Cancer remains one of the most significant challenges in modern medicine, with growing evidence underscoring the critical role of diet and nutrition in both disease prevention and management. As the field of food science evolves, the application of foodomics—integrating advanced metabolomics, proteomics, and genomics—offers unprecedented insights into how food bioactives interact with biological systems to modulate cancer pathways.

This special issue aims to explore the cutting-edge intersection of food science and oncology. We seek to understand how functional foods, dietary patterns, and specific bioactive compounds can influence carcinogenesis, enhance the efficacy of conventional therapies, and improve cancer survivors’ quality of life. By leveraging foodomics, researchers can uncover the intricate metabolic signatures and biomarkers that define the diet-cancer interface, paving the way for personalized nutritional strategies.

We invite authors to submit all types of papers (including Original Articles, Reviews, Systematic Reviews, Perspectives, and Short Communications) that address topics such as, but not limited to:

• The role of dietary bioactive compounds in cancer chemoprevention and therapy.

• Foodomics approaches (metabolomics, proteomics, transcriptomics) to study diet-cancer  interactions.

• Nutritional support and metabolic interventions during cancer treatment.

• The impact of food processing on the anti-cancer properties of natural products.

• Gut microbiota modulation by dietary components and its implications for oncology.

• Clinical studies and epidemiological evidence linking nutrition to cancer outcomes.

We look forward to receiving your contributions to this vital and rapidly advancing field.

Keywords: Foodomics, cancer chemoprevention, dietary bioactives, nutritional oncology, precision nutrition