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    Short Communication
    Preliminary evaluation of FAPI-04-PET/CT for differentiating recurrence and post-treatment changes in high-grade gliomas
    Fibroblast-activated protein (FAP) expression in glial cells is attributed to FAP-positive foci on tumor vessels and neoplastic cells. Preclinical and pilot studies have shown FAP expression in high...
    Indraja D. Dev ... Archi Agrawal
    Published: October 31, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00276
    Viewed:110
    Downloaded:9
    Open Access
    Review
    Addressing the unmet need in NSCLC progression with advances in second-line therapeutics
    Lung cancer is the leading cause of cancer mortality globally, with non-small cell lung cancer (NSCLC) accounting for 85% of cases. Despite advancements in first-line treatments such as immunotherap...
    Kinsley Wang ... Robert Hsu
    Published: November 1, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00277
    Viewed:92
    Downloaded:7
    Open Access
    Case Report
    Upper tract urothelial cancer (UTUC) genomic profiling and correlation regarding benefit of platinum-based chemotherapy
    Upper tract urothelial cancer (UTUC) are rare subsets of urothelial cancer, which typically present with more aggressive course. Molecular markers stratifying urothelial tumors as luminal subtype an...
    Min Woo Hwang ... Jeanny B. Aragon-Ching
    Published: October 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00274
    Viewed:281
    Downloaded:17
    Open Access
    Original Article
    Predictive markers of response to immune checkpoint inhibitor rechallenge in metastatic non-small cell lung cancer
    Aim: The present study aims to evaluate the efficacy of rechallenge with immune checkpoint inhibitors (ICIs) compared to chemotherapy and the predictive role of clinical parameters in non-small c...
    Aram A. Musaelyan ... Sergey V. Orlov
    Published: October 18, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00275
    Viewed:403
    Downloaded:17
    Open Access
    Review
    Exploring the therapeutic potential of lipid-based nanoparticles in the management of oral squamous cell carcinoma
    Oral squamous cell carcinoma (OSCC) is a highly malignant and invasive tumor with significant mortality and morbidity. Current treatment modalities such as surgery, radiotherapy, and chemotherapy en...
    Anis Ahmad Chaudhary ... Md. Rizwanullah
    Published: September 29, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00272
    Viewed:382
    Downloaded:17
    Open Access
    Review
    Evidence for the evolving role of neoadjuvant and perioperative immunotherapy in resectable non-small cell lung cancer
    The treatment of early-stage non-small cell lung cancer (NSCLC) is becoming increasingly complex. Standard of care management for the past decade has been adjuvant chemotherapy following curative in...
    Thomas Hansen ... Udit Nindra
    Published: September 29, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00273
    Viewed:511
    Downloaded:17
    Open Access
    Systematic Review
    Diagnostic and prognostic role of NLR in testicular cancer
    Background: To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa). Methods: The search was conducted on...
    Shirin Sarejloo ... Brandon Lucke-Wold
    Published: September 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00270
    Viewed:374
    Downloaded:17
    Open Access
    Review
    Blood-based circulating biomarkers for prediction of immune-checkpoint inhibitors efficacy in renal cell carcinoma
    Immune checkpoint inhibitors (ICI)-based combinations have become the standard first-line treatment for advanced clear cell renal cell carcinoma (ccRCC). Despite significant improvements in survival...
    Loubna Omri ... Lucía Carril-Ajuria
    Published: September 20, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00271
    Viewed:409
    Downloaded:24
    Open Access
    Original Article
    Diagnostic utility of prostate health index density prior to MRI-ultrasound fusion targeted biopsy
    Aim: Prostate biopsy can be prone to complications and thus should be avoided when unnecessary. Although the combination of magnetic resonance imaging (MRI), the prostate health index (PHI), and ...
    Benjamin H. Press ... Preston C. Sprenkle
    Published: September 13, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00269
    Viewed:369
    Downloaded:18
    Open Access
    Review
    GPCRs as targets for flavonoids in cancer cells: new options for intervention
    For a long time, the family of receptor tyrosine kinases, including epidermal growth factor receptor and insulin-like growth factor 1 receptor, was regarded as the main players stimulating cell prol...
    Katrin Sak
    Published: August 30, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00268
    Viewed:485
    Downloaded:27
    Open Access
    Review
    Emerging molecular therapies in the treatment of bladder cancer
    Bladder cancer is a leading cancer type in men. The complexity of treatment in late-stage bladder cancer after systemic spread through the lymphatic system highlights the importance of modulating di...
    Scott D. Bell ... Yujiang Fang
    Published: August 29, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00267
    Viewed:647
    Downloaded:24
    Open Access
    Review
    Therapy resistance in prostate cancer: mechanism, signaling and reversal strategies
    Prostate cancer (PC) depicts a major health challenge all over the globe due to its complexities in the treatment and diverse clinical trajectories. Even in the advances in the modern treatment stra...
    Neha Thakur ... Sunny Dholpuria
    Published: August 29, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00266
    Viewed:784
    Downloaded:24
    Open Access
    Original Article
    Evaluation of HER2 immunohistochemistry expression in non-standard solid tumors from a Single-Institution Prospective Cohort
    Aim: Human epidermal growth factor receptor-2 (HER2) is a well-established prognostic and predictive biomarker. It is an FDA-approved therapeutic target for HER2 positive breast, gastroesophageal...
    Saurav Verma ... Daniel Breadner
    Published: August 22, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00265
    Viewed:633
    Downloaded:13
    Open Access
    Review
    Anticancer peptides as novel immunomodulatory therapeutic candidates for cancer treatment
    Cancer remains a concern after years of research in this field. Conventional therapies such as chemotherapy, radiation, and surgery are available for cancer treatment, but they are characterized by ...
    Apurva Sood ... Anuradha Sharma
    Published: August 21, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00264
    Viewed:692
    Downloaded:29
    Open Access
    Review
    Harnessing endoscopic ultrasound-guided radiofrequency ablation to reshape the pancreatic ductal adenocarcinoma microenvironment and elicit systemic immunomodulation
    Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognostics and substantial therapeutic challenges, with dismal survival rates. Tumor resistance in PDAC is primarily attributed to i...
    Vishali Moond ... Nirav C. Thosani
    Published: August 15, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00263
    Viewed:1018
    Downloaded:31
    Open Access
    Review
    Hematopoietic and leukemic stem cells homeostasis: the role of bone marrow niche
    The bone marrow microenvironment (BMM) has highly specialized anatomical characteristics that provide a sanctuary place for hematopoietic stem cells (HSCs) that allow appropriate proliferation, main...
    Shaimaa Khattab ... Pier Paolo Piccaluga
    Published: August 15, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00262
    Viewed:645
    Downloaded:16
    Open Access
    Review
    Prospects for breast cancer immunotherapy using microRNAs and transposable elements as objects
    One of the directions in treatment of chemoresistant breast cancer (BC) may include new methods of activating the immune response against tumor cells. Clinically used checkpoint inhibition using ant...
    Rustam Nailevich Mustafin
    Published: August 06, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00261
    Viewed:759
    Downloaded:21
    Open Access
    Review
    Combination of the PARPi and ARSi in advanced castration resistant prostate cancer: a review of the recent phase III trials
    Tumors with an impaired ability to repair DNA double-strand breaks by homologous recombination, including those with alterations in breast cancer 1 and 2 (BRCA1 and BRCA2) genes, are very sensitive ...
    Martina Panebianco ... Mario Rosario D’Andrea
    Published: August 02, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00260
    Viewed:577
    Downloaded:22
    Open Access
    Review
    Risk factors for Gleason score upgrade from prostate biopsy to radical prostatectomy
    Accurate identification of prostate cancer Gleason grade group remains an important component of the initial management of clinically localized disease. However, Gleason score upgrading (GSU) from b...
    Shayan Smani ... Michael S. Leapman
    Published: July 30, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00259
    Viewed:585
    Downloaded:22
    Open Access
    Commentary
    The rapidly changing treatment landscape of first-line advanced urothelial cancer (aUC) or metastatic urothelial cancer (mUC)
    The landscape of treatment for first-line therapy in advanced urothelial cancer (aUC) and metastatic urothelial cancer (mUC) has rapidly changed in the last year alone. Maintenance avelumab remains ...
    Minira Aslanova ... Jeanny B. Aragon-Ching
    Published: July 29, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00258
    Viewed:648
    Downloaded:40
    Open Access
    Review
    A narrative review on perioperative systemic therapy in non-small cell lung cancer
    Non-small cell lung cancer (NSCLC) that is operable still carries a high risk of recurrence, approaching 50% of all operable cases despite adding adjuvant chemotherapy. However, the utilization of i...
    Robert Hsu ... David J. Benjamin
    Published: July 26, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00256
    Viewed:1121
    Downloaded:22
    Open Access
    Review
    Hepatobiliary complications of immune checkpoint inhibitors in cancer
    Immune checkpoint inhibitors (ICIs) have dramatically changed the landscape of cancer therapy. Over the last decade, both their primary focus in trials and clinical application have exponentially ri...
    Donna Zhuang ... Stephen Riordan
    Published: July 26, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00257
    Viewed:566
    Downloaded:15
    Open Access
    Review
    Therapy-induced senescence in breast cancer: an overview
    Outcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer dr...
    Suraj Narayanan Chembukavu, Andrew J Lindsay
    Published: July 25, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00254
    Viewed:1089
    Downloaded:23
    Open Access
    Case Report
    Oligometastatic esophageal cancer cured by systemic therapy combined with radiotherapy to primary tumor and metastasis (metastasis-directed therapy)—small case series
    The prognosis of metastatic esophageal cancer (EC) remains poor with an average life expectancy of around 9–12 months with standard systemic chemotherapy. The concept of oligometastatic disease (O...
    Mohan Hingorani, Hannah Stubley
    Published: July 26, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00255
    Viewed:497
    Downloaded:13
    Open Access
    Review
    The genomic and molecular landscape of splenic marginal zone lymphoma, biological and clinical implications
    Splenic marginal zone lymphoma (SMZL) is a rare, predominantly indolent B-cell lymphoma constituting fewer than 2% of lymphoid neoplasms. However, around 30% of patients have...
    Amatta Mirandari ... Jonathan C. Strefford
    Published: July 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00253
    Viewed:730
    Downloaded:24
    Open Access
    Review
    Regulatory RNAs: role as scaffolds assembling protein complexes and their epigenetic deregulation
    Over the last decade, immune checkpoint inhibitors (ICIs) have dramatically improved the systemic treatment of multiple solid tumour types. However, they can also induce inflammation in an extensive...
    Palmiro Poltronieri
    Published: July 22, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00252
    Viewed:656
    Downloaded:27
    Open Access
    Case Report
    Immune checkpoint inhibitor-induced cholangitis—a three-case series
    Over the last decade, immune checkpoint inhibitors (ICIs) have dramatically improved the systemic treatment of multiple solid tumour types. However, they can also induce inflammation in an extensive range of normal tissues types. ...
    Simon Gray ... Anna Olsson-Brown
    Published: July 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00250
    Viewed:411
    Downloaded:9
    Open Access
    Review
    It might be a dead end: immune checkpoint inhibitor therapy in EGFR-mutated NSCLC
    Despite innovative advances in molecular targeted therapy, treatment strategies using immune checkpoint inhibitors (ICIs) for epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer...
    Ken Akao ... Kazuyoshi Imaizumi
    Published: July 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00251
    Viewed:770
    Downloaded:20
    Open Access
    Review
    Immunopeptidomics in the cancer immunotherapy era
    Cancer is the primary cause of death worldwide, and conventional treatments are painful, complicated, and have negative effects on healthy cells. However, cancer immunotherapy has emerged as a promi...
    Sutatip Pongcharoen ... Supachai Topanurak
    Published: July 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00249
    Viewed:1451
    Downloaded:59
    Open Access
    Correction
    Correction: Deep learning based automated epidermal growth factor receptor and anaplastic lymphoma kinase status prediction of brain metastasis in non-small cell lung cancer
    Abhishek Mahajan ... Kumar Prabhash
    Published: July 08, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00248
    Viewed:403
    Downloaded:17
    Open Access
    Case Report
    Response to trametinib, hydroxychloroquine, and bevacizumab in a young woman with NRAS-mutated metastatic intrahepatic cholangiocarcinoma: a case report
    Systemic chemotherapy is the main treatment option for patients with advanced intrahepatic cholangiocarcinoma (iCCA), however, its efficacy is limited. Herein, we report a young patient with NRAS-mu...
    Aram A. Musaelyan ... Sergey V. Orlov
    Published: June 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00246
    Viewed:574
    Downloaded:16
    Open Access
    Meeting Abstracts
    Selected meeting abstracts of 2nd International Conference on Contemporary Oncology
    Chouaib Salem
    Published: June 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00247
    Viewed:490
    Downloaded:17
    Open Access
    Review
    Current status of molecular diagnostics for lung cancer
    The management of lung cancer (LC) requires the analysis of a diverse spectrum of molecular targets, including kinase activating mutations in EGFR, ERBB2 (HER2), BRAF and MET oncogenes,...
    Evgeny N. Imyanitov ... Sergey V. Orlov
    Published: June 27, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00244
    Viewed:1078
    Downloaded:33
    Open Access
    Review
    Antibody-drug conjugates combinations in cancer treatment
    Antibody-drug conjugates (ADCs) have emerged as a promising class of anticancer agents. Currently, the Food and Drug Administration has granted approval to 12 compounds, with 2 later undergoing with...
    Giulia Pretelli ... Anastasios Stathis
    Published: June 27, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00243
    Viewed:668
    Downloaded:20
    Open Access
    Original Article
    Imaging of supratentorial ependymomas with radio-pathological correlation
    Aim: Supratentorial ependymoma (STE) is a rare tumor with distinct genetic alterations, whose imaging features have been scarcely studied. This study aims to review the computed tomography (CT) a...
    Arpita Sahu ... Epari Sridhar
    Published: June 27, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00245
    Viewed:613
    Downloaded:10
    Open Access
    Review
    Promising immunotherapeutic approaches for primary effusion lymphoma
    Primary effusion lymphoma (PEL) is a large B-cell neoplasm usually presenting as a serious effusion in body cavities without detectable tumor masses. It is an AIDS-related non-Hodgkin’s lymphoma (...
    Jutatip Panaampon, Seiji Okada
    Published: June 26, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00242
    Viewed:756
    Downloaded:20
    Open Access
    Review
    DNA damage targeted therapy for advanced breast cancer
    Breast cancer (BC) is the most prevalent malignancy affecting women worldwide, including Portugal. While the majority of BC cases are sporadic, hereditary forms account for 5-10% of cases. The most ...
    Vanessa Patel ... Luís Costa
    Published: June 25, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00241
    Viewed:755
    Downloaded:18
    Open Access
    Review
    Landscape of targeted therapies for advanced urothelial carcinoma
    Bladder cancer (BC) is the tenth most common malignancy globally. Urothelial carcinoma (UC) is a major type of BC, and advanced UC (aUC) is associated with poor clinical outcomes and limited surviva...
    Shihao Shang ... Zheng Zhu
    Published: June 21, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00240
    Viewed:817
    Downloaded:31
    Open Access
    Review
    Clinical relevance of circulating tumor DNA in ovarian cancer: current issues and future opportunities
    Ovarian cancer (OC) is the most lethal gynecologic malignancy worldwide. Due to the lack of effective screening and early detection strategies, many patients with OC are diagnosed with advanced dise...
    Elena Trevisi ... Ilaria Colombo
    Published: June 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00239
    Viewed:730
    Downloaded:21
    Open Access
    Original Article
    Evaluation of antitumor potential of an anti-glypican-1 monoclonal antibody in preclinical lung cancer models reveals a distinct mechanism of action
    Aim: The main objective of this study was to investigate the antitumor effect of a mouse anti-human glypican-1 (GPC1) monoclonal antibody (mAb) on non-small cell lung carcinoma (NSCLC) and associ...
    Minghua Li ... Qingyu Zhou
    Published: June 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00238
    Viewed:621
    Downloaded:14
    Open Access
    Meta-Analysis
    Anti-PD-1/L1 antibody plus anti-VEGF antibody vs. plus VEGFR-targeted TKI as first-line therapy for unresectable hepatocellular carcinoma: a network meta-analysis
    Background: This article is based on our previous research, which was presented at the 2023 ASCO Annual Meeting I and published in Journal of Clinical Oncology as Conference Abstract (JCO. 2023;4...
    Yiwen Zhou ... Jieer Ying
    Published: June 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00236
    Viewed:875
    Downloaded:28
    Open Access
    Review
    Comparison of primary and passaged tumor cell cultures and their application in personalized medicine
    Passaged cell lines represent currently an integral component in various studies of malignant neoplasms. These cell lines are utilized for drug screening both in monolayer cultures or as part of thr...
    Vladislava V. Pipiya ... Valeriya V. Solovyeva
    Published: June 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00237
    Viewed:569
    Downloaded:21
    Open Access
    Original Article
    Evaluation of molecular effects associated with apoptosis, tumour progression, angiogenesis and metastasis by a novel combination of drugs with ormeloxifene in triple negative breast cancer cells
    Aim: To investigate the molecular effects of a novel combination [sertraline and plumbagin (comb) with ormeloxifene (Orm)] for anticancer activity in triple negative breast cancer cell line “MD...
    Shehna Sharaf ... Lakshmi S
    Published: June 11, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00235
    Viewed:664
    Downloaded:20
    Open Access
    Original Article
    Chemotherapy related changes in cfDNA levels in squamous non-small cell lung cancer: correlation with symptom scores and radiological responses
    Aim: There is limited data on prognostic value of baseline plasma cell free DNA (cfDNA) in advanced squamous non-small cell lung cancer (sq-NSCLC). This prospective observational study aimed to a...
    Nithiyanandan Ravi ... Navneet Singh
    Published: May 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00232
    Viewed:633
    Downloaded:14
    Open Access
    Original Article
    Cadmium nanocluster as a safe nanocarrier: biodistribution in BALB/c mice and application to carry crocin to breast cancer cell lines
    Aim: Metal nanoclusters are emerging nanomaterials applicable for drug delivery. Here, the toxicity and oxidative stress induction of divalent cationic cadmium (Cd2+) was compared with a Cd in th...
    Moslem Jafarisani ... S. Zahra Bathaie
    Published: May 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00233
    Viewed:551
    Downloaded:15
    Open Access
    Perspective
    Practical implications of androgen receptor inhibitors for prostate cancer treatment
    Antiandrogens have been used for the treatment of prostate cancer as a single agent or in combination with hormone deprivation therapy. New generation antiandrogens act like androgen receptor inhibi...
    Fabio Campodonico ... Carlo Introini
    Published: May 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00234
    Viewed:920
    Downloaded:37
    Open Access
    Review
    Advancements and recent explorations of anti-cancer activity of chrysin: from molecular targets to therapeutic perspective
    In recent times, there have been notable advancements in comprehending the potential anti-cancer effects of chrysin (CH), a naturally occurring flavonoid compound found abundantly in various plant s...
    Abhilasha Sood ... Manoj Kumar
    Published: May 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00230
    Viewed:1382
    Downloaded:48
    Open Access
    Perspective
    Resistance to immune checkpoint inhibitors in colorectal cancer with deficient mismatch repair/microsatellite instability: misdiagnosis, pseudoprogression and/or tumor heterogeneity?
    Colorectal carcinoma (CRC) with deficiency of the deficient mismatch repair (dMMR) pathway/ microsatellite instability (MSI) is characterized by a high mutation load and infiltration of immune cells...
    Nicola Normanno ... Carmine Pinto
    Published: May 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00231
    Viewed:974
    Downloaded:28
    Open Access
    Perspective
    Immunotherapy in thymic epithelial tumors: tissue predictive biomarkers for immune checkpoint inhibitors
    Thymic epithelial tumors (TETs) are rare malignant neoplasms arising in the thymus gland. Nevertheless, TETs, including thymomas (TMs), thymic carcinomas (TCs), and thymic neuroendocrine neoplasms (...
    Stefano Lucà ... Renato Franco
    Published: May 21, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00229
    Viewed:661
    Downloaded:16
    Open Access
    Review
    Management of oligometastatic and oligoprogressive epidermal growth factor receptor mutated non-small cell lung cancer patients: state of the art of a combined approach
    Recently, the development of targeted therapy approaches such as those based on tyrosine kinase inhibitor (TKI) greatly improved the clinical outcomes of patients affected by oncogene addicted advan...
    Francesca Di Pressa ... Alessio Bruni
    Published: May 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00228
    Viewed:1044
    Downloaded:35
    Open Access
    Review
    Tri-specific killer engager: unleashing multi-synergic power against cancer
    Cancer continues to be a global health concern, necessitating innovative solutions for treatment. Tri-specific killer engagers (TriKEs) have emerged as a promising class of immunotherapeutic agents,...
    Peeranut Winidmanokul ... Seiji Okada
    Published: April 25, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00227
    Viewed:1705
    Downloaded:54
    Open Access
    Review
    Spheroids and organoids derived from colorectal cancer as tools for in vitro drug screening
    Colorectal cancer (CRC) is a heterogeneous disease. Conventional two-dimensional (2D) culture employing cell lines was developed to study the molecular properties of CRC in vitro. Although these cel...
    Sahira Syamimi Ahmad Zawawi ... Marahaini Musa
    Published: April 25, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00226
    Viewed:2363
    Downloaded:81
    Open Access
    Review
    Magnetite nanoparticles: an emerging adjunctive tool for the improvement of cancer immunotherapy
    Cancer immunotherapy has emerged as a groundbreaking field, offering promising and transformative tools for oncological research and treatment. However, it faces several limitations, including varia...
    Phoomipat Jungcharoen ... Charupong Saengboonmee
    Published: April 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00220
    Viewed:1217
    Downloaded:29
    Open Access
    Perspective
    Artificial intelligence and classification of mature lymphoid neoplasms
    Hematologists, geneticists, and clinicians came to a multidisciplinary agreement on the classification of lymphoid neoplasms that combines clinical features, histological characteristics, immunophen...
    Joaquim Carreras ... Naoya Nakamura
    Published: April 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00221
    Viewed:1194
    Downloaded:39
    Open Access
    Review
    Tumor metabolism in pheochromocytomas: clinical and therapeutic implications
    Pheochromocytomas and paragangliomas (PPGLs) have emerged as one of the most common endocrine tumors. It epitomizes fascinating crossroads of genetic, metabolic, and endocrine oncology, providing a ...
    Mohammad Sadiq Jeeyavudeen ... Joseph M. Pappachan
    Published: April 24, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00222
    Viewed:957
    Downloaded:27
    Open Access
    Case Report
    Improving single nucleotide polymorphisms genotyping accuracy for dihydropyrimidine dehydrogenase testing in pharmacogenetics
    Fluoropyrimidines, crucial in cancer treatment, often cause toxicity concerns even at standard doses. Toxic accumulation of fluoropyrimidine metabolites, culminating in adverse effects, can stem fro...
    Annalaura Montella ... Mario Capasso
    Published: April 24, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00223
    Viewed:736
    Downloaded:18
    Open Access
    Review
    Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer
    Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties a...
    Fatima Ben Ali ... Rabii Ameziane El Hassani
    Published: April 24, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00224
    Viewed:1102
    Downloaded:29
    Open Access
    Perspective
    Cancer symptom cluster research in pediatric oncology: a work in progress
    In the 21st century, advances in basic research have provided new insights in the field of pediatric oncology. Pediatric patients tend to experience higher levels of distressing symptoms, which toge...
    Luciana Chain Veronez, Luís Carlos Lopes-Júnior
    Published: April 24, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00225
    Viewed:609
    Downloaded:22
    Open Access
    Review
    Emerging roles of type 1 innate lymphoid cells in tumour pathogenesis and cancer immunotherapy
    Innate lymphoid cells (ILCs) are the most recently discovered class of innate immune cells found to have prominent roles in various human immune-related pathologies such as infection and autoimmune ...
    James Michael Verner ... Eric Jou
    Published: April 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00219
    Viewed:1092
    Downloaded:30
    Open Access
    Original Article
    Hexachlorobenzene as a differential modulator of the conventional and metronomic chemotherapy response in triple negative breast cancer cells
    Aim: Triple negative breast cancer (TNBC) is usually treated with high doses of paclitaxel, whose effectiveness may be modulated by the action of environmental contaminants such as hexachlorobenz...
    Yamila Sanchez ... Alejandro Español
    Published: March 21, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00218
    Viewed:926
    Downloaded:27
    Open Access
    Review
    Improving the quality of patient care in lung cancer: key factors for successful multidisciplinary team working
    International Guidelines as well as Cancer Associations recommend a multidisciplinary approach to lung cancer care. A multidisciplinary team (MDT) can significantly improve treatment decision-making...
    Alessandro Morabito ... Giacomo Pascarella
    Published: March 21, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00217
    Viewed:1625
    Downloaded:43
    Open Access
    Mini Review
    Potential of targeting signal-transducing adaptor protein-2 in cancer therapeutic applications
    Adaptor proteins play essential roles in various intracellular signaling pathways. Signal-transducing adaptor protein-2 (STAP-2) is an adaptor protein that possesses pleckstrin homology (PH) and Src...
    Taiga Maemoto ... Tadashi Matsuda
    Published: March 07, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00216
    Viewed:890
    Downloaded:27
    Open Access
    Review
    Novel therapeutic strategies targeting myeloid-derived suppressor cell immunosuppressive mechanisms for cancer treatment
    Cancer is the leading cause of death globally superseded only by cardiovascular diseases, and novel strategies to overcome therapeutic resistance against existing cancer treatments are urgently requ...
    Eric Jou ... Fizza Nasim
    Published: February 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00212
    Viewed:2051
    Downloaded:27
    Open Access
    Review
    Conceptual breakthroughs of the long noncoding RNA functional system and its endogenous regulatory role in the cancerous regime
    Long noncoding RNAs (lncRNAs) derived from noncoding regions in the human genome were once regarded as junks with no biological significance, but recent studies have shown that these molecules are h...
    Anyou Wang
    Published: February 27, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00211
    Viewed:905
    Downloaded:16
    Open Access
    Review
    Recent preclinical and clinical advances in radioimmunotherapy for non-Hodgkin’s lymphoma
    Radioimmunotherapy (RIT) is a therapy that combines a radioactive nucleotide with a monoclonal antibody (mAb). RIT enhances the therapeutic effect of mAb and reduces toxicity compared with conventio...
    Hiroki Goto ... Seiji Okada
    Published: February 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00213
    Viewed:1379
    Downloaded:44
    Open Access
    Case Report
    A case of immunotherapy-induced thyroiditis
    Immunotherapy treatments for cancer are known to cause adverse thyroid events which present a diagnostic challenge to clinicians and radiologists. This case report highlights the importance of a hig...
    George Pears ... Joseph Sacco
    Published: February 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00214
    Viewed:1573
    Downloaded:24
    Open Access
    Review
    Early-stage triple negative breast cancer: the therapeutic role of immunotherapy and the prognostic value of pathological complete response
    Triple negative breast cancer (TNBC) represents an aggressive disease associated with a high risk of recurrence after curative treatment and a poor prognosis in the metastatic setting. Chemotherapy ...
    Pierluigi De Santis ... Palma Fedele
    Published: February 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00215
    Viewed:3361
    Downloaded:101
    Open Access
    Review
    Exploring monocarboxylate transporter inhibition for cancer treatment
    Cells are separated from the environment by a lipid bilayer membrane that is relatively impermeable to solutes. The transport of ions and small molecules across this membrane is an essential process...
    Tomas Koltai, Larry Fliegel
    Published: February 23, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00210
    Viewed:1184
    Downloaded:40
    Open Access
    Review
    The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updates
    Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancers with high mortality rate. Among its various etiological factors, one of the major risk factors for HCC is a chronic...
    Agustiningsih Agustiningsih ... Caecilia Sukowati
    Published: February 20, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00209
    Viewed:1342
    Downloaded:36
    Open Access
    Original Article
    Efficacy of metformin and electrical pulses in breast cancer MDA-MB-231 cells
    Aim: Triple-negative breast cancer (TNBC) is a very aggressive subset of breast cancer, with limited treatment options, due to the lack of three commonly targeted receptors, which merits the need...
    Praveen Sahu ... Raji Sundararajan
    Published: February 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00204
    Viewed:1057
    Downloaded:19
    Open Access
    Original Article
    Quantitative peritumoral magnetic resonance imaging fingerprinting improves machine learning-based prediction of overall survival in colorectal cancer
    Aim: To investigate magnetic resonance imaging (MRI)-based peritumoral texture features as prognostic indicators of survival in patients with colorectal liver metastasis (CRLM). Methods: Fr...
    Azadeh Tabari ... Dania Daye
    Published: February 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00205
    Viewed:988
    Downloaded:21
    Open Access
    Mini Review
    Management of stage III non-small-cell lung cancer: rays of hope
    Lung cancer remains the most common cause of cancer death across the world. Non-small-cell lung cancer (NSCLC) represents the most frequent type of lung cancer and is frequently diagnosed at an adva...
    Floryane Kim ... Alex Friedlaender
    Published: February 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00206
    Viewed:1540
    Downloaded:58
    Open Access
    Review
    CD99 tumor associated antigen is a potential target for antibody therapy of T-cell acute lymphoblastic leukemia
    Monoclonal antibodies (mAbs) are an effective drug for targeted immunotherapy in several cancer types. However, so far, no antibody has been successfully developed for certain types of cancer, inclu...
    Kamonporn Kotemul ... Nuchjira Takheaw
    Published: February 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00207
    Viewed:1191
    Downloaded:23
    Open Access
    Mini Review
    Exploring the function of myeloid cells in promoting metastasis in head and neck cancer
    Head and neck cancer (HNC) is a challenging disease that lacks effective treatment, particularly in the cases that spread locoregionally and metastasize distantly, dramatically reducing patient surv...
    Dakota Dike Dimegwu Okwuone ... Gregory N. Gan
    Published: February 19, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00208
    Viewed:2266
    Downloaded:24
    Open Access
    Review
    DNA methylation modulates epigenetic regulation in colorectal cancer diagnosis, prognosis and precision medicine
    Colorectal cancer (CRC) is a multifaceted disease influenced by the interplay of genetic and environmental factors. The clinical heterogeneity of CRC cannot be attributed exclusively to genetic dive...
    Jingxin Ye ... Weifeng Ding
    Published: January 28, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00203
    Viewed:1572
    Downloaded:43
    Open Access
    Review
    Role of STAT3 in pancreatic cancer
    Pancreatic cancer remains a serious and deadly disease, impacting people globally. There remain prominent gaps in the current understanding of the disease, specifically regarding the role of the sig...
    Zachary Hamel ... Shrikant Anant
    Published: January 17, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00202
    Viewed:1353
    Downloaded:32
    Open Access
    Original Article
    Identification of lysyl oxidase as an adipocyte-secreted mediator that promotes a partial mesenchymal-to-epithelial transition in MDA-MB-231 cells
    Aim: Breast cancer (BC) is the most common cancer in women worldwide, where adiposity has been linked to BC morbidity. In general, obese premenopausal women diagnosed with triple-negative BC (TNB...
    Cassidy M. Van Stiphout ... Alicia M. Viloria-Petit
    Published: January 16, 2024 Explor Target Antitumor Ther. DOI: 10.37349/etat.2024.00201
    Viewed:1207
    Downloaded:23
    Open Access
    Original Article
    Cola rostrata K. Schum. constituents induce cytotoxicity through reactive oxygen species generation and mitochondrial membrane depolarisation
    Aim: While the traditional use of Cola rostrata in treating illnesses and diseases has not been reported, the presence of cytotoxic principles has been reported in phylogenetically and biogeograp...
    Babatunde E. Ajayi ... Amos A. Fatokun
    Published: December 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00200
    Viewed:1087
    Downloaded:16
    Open Access
    Perspective
    Facing the conundrum: which first-line therapy should be used for patients with metastatic triple-negative breast cancer carrying germline BRCA mutation?
    Pembrolizumab combined with chemotherapy has been established as the preferred first-line therapy for treating metastatic triple-negative breast cancer (mTNBC) with programmed cell death ligand-1 (P...
    Sabah Alaklabi ... Shipra Gandhi
    Published: December 27, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00198
    Viewed:1105
    Downloaded:18
    Open Access
    Review
    Therapeutic significance of tumor microenvironment in cholangiocarcinoma: focus on tumor-infiltrating T lymphocytes
    Cholangiocarcinoma (CCA) is a highly aggressive type of adenocarcinoma distinguished by its invasiveness. Depending on specific anatomical positioning within the biliary tree, CCA can be categorized...
    Chaoqun Li ... Jieer Ying
    Published: December 28, 2023 Explor Target Antitumor Ther DOI: 10.37349/etat.2023.00199
    Viewed:1185
    Downloaded:11
    Open Access
    Review
    Telehealth in breast cancer following the coronavirus disease 2019 pandemic
    Breast cancer (BC) is the second most diagnosed cancer in 2018 with around 2.3 million cases globally in 2020. In March 2020 and after its worldwide spread, the World Health Organization (WHO) decla...
    Jean Zeghondy ... Barbara Pistilli
    Published: December 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00195
    Viewed:849
    Downloaded:11
    Open Access
    Review
    Post-translational modulation of cell signalling through protein succinylation
    Cells need to adapt their activities to extra- and intracellular signalling cues. To translate a received extracellular signal, cells have specific receptors that transmit the signal to downstream p...
    Katharina F. Kubatzky ... Dayoung Yu
    Published: December 27, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00196
    Viewed:2389
    Downloaded:44
    Open Access
    Review
    Current implications and challenges of artificial intelligence technologies in therapeutic intervention of colorectal cancer
    Irrespective of men and women, colorectal cancer (CRC), is the third most common cancer in the population with more than 1.85 million cases annually. Fewer than 20% of patients only survive beyond f...
    Kriti Das ... Chakresh Kumar Jain
    Published: December 27, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00197
    Viewed:1271
    Downloaded:24
    Open Access
    Review
    Recent advancements in targeted protein knockdown technologies—emerging paradigms for targeted therapy
    A generalized therapeutic strategy for various disease conditions, including cancer, is to deplete or inactivate harmful protein targets. Various forms of protein or gene silencing molecules, e.g., ...
    Mansi Joshi ... Abhijit De
    Published: December 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00194
    Viewed:1722
    Downloaded:52
    Open Access
    Original Article
    Receptor tyrosine kinase-like orphan receptor 1 inhibitor strictinin exhibits anti-cancer properties against highly aggressive androgen-independent prostate cancer
    Aim: It is important to identify anti-cancer compounds that can inhibit specific molecular targets to eradicate androgen-receptor negative (ARneg), androgen-independent (AI) prostate cancer, whic...
    Vignesh Sivaganesh, Bela Peethambaran
    Published: December 20, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00192
    Viewed:1267
    Downloaded:16
    Open Access
    Original Article
    Investigations of the novel checkpoint kinase 1 inhibitor SRA737 in non-small cell lung cancer and colorectal cancer cells of differing tumour protein 53 gene status
    Aim: In response to DNA damage the serine/threonine-specific protein kinase checkpoint kinase 1 (CHK1) is activated allowing cells to enter S phase (S) and G2 phase (G2) cell-cycle arrest. CHK1 i...
    Ali JN Duabil ... George DD Jones
    Published: December 21, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00193
    Viewed:1064
    Downloaded:19
    Open Access
    Case Report
    Is oligoprogression a potentially curable disease in epidermal growth factor receptor mutant lung adenocarcinoma?
    Third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) have shown impressive results in EGFR mutant lung cancer (LC) patients in terms of disease control rate wit...
    Sviatoslav Chekhun ... Maria Saigí
    Published: December 13, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00191
    Viewed:1396
    Downloaded:17
    Open Access
    Review
    Targeting cancer stem cell plasticity in triple-negative breast cancer
    Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype with limited treatment options. Cancer stem cells (CSCs) are thought to play a crucial role in TNBC progression and ...
    Zhengwang Guo, Shuyan Han
    Published: December 11, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00190
    Viewed:991
    Downloaded:16
    Open Access
    Original Article
    Chimeric single-chain variable fragment-human immunoglobulin G crystallizable fragment antibody against GD2 for neuroblastoma targeted immunotherapy
    Aim: The present study aims to generate chimeric mouse single-chain variable fragment (scFv) and immunoglobulin G1 (IgG1) crystallizable fragment (Fc) antibody against disialoganglioside (GD2) fo...
    Witida Laopajon ... Watchara Kasinrerk
    Published: December 06, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00188
    Viewed:1294
    Downloaded:24
    Open Access
    Case Report
    Unexpected “Lazarus response” to single-agent bevacizumab in heavily pretreated patients with HER2-positive breast cancer
    Early clinical trials aimed to halt cancer progression by inhibiting the growth of new blood vessels in tumors through single-agent targeted therapy with bevacizumab. These trials largely proved uns...
    Alexey V. Emshanov ... Evgeny N. Imyanitov
    Published: December 06, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00189
    Viewed:901
    Downloaded:18
    Open Access
    Meta-Analysis
    Comparing efficacy and safety of upfront treatment strategies for anaplastic lymphoma kinase-positive non-small cell lung cancer: a network meta-analysis
    Aim: This article is based on our previous research, which was presented as a post at the Congress Aiom 2022 Congress and published in Tumori Journal as Conference Abstract (Tumori J. 2022;108:1...
    Marco Filetti ... Gennaro Daniele
    Published: December 01, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00187
    Viewed:1325
    Downloaded:43
    Open Access
    Commentary
    A decade of CD4+ chimeric antigen receptor T-cell evolution in two chronic lymphocytic leukemia patients: were chronic lymphocytic leukemia cells present?
    On Feb 2, 2022, Nature published the paper titled “Decade-long leukemia remissions with the persistence of CD4+ CAR T-cells” (Nature. 2022;602:503–9. doi: 10.1038/s41586-021-04390-6). Accordin...
    Dimitrios Bouzianas, Stella Bouziana
    Published: October 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00186
    Viewed:1292
    Downloaded:18
    Open Access
    Review
    Overcoming phenotypic switching: targeting protein-protein interactions in cancer
    Alternative protein-protein interactions (PPIs) arising from mutations or post-translational modifications (PTMs), termed phenotypic switching (PS), are critical for the transmission of alternative ...
    Christos Ladias ... Nikolaos A. Papanikolaou
    Published: October 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00181
    Viewed:941
    Downloaded:19
    Open Access
    Review
    Coronavirus disease 2019 and lung cancer: where are we?
    Oncology patients are more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection due to hospital contact and an immunological system that can be compromised by antine...
    Abrahams Ocanto ... Felipe Couñago
    Published: October 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00182
    Viewed:1145
    Downloaded:15
    Open Access
    Systematic Review
    Impact of coronavirus disease 2019 pandemic on good clinical practice trials in oncology
    Aim: Coronavirus disease 2019 (COVID-19) became pandemic on 11th March 2020 and it deeply stressed the healthcare system. Cancer patients represent a vulnerable population, so many recommendation...
    Veronica Agostinelli ... Rossana Berardi
    Published: October 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00183
    Viewed:959
    Downloaded:9
    Open Access
    Original Article
    Acryl-3,5-bis(2,4-difluorobenzylidene)-4-piperidone targeting cellular JUN proto-oncogene, AP-1 transcription factor subunit inhibits head and neck squamous cell carcinoma progression
    Aim: Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer worldwide with a survival rate below fifty percent. Addressing meager therapeutic options, a series of small m...
    Levi Arnold ... Sufi Mary Thomas
    Published: October 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00184
    Viewed:1725
    Downloaded:85
    Open Access
    Perspective
    Cholesterol esterification and p53-mediated tumor suppression
    Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism...
    Youjun Li ... Edward V. Prochownik
    Published: October 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00185
    Viewed:1301
    Downloaded:26
    Open Access
    Original Article
    Effect of vitamin D supplementation on inflammatory markers and total antioxidant capacity in breast cancer women using a machine learning technique
    Aim: This study aimed to establish a learning system using an artificial neural network (ANN) to predict the effects of vitamin D supplementation on the serum levels of vitamin D, inflammatory fa...
    Marzieh Tahmasebi ... Amir Jamshidnezhad
    Published: October 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00180
    Viewed:1050
    Downloaded:18
    Open Access
    Review
    A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors
    The present coronavirus disease 2019 (COVID-19) pandemic scenario has posed a difficulty for cancer treatment. Even under ideal conditions, malignancies like small cell lung cancer (SCLC) are challe...
    Babak Sokouti
    Published: October 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00177
    Viewed:1126
    Downloaded:26
    Open Access
    Review
    Integration of signaling pathway and bromodomain and extra-terminal domain inhibition for the treatment of mutant Kirsten rat sarcoma viral oncogene homolog cancer
    Mutant Kirsten rat sarcoma viral oncogene homolog (KRAS) is now a drugable oncogenic driver and the KRAS G12C variant responds clinically to sotorasib and adagrasib that covalently block the cystein...
    Gerhard Hamilton ... Barbara Rath
    Published: October 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00178
    Viewed:1521
    Downloaded:21
    Open Access
    Systematic Review
    Effect of coronavirus disease 2019 on diagnosis and treatment of hepatocellular carcinoma: a systematic review
    Aim: Changes in strategies in the coronavirus disease 2019 (COVID-19) crisis and the imposing of restrictions have isolated many vulnerable patients including those with hepatocellular carcinoma ...
    Afrooz Mazidimoradi ... Hamid Salehiniya
    Published: October 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00179
    Viewed:1056
    Downloaded:13
    Open Access
    Systematic Review
    Current role of artificial intelligence in head and neck cancer surgery: a systematic review of literature
    Aim: Artificial intelligence (AI) is a new field of science in which computers will provide decisions-supporting tools to help doctors make difficult clinical choices. Recent AI applications in o...
    Antonella Loperfido ... Gianluca Bellocchi
    Published: October 24, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00174
    Viewed:1508
    Downloaded:32
    Open Access
    Review
    Biomarkers in renal cell carcinoma and their targeted therapies: a review
    Renal cell carcinoma (RCC) is one of the most life-threatening urinary malignancies displaying poor response to radiotherapy and chemotherapy. Although in the recent past there have been tremendous ...
    Shruti Gupta, Shamsher Singh Kanwar
    Published: October 25, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00175
    Viewed:1327
    Downloaded:27
    Open Access
    Review
    Melatonin, BAG-1 and cortisol circadian interactions in tumor pathogenesis and patterned immune responses
    A dysregulated circadian rhythm is significantly associated with cancer risk, as is aging. Both aging and circadian dysregulation show suppressed pineal melatonin, which is indicated in many studies...
    George Anderson
    Published: October 25, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00176
    Viewed:1612
    Downloaded:22
    Open Access
    Review
    Molecular interaction of metastasis suppressor genes and tumor microenvironment in breast cancer
    Breast cancer (BC) is a leading cause of cancer-related deaths in women worldwide where the process of metastasis is a major contributor to the mortality associated with this disease. Metastasis sup...
    Sathammai Sathappa Supuramanian ... Sitaram Harihar
    Published: October 11, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00173
    Viewed:1334
    Downloaded:29
    Open Access
    Review
    Understanding the feasibility of chemotherapeutic and immunotherapeutic targets against non-small cell lung cancers: an update of resistant responses and recent combinatorial therapies
    Despite consistent progress in prompt diagnosis and curative therapies in the last decade, lung cancer (LC) continues to threaten mankind, accounting for nearly twice the casualties compared to pros...
    Parth Malik ... Tapan Kumar Mukherjee
    Published: October 10, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00171
    Viewed:1650
    Downloaded:40
    Open Access
    Original Article
    Exploring the implications of modified advanced lung cancer inflammation index on outcomes in patients with advanced non-small cell lung cancer
    Aim: Sarcopenia and skeletal muscle density (SMD) have been shown to be both predictive and prognostic marker in oncology. Advanced lung cancer inflammation index (ALI) has been shown to predict ...
    Abhishek Mahajan ... Kumar Prabhash
    Published: October 11, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00172
    Viewed:1200
    Downloaded:22
    Open Access
    Review
    AGEs and RAGE: metabolic and molecular signatures of the glycation-inflammation axis in malignant or metastatic cancers
    From attributing mutations to cancers with the advent of cutting-edge genetic technology in recent decades, to re-searching the age-old theory of intrinsic metabolic shift of cancers (Warburg’s gl...
    Gowri Palanissami, Solomon F.D. Paul
    Published: September 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00170
    Viewed:2593
    Downloaded:39
    Open Access
    Review
    Malignant tumors of the external auditory canal: diagnosis, treatment, genetic landscape, biomarkers, and clinical outcome
    Malignant tumors of the external auditory canal (EAC) are rare neoplasms that appear in the head and neck area. A common feature of these malignancies is their rarity, as well as their delayed diagn...
    Pinelopi Samara ... Ioannis Athanasopoulos
    Published: September 21, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00169
    Viewed:1738
    Downloaded:32
    Open Access
    Original Article
    A single experience in the conduction of clinical trial during COronaVIrusDisease-2019 pandemic
    Aim: From the start of the pandemic, several aspects of healthcare policies changed, not least the clinical trials management from recruiting capabilities to the protocol compliance in terms of s...
    Zelmira Ballatore ... Rossana Berardi
    Published: September 07, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00168
    Viewed:1040
    Downloaded:19
    Open Access
    Original Article
    Aflatoxin B1-DNA adducts modify the effects of post-operative adjuvant transarterial chemoembolization improving hepatocellular carcinoma prognosis
    Aim: DNA damage involves in the carcinogenesis of some cancer and may act as a target for therapeutic intervention of cancers. However, it is unclear whether aflatoxin B1 (AFB1)-DNA adducts (ADAs)...
    Liyan Huang ... Xidai Long
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00167
    Viewed:909
    Downloaded:19
    Open Access
    Original Article
    In silico targeting of colony-stimulating factor-1 receptor: delineating immunotherapy in cancer
    Aim: Delineate structure-based inhibition of colony-stimulating factor-1 receptor (CSF1R) by small molecule CSF1R inhibitors in clinical development for target identification and potential lead o...
    Zahra Azhar ... Zohaib Raza
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00164
    Viewed:978
    Downloaded:23
    Open Access
    Original Article
    Retrospective immunophenotypical evaluation of MET, PD-1/PD-L1, and mTOR pathways in primary tumors and pulmonary metastases of renal cell carcinoma: the RIVELATOR study addresses the issue of biomarkers heterogeneity
    Aim: In renal cell carcinoma (RCC), tumor heterogeneity generated challenges to biomarker development and therapeutic management, often becoming responsible for primary and acquired drug resistan...
    Melissa Bersanelli ... Luca Ampollini
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00165
    Viewed:814
    Downloaded:13
    Open Access
    Review
    Medicinal chemistry advances in targeting class I histone deacetylases
    Histone deacetylases (HDACs) are a class of zinc (Zn)-dependent metalloenzymes that are responsible for epigenetic modifications. HDACs are largely associated with histone proteins that regulate gen...
    Diaaeldin I. Abdallah ... Patrick T. Gunning
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00166
    Viewed:2020
    Downloaded:59
    Open Access
    Review
    Nanomedicine strategies to counteract cancer stemness and chemoresistance
    Cancer stem-like cells (CSCs) identified by self-renewal ability and tumor-initiating potential are responsible for tumor recurrence and metastasis in many cancers. Conventional chemotherapy fails t...
    Huayu Liu ... Ran Mo
    Published: August 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00157
    Viewed:1027
    Downloaded:28
    Open Access
    Original Article
    Deep learning based automated epidermal growth factor receptor and anaplastic lymphoma kinase status prediction of brain metastasis in non-small cell lung cancer
    Aim: The aim of this study was to investigate the feasibility of developing a deep learning (DL) algorithm for classifying brain metastases from non-small cell lung cancer (NSCLC) into epidermal ...
    Abhishek Mahajan ... Kumar Prabhash
    Published: August 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00158
    Viewed:1260
    Downloaded:29
    Open Access
    Original Article
    Deep learning based clinico-radiological model for paediatric brain tumor detection and subtype prediction
    Aim: Early diagnosis of paediatric brain tumors significantly improves the outcome. The aim is to study magnetic resonance imaging (MRI) features of paediatric brain tumors and to develop an auto...
    Abhishek Mahajan ... Aliasgar Moiyadi
    Published: August 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00159
    Viewed:1211
    Downloaded:19
    Open Access
    Perspective
    Artificial intelligence ethics in precision oncology: balancing advancements in technology with patient privacy and autonomy
    Precision oncology is a rapidly evolving field that uses advanced technologies to deliver personalized cancer care based on a patient’s unique genetic and clinical profile. The use of artificial i...
    Bahareh Farasati Far
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00160
    Viewed:1176
    Downloaded:30
    Open Access
    Review
    Anticancer action of naturally occurring emodin for the controlling of cervical cancer
    One of the major causes of death on the globe is cancer. The fourth most frequent malignancy in women worldwide is cervical cancer. Several cancer patients are remaining incurable due to the emergen...
    Priyanka S. Lande ... Leena P. Joge
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00161
    Viewed:1159
    Downloaded:29
    Open Access
    Original Article
    Clinical and mutational profile of AT-rich interaction domain 1A-mutated cancers
    Aim: AT-rich interaction domain 1A (ARID1A) encodes a key component of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex that participates in gene expression. ARID1A alter...
    Rosa Falcone ... Gennaro Daniele
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00163
    Viewed:856
    Downloaded:16
    Open Access
    Review
    Protein ISGylation: a posttranslational modification with implications for malignant neoplasms
    Interferon (IFN)-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (UBL) protein family that can modify specific proteins via a catalytic process called ISGylation. This posttranslational...
    Angeles C. Tecalco-Cruz, Jesús Zepeda-Cervantes
    Published: August 31, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00162
    Viewed:1202
    Downloaded:23
    Open Access
    Review
    Nuclear epidermal growth factor receptor as a therapeutic target
    Epidermal growth factor receptor (EGFR) is one of the most well-studied oncogenes with roles in proliferation, growth, metastasis, and therapeutic resistance. This intense study has led to the devel...
    Benjamin Atwell ... Joyce Schroeder
    Published: August 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00156
    Viewed:1198
    Downloaded:25
    Open Access
    Review
    Aspirin and the metabolic hallmark of cancer: novel therapeutic opportunities for colorectal cancer
    Aspirin is a well-known nonsteroidal anti-inflammatory drug (NSAID) that has a recognized role in cancer prevention as well as evidence to support its use as an adjuvant for cancer treatment. Import...
    Ashley J. Hoskin ... Emma E. Vincent
    Published: August 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00155
    Viewed:1571
    Downloaded:30
    Open Access
    Perspective
    Potential tactics with certain gut microbiota for the treatment of unresectable hepatocellular carcinoma
    Hepatocellular carcinoma (HCC) constitutes an extremely malignant form of primary liver cancer. Intricate connections linking to the immune system might be associated with the pathogenesis of HCC. M...
    Sayuri Yoshikawa ... Satoru Matsuda
    Published: August 24, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00152
    Viewed:2667
    Downloaded:961
    Open Access
    Review
    Emerging role of quantitative imaging (radiomics) and artificial intelligence in precision oncology
    Cancer is a fatal disease and the second most cause of death worldwide. Treatment of cancer is a complex process and requires a multi-modality-based approach. Cancer detection and treatment starts w...
    Ashish Kumar Jha ... Andre Dekker
    Published: August 24, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00153
    Viewed:1770
    Downloaded:24
    Open Access
    Review
    B-cell lymphoma 2 family members and sarcomas: a promising target in a heterogeneous disease
    Targeting the B-cell lymphoma 2 (Bcl-2) family proteins has been the backbone for hematological malignancies with overall survival improvements. The Bcl-2 family is a major player in apoptosis regul...
    Rui Caetano Oliveira ... José Casanova
    Published: August 24, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00154
    Viewed:992
    Downloaded:24
    Open Access
    Review
    Current role of machine learning and radiogenomics in precision neuro-oncology
    In the past few years, artificial intelligence (AI) has been increasingly used to create tools that can enhance workflow in medicine. In particular, neuro-oncology has benefited from the use of AI a...
    Teresa Perillo ... Andrea Manto
    Published: July 19, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00151
    Viewed:1204
    Downloaded:36
    Open Access
    Review
    Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential
    Cancer remains the second leading cause of death worldwide despite modern breakthroughs in medicine, and novel treatments are urgently needed. The revolutionary success of immune checkpoint inhibito...
    Eric Jou
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00146
    Viewed:1355
    Downloaded:30
    Open Access
    Case Report
    Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
    Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive th...
    Mikhail V. Kiselevskiy ... Irina Zh. Shubina
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00148
    Viewed:824
    Downloaded:15
    Open Access
    Review
    Increasing differential diagnosis between lipoma and liposarcoma through radiomics: a narrative review
    Soft tissue sarcomas (STSs) are rare, heterogeneous, and very often asymptomatic diseases. Their diagnosis is fundamental, as is the identification of the degree of malignancy, which may be high, me...
    Raffaele Natella ... Antonella Santone
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00147
    Viewed:1723
    Downloaded:31
    Open Access
    Review
    Glucose metabolism reprogramming promotes immune escape of hepatocellular carcinoma cells
    Hepatocellular carcinoma (HCC) is a complex process that plays an important role in its progression. Abnormal glucose metabolism in HCC cells can meet the nutrients required for the occurrence and d...
    Qiuyue Zhang ... Mengsen Li
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00149
    Viewed:1567
    Downloaded:32
    Open Access
    Review
    An introductory review of post-resection chemotherapeutics for primary brain tumors
    The treatment of central nervous system (CNS) tumors is complicated by high rates of recurrence and treatment resistance that contribute to high morbidity and mortality (Nat Rev Neurol. 2022;18:221...
    Meaghan McGovern ... Brandon Lucke-Wold
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00150
    Viewed:1235
    Downloaded:35
    Open Access
    Review
    Artificial intelligence and radiomics in magnetic resonance imaging of rectal cancer: a review
    Rectal cancer (RC) is one of the most common tumours worldwide in both males and females, with significant morbidity and mortality rates, and it accounts for approximately one-third of colorectal ca...
    Giuseppe Di Costanzo ... Enrico Cavaglià
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00142
    Viewed:1394
    Downloaded:29
    Open Access
    Original Article
    Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers
    Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets...
    Lisa T. Huber ... Cornelia Brunner
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00143
    Viewed:1386
    Downloaded:21
    Open Access
    Original Article
    Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors
    Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several clas...
    Markus Schweipert ... Franz-Josef Meyer-Almes
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00144
    Viewed:905
    Downloaded:30
    Open Access
    Perspective
    Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies
    Immunotherapy strategies targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) are revolutionizing oncology. However, ...
    Ai Tsuji ... Satoru Matsuda
    Published: June 30, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00145
    Viewed:2768
    Downloaded:1073
    Open Access
    Review
    Capitalizing glycomic changes for improved biomarker-based cancer diagnostics
    Cancer serum biomarkers are valuable or even indispensable for cancer diagnostics and/or monitoring and, currently, many cancer serum markers are routinely used in the clinic. Most of those markers ...
    Maria Luísa S. Silva
    Published: June 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00140
    Viewed:1088
    Downloaded:26
    Open Access
    Original Article
    Real world outcomes in patients with neuroendocrine tumor receiving peptide receptor radionucleotide therapy
    Aim: 177Lu-Dotatate (Lu-177), a form of peptide receptor radionuclide therapy (PRRT), was approved by Food and Drug Administration (FDA) for the treatment of somatostatin-receptor-positive neur...
    Stijn Hentzen ... Anup Kasi
    Published: June 29, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00141
    Viewed:1107
    Downloaded:17
    Open Access
    Review
    Transforming growth factor-β signaling: from tumor microenvironment to anticancer therapy
    Transforming growth factor-β (TGF-β) signaling is an important pathway for promoting the pathogenesis of inflammatory diseases, including cancer. The roles of TGF-β signaling are heterogeneous and versatile in cancer development and progression, both anticancer and protumoral actions are reported. Interestingly, increasing evidence suggests that TGF-β enhances disease progression and drug resistance via immune-modulatory actions in the tumor microenvironment (TME) of solid tumors. A better understanding of its regulatory mechanisms in the TME at the molecular level can facilitate the development of precision medicine to block the protumoral actions of TGF-β in the TME. Here, the latest information about the regulatory mechanisms and translational research of TGF-β signaling in the TME for therapeutic development had been summarized....
    Max Kam-Kwan Chan ... Patrick Ming-Kuen Tang
    Published: April 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00137
    Viewed:2113
    Downloaded:64
    Open Access
    Review
    Role of artificial intelligence in oncologic emergencies: a narrative review
    Oncologic emergencies are a wide spectrum of oncologic conditions caused directly by malignancies or their treatment. Oncologic emergencies may be classified according to the underlying physiopathol...
    Salvatore Claudio Fanni ... Emanuele Neri
    Published: April 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00138
    Viewed:1695
    Downloaded:41
    Open Access
    Original Article
    Small cell lung cancer: circulating tumor cell lines and expression of mediators of angiogenesis and coagulation
    Aim: Coagulation is frequently activated in cancer patients and has been correlated with an unfavorable prognosis. To evaluate whether a putative release of tissue factor (TF) by circulating tumor ...
    Barbara Rath ... Gerhard Hamilton
    Published: April 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00139
    Viewed:1245
    Downloaded:30
    Open Access
    Original Article
    Development and validation of an infrared-artificial intelligence software for breast cancer detection
    Aim: In countries where access to mammography equipment and skilled personnel is limited, most breast cancer (BC) cases are detected in locally advanced stages. Infrared breast thermography is reco...
    Enrique Martín-Del-Campo-Mena ... Yessica González-Mejía
    Published: April 27, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00135
    Viewed:2389
    Downloaded:42
    Open Access
    Systematic Review
    Anticancer of genus Syzygium: a systematic review
    Aim: One in eight fatalities globally are considered cancer-related. The need for cancer therapy is growing. Natural products continue to play a role in drug development, as up to 50% of authorized...
    Mahmoud Dogara Abdulrahman, Harmand A. Hama
    Published: April 27, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00134
    Viewed:2005
    Downloaded:50
    Open Access
    Case Report
    Complete response to third-line treatment with trifluridine/tipiracil (TAS-102) in stage IV colon adenocarcinoma
    A clinical case of a 61-year-old female diagnosed with stage IV right colon adenocarcinoma (unresectable liver and multiple lymph node metastases at the time of diagnosis), Kirsten rat sarcoma viral...
    Celia Lara-Morga ... Luis Cabezón-Gutiérrez
    Published: April 27, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00136
    Viewed:1124
    Downloaded:21
    Open Access
    Case Report
    Cystic presentation of primary hepatic neuroendocrine tumour: a case report with a brief review of literature
    Neuroendocrine tumours (NETs) are a rare type of tumours that arise from the neuroendocrine cells which are distributed throughout the body. Of all the gastrointestinal tumours only 1–2% account for NETs. They have an extremely low incidence of 0.17% arising in the intrahepatic bile duct epithelium. Majority of hepatic NETs occur as a result of metastases from the primary NETs. Most cases of primary hepatic NET (PHNET) present as a solid nodular mass. However, predominantly cystic PHNET is extremely rare which mimics other cystic space-occupying lesions clinically and radiologically as seen in this case....
    Mangesh Londhe ... Charusheela Gore
    Published: April 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00133
    Viewed:1048
    Downloaded:13
    Open Access
    Review
    Gut microbiota, an emergent target to shape the efficiency of cancer therapy
    It is now well-acknowledged that microbiota has a profound influence on both human health and illness. The gut microbiota has recently come to light as a crucial element that influences cancer throu...
    Soumaya Kouidhi ... Amel Ben Ammar El Gaaied
    Published: April 26, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00132
    Viewed:2205
    Downloaded:53
    Open Access
    Original Article
    A potent bioactive fraction against colon cancer from Plectranthus vettiveroides
    Aim: This study was designed to investigate the anticancer efficacy of the organic leaf extracts of the plant, Plectranthus vettiveroides (P. vettiveroides), and to analyze the molecular mechanism ...
    Faisal M. Athikkavil ... Smitha V. Bava
    Published: April 24, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00131
    Viewed:1624
    Downloaded:29
    Open Access
    Letter to the Editor
    Clinicopathological relevance of stem cell marker growth and differentiation factor 3 in esophageal squamous cell carcinoma
    Esophageal squamous cell carcinoma (ESCC) is the second leading cause of cancer-related deaths in Iran, often diagnosed in advanced stages with a poor prognosis. Growth and differentiation factor 3 ...
    Sara Tahbazzadeh Moghaddam, Mohammad Mahdi Forghanifard
    Published: April 24, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00130
    Viewed:918
    Downloaded:16
    Open Access
    Review
    Cancer resistance via the downregulation of the tumor suppressors RKIP and PTEN expressions: therapeutic implications
    The Raf kinase inhibitor protein (RKIP) has been reported to be underexpressed in many cancers and plays a role in the regulation of tumor cells' survival, proliferation, invasion, and me...
    Matthew Moghaddam ... Benjamin Bonavida
    Published: April 20, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00128
    Viewed:1633
    Downloaded:36
    Open Access
    Review
    Ginnalin A and hamamelitannin: the unique gallotannins with promising anti-carcinogenic potential
    Tannins are secondary metabolites that belong to the family of polyphenolic compounds and have gained a huge interest among researchers due to their versatile therapeutic potential. After lignin, th...
    Rippin ... Anil K. Sharma
    Published: April 21, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00129
    Viewed:1387
    Downloaded:24
    Open Access
    Review
    Diagnostic value of liquid biopsy in the era of precision medicine: 10 years of clinical evidence in cancer
    Liquid biopsy is a diagnostic repeatable test, which in last years has emerged as a powerful tool for profiling cancer genomes in real-time with minimal invasiveness and tailoring oncological decisi...
    Vincenza Caputo ... Stefania Napolitano
    Published: February 28, 2023 Explor Target Antitumor Ther DOI: 10.37349/etat.2023.00125
    Viewed:2977
    Downloaded:82
    Open Access
    Review
    Research progress in molecular pathology markers in medulloblastoma
    Medulloblastoma (MB) is the commonest primary malignant brain cancer. The current treatment of MB is usually surgical resection combined with radiotherapy or chemotherapy. Although great...
    Zixuan Zhou ... Shangfeng Gao
    Published: February 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00126
    Viewed:1499
    Downloaded:29
    Open Access
    Review
    Artificial intelligence applications in pediatric oncology diagnosis
    Artificial intelligence (AI) algorithms have been applied in abundant medical tasks with high accuracy and efficiency. Physicians can improve their diagnostic efficiency with the assistance of AI techniques for improving the subsequent personalized treatment and surveillance. AI algorithms fundamentally capture data, identify underlying patterns, achieve preset endpoints, and provide decisions and predictions about real-world events with working principles of machine learning and deep learning. AI algorithms with sufficient graphic processing unit power have been demonstrated to provide timely diagnostic references based on preliminary training of large amounts of clinical and imaging data. The sample size issue is an inevitable challenge for pediatric oncology considering its low morbidity and individual heterogeneity. However, this problem may be solved in the near future considering the exponential advancements of AI algorithms technically to decrease the dependence of AI operation on the amount of data sets and the efficiency of computing power. For instance, it could be a feasible solution by shifting convolutional neural networks (CNNs) from adults and sharing CNN algorithms across multiple institutions besides original data. The present review provides important insights into emerging AI applications for the diagnosis of pediatric oncology by systematically overviewing of up-to-date literature....
    Yuhan Yang ... Yuan Li
    Published: February 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00127
    Viewed:1697
    Downloaded:37
    Open Access
    Original Article
    Enhancement of reactive oxygen species production in triple negative breast cancer cells treated with electric pulses and resveratrol
    Aim: Triple negative breast cancer (TNBC) is difficult to treat since it lacks all the three most commonly targeted hormone receptors. Patients afflicted with TNBC are treated with platinum core ...
    Pragatheiswar Giri ... Raji Sundararajan
    Published: February 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00122
    Viewed:1269
    Downloaded:32
    Open Access
    Systematic Review
    Crude extract of Ficus deltoidea Jack (FD) as a natural biological therapy
    Aim: This study shows how important it is to coordinate research on Ficus deltoidea Jack (FD) so that results from different sources can be compared directly and a scientific conclusion can be made. Methods: The author looked for research papers on Ficus (F.) deltoidea on Google Scholar, Science Direct, Google.com, Wiley, PubMed, Hindawi, Springer, and other related databases. This analysis excludes data that cannot be trusted, thesis papers, and review articles about F. deltoidea. Results: In traditional medicine, the plant’s leaves and syconia are used to cure a wide variety of ailments, including itchiness, diarrhoea, cancer, sexual dysfunction, age-related issues, malaria, cancer, anxiety, pain, constipation, fever, diabetes, tooth pain, and tooth decay. In vitro and in vivo studies showed the effectiveness of the leaves against cancer cell lines. Conclusions: Based on the existing research on the health benefits of FD, it is critical to focus on its more active constituents and their identification, determination, further development, and, most importantly, standardization of the leaves for the management and treatment of cancer and its related cases. More research is needed before it can be considered a promising herbal source of novel medication candidates for treating various disorders....
    Mahmoud Dogara Abdulrahman
    Published: February 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00123
    Viewed:1466
    Downloaded:22
    Open Access
    Review
    Macrophages as potential targets in gene therapy for cancer treatment
    Macrophages, as ubiquitous and functionally diverse immune cells, play a central role in innate immunity and initiate adaptive immunity. Especially, tumor-associated macrophages (TAMs) are crucial c...
    Yuanzheng Huang ... Xiaoxuan Liu
    Published: February 28, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00124
    Viewed:2179
    Downloaded:50
    Open Access
    Review
    Liquid biopsy and glioblastoma
    Glioblastoma is the most common and malignant primary brain tumor. Despite a century of research efforts, the survival of patients has not significantly improved. Currently, diagnosis is based on ne...
    Robert H. Eibl, Markus Schneemann
    Published: February 25, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00121
    Viewed:2678
    Downloaded:51
    Open Access
    Perspective
    A primer on cancer-associated fibroblast mechanics and immunosuppressive ability
    Cancer-associated fibroblasts (CAFs) are a major point of interest in modern oncology. Their interest resides in their ability to favor tumor growth without carrying genetic mutations. From a transl...
    Vanessa C. Talayero, Miguel Vicente-Manzanares
    Published: February 20, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00120
    Viewed:1239
    Downloaded:26
    Open Access
    Original Article
    Artificial intelligence fusion for predicting survival of rectal cancer patients using immunohistochemical expression of Ras homolog family member B in biopsy
    Aim: The process of biomarker discovery is being accelerated with the application of artificial intelligence (AI), including machine learning. Biomarkers of diseases are useful because they are i...
    Tuan D. Pham ... Xiao-Feng Sun
    Published: February 07, 2023 Explor Target Antitumor Ther. DOI: 10.37349/etat.2023.00119
    Viewed:1394
    Downloaded:38
    Open Access
    Review
    New phase therapeutic pursuits for targeted drug delivery in glioblastoma multiforme
    Glioblastoma multiforme (GBM) is known as the most aggressive and prevalent brain tumor with a high mortality rate. It is reported in people who are as young as 10 years old to as old as over 70 years old, exhibiting inter and intra tumor heterogeneity. There are several genomic and proteomic investigations that have been performed to find the unexplored potential targets of the drug against GBM. Therefore, certain effective targets have been taken to further validate the studies embarking on the robustness in the field of medicinal chemistry followed by testing in clinical trials. Also, The Cancer Genome Atlas (TCGA) project has identified certain overexpressed targets involved in the pathogenesis of GBM in three major pathways, i.e., tumor protein 53 (p53), retinoblastoma (RB), and receptor tyrosine kinase (RTK)/rat sarcoma virus (Ras)/phosphoinositide 3-kinase (PI3K) pathways. This review focuses on the compilation of recent developments in the fight against GBM thus, directing future research into the elucidation of pathogenesis and potential cure for GBM. Also, it highlights the potential biomarkers that have undergone extensive research and have promising prognostic and predictive values. Additionally, this manuscript analyses the advent of gene therapy and immunotherapy, unlocking the way to consider treatment approaches other than, or in addition to, conventional chemo-radiation therapies. This review study encompasses all the relevant research studies associated with the pathophysiology, occurrence, diagnostic tools, and therapeutic intervention for GBM. It highlights the evolution of various therapeutic perspectives against GBM from the most conventional form of radiotherapy to the recent advancement of gene/cell/immune therapy. Further, the review focuses on various targeted therapies for GBM including chemotherapy sensitization, radiotherapy, nanoparticles based, immunotherapy, cell therapy, and gene therapy which would offer a comprehensive account for exploring several facets related to GBM prognostics....
    Manisha Singh ... Rachana
    Published: December 30, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00118
    Viewed:1797
    Downloaded:56
    Open Access
    Original Article
    Evaluating immune response in vitro in a relevant microenvironment: a high-throughput microfluidic model for clinical screening
    Aim: Functional screening of new pharmaceutical compounds requires clinically relevant models to monitor essential cellular and immune responses during cancer progression, with or without treatment. Beyond survival, the emergence of resistant tumor cell clones should also be considered, including specific properties related to plasticity, such as invasiveness, stemness, escape from programmed cell death, and immune response. Numerous pathways are involved in these processes. Defining the relevant ones in the context of a specific tumor type will be key to designing an appropriate combination of inhibitors. However, the diversity and potential redundancy of these pathways remain a challenge for therapy. Methods: A new microfluidic device developed by Okomera was dedicated to the screening of drug treatment for breast cancer. This microchip includes 150 droplet-trapping microwells, offering multi-chip settings and multiple treatment choices. Results: After validating the system with established cell lines and a panel of drugs used clinically at Gustave Roussy, preclinical experiments were initiated including patient-derived xenograft (PDX) and primary tumor cells-derived tumoroids with the collaboration of Gustave Roussy clinicians. Tumor-isolated lymphocytes were also added to the tumoroids, using secondary droplets in proof-of-concept experiments. Conclusions: These results show the relevance of the methodology for screening large numbers of drugs, a wide range of doses, and multiple drug combinations. This methodology will be used for two purposes: 1) new drug screening from the compound library, using the high throughput potential of the chip; and 2) pre-clinical assay for a two-weeks response for personalized medicine, allowing evaluation of drug combinations to flag an optimized treatment with potential clinical application....
    Flora Doffe ... Pierre Savagner
    Published: December 29, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00117
    Viewed:2274
    Downloaded:88
    Open Access
    Commentary
    De novo cholesterol biosynthesis: an additional therapeutic target for the treatment of postmenopausal breast cancer with excessive adipose tissue
    The onset and development of breast cancer in postmenopausal women are associated with closely related individual-dependent factors, including weight gain and high levels of circulating androgens. Adipose tissue is the most peripheral site of aromatase enzyme synthesis; therefore, the excessive accumulation of visceral fat results in increased androgens aromatization and estradiol production that provides the microenvironment favorable to tumorigenesis in mammary epithelial cells expressing estrogen receptors (ERs). Moreover, to meet the increased requirement of cholesterol for cell membrane assembly and the production of steroid hormones to sustain their proliferation, ER-positive cells activate de novo cholesterol biosynthesis and subsequent steroidogenesis. Several approaches have been followed to neutralize the de novo cholesterol synthesis, including specific enzyme inhibitors, statins, and, more recently, metformin. Cumulating evidence indicated that inhibiting cholesterol biosynthesis by statins and metformin may be a promising therapeutic strategy to block breast cancer progression. Unlike antiestrogens and aromatase inhibitors (AIs) which compete for binding to ER and inhibit androgens aromatization, respectively, statins block the production of mevalonic acid by inhibiting the activity of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and metformin hampers the activation of the sterol regulatory element-binding protein 2 (SREBP2) transcription factor, thus inhibiting the synthesis of several enzymes involved in cholesterol biosynthesis. Noteworthy, statins and metformin not only improve the prognosis of overweight patients with ER-positive cancer but also improve the prognosis of patients with triple-negative breast cancer, the aggressive tumor subtype that lacks, at present, specific therapy....
    Danila Coradini
    Published: December 28, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00116
    Viewed:1300
    Downloaded:24
    Open Access
    Review
    Antibody-drug conjugates for lymphoma patients: preclinical and clinical evidences
    Antibody-drug conjugates (ADCs) are a recent, revolutionary approach for malignancies treatment, designed to provide superior efficacy and specific targeting of tumor cells, compared to systemic cyt...
    Marilia Barreca ... Francesco Bertoni
    Published: December 26, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00112
    Viewed:2575
    Downloaded:69
    Open Access
    Review
    Artificial intelligence in breast cancer imaging: risk stratification, lesion detection and classification, treatment planning and prognosis—a narrative review
    The advent of artificial intelligence (AI) represents a real game changer in today’s landscape of breast cancer imaging. Several innovative AI-based tools have been developed and validated in recent years that promise to accelerate the goal of real patient-tailored management. Numerous studies confirm that proper integration of AI into existing clinical workflows could bring significant benefits to women, radiologists, and healthcare systems. The AI-based approach has proved particularly useful for developing new risk prediction models that integrate multi-data streams for planning individualized screening protocols. ...
    Maurizio Cè ... Michaela Cellina
    Published: December 27, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00113
    Viewed:2566
    Downloaded:72
    Open Access
    Perspective
    Encouraging probiotics for the prevention and treatment of immune-related adverse events in novel immunotherapies against malignant glioma
    Among the malignant tumors in the central nervous system (CNS), glioma is the most challenging tumor to the public society, which accounts for the majority of intracranial malignant tumors with impa...
    Sayuri Yoshikawa ... Satoru Matsuda
    Published: December 27, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00114
    Viewed:3967
    Downloaded:1592
    Open Access
    Original Article
    Dendritic cell-targeting chemokines inhibit colorectal cancer progression
    Aim: Recent progress in cancer immunotherapy has shown its promise and prompted researchers to develop novel therapeutic strategies. Dendritic cells (DCs) are professional antigen-presenting cell...
    Pengkun Yuan ... Bin Ma
    Published: December 27, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00115
    Viewed:1617
    Downloaded:30
    Open Access
    Review
    Mutant and non-mutant neoantigen-based cancer vaccines: recent advances and future promises
    Major advances in cancer treatment have emerged with the introduction of immunotherapies using blocking antibodies that target T-cell inhibitory receptors, such as programmed death-1 (PD-1) and cyto...
    Mohamad Omar Ashi ... Stéphanie Corgnac
    Published: December 22, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00111
    Viewed:1987
    Downloaded:64
    Open Access
    Systematic Review
    Diffusion-weighted imaging and apparent diffusion coefficient mapping of head and neck lymph node metastasis: a systematic review
    Aim: Head and neck squamous cell cancer (HNSCC) is the ninth most common tumor worldwide. Neck lymph node (LN) status is the major indicator of prognosis in all head and neck cancers, and the early detection of LN involvement is crucial in terms of therapy and prognosis. Diffusion-weighted imaging (DWI) is a non-invasive imaging technique used in magnetic resonance imaging (MRI) to characterize tissues based on the displacement motion of water molecules. This review aims to provide an overview of the current literature concerning quantitative diffusion imaging for LN staging in patients with HNSCC. Methods: This systematic review performed a literature search on the PubMed database (https://pubmed.ncbi.nlm.nih.gov/) for all relevant, peer-reviewed literature on the subject following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) criteria, using the keywords: DWI, MRI, head and neck, staging, lymph node. Results: After excluding reviews, meta-analyses, case reports, and bibliometric studies, 18 relevant papers out of the 567 retrieved were selected for analysis. Conclusions: DWI improves the diagnosis, treatment planning, treatment response evaluation, and overall management of patients affected by HNSCC. More robust data to clarify the role of apparent diffusion coefficient (ADC) and DWI parameters are needed to develop models for prognosis and prediction in HNSCC cancer using MRI. ...
    Maria Paola Belfiore ... Salvatore Cappabianca
    Published: December 13, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00110
    Viewed:2681
    Downloaded:36
    Open Access
    Review
    Onosma L. as a source of anticancer agents: phytochemistry to mechanistic insight
    Onosma (O.) is a genus of perennial flowering plants in the family Boraginaceae with approximately 250 species widely dispersed in temperate, tropical, and subtropical areas. It is traditionally use...
    Ajay Kumar ... Satwinderjeet Kaur
    Published: October 31, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00109
    Viewed:1659
    Downloaded:52
    Open Access
    Review
    Clinical utility of liquid biopsy-based companion diagnostics in the non-small-cell lung cancer treatment
    Recently, technological advances in the detection and biological characterization of circulating tumor DNA (ctDNA) have enabled the implementation of liquid biopsy testing into clinical practice. Me...
    Yoshiharu Sato
    Published: October 31, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00104
    Viewed:2045
    Downloaded:29
    Open Access
    Review
    Potential role of resveratrol and its nano-formulation as anti-cancer agent
    The uncontrolled and metastatic nature of cancer makes it worse and more unpredictable. Hence, many therapy and medication are used to control and treat cancer. However, apart from this, many medica...
    Akshay Kumar ... Dilpreet Singh
    Published: October 31, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00105
    Viewed:2132
    Downloaded:42
    Open Access
    Review
    Steroid utility, immunotherapy, and brain tumor management: an update on conflicting therapies
    Steroid use is a widely accepted practice for both the treatment and prevention of tumor-induced edema, but there are many unknowns regarding their current clinical utility with modern anti-tumor th...
    Matthew Goldman ... Stephan Quintin
    Published: October 31, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00106
    Viewed:1777
    Downloaded:42
    Open Access
    Review
    Perspectives of traditional Chinese medicine to patch up immune checkpoint blockers
    In this era of cancer immunotherapy, the response rates of immune checkpoint blockers (ICBs) are still too low and the adverse events may also be significant. Of the ways of patching up such deficit...
    Shiu Ying Tsao
    Published: October 31, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00107
    Viewed:1908
    Downloaded:25
    Open Access
    Review
    The tumor innate immune microenvironment in prostate cancer: an overview of soluble factors and cellular effectors
    Prostate cancer (PCa) accounts as the most common non-cutaneous disease affecting males, and as the first cancer, for incidence, in male. With the introduction of the concept of immunoscore, PCa has...
    Maria Teresa Palano ... Lorenzo Mortara
    Published: October 31, 2022 Explor Target Antitumor Ther. DOI: 10.37349/etat.2022.00108
    Abstract