• 62 results in Exploration of Digestive Diseases
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    Editorial
    Extra-hepatic cancers in metabolic fatty liver syndromes
    Amedeo Lonardo
    Published: February 24, 2023 Explor Dig Dis. 2023;2:11–17
    DOI: https://doi.org/10.37349/edd.2023.00014
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    Open Access
    Review
    Principles of risk stratification in nonalcoholic fatty liver disease. A narrative review emphasizing non-invasive strategies
    Nonalcoholic fatty liver disease (NAFLD) is an umbrella definition that describes the ectopic deposition of fat within the liver that occurs in the absence of inciting factors other than the metabol [...] Read more.
    Amedeo Lonardo
    Published: August 30, 2023 Explor Dig Dis. 2023;2:188–201
    DOI: https://doi.org/10.37349/edd.2023.00026
    This article belongs to the special issue Advances in Hepato-gastroenterology: Diagnosis, Prognostication, and Disease Stratification
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    Review
    Extracellular vesicles in metabolic dysfunction associated fatty liver disease: mechanisms, diagnostic and therapeutic implications
    The prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is increasing rapidly worldwide due to the obesity epidemic. Advanced stages of the MAFLD, such as non-alcoholic steato [...] Read more.
    Zongmei Wu ... Han Moshage
    Published: July 13, 2022 Explor Dig Dis. 2022;1:4–20
    DOI: https://doi.org/10.37349/edd.2022.00002
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    Review
    Zebrafish as a model for drug induced liver injury: state of the art and beyond
    Zebrafish as a preclinical drug induced liver injury (DILI) model provides multiple advantages ranging from ease of breeding and maintenance, availability of different strains and transgenic fish am [...] Read more.
    Gulcin Cakan-Akdogan ... Ozlen Konu
    Published: April 26, 2023 Explor Dig Dis. 2023;2:44–55
    DOI: https://doi.org/10.37349/edd.2023.00017
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
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    Open Access
    Review
    Alcohol-related liver disease: also a question of what you drink?
    Excessive alcohol intake is still among the leading causes of chronic liver diseases. Epidemiological studies suggest that per capita consumption of alcohol from various alcohol beverages e.g., beer [...] Read more.
    Finn Jung ... Ina Bergheim
    Published: June 30, 2023 Explor Dig Dis. 2023;2:118–132
    DOI: https://doi.org/10.37349/edd.2023.00022
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    Review
    The central role of mitochondrial metabolism in hepatic steatosis
    Mitochondria are present in all mammalian cells except matured red blood cells. Mitochondria consist of several metabolic pathways for glucose, fatty acids, amino acids, and bioenergetic pathways fo [...] Read more.
    Sanda Win ... Filbert Win Min Aung
    Published: February 29, 2024 Explor Dig Dis. 2024;3:42–68
    DOI: https://doi.org/10.37349/edd.2024.00039
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
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    Review
    Helicobacter pylori and gastric cancer: a critical approach to who really needs eradication
    It is generally accepted that eradication of Helicobacter pylori (H. pylori) infection may reduce the risk of the development of gastric cancer. Recommendations for global generalized tests and trea [...] Read more.
    Elias Kouroumalis ... Argyro Voumvouraki
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    Review
    Role of cholesterol homeostasis in MASH-driven hepatocellular carcinoma: not just a neutral fat
    Hepatocellular carcinoma (HCC) is the most common type of liver cancer and its death rate is rising faster than that of any other cancer, while we still lack effective treatments. The increasing inc [...] Read more.
    Vicent Ribas
    Published: June 14, 2024 Explor Dig Dis. 2024;3:203–225
    DOI: https://doi.org/10.37349/edd.2024.00048
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    View:1204
    Download:38
    Open Access
    Perspective
    The intermicrovillar adhesion complex in gut barrier function and inflammation
    The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to b [...] Read more.
    Bernadette Mödl ... Robert Eferl
    Published: October 11, 2022 Explor Dig Dis. 2022;1:72–79
    DOI: https://doi.org/10.37349/edd.2022.00006
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    Open Access
    Review
    Etiopathogenesis and pathophysiology of cholestasis
    Normal hepatobiliary function depends on an adequate bile flow from the liver through the biliary tree to the gallbladder, where bile is stored and concentrated, and from the gallbladder to the duod [...] Read more.
    Maitane Asensio ... Jose J. G. Marin
    Published: October 31, 2022 Explor Dig Dis. 2022;1:97–117
    DOI: https://doi.org/10.37349/edd.2022.00008
    This article belongs to the special issue CHOLESTASIS
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    Open Access
    Review
    Ultra-processed food consumption and the risk of non-alcoholic fatty liver disease—What are the proposed mechanisms?
    A high consumption of ultra-processed food (UPF) is a hallmark of Western diets that has been related to increased risk of non-communicable diseases. As an underlying mechanism, UPF may promote non- [...] Read more.
    Franziska A. Hägele ... Anja Bosy-Westphal
    Published: August 24, 2023 Explor Dig Dis. 2023;2:133–148
    DOI: https://doi.org/10.37349/edd.2023.00023
    View:1529
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    Review
    SERPINB3 in fibrogenic chronic liver diseases and primary liver cancers
    Chronic liver diseases (CLDs), which are typically characterized by fibrogenic progression towards liver cirrhosis and related complications eventually leading to organ failure and can also lead to  [...] Read more.
    Patrizia Pontisso, Maurizio Parola
    Published: February 28, 2024 Explor Dig Dis. 2024;3:22–41
    DOI: https://doi.org/10.37349/edd.2024.00038
    This article belongs to the special issue Fibrosis and Hepatobiliary Cancer
    Open Access
    Review
    Impact of mitochondrial lipid alterations on liver disease mechanisms and progression
    Lipids are intricate biomolecules responsible for the building up of biological membranes. Besides this structural function, they also display crucial roles in signaling, acting as second messengers [...] Read more.
    Laura Fàbrega ... Carmen Garcia-Ruiz
    Published: September 10, 2024 Explor Dig Dis. 2024;3:382–413
    DOI: https://doi.org/10.37349/edd.2024.00057
    This article belongs to the special issue Mitochondria and Lipid Signalling in Liver Diseases
    View:1015
    Download:41
    Open Access
    Review
    Tumor immune microenvironment modulation by cholesterol in hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) is considered one of the most aggressive tumors worldwide. The consumption of lipid-enriched diets, mainly high cholesterol, induces oxidative stress and chronic infla [...] Read more.
    Alejandro Escobedo-Calvario ... María Concepción Gutiérrez-Ruíz
    Published: July 29, 2022 Explor Dig Dis. 2022;1:21–39
    DOI: https://doi.org/10.37349/edd.2022.00003
    View:3810
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    Open Access
    Review
    Fructose, a trigger of metabolic diseases?—a narrative review
    Worldwide the number of individuals being overweight or obese has dramatically increased during the last decades, which is also associated with a similar dramatic increase of individuals afflicted w [...] Read more.
    Anja Baumann ... Ina Bergheim
    Published: August 29, 2022 Explor Dig Dis. 2022;1:51–71
    DOI: https://doi.org/10.37349/edd.2022.00005
    View:4991
    Download:139
    Open Access
    Review
    Caspase-2 in liver disease and hepatocellular carcinoma
    Caspases are key factors in the regulation of the apoptotic and/or inflammatory responses, both crucial in the pathogenesis of diverse diseases. Caspase-2 is the most evolutionary conserved albeit f [...] Read more.
    Amaya Lopez-Pascual ... Maite G. Fernández-Barrena
    Published: October 31, 2022 Explor Dig Dis. 2022;1:80–96
    DOI: https://doi.org/10.37349/edd.2022.00007
    View:1676
    Download:37
    Open Access
    Review
    Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis
    Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modul [...] Read more.
    María Fernández-Fernández ... Anna Moles
    Published: February 22, 2023 Explor Dig Dis. 2023;2:1–10
    DOI: https://doi.org/10.37349/edd.2023.00013
    View:2299
    Download:44
    Open Access
    Review
    Monitoring the hepatobiliary function using image techniques and labeled cholephilic compounds
    Evaluation of the hepatobiliary function is critical for the clinicians, not only for the diagnosis of a large variety of liver diseases but also in the follow-up and management of some patients, for instance, those with different [...] Read more.
    Beatriz Sanchez de Blas ... Marta R. Romero
    Published: February 28, 2023 Explor Dig Dis. 2023;2:18–33
    DOI: https://doi.org/10.37349/edd.2023.00015
    This article belongs to the special issue CHOLESTASIS
    View:1555
    Download:41
    Open Access
    Case Report
    Diagnostic workup of suspected hereditary cholestasis in adults: a case report
    Hereditary cholestasis comprises a broad spectrum of clinical phenotypes of varying severity. Severe forms such as progressive familial intrahepatic cholestasis (PFIC) mostly affect children with di [...] Read more.
    Carola Dröge ... Verena Keitel
    Published: April 21, 2023 Explor Dig Dis. 2023;2:34–43
    DOI: https://doi.org/10.37349/edd.2023.00016
    This article belongs to the special issue CHOLESTASIS
    View:2186
    Download:74
    Open Access
    Review
    Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury
    The pathogenesis of drug-induced liver injury (DILI) is still in an early stage of research. However, investigators have shown that both oxidative stress and endoplasmic reticulum (ER) stress play a [...] Read more.
    Hanghang Wu ... Francisco Javier Cubero
    Published: June 28, 2023 Explor Dig Dis. 2023;2:83–99
    DOI: https://doi.org/10.37349/edd.2023.00020
    This article belongs to the special issue Drug-induced Liver Injury: From Bench to Clinical Application
    View:3488
    Download:61