Recommendations for treatment of HCV-infected treatment-experienced adults with or without compensated cirrhosis according to the AASLD/IDSA 2023 guidelines.
Regimen
Duration
Failed regimen
Comments
SOF/VEL/VOX ± weight-based RBV
12 weeks
SOF-based regimens or EBR/GZR
Ribavirin is added in patients with GT3 and compensated cirrhosis
SOF/VEL/VOX ± weight-based RBV
12 weeks
G/P
Ribavirin is added in patients with compensated cirrhosis
SOF/VEL/VOX ± weight-based RBV
24 weeks
Multiple DAA treatment failure (including SOF/VEL/VOX or SOF + G/P)
G/P
16 weeks
SOF-based regimens
Not for NS3/41 inhibitor-inclusive regimens. Not for GT3
G/P + SOF + weight-based RBV
16 weeks
G/P or multiple DAA treatment failure (including SOF/VEL/VOX or SOF + G/P)
SHB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. ABER: Conceptualization, Investigation, Writing—review & editing, Supervision. KHH: Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
Kareem H. Hassan and Azza B. El-Remessy are employed by Nour Therapeutics. Nour Therapeutics had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Besides, these two authors have no other conflicts of interest that need to be disclosed. Salma H. Bahram has no conflicts of interest that need to be disclosed.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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