• 6 results in Exploration of Drug Science
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    Original Article
    Subacute toxicity of isoliquiritigenin-zein phosphatidylcholine nanoparticles on biochemical, hematological, and histopathological parameters in Sprague-Dawley rats
    Aim: Isoliquiritigenin (ISL) is a natural flavonoid found in many natural plants, which exhibits numerous pharmacological properties including anti-inflammatory, antioxidant, antitumor, and antiv [...] Read more.
    Ke Yang ... Jianping Chen
    Published: April 29, 2024 Explor Drug Sci. 2024;2:234–253
    DOI: https://doi.org/10.37349/eds.2024.00044
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    Review
    Lipopeptide adjuvants for antibiotics and vaccines: the future step in the fight against multidrug-resistant and extensively drug-resistant pathogens
    With the surge of antibiotic resistance in bacteria, the need for a larger arsenal of effective antibiotics and vaccines has drastically increased in the past decades. Antibiotics like vaccines can  [...] Read more.
    Chloé O. Sebilleau, Steven J. Sucheck
    Published: April 29, 2024 Explor Drug Sci. 2024;2:203–233
    DOI: https://doi.org/10.37349/eds.2024.00043
    This article belongs to the special issue Bioactive Peptides discovery and development
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    Perspective
    Daropeptide natural products
    Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post- [...] Read more.
    Suze Ma ... Qi Zhang
    Published: April 19, 2024 Explor Drug Sci. 2024;2:190–202
    DOI: https://doi.org/10.37349/eds.2024.00042
    This article belongs to the special issue Bioactive Peptides discovery and development
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    Review
    Stapled peptides: targeting protein-protein interactions in drug development
    Protein-protein interactions (PPIs) impersonate a significant role in many biological processes and are potential therapeutic targets in numerous human diseases. Stapled peptides, as the most promis [...] Read more.
    Qian Zhang ... Chunqiu Zhang
    Published: April 18, 2024 Explor Drug Sci. 2024;2:154–189
    DOI: https://doi.org/10.37349/eds.2024.00041
    This article belongs to the special issue Bioactive Peptides discovery and development
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    Open Access
    Perspective
    Clinical studies with drugs and biologics aimed at slowing or reversing normal aging processes—emerging results and future perspectives
    Five families of investigational products are in clinical investigation to slow or reverse normal aging processes [longevity candidates, mesenchymal stem cells, senolytics drugs, sirtuin activators, [...] Read more.
    Ricardo P. Garay
    Published: April 10, 2024 Explor Drug Sci. 2024;2:144–153
    DOI: https://doi.org/10.37349/eds.2024.00040
    This article belongs to the special issue Recent Advances with Investigational Compounds and Strategies to Delay or Reverse Normal Aging Processes
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    Review
    Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus
    Pharmaceutical interventions play a vital role in managing various conditions, including weight-related issues such as obesity. In this context, lifestyle changes are often challenging to maintain,  [...] Read more.
    Alexander C. Martins ... Fernando Albericio
    Published: April 03, 2024 Explor Drug Sci. 2024;2:126–143
    DOI: https://doi.org/10.37349/eds.2024.00039
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