• 17 results in Exploration of Targeted Anti-tumor Therapy
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    Original Article
    Aflatoxin B1-DNA adducts modify the effects of post-operative adjuvant transarterial chemoembolization improving hepatocellular carcinoma prognosis
    Aim: DNA damage involves in the carcinogenesis of some cancer and may act as a target for therapeutic intervention of cancers. However, it is unclear whether aflatoxin B1 (AFB1)-DNA adducts (ADAs) [...] Read more.
    Liyan Huang ... Xidai Long
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:780–792
    DOI: https://doi.org/10.37349/etat.2023.00167
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    Times Cited: 0
    Open Access
    Review
    Medicinal chemistry advances in targeting class I histone deacetylases
    Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gen [...] Read more.
    Diaaeldin I. Abdallah ... Patrick T. Gunning
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:757–779
    DOI: https://doi.org/10.37349/etat.2023.00166
    This article belongs to the special issue Posttranslational Modifications in Health and Disease
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    Open Access
    Original Article
    Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity
    Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistan [...] Read more.
    Melissa Bersanelli ... Luca Ampollini
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:743–756
    DOI: https://doi.org/10.37349/etat.2023.00165
    Open Access
    Original Article
    In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancer
    Aim: Delineate structure-based inhibition of colony-stimulating factor-1 receptor (CSF1R) by small molecule CSF1R inhibitors in clinical development for target identification and potential lead o [...] Read more.
    Zahra Azhar ... Zohaib Raza
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:727–742
    DOI: https://doi.org/10.37349/etat.2023.00164
    Open Access
    Original Article
    Clinical and mutational profile of AT-rich interaction domain 1A-mutated cancers
    Aim: AT-rich interaction domain 1A (ARID1A) encodes a key component of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex that participates in gene expression. ARID1A alter [...] Read more.
    Rosa Falcone ... Gennaro Daniele
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:716–726
    DOI: https://doi.org/10.37349/etat.2023.00163
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    Times Cited: 0
    Open Access
    Review
    Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
    Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational [...] Read more.
    Angeles C. Tecalco-Cruz, Jesús Zepeda-Cervantes
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:699–715
    DOI: https://doi.org/10.37349/etat.2023.00162
    This article belongs to the special issue Posttranslational Modifications in Health and Disease
    Open Access
    Review
    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
    One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergen [...] Read more.
    Priyanka S. Lande ... Leena P. Joge
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:690–698
    DOI: https://doi.org/10.37349/etat.2023.00161
    This article belongs to the special issue Plant Extracts as an Infinite Resource for New Anticancer Agents
    Open Access
    Perspective
    Artificial intelligence ethics in precision oncology: balancing advancements in technology with patient privacy and autonomy
    Precision oncology is a rapidly evolving field that uses advanced technologies to deliver personalized cancer care based on a patient’s unique genetic and clinical profile. The use of artificial i [...] Read more.
    Bahareh Farasati Far
    Published: August 31, 2023 Explor Target Antitumor Ther. 2023;4:685–689
    DOI: https://doi.org/10.37349/etat.2023.00160
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    Open Access
    Original Article
    Deep learning based clinico-radiological model for paediatric brain tumor detection and subtype prediction
    Aim: Early diagnosis of paediatric brain tumors significantly improves the outcome. The aim is to study magnetic resonance imaging (MRI) features of paediatric brain tumors and to develop an auto [...] Read more.
    Abhishek Mahajan ... Aliasgar Moiyadi
    Published: August 30, 2023 Explor Target Antitumor Ther. 2023;4:669–684
    DOI: https://doi.org/10.37349/etat.2023.00159
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment
    Open Access
    Original Article
    Deep learning based automated epidermal growth factor receptor and anaplastic lymphoma kinase status prediction of brain metastasis in non-small cell lung cancer
    Aim: The aim of this study was to investigate the feasibility of developing a deep learning (DL) algorithm for classifying brain metastases from non-small cell lung cancer (NSCLC) into epidermal  [...] Read more.
    Abhishek Mahajan ... Kumar Prabhash
    Published: August 30, 2023 Explor Target Antitumor Ther. 2023;4:657–668
    DOI: https://doi.org/10.37349/etat.2023.00158
    This article belongs to the special issue Biomarkers for Personalized and Precise Cancer Diagnosis and Treatment