• 12 results in Exploration of Targeted Anti-tumor Therapy
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    Tri-specific killer engager: unleashing multi-synergic power against cancer
    Cancer continues to be a global health concern, necessitating innovative solutions for treatment. Tri-specific killer engagers (TriKEs) have emerged as a promising class of immunotherapeutic agents, [...] Read more.
    Peeranut Winidmanokul ... Seiji Okada
    Published: April 25, 2024 Explor Target Antitumor Ther. 2024;5:432–448
    DOI: https://doi.org/10.37349/etat.2024.00227
    This article belongs to the special issue Novel Strategies and Targets for Immunotherapy of Cancer
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    Spheroids and organoids derived from colorectal cancer as tools for in vitro drug screening
    Colorectal cancer (CRC) is a heterogeneous disease. Conventional two-dimensional (2D) culture employing cell lines was developed to study the molecular properties of CRC in vitro. Although these cel [...] Read more.
    Sahira Syamimi Ahmad Zawawi ... Marahaini Musa
    Published: April 25, 2024 Explor Target Antitumor Ther. 2024;5:409–431
    DOI: https://doi.org/10.37349/etat.2024.00226
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    Cancer symptom cluster research in pediatric oncology: a work in progress
    In the 21st century, advances in basic research have provided new insights in the field of pediatric oncology. Pediatric patients tend to experience higher levels of distressing symptoms, which toge [...] Read more.
    Luciana Chain Veronez, Luís Carlos Lopes-Júnior
    Published: April 24, 2024 Explor Target Antitumor Ther. 2024;5:400–408
    DOI: https://doi.org/10.37349/etat.2024.00225
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    Alteration of glucose metabolism and expression of glucose transporters in ovarian cancer
    Aerobic glycolysis also known as the Warburg effect, remains a hallmark of various cancers, including ovarian cancer. Cancer cells undergo metabolic changes to sustain their tumorigenic properties a [...] Read more.
    Fatima Ben Ali ... Rabii Ameziane El Hassani
    Published: April 24, 2024 Explor Target Antitumor Ther. 2024;5:384–399
    DOI: https://doi.org/10.37349/etat.2024.00224
    This article belongs to the special issue Recent Approaches in Tumor Metabolism
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    Case Report
    Improving single nucleotide polymorphisms genotyping accuracy for dihydropyrimidine dehydrogenase testing in pharmacogenetics
    Fluoropyrimidines, crucial in cancer treatment, often cause toxicity concerns even at standard doses. Toxic accumulation of fluoropyrimidine metabolites, culminating in adverse effects, can stem fro [...] Read more.
    Annalaura Montella ... Mario Capasso
    Published: April 24, 2024 Explor Target Antitumor Ther. 2024;5:374–383
    DOI: https://doi.org/10.37349/etat.2024.00223
    This article belongs to the special issue Molecular Diagnosis and Personalized Therapy of Cancer
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    Tumor metabolism in pheochromocytomas: clinical and therapeutic implications
    Pheochromocytomas and paragangliomas (PPGLs) have emerged as one of the most common endocrine tumors. It epitomizes fascinating crossroads of genetic, metabolic, and endocrine oncology, providing a  [...] Read more.
    Mohammad Sadiq Jeeyavudeen ... Joseph M. Pappachan
    Published: April 24, 2024 Explor Target Antitumor Ther. 2024;5:349–373
    DOI: https://doi.org/10.37349/etat.2024.00222
    This article belongs to the special issue Recent Approaches in Tumor Metabolism
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    Artificial intelligence and classification of mature lymphoid neoplasms
    Hematologists, geneticists, and clinicians came to a multidisciplinary agreement on the classification of lymphoid neoplasms that combines clinical features, histological characteristics, immunophen [...] Read more.
    Joaquim Carreras ... Naoya Nakamura
    Published: April 23, 2024 Explor Target Antitumor Ther. 2024;5:332–348
    DOI: https://doi.org/10.37349/etat.2024.00221
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
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    Magnetite nanoparticles: an emerging adjunctive tool for the improvement of cancer immunotherapy
    Cancer immunotherapy has emerged as a groundbreaking field, offering promising and transformative tools for oncological research and treatment. However, it faces several limitations, including varia [...] Read more.
    Phoomipat Jungcharoen ... Charupong Saengboonmee
    Published: April 23, 2024 Explor Target Antitumor Ther. 2024;5:316–331
    DOI: https://doi.org/10.37349/etat.2024.00220
    This article belongs to the special issue Novel Strategies and Targets for Immunotherapy of Cancer
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    Emerging roles of type 1 innate lymphoid cells in tumour pathogenesis and cancer immunotherapy
    Innate lymphoid cells (ILCs) are the most recently discovered class of innate immune cells found to have prominent roles in various human immune-related pathologies such as infection and autoimmune  [...] Read more.
    James Michael Verner ... Eric Jou
    Published: April 23, 2024 Explor Target Antitumor Ther. 2024;5:296–315
    DOI: https://doi.org/10.37349/etat.2024.00219
    This article belongs to the special issue Novel Insights into Immunotherapy Targeting Tumor Microenvironment in Cancer
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    Original Article
    Hexachlorobenzene as a differential modulator of the conventional and metronomic chemotherapy response in triple negative breast cancer cells
    Aim: Triple negative breast cancer (TNBC) is usually treated with high doses of paclitaxel, whose effectiveness may be modulated by the action of environmental contaminants such as hexachlorobenz [...] Read more.
    Yamila Sanchez ... Alejandro Español
    Published: March 21, 2024 Explor Target Antitumor Ther. 2024;5:278–295
    DOI: https://doi.org/10.37349/etat.2024.00218
    This article belongs to the special issue Innovative Strategies to Target Triple-negative Breast Cancer