Exploration of Drug Science

Open Access Original Article

Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives

Cristina Martín-Escura ... Rosario González-Muñiz

Published: January 13, 2025 Explor Drug Sci. 2025;3:100882

DOI: https://doi.org/10.37349/eds.2025.100882

This article belongs to the special issue Mimicking Nature: Biomimetics as Tools for Diagnosis and Therapeutics

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Open Access Original Article

Identification of an inter-cysteine loop potentially involved in the activity of Opisthorchis viverrini-granulin-1

Rozita Takjoo ... Norelle L. Daly

Published: June 30, 2023 Explor Drug Sci. 2023;1:172–179

DOI: https://doi.org/10.37349/eds.2023.00012

This article belongs to the special issue Exploring Potential Drugs from Natural Products

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1674 17 1

Open Access Review

Novel progression on clinical therapy of COVID-19: Western and Traditional Chinese Medicines

Yongjia Xiong ... Feiyue Xing

Published: March 26, 2025 Explor Drug Sci. 2025;3:1008102

DOI: https://doi.org/10.37349/eds.2025.1008102

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1063 17 0

Open Access Review

Critical review on nutritional, bioactive and medicinal potential of Bunium persicum

Prachi Bhatt ... Mamta Baunthiyal

Published: February 27, 2025 Explor Drug Sci. 2025;3:100893

DOI: https://doi.org/10.37349/eds.2025.100893

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1258 18 0

Open Access Review

Potential use of peptides mimicking CRAC/CARC domains as antivirulence therapies to inhibit RTX toxins activities

Vanesa Herlax

Published: November 20, 2024 Explor Drug Sci. 2024;2:836–850

DOI: https://doi.org/10.37349/eds.2024.00076

This article belongs to the special issue Bioactive Peptides: Pioneering Innovations in Latin American Research

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Open Access Review

Dimeric dipeptide mimetics of neurotrophins as molecular tools and potential neuroprotective drugs

Tatiana Gudasheva ... Vladimir Dorofeev

Published: March 21, 2025 Explor Drug Sci. 2025;3:1008100

DOI: https://doi.org/10.37349/eds.2025.1008100

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871 16 0

Open Access Original Article

Control of diabetic nephropathy in male Wistar rats using ethanolic extract of Monodora myristica seeds and its biosynthesized selenium nanoparticles

Babalola Ola Yusuf ... Rasheed Bolaji Ibrahim

Published: February 19, 2025 Explor Drug Sci. 2025;3:100889

DOI: https://doi.org/10.37349/eds.2025.100889

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Open Access Retraction

Retraction: Controlled release of dexamethasone phosphate from modified mesoporous biocompatible silica nanoparticles: synthesis, characterization, and kinetic studies

Juan Manuel Galdopórpora ... María Victoria Tuttolomondo

Published: March 17, 2025 Explor Drug Sci. 2025;3:100896

DOI: https://doi.org/10.37349/eds.2025.100896

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Open Access Mini Review

Impact of the crosstalk between the PTEN and PAFR as well as PAFR and EGFR pathways in cancer

Anita Thyagarajan ... Ravi P. Sahu

Published: January 14, 2025 Explor Drug Sci. 2025;3:100883

DOI: https://doi.org/10.37349/eds.2025.100883

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894 15 0

Open Access Original Article

High-risk neuroblastoma stage 4 (NBS4): multi-target inhibitors for c-Src kinases (Csk) and retinoic acid (RA) signalling pathways

Amgad Gerges, Una Canning

Published: May 09, 2025 Explor Drug Sci. 2025;3:1008109

DOI: https://doi.org/10.37349/eds.2025.1008109

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618 15 0

Open Access Original Article

Interaction of brequinar and analogs with PD-L1: a molecular docking analysis

Gérard Vergoten, Christian Bailly

Published: June 09, 2025 Explor Drug Sci. 2025;3:1008113

DOI: https://doi.org/10.37349/eds.2025.1008113

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572 16 0

Open Access Review

Molecular mechanisms and therapeutic prospects of 4-aminobenzoic acid in neuropsychiatric disorders: a comprehensive review of neurotransmitter modulation, anti-inflammatory pathways, and antioxidant defense

Siyu Chen ... Yangyang Liu

Published: March 19, 2025 Explor Drug Sci. 2025;3:100898

DOI: https://doi.org/10.37349/eds.2025.100898

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Open Access Original Article

Revolutionizing diabetes treatment: computational insights into 4-hydroxy isoleucine derivatives and advanced molecular screening for antidiabetic compounds

Lakshmi Mounika Kelam ... M. Elizabeth Sobhia

Published: April 10, 2025 Explor Drug Sci. 2025;3:1008104

DOI: https://doi.org/10.37349/eds.2025.1008104

This article belongs to the special issue Bioactive Molecules from Natural Sources

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Open Access Original Article

A simple quantitative model for the prediction of exposure of renally excreted drugs in pregnant women: a comparison with whole body PBPK model

Iftekhar Mahmood

Published: July 01, 2025 Explor Drug Sci. 2025;3:1008115

DOI: https://doi.org/10.37349/eds.2025.1008115

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295 14 0

Open Access Original Article

Combinatorial and fragment-based in silico design of PI3K-alpha natural hybrid antagonists for breast cancer therapeutics

Navya Aggarwal ... Banashree Bondhopadhyay

Published: April 29, 2025 Explor Drug Sci. 2025;3:1008108

DOI: https://doi.org/10.37349/eds.2025.1008108

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676 13 0

Open Access Original Article

Cytochrome P450 2C9-mediated interactions: molecular docking studies of natural anti-arthritic compounds

Boon Hooi Tan ... Chin Eng Ong

Published: May 27, 2025 Explor Drug Sci. 2025;3:1008111

DOI: https://doi.org/10.37349/eds.2025.1008111

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486 13 0

Open Access Review

Inflammatory bowel disease in Africa: the current landscape of pharmacological treatments and the promise of emerging innovations

Murtada A. Oshi

Published: July 10, 2025 Explor Drug Sci. 2025;3:1008117

DOI: https://doi.org/10.37349/eds.2025.1008117

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