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  • 77 results in Exploration of Digestive Diseases
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    Open Access
    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
    View:4968
    Download:95
    Open Access
    Editorial
    Extra-hepatic cancers in metabolic fatty liver syndromes
    Amedeo Lonardo
    Published: February 24, 2023 Explor Dig Dis. 2023;2:11–17
    DOI: https://doi.org/10.37349/edd.2023.00014
    View:2391
    Download:40
    Open Access
    Review
    Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication
    It is generally accepted that eradication of Helicobacter pylori (H. pylori) infection may reduce the risk of the development of gastric cancer. Recommendations for global generalized tests and trea [...] Read more.
    Elias Kouroumalis ... Argyro Voumvouraki
    View:7856
    Download:119
    Open Access
    Review
    Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategies
    Nonalcoholic fatty liver disease (NAFLD) is an umbrella definition that describes the ectopic deposition of fat within the liver that occurs in the absence of inciting factors other than the metabol [...] Read more.
    Amedeo Lonardo
    Published: August 30, 2023 Explor Dig Dis. 2023;2:188–201
    DOI: https://doi.org/10.37349/edd.2023.00026
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
    View:2991
    Download:54
    Open Access
    Review
    Drug-induced cholestasis: causative agents and challenges in diagnosis and management
    Drug-induced liver injury (DILI) is an adverse reaction to drugs and other xenobiotics that can have serious consequences and jeopardise progress in pharmacological therapy. While DILI is predominan [...] Read more.
    Jose M. Pinazo-Bandera ... Miren García-Cortés
    Published: September 18, 2023 Explor Dig Dis. 2023;2:202–222
    DOI: https://doi.org/10.37349/edd.2023.00027
    This article belongs to the special issue CHOLESTASIS
    View:18586
    Download:251
    Open Access
    Review
    The central role of mitochondrial metabolism in hepatic steatosis
    Mitochondria are present in all mammalian cells except matured red blood cells. Mitochondria consist of several metabolic pathways for glucose, fatty acids, amino acids, and bioenergetic pathways fo [...] Read more.
    Sanda Win ... Filbert Win Min Aung
    Published: February 29, 2024 Explor Dig Dis. 2024;3:42–68
    DOI: https://doi.org/10.37349/edd.2024.00039
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    View:4994
    Download:82
    Open Access
    Perspective
    The intermicrovillar adhesion complex in gut barrier function and inflammation
    The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.
    Bernadette Mödl ... Robert Eferl
    Published: October 11, 2022 Explor Dig Dis. 2022;1:72–79
    DOI: https://doi.org/10.37349/edd.2022.00006
    View:3371
    Download:67
    Open Access
    Review
    Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms?
    A high consumption of ultra-processed food (UPF) is a hallmark of Western diets that has been related to increased risk of non-communicable diseases. As an underlying mechanism, UPF may promote non- [...] Read more.
    Franziska A. Hägele ... Anja Bosy-Westphal
    Published: August 24, 2023 Explor Dig Dis. 2023;2:133–148
    DOI: https://doi.org/10.37349/edd.2023.00023
    View:2756
    Download:56
    Open Access
    Review
    SERPINB3 in fibrogenic chronic liver diseases and primary liver cancers
    Chronic liver diseases (CLDs), which are typically characterized by fibrogenic progression towards liver cirrhosis and related complications eventually leading to organ failure and can also lead to  [...] Read more.
    Patrizia Pontisso, Maurizio Parola
    Published: February 28, 2024 Explor Dig Dis. 2024;3:22–41
    DOI: https://doi.org/10.37349/edd.2024.00038
    This article belongs to the special issue Fibrosis and Hepatobiliary Cancer
    View:1544
    Download:17
    Open Access
    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:5445
    Download:141
    Open Access
    Review
    Alcohol-related liver disease: also a question of what you drink?
    Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer [...] Read more.
    Finn Jung ... Ina Bergheim
    Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132
    DOI: https://doi.org/10.37349/edd.2023.00022
    View:8566
    Download:83
    Open Access
    Review
    Helicobacter pylori infection and metabolic syndrome
    The formation of metabolic changes is based on many factors. In particular, the infectious theory of the development of metabolic “breakdowns” has not lost its relevance. In this regard, many sc [...] Read more.
    Natalia V. Baryshnikova ... Alexander N. Suvorov
    View:3043
    Download:45
    Open Access
    Review
    Role of cholesterol homeostasis in MASH-driven hepatocellular carcinoma: not just a neutral fat
    Hepatocellular carcinoma (HCC) is the most common type of liver cancer and its death rate is rising faster than that of any other cancer, while we still lack effective treatments. The increasing inc [...] Read more.
    Vicent Ribas
    Published: June 14, 2024 Explor Dig Dis. 2024;3:203–225
    DOI: https://doi.org/10.37349/edd.2024.00048
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    View:2137
    Download:46
    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
    View:11979
    Download:329
    Open Access
    Review
    Monitoring the hepatobiliary function using image techniques and labeled cholephilic compounds
    Evaluation of the hepatobiliary function is critical for the clinicians, not only for the diagnosis of a large variety of liver diseases but also in the follow-up and management of some patients, for instance, those with different [...] Read more.
    Beatriz Sanchez de Blas ... Marta R. Romero
    Published: February 28, 2023 Explor Dig Dis. 2023;2:18–33
    DOI: https://doi.org/10.37349/edd.2023.00015
    This article belongs to the special issue CHOLESTASIS
    View:2215
    Download:47
    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:9553
    Download:187
    Open Access
    Original Article
    Human liver stem cell-derived extracellular vesicles modulate long non-coding RNA expression profile in an in vivo model of non-alcoholic steatohepatitis
    Aim: Modifications in long non-coding RNA (lncRNA) expression are associated with inflammation and fibrosis in chronic liver diseases. It has been recently demonstrated that human liver stem cell [...] Read more.
    Giulia Chiabotto ... Stefania Bruno
    Published: August 30, 2023 Explor Dig Dis. 2023;2:172–187
    DOI: https://doi.org/10.37349/edd.2023.00025
    View:1871
    Download:45
    Open Access
    Review
    Bile as a liquid biopsy matrix: potential applications and limitations
    Hunting for tumoral material in body fluids, traditionally in blood, the so-called liquid biopsy is set to revolutionize the diagnosis and management of oncological patients. However, other biofluid [...] Read more.
    Maria Arechederra ... Carmen Berasain
    Published: February 04, 2024 Explor Dig Dis. 2024;3:5–21
    DOI: https://doi.org/10.37349/edd.2024.00037
    View:2144
    Download:45
    Open Access
    Review
    Therapeutic targets for metabolic dysfunction-associated steatotic liver disease and their roles in hepatocellular carcinoma
    Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common chronic liver diseases. Over time, there has been a significant increase in the prevalence of MASLD. It has [...] Read more.
    Chenyu Wei ... Xianguang Yang
    Published: December 13, 2023 Explor Dig Dis. 2023;2:282–296
    DOI: https://doi.org/10.37349/edd.2023.00031
    This article belongs to the special issue Cellular and Molecular Targets for NAFLD or MAFLD Treatments and Their Functions in Liver Fibrosis, Cirrhosis, and Cancer
    View:1894
    Download:35
    Open Access
    Review
    Liver injury related to Japanese herbal medicines: clinical features and diagnosis
    The word “Kampo medicine” means the traditional Japanese herbal medicine. Even “natural herb” can cause drug-induced liver injury (DILI). In this review, the characteristics of Kampo medicin [...] Read more.
    Naoki Mantani
    Published: June 27, 2023 Explor Dig Dis. 2023;2:77–82
    DOI: https://doi.org/10.37349/edd.2023.00019
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:2187
    Download:22