From:  AI-integrated nanotherapeutics for schizophrenia: advancing precision oral drug delivery

 Recent studies of advanced oral drug delivery systems.

Delivery systemAI role/innovationKey findings/benefitsReference
LRP1-targeted nanoparticle delivering KS-133AIguided ligand design for BBB transcytosisAchieved brain penetration in schizophrenia mouse model; improved CNS exposure of peptide therapeutic[51]
Weekly oral risperidone formulationAlgorithm-assisted PK modelling to extend dosing intervalOnce-weekly oral dosing matched daily risperidone efficacy; maintained plasma levels and clinical stability[52]
Intranasal brexpiprazole NLCsAIinspired nanoformulation designEnhanced brain targeting of antipsychotic via nasal path, suggesting alternative to oral route[53]
NS-136 (M4 PAM Oral Candidate)AI-assisted medicinal chemistry and PK predictionOral Phase I candidate with pro-cognitive effect designed via AI; targets schizophrenia and Alzheimer’s[54]
Evenamide (NW-3509) AddOn TherapyAI-supported pharmacodynamic and repurposing profilingOral adjunct therapy reduced symptoms in treatment-resistant schizophrenia in Phase II/III studies[55]

AI: artificial intelligence; BBB: blood-brain barrier; CNS: central nervous system; NLCs: nanostructured lipid carriers; PK: pharmacokinetics.