• 8 results in Exploration of Immunology
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    Anti-cancer γδ T lymphocytes: contradictory past and promising future
    Recent anti-cancer strategies are based on the stimulation of anti-tumor immune reaction, exploiting distinct lymphocyte subsets. Among them, γδ T cells represent optimal anti-cancer candidates, especially in those tissues where [...] Read more.
    Alessandro Poggi, Maria Raffaella Zocchi
    Published: April 28, 2022 Explor Immunol. 2022;2:220–228
    DOI: https://doi.org/10.37349/ei.2022.00047
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
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    Review
    A proposed new paradigm for an anti-AIDS tolerogenic vaccine
    Until now, despite 30 years of intensive work, the RV144 human immunodeficiency virus (HIV) vaccine trial initiated in 2003 remains so far the most protective vaccine prototype of all those tested ( [...] Read more.
    Christine Jacomet
    Published: April 24, 2022 Explor Immunol. 2022;2:211–219
    DOI: https://doi.org/10.37349/ei.2022.00046
    This article belongs to the special issue Old and New Paradigms in Viral Vaccinology
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    Original Article
    Thymosin alpha 1 therapy alleviates organ dysfunction of sepsis patients: a retrospective cohort study
    Aim: Thymosin alpha 1 (Tα1) is a promising treatment for the improvement of sepsis patients. Until now, its function in reducing acute organ damage of sepsis patients is still unclear. The aim of this study was to determine wheth [...] Read more.
    Fei Pei ... on behalf of the China Critical Care Immunotherapy Research Group
    Published: April 22, 2022 Explor Immunol. 2022;2:200–210
    DOI: https://doi.org/10.37349/ei.2022.00045
    This article belongs to the special issue The‌ ‌Sepsis‌ ‌induced‌ ‌Immune‌ ‌Conundrum
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    Original Article
    Single-cell differentiation trajectories define early stages of a human cutaneous T-cell lymphoma
    Aim: The aim of this article is to characterize in detail the γδ T lymphocytes from an adult patient with primary cutaneous T-cell lymphoma of γδ s [...] Read more.
    Juan-Pablo Cerapio ... Jean-Jacques Fournie
    Published: April 15, 2022 Explor Immunol. 2022;2:185–199
    DOI: https://doi.org/10.37349/ei.2022.00044
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
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    Review
    Paradigms in HIV vaccine research
    Although a large number of preventative human immunodeficiency virus (HIV) vaccine trials have been carried out during the last 30 years, it is remarkable that an effective HIV vaccine has not yet b [...] Read more.
    Marc H.V. Van Regenmortel
    Published: March 17, 2022 Explor Immunol. 2022;2:180–184
    DOI: https://doi.org/10.37349/ei.2022.00043
    This article belongs to the special issue Old and New Paradigms in Viral Vaccinology
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    Augmenting human gamma delta lymphocytes for cancer therapy with chimeric antigen receptors
    Gamma delta lymphocytes (γδ T) sit at the interface between innate and adaptive immunity. They have the capacity to recognize cancer cells by interaction of their surface receptors with an array of cancer cell surface target ant [...] Read more.
    Gabrielle M. Ferry, John Anderson
    Published: March 17, 2022 Explor Immunol. 2022;2:168–179
    DOI: https://doi.org/10.37349/ei.2022.00042
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
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    The role of γδ T cells in the context of allogeneic stem cell transplantation
    Allogeneic stem cell transplantation is currently the only curative approach for a variety of malignant and non-malignant diseases. In the early transplant era, the intent of this treatment was to a [...] Read more.
    Rupert Handgretinger ... Manon Queudeville
    Published: March 16, 2022 Explor Immunol. 2022;2:157–167
    DOI: https://doi.org/10.37349/ei.2022.00041
    This article belongs to the special issue Interplay of γδ T cells and Tumor Cells
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    Review
    High avidity of vaccine-induced immunoglobulin G against SARS-CoV-2: potential relevance for protective humoral immunity
    Avidity of immunoglobulin G (IgG) is defined as its binding strength to its target antigen. As a consequence of affinity maturation of the IgG response, avidity is maturing as well. Therefore, acute [...] Read more.
    Georg Bauer
    Published: March 16, 2022 Explor Immunol. 2022;2:133–156
    DOI: https://doi.org/10.37349/ei.2022.00040
    This article belongs to the special issue Vaccine-induced Immune Responses Against SARS-CoV-2 Infections