Exploration of Drug Science

Table 4. Excluded studies after full text review and reasons for exclusion.

Article title	Year of publication	Reason for exclusion	Reference
Effect of ultrasonic treatments on nanoparticle preparation of acid-hydrolyzed waxy maize starch	2013	Lower crystallinity	[10]
Starch nanocrystal stabilized Pickering emulsion polymerization for nanocomposites with improved performance	2014	Crystallinity of Starch nanocrystal (SNC) not reported	[16]
Starch nanocrystals based hydrogel: construction, characterizations and transdermal application	2016	Comparison related to crystallinity not reported with native starch	[21]
Native and modified starch nano-crystals loaded with doxorubicin mediated apoptosis in human breast cancer MCF7 cells	2024	No X-ray diffraction (XRD) based or quantitative crystallinity assessment was provided	[22]
Native and modified Digitaria exilis starch nanoparticles as a carrier system for the controlled release of naproxen	2019	Qualitative structural changes were reported, but no quantitative XRD crystallinity comparison with native starch was provided	[24]
First-line anti-tubercutilosis drugs-loaded starch nanocrystals for combating the threat of M. tuberculosis H37Rv strain	2020	Crystallinity of SNC not reported	[25]
Acetylated starch nanocrystals: preparation and antitumor drug delivery study	2016	Nanostarch structured modified	[23]
Effect of the mode of incorporation on the disintegrant properties of acid modified water and white yam starches	2012	Crystallinity of SNC not reported	[29]
Design of bilayer tablets using modified Dioscorea starches as novel excipients for immediate and sustained release of aceclofenac sodium	2015	The modified Dioscorea starches were not identified or sufficiently characterized as acid-hydrolyzed nanocrystalline starch	[27]
Use of cassava starch nanocrystals to make a robust rupturable pulsatile release pellet	2018	Crystallinity of SNC not reported	[28]
Evidence of micro- and nanoscaled particles during starch nanocrystals preparation and their isolation	2011	Crystallinity of SNC not reported	[30]
Evaluation of rheological behavior of starch nanocrystals by acid hydrolysis and starch nanoparticles by self-assembly: a comparative study	2016	Insufficient crystallinity characterization to confirm eligibility according to the review criteria	[31]
Characterization of Starch Nanocrystals from Lablab purpureus (L.) Sweet and Its Application as a Stabilizer in Pickering Emulsions	2023	Crystallinity of SNC not reported	[18]
Surface chemical compositions and dispersity of starch nanocrystals formed by sulfuric and hydrochloric acid hydrolysis	2014	Crystallinity of SNC not reported	[32]
Characterization of nanoparticles prepared by acid hydrolysis of various starches	2012	Lower crystallinity	[9]
Characterization of acid hydrolysis of granular potato starch under induced electric field	2017	Lower crystallinity	[33]
Enhancement of the gut-retention time of resveratrol using waxy maize starch nanocrystal-stabilized and chitosan-coated Pickering emulsions	2021	Crystallinity of SNC not reported	[34]

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Declarations

Acknowledgments

During the preparation of this work, the authors used Grammarly tool for language editing, grammar improvement, and formatting assistance. After utilizing the tool/service, the authors reviewed and edited the content as necessary and take full responsibility for the final content of the publication.

Author contributions

MF: Conceptualization, Methodology, Investigation, Data curation, Formal analysis, Resources, Supervision, Visualization, Writing—original draft, Writing—review & editing. SS: Conceptualization, Methodology, Formal analysis, Validation, Visualization, Writing—review & editing. Both authors read and approved the submitted version.

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Data are available upon reasonable request.

Funding

Not applicable.

Copyright

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