• 6 results in Exploration of Drug Science
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    Decoding vascular aging: implications for atherosclerosis progression and clinical intervention
    Age-related pathologies, particularly cardiovascular disorders, pose a significant global health concern. The World Health Organization (WHO) predicts an increase in advanced mortality by 2030 unles [...] Read more.
    Silumbwe Ceaser Wankumbu ... Ming Xu
    Published: August 02, 2024 Explor Drug Sci. 2024;2:449–472
    DOI: https://doi.org/10.37349/eds.2024.00056
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    Open Access
    Review
    Metformin in COVID-19: a magical role beyond the hyperglycemia
    Coronavirus disease-2019 (COVID-19) has emerged as an aggressive viral infection in the last few years. Initially reported in the Wuhan area of the People’s Republic of China, it soon emerged acro [...] Read more.
    Gaurav Kumar Chaubey ... Manoj Raje
    Published: July 31, 2024 Explor Drug Sci. 2024;2:428–448
    DOI: https://doi.org/10.37349/eds.2024.00055
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    Open Access
    Review
    Natural products as anticancer agents and enhancing their efficacy by a mechanism-based precision approach
    Traditional medicines and their active ingredients and some natural products and derived analogs have been used for treating multiple diseases including cancer. Among these compounds cytotoxic agent [...] Read more.
    Stephen Safe
    Published: July 30, 2024 Explor Drug Sci. 2024;2:408–427
    DOI: https://doi.org/10.37349/eds.2024.00054
    This article belongs to the special issue Exploring Potential Drugs from Natural Products
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    Original Article
    From canonical to unique: extension of a lipophilicity scale of amino acids to non-standard residues
    Aim: The lipophilicity of amino acids plays a crucial role in delineating their physicochemical properties, offering insights into solubility, binding affinity, and bioavailability, properties th [...] Read more.
    Antonio Viayna ... William J. Zamora
    Published: July 30, 2024 Explor Drug Sci. 2024;2:389–407
    DOI: https://doi.org/10.37349/eds.2024.00053
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    Open Access
    Original Article
    Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration
    Aim: Evaluate the selective cytotoxic effect of the palindromic sequence RWQWRWQWR and its analogues obtained by replacement of L-amino acids by D-amino acids or the functionalization by adding t [...] Read more.
    Andrea Barragán-Cárdenas ... Javier García-Castañeda
    Published: July 19, 2024 Explor Drug Sci. 2024;2:369–388
    DOI: https://doi.org/10.37349/eds.2024.00052
    This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research
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    Perspective
    Plants and fungi metabolites as novel autophagy inducers and senescence inhibitors
    Premature aging can be partially explained by inefficient autophagy (the process of cellular self-digestion that recycles intracellular components) and premature senescence (cease of cellular divisi [...] Read more.
    Rivka Ofir
    Published: July 01, 2024 Explor Drug Sci. 2024;2:361–368
    DOI: https://doi.org/10.37349/eds.2024.00051
    This article belongs to the special issue Remedial benefits of natural products in inflammation and cancer
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