• 5 results in Exploration of Targeted Anti-tumor Therapy
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    Review
    Targeting cytoskeletal phosphorylation in cancer
    Phosphorylation of cytoskeletal proteins regulates the dynamics of polymerization, stability, and disassembly of the different types of cytoskeletal polymers. These control the ability of cells to m...
    Clara Llorente-González ... Miguel Vicente-Manzanares
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:292-308
    DOI: https://doi.org/10.37349/etat.2021.00047
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    Open Access
    Review
    Advances in the study of cancer metastasis and calcium signaling as potential therapeutic targets
    Metastasis is still the primary cause of cancer-related mortality. However, the underlying mechanisms of cancer metastasis are not yet fully understood. Currently, the epithelial-mesenchymal transit...
    Chaochu Cui ... Xianwei Wang
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:266-291
    DOI: https://doi.org/10.37349/etat.2021.00046
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
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    Open Access
    Review
    Overview of Ca2+ signaling in lung cancer progression and metastatic lung cancer with bone metastasis
    Intracellular Ca2+ ions that are thought to be one of the most important second messengers for cellular signaling, have a substantial diversity of roles in regulating a plethora of funda...
    Manh Tien Tran
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:249-265
    DOI: https://doi.org/10.37349/etat.2021.00045
    This article belongs to the special issue Calcium Signaling Apparatus in Cancers
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    Open Access
    Case Report
    Lynch syndrome-associated lung cancer: pitfalls of an immunotherapy-based treatment strategy in an unusual tumor type
    Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline alterations in mismatch repair (MMR) genes leading to increased risk of colon cancer as well as other cancer types. N...
    Elena Maccaroni ... Rossana Berardi
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:240-248
    DOI: https://doi.org/10.37349/etat.2021.00044
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    Open Access
    Original Article
    Tumor burden as possible biomarker of outcome in advanced NSCLC patients treated with immunotherapy: a single center, retrospective, real-world analysis
    Aim: The role of tumor burden (TB) for patients with non-small cell lung cancer (NSCLC) receiving immunotherapy is still unknown. The aim of this analysis was to analyze the prognostic value of T...
    Edoardo Lenci ... Rossana Berardi
    Published: June 28, 2021 Explor Target Antitumor Ther. 2021;2:227-239
    DOI: https://doi.org/10.37349/etat.2021.00043
    This article belongs to the special issue Immunotherapy in Cancer Patients
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