrosis progression
    Chronic kidney disease (CKD) is a major health problem but there are many modalities to prevent and manage CKD progression. Diet is one of these factors, which needs to be evaluated more. Adenine is a water-soluble nucleoprotein that exists in both vegetables and animal foods, which triggers and aggravates fibrosis process besides other metabolic derangements such as diabetes mellitus affection that accelerates glomerular filtration rate decline rapidly....
    Majid Malaki
    Published: July 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00095
    Viewed:2106
    Downloaded:107
    Open Access
    Original Article
    Construction and validation of gastric cancer diagnosis model based on machine learning
    Aim: To screen differentially expressed genes related to gastric cancer based on The Cancer Genome Atlas (TCGA) database and construct a gastric cancer diagnosis model by machine learning. Methods:...
    Fei Kong ... Wenzhen Yuan
    Published: June 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00094
    Viewed:1254
    Downloaded:103
    Open Access
    Original Article
    Pyogenic liver abscess: contrast-enhanced ultrasound allows morpho-evolutive classification and guides personalized management
    Aim: The aim of this study is to propose a contrast-enhanced ultrasound (CEUS)-based morphologic classification of pyogenic liver abscess (PLA) reflecting different evolutive stages and to assess th...
    Giampiero Francica
    Published: June 28, 2022 Explor Med. DOI: 10.37349/emed.2022.00093
    Viewed:1762
    Downloaded:75
    Open Access
    Editorial
    Does our microbiota eat with or without gluten?
    Giuseppe Merra ... Marco Marchetti
    Published: June 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00091
    Viewed:1103
    Downloaded:29
    Open Access
    Review
    Involvement of retroelements in the autoimmune response in humans
    Retroelements are mobile genomic components requiring reverse transcription into an RNA intermediate and then synthesis of complementary DNA for transposition. Human genome contains a vast amount of retroelements including retrotransposons and endogenous retroviruses. ...
    Sezer Okay
    Published: June 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00092
    Viewed:1355
    Downloaded:41
    Open Access
    Meta-Analysis
    Hyperuricemia—a serious complication among patients with chronic kidney disease: a systematic review and meta-analysis
    Aim: Hyperuricemia as a putative risk factor for chronic kidney disease (CKD) progression remains controversial and debatable. This systematic review aims to explore the prevalence of hyperuricem...
    Ishfaq Rashid ... Gautam Sahu
    Published: June 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00089
    Viewed:2898
    Downloaded:63
    Open Access
    Review
    Recent advances of gut microbiota in chronic kidney disease patients
    Chronic kidney disease (CKD) is a worldwide public health issue and has ultimately progressed to an end-stage renal disease that requires life-long dialysis or renal transplantation. However, the underlying molecular mechanism of these pathological development and progression remains to be fully understood. ...
    Ying-Yong Zhao
    Published: June 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00090
    Viewed:1996
    Downloaded:78
    Open Access
    Review
    Early taurine administration as a means for halting the cytokine storm progression in COVID-19 patients
    Around the world, more than 6.2 million individuals have died as a result of COVID-19. According to a recent survey conducted among immunologists, epidemiologists, and virologists, this disease is expected to become endemic. This implies that the disease could have a continuous presence and/or normal frequency in the population. ...
    Alberto Rubio-Casillas ... Raied Badierah
    Published: June 08, 2022 Explor Med. DOI: 10.37349/emed.2022.00088
    Viewed:2871
    Downloaded:65
    Open Access
    Review
    The gut microbiome and the immune system
    The human body contains trillions of microbes which generally live in symbiosis with the host. The interaction of the gut microbiome with elements of the host immune system has far-reaching effects ...
    Tenzin Choden, Nathaniel Aviv Cohen
    Published: May 31, 2022 Explor Med. DOI: 10.37349/emed.2022.00087
    Viewed:5787
    Downloaded:238
    Open Access
    Review
    Reactive oxygen species in cardiovascular diseases: an update
    Cardiovascular diseases are among the leading causes of death worldwide, imposing major health threats. Reactive oxygen species (ROS) are one of the most important products from the process of redox...
    Juanjuan Fei ... Jun Ren
    Published: April 26, 2022 Explor Med. DOI: 10.37349/emed.2022.00085
    Viewed:1141
    Downloaded:48
    Open Access
    Original Article
    High salt induced augmentation of angiotensin II mediated hypertension is associated with differential expression of tumor necrosis factor-alpha receptors in the kidney
    Aim: Chronic high salt (HS) intake causes minimal changes in blood pressure (BP) but it induces augmented hypertensive response to angiotensin II (AngII) administration in rodents. The mechanism ...
    Dewan S. A. Majid ... L. Gabriel Navar
    Published: April 26, 2022 Explor Med. DOI: 10.37349/emed.2022.00086
    Viewed:1444
    Downloaded:61
    Open Access
    Case Report
    Complex liver injury induced by combined Aloe Vera and vitamin A oral supplements, as assessed by histology and the updated RUCAM
    A case of combined acute and chronic liver injury related to consumption of multi-ingredient nutritional oral supplements containing Aloe Vera gel and vitamin A among other vitamins, minerals and di...
    Katerina Delladetsima ... Stratigoula Sakellariou
    Published: April 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00084
    Viewed:2801
    Downloaded:54
    Open Access
    Commentary
    Semaglutide: a game changer for metabolic diseases?
    Semaglutide is a glucagon-like peptide 1 receptor agonist (GLP-1 RA) molecule approved for the treatment of both type 2 diabetes (T2D) and obesity. Semaglutide has a greater impact on glycated haemo...
    Agostino Milluzzo ... Laura Sciacca
    Published: April 19, 2022 Explor Med. DOI: 10.37349/emed.2022.00083
    Viewed:2708
    Downloaded:78
    Open Access
    Original Article
    Development of systolic dysfunction unrelated to myocardial infarction in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: While it is commonly thought that left ventricular (LV) systolic function may insidiously deteriorate in hypertensive patients, few prospective data are available to support this notion. ...
    Marcello Chinali ... Richard B. Devereux
    Published: April 02, 2022 Explor Med. DOI: 10.37349/emed.2022.00082
    Viewed:1301
    Downloaded:36
    Open Access
    Original Article
    Incident left bundle branch block predicts cardiovascular events and death in hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: Whether incident left bundle branch block (LBBB) is associated with increased cardiovascular (CV) morbidity and mortality in treated hypertensive patients with left ventricular hypertrophy (...
    Casper N. Bang ... Peter M. Okin
    Published: March 29, 2022 Explor Med. DOI: 10.37349/emed.2022.00081
    Viewed:1561
    Downloaded:31
    Open Access
    Original Article
    Incident atrial fibrillation and heart failure in treated hypertensive patients with left ventricular hypertrophy. The LIFE Study
    Aim: The present study investigated the appearance and severity of atrial fibrillation (AF) and heart failure (HF) in 8,702 hypertensive patients with left ventricular hypertrophy (LVH) receiving...
    Casper N. Bang ... Peter M. Okin
    Published: March 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00080
    Viewed:1327
    Downloaded:33
    Open Access
    Original Article
    Time-varying serum uric acid predicts new-onset atrial fibrillation in treated hypertensive patients. The LIFE Study
    Aim: The Losartan Intervention For Endpoint reduction in hypertension (LIFE) study showed less new-onset atrial fibrillation (AF) in hypertensive patients receiving losartan- vs. atenolol-based t...
    Eran S. Zacks ... Richard B. Devereux
    Published: March 17, 2022 Explor Med. DOI: 10.37349/emed.2022.00079
    Viewed:1314
    Downloaded:41
    Open Access
    Editorial
    Elimination of hepatitis C virus infection in Europe: targeting the obstacles
    Dante Romagnoli
    Published: February 24, 2022 Explor Med. DOI: 10.37349/emed.2022.00075
    Viewed:1026
    Downloaded:24
    Open Access
    Review
    Multi-faced roles of reactive oxygen species in anti-tumor T cell immune responses and combination immunotherapy
    T cells play a central role in anti-tumor immunity, and reactive oxygen species (ROS) lie at the crossroad on the anti-tumor T cell responses. To activate efficient T cell immunity, a moderate level...
    Tao Wang, Haiyan Xu
    Published: February 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00076
    Viewed:2172
    Downloaded:71
    Open Access
    Original Article
    Placental CD4+ T cells from preeclamptic patients cause autoantibodies to the angiotensin II type I receptor and hypertension in a pregnant rat model of preeclampsia
    Aim: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with activated CD4+ T cells and autoantibodies to angiotensin II type 1 receptor (AT1-AA). We have previously...
    Kristin E. Reeve ... Babbette LaMarca
    Published: February 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00077
    Viewed:1575
    Downloaded:62
    Open Access
    Review
    The potential anti-cancer effects of melatonin on breast cancer
    Melatonin is the primary hormone of the pineal gland that is secreted at night. It regulates many physiological functions, including the sleep-wake cycle, gonadal activity, free radical scavenging, ...
    Naba Kumar Das, Saptadip Samanta
    Published: February 25, 2022 Explor Med. DOI: 10.37349/emed.2022.00078
    Viewed:11228
    Downloaded:195
    Open Access
    Review
    Oxidative stress in obesity and insulin resistance
    Since obesity is one of the main factors in the development of insulin resistance (IR) and is also associated with increased oxidative stress (OxS) rate, this study aims to review the published lite...
    Anastasija Panic ... Esma R. Isenovic
    Published: February 23, 2022 Explor Med. DOI: 10.37349/emed.2022.00074
    Viewed:3463
    Downloaded:148
    Open Access
    Review
    Reactive oxygen species in cancer progression and its role in therapeutics
    The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above the cellular tole...
    Ranjeet Singh, Partha Pratim Manna
    Published: February 22, 2022 Explor Med. DOI: 10.37349/emed.2022.00073
    Viewed:5870
    Downloaded:230
    Open Access
    Review
    Nano-immunotherapeutics: targeting approach as strategic regulation at tumor microenvironment for cancer treatment
    Cancer is the leading cause of mortality worldwide, which necessitates our consideration related to novel treatment approach. Tumor cells at the tumor microenvironment (TME), regulate a plethora of ...
    Priyanka Singh ... Anita Kamra Verma
    Published: February 16, 2022 Explor Med. DOI: 10.37349/emed.2022.00072
    Viewed:1827
    Downloaded:48
    Open Access
    Original Article
    Preclinical toxicity test results of a new antiviral–immune-modulator compound consisting of flavonoid molecules (COVID-19 clinical trial preliminary data)
    Aim: Isolated specific glycone–aglycone conjugated flavonoids which are investigated for their effect of bioavailability and molecular concentrations. The specific formula is then tested...
    Gürer G. Budak ... Orkun Tarkun
    Published: January 18, 2022 Explor Med. DOI: 10.37349/emed.2022.00071
    Viewed:1515
    Downloaded:62
    Open Access
    Review
    A global genetic epidemiological review of pseudoexfoliation syndrome
    Pseudoexfoliation (PXF) syndrome is an important public health concern requiring individual population level analysis. Disease prevalence differs by geographic location and ethnicity, and has environmental, demographic, genetic, and molecular risk factors have been demonstrated. Epidemiological factors that have been associated with PXF include age, sex, environmental factors, and diet. Genetic and molecular components have also been identified that are associated with PXF....
    Patrice M. Hicks ... Margaret M. DeAngelis
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00069
    Viewed:1999
    Downloaded:63
    Open Access
    Review
    Antioxidant enzymes and vascular diseases
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play a fundamental role in regulating endothelial function and vascular tone in the physiological conditions of a vascular system. However, oxidative stress has detrimental effects on human health, and numerous studies confirmed that high ROS/RNS production contributes to the initiation and progression of cardiovascular diseases. The antioxidant defense has an essential role in the homeostatic functioning of the vascular endothelial system. Endogenous antioxidative defense includes various molecules and enzymes such as superoxide dismutase, catalase, glutathione reductase, and glutathione peroxidase. ...
    Jelena Radovanovic ... Esma R. Isenovic
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00070
    Viewed:2035
    Downloaded:71
    Open Access
    Review
    Key roles of CCCTC-binding factor in cancer evolution and development
    The processes of cancer and embryonic development have a partially overlapping effect. Several transcription factor families, which are highly conserved in the evolutionary history of biology, play a key role in the development of cancer and are often responsible for the pivotal developmental processes such as cell survival, expansion, senescence, and differentiation. As an evolutionary conserved and ubiquitously expression protein, CCCTC-binding factor (CTCF) has diverse regulatory functions, including gene regulation, imprinting, insulation, X chromosome inactivation, and the establishment of three-dimensional (3D) chromatin structure during human embryogenesis. ...
    Zishuai Li ... Guangwen Cao
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00068
    Viewed:1454
    Downloaded:38
    Open Access
    Commentary
    Functions of two distinct Kupffer cells in the liver
    Tissue-resident macrophages play critically important roles in host homeostasis and pathogenesis of diseases, with the functions of phagocytosis, metabolism, and immune modulation. Recently, two research studies accomplished by a collaborated group of researchers showed that there are two populations of liver resident Kupffer cells (KCs), including a major cluster of differentiation 206 low expression (CD206low)endothelial cell-selective adhesion molecule negative (ESAM−) population (KC1) and a minor CD206highESAM+ population (KC2). ...
    Chunye Zhang ... Ming Yang
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00067
    Viewed:2500
    Downloaded:120
    Open Access
    Review
    Molecular targets regulating endoplasmic reticulum-mitochondria crosstalk for NAFLD treatment
    Non-alcoholic fatty liver disease (NAFLD) as the most common chronic liver disease poses a significant impact on public healthcare and economic risk worldwide. As a multifactorial disease, NAFLD is usually associated with many comorbidities such as obesity, insulin resistance, hypertension, hyperlipidemia, diabetes, and cardiovascular disease. Without effectively preventive intervention, the advanced stage of NAFLD, non-alcoholic steatohepatitis (NASH), can progress to cirrhosis and hepatocellular carcinoma (HCC). ...
    Chunye Zhang, Ming Yang
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00066
    Viewed:1697
    Downloaded:68
    Open Access
    Original Article
    Cross-cultural adaptation of Delphi definitions of low back pain prevalence in French (Delphi DOLBaPP-F)
    Aim: The high heterogeneity in the definitions of low back pain encountered in the literature has led to the development of standardized definitions of this condition called “Delphi definitions of low back pain prevalence (Delphi DOLBaPP)” by a group of international researchers. In order to be widely used, these definitions need to be adapted according to the cultural and linguistic context. The aim of this work was to perform the cross-cultural adaptation of the Delphi DOLBaPP definitions in Quebec French and to pre-test them among French-speaking adults. ...
    Antarou Ly ... Clermont E. Dionne
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00065
    Viewed:1134
    Downloaded:44
    Open Access
    Review
    Obstetric implications of maternal chronic hepatitis B virus infection
    Antenatal screening for hepatitis B surface antigen seropositivity is widely adopted to identify pregnant women with chronic hepatitis B virus (HBV) infection in order to target their newborn infants for combined passive-active neonatal immunization to prevent the maternal-to-child transmission of HBV. It is less certain whether the presence of chronic HBV infection in these largely asymptomatic women could impact their pregnancy outcome. There is now gathering ...
    Terence T. Lao
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00064
    Viewed:1300
    Downloaded:40
    Open Access
    Review
    Future incidence and mortality of colorectal carcinoma in the United States: an updated overview of risk factors and preventative measures
    According to the Global Cancer Observatory (GLOBOCAN) 2020, colorectal carcinoma (CRC) was the second leading cause of cancer death globally. Current literature utilizes reported databases such as Surveillance, Epidemiology, and End Results (SEER) to better understand the epidemiology of CRC. The global cancer observatory’s “Cancer Tomorrow” data visualization tools were used to predict the future incidence and mortality of colorectal cancers until 2030 as a guided tool to look over ways to reduce incidence by controlling risk factors of CRC. The total number of CRC is expected to rise by 2030, with a percent change of 17.3%. ...
    Hassam Ali
    Published: December 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00063
    Viewed:1262
    Downloaded:39
    Open Access
    Review
    Aortic complications in pregnancy: the less remembered chapter—a narrative review
    Pregnancy increases the risk of common vascular events and also the rarer events like aortic dissection (AD)/aortic rupture and this is even more pronounced in patients with predisposing aortopathies. AD was found to occur in 0.0004% of all pregnancies, and it is more pronounced in patients with underlying connective tissue disorders. The normal hemodynamic changes on a weak aorta will lead to AD and/or rupture, more so with increase in the period of gestation....
    Preetha Rajasekaran ... Bashi V. Velayudhan
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00060
    Viewed:1666
    Downloaded:62
    Open Access
    Commentary
    Separating the apples from the oranges: from NAFLD heterogeneity to personalized medicine
    Recently, Arrese and Colleagues have published a review article entitled, “Insights into Nonalcoholic Fatty-Liver Disease (NAFLD) Heterogeneity” (Semin Liver Dis. 2021;41:421–34. doi: 10.1055/s-0041-1730927). This milestone publication clearly and exhaustively explains the multitude of pathogenic pathways involved in the development and progression of disease eventually conducive to heterogeneous clinical phenotypes and different disease outcomes. ...
    Amedeo Lonardo
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00061
    Viewed:1502
    Downloaded:75
    Open Access
    Perspective
    Reactive oxygen species may influence on the crossroads of stemness, senescence, and carcinogenesis in a cell via the roles of APRO family proteins
    Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS is even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. ...
    Yuka Ikeda ... Satoru Matsuda
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00062
    Viewed:4962
    Downloaded:1919
    Open Access
    Meta-Analysis
    A review of aortic thrombosis in COVID-19 infection
    Aim: As the novel coronavirus disease 2019 (COVID-19) pandemic impacts the global healthcare system, evolving data show increased frequency of arterial and venous thromboembolism among patients with COVID-19 infection. Aortic thrombus is a rare thrombotic event with a wide spectrum of clinical manifestations and potential catastrophic complications. This study aimed to elucidate the clinical manifestations, diagnosis and treatment dilemmas of aortic thrombus with COVID-19 infection and raise awareness among frontline medical providers. Aortic thrombosis is rare, but if not considered early in the course of COVID-19 infection, the data suggest that the diagnosis will probably not be made until potentially serious complications arise. ...
    Korin Karabulut ... James Morgan
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00059
    Viewed:2053
    Downloaded:31
    Open Access
    Review
    Exploring evidence-based innovative therapy for the treatment of chronic HBV infection: experimental and clinical
    With the advent of various vaccines and antimicrobial agents during the 20th century, the control and containment of infectious diseases appeared to be a matter of time. However, studies unveiled the diverse natures of microbes, their lifestyle, and pathogenetic potentials. Since the ground-breaking discovery of the hepatitis B virus (HBV) by Baruch Blumberg and the subsequent development of a vaccine in the early 1980s, the main task of the scientific community has been to develop a proper management strategy for HBV-induced chronic liver diseases. In the early 1980’s, standard interferon (IFN) induced a reduction of HBV DNA levels, followed by the normalization of serum transaminases (alanine aminotransferase, ALT), in some chronic hepatitis B (CHB) patients. ...
    Sheikh Mohammad Fazle Akbar ... Yoichi Hiasa
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00058
    Viewed:1338
    Downloaded:26
    Open Access
    Original Article
    Objective measurement of sleep by smartphone application: comparison with actigraphy and relation to self-reported sleep
    Aim: Smartphone technology is increasingly used by the public to assess sleep. Specific features of some sleep-tracking applications are comparable to actigraphy in objectively monitoring sleep. The clinical utility of smartphone apps should be investigated further to increase access to convenient means of monitoring sleep....
    Taylor Maynard ... Sandy Neargarder
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00057
    Viewed:2054
    Downloaded:45
    Open Access
    Commentary
    Breastfeeding duration and reduced risk of NAFLD in midlife of parous women
    Alessandro Mantovani ... Andrea Dalbeni
    Published: October 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00056
    Viewed:1225
    Downloaded:15
    Open Access
    Review
    Role of angiotensin II in the development of subcellular remodeling in heart failure
    The development of heart failure under various pathological conditions such as myocardial infarction (MI), hypertension and diabetes are accompanied by adverse cardiac remodeling and cardiac dysfunction. Since heart function is mainly determined by coordinated activities of different subcellular organelles including sarcolemma, sarcoplasmic reticulum, mitochondria and myofibrils for regulating the intracellular concentration of Ca2+, it has been suggested that the occurrence of heart failure is a consequence of subcellular remodeling, metabolic alterations and Ca2+-handling abnormalities in cardiomyocytes. ...
    Sukhwinder K. Bhullar ... Naranjan S. Dhalla
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00054
    Viewed:2346
    Downloaded:54
    Open Access
    Original Article
    High prevalence of false positive SARS-CoV2 serology in a cohort of patients with liver autoimmune diseases
    Aim: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) immunization in patients with autoimmune diseases is of particular concern to understand their response to the infection and to the vaccine. In fact, the immunological disorder and the immunosuppressive therapies could affect the serological response....
    Maria Giulia Cornacchia ... Gaetano Serviddio
    Published: August 31, 2021 Explor Med. DOI: 10.37349/emed.2021.00055