• 58 results in Exploration of Digestive Diseases
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    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
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    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
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    Drug-induced cholestasis: causative agents and challenges in diagnosis and management
    Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominan [...] Read more.
    Jose M. Pinazo-Bandera ... Miren García-Cortés
    Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222
    DOI: https://doi.org/10.37349/edd.2023.00027
    This article belongs to the special issue CHOLESTASIS
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    Times Cited: 0
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    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
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    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
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    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
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    Immunophenotyping to improve the mechanistic understanding of idiosyncratic drug-induced liver injury: clinical implications and future directions
    The late event onset of a fraction of idiosyncratic drug-induced liver injury (DILI) cases and the link observed by genome-wide association studies (GWASs) of certain human leucocyte antigen (HLA) a [...] Read more.
    Alejandro Cueto-Sánchez ... Marina Villanueva-Paz
    Published: April 26, 2023 Explor Dig Dis. 2023;2:56–76
    DOI: https://doi.org/10.37349/edd.2023.00018
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
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    Original Article
    The hepatocyte growth factor induces an anti-inflammatory and repairing response in the cholestasis-induced colon damage
    Aim: Cholestasis remains a partially characterized disease. Evidence has been gained that it is a systemic disease that begins in the liver but significantly impacts other organs and systems such [...] Read more.
    Jocelyn López-Ramirez ... Leticia Bucio-Ortiz
    Published: August 11, 2022 Explor Dig Dis. 2022;1:40–50
    DOI: https://doi.org/10.37349/edd.2022.00004
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    Review
    Cholestasis associated to inborn errors in bile acid synthesis
    Several metabolic pathways are involved in the biotransformation of C27 neutral cholesterol to C24 primary bile acids (BAs), mainly cholic acid (CA) and chenodeoxycholic acid (CDCA), which are then conjugated with glycine or tauri [...] Read more.
    Ricardo Espinosa-Escudero ... Maria J. Monte
    Published: December 7, 2022 Explor Dig Dis. 2022;1:137–153
    DOI: https://doi.org/10.37349/edd.2022.00010
    This article belongs to the special issue CHOLESTASIS
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    Times Cited: 0
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    Review
    Molecular mechanisms of metabolic disease-associated hepatic inflammation in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
    Non-alcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide, with a progressive form of non-alcoholic steatohepatitis (NASH). It may progress to advanced liver diseases, [...] Read more.
    Chunye Zhang ... Ming Yang
    Published: October 25, 2023 Explor Dig Dis. 2023;2:246–275
    DOI: https://doi.org/10.37349/edd.2023.00029
    This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
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