Exploration of Drug Science

Table 2. Recommendations for initial treatment of HCV-infected treatment-naïve adults according to the AASLD/IDSA 2023.

Regimen	Duration	Genotypes ± compensated cirrhosis	Considerations
G/P (300 mg/120 mg)	8 weeks	GT1–GT6	Taken with food
SOF/VEL (400 mg/100 mg)	12 weeks	GT1–GT6	If GT3 + NS5A RAS Y93H is present, add weight-based RBV or choose another regimen
LDV/SOF (90 mg/400 mg)	12 weeks	GT1/GT4/GT5/GT6	Not recommended for genotype 6e infection if subtype is known
LDV/SOF (90 mg/400 mg)	8 weeks	GT1 without cirrhosis	In non-cirrhotic patients with no HIV and whose HCV RNA is < 6 million IU/mL
ELB/GZR (50 mg/100 mg)	12 weeks	GT1/GT4	For GT1a, if NS5A baseline RASs are present, choose another regimen
SOF/VEL (400 mg/100 mg) + weight-based RBV	12 weeks	GT3 with cirrhosis	For GT3, with cirrhosis and baseline NS5A Y93 RAS
SOF/VEL/VOX (400 mg/100 mg/100 mg)	12 weeks	GT3 with cirrhosis	For GT3, with cirrhosis and baseline NS5A Y93 RAS

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G/P: glecaprevir/pibrentasvir; LDV/SOF: ledipasvir/sofosbuvir; VOX: voxilaprevir; GT: genotype; RAS: resistance-associated substitutions; RBV: ribavirin; ELB/GZR: elbasvir/grazoprevir.

Declarations

Author contributions

SHB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. ABER: Conceptualization, Investigation, Writing—review & editing, Supervision. KHH: Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

Kareem H. Hassan and Azza B. El-Remessy are employed by Nour Therapeutics. Nour Therapeutics had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Besides, these two authors have no other conflicts of interest that need to be disclosed. Salma H. Bahram has no conflicts of interest that need to be disclosed.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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