Exploration of Drug Science

Table 1. List of direct-acting antivirals released in the market.

Generic name	Brand name	Approval year	Mechanism of action	Notes
Boceprevir	Victrelis	2011	NS3/4A inhibitor	Withdrawn in 2015
Telaprevir	Incivek/Incivo	2011	NS3/4A inhibitor	Withdrawn in 2015
Asunaprevir	Sunvepra	2014	NS3/4A inhibitor	Withdrawn
Simeprevir	Olysio	2013	NS3/4A inhibitor	Withdrawn in 2018
Sofosbuvir	Sovaldi	2013	NI NS5B inhibitor
Daclatasvir	Daklinza	2014 EMA 2015 FDA	NS5A inhibitor
Ledipasvir + sofosbuvir	Harvoni	2014	NS5A inhibitor + NI NS5B inhibitor
Ombitasvir + paritaprevir, + ritonavir, + dasabuvir	Viekira Pak/Viekira XR	2014	NS5A inhibitor + NS3/4A inhibitor + HIV-1 protease inhibitor + NNI NS5B inhibitor	Withdrawn
Elbasvir + grazoprevir	Zepatier	2016	NS5A inhibitor + NS3/4A inhibitor
Sofosbuvir + velpatasvir	Epclusa	2016	NI NS5B inhibitor + NS5A inhibitor
Sofosbuvir + velpatasvir + voxilaprevir	Vosevi	2017	NI NS5B inhibitor + NS5A inhibitor + NS3/4A inhibitor
Glecaprevir + pibrentasvir	Mavyret	2017	NS3/4A inhibitor + NS5A inhibitor
Ravidasvir	Ravida	2020	NS5A inhibitor	Not approved by the FDA
Coblopasvir	Kailiwei	2020	NS5A inhibitor	Approved in China only

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NI: nucleotide inhibitors; NNI: non-nucleoside inhibitors.

Declarations

Author contributions

SHB: Conceptualization, Investigation, Writing—original draft, Writing—review & editing. ABER: Conceptualization, Investigation, Writing—review & editing, Supervision. KHH: Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

Kareem H. Hassan and Azza B. El-Remessy are employed by Nour Therapeutics. Nour Therapeutics had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Besides, these two authors have no other conflicts of interest that need to be disclosed. Salma H. Bahram has no conflicts of interest that need to be disclosed.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Not applicable.

Funding

Not applicable.

Copyright

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Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.

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