Exploration of Drug Science

From: Prediction of absolute bioavailability of medicines in adults and children from oral clearance

Table 4. Within fold-error and statistical analysis for the prediction of absolute bioavailability in children (n = 35).

Fold-error and statistical analysis
Fold-error	LBF	LPF
0.5–2	33 (94.3%)	35 (100.0%)
0.5–1.5	23 (65.7%)	31 (88.6%)
0.7–1.3	18 (51.4%)	28 (80.0%)
> 2	2 (5.7%)	0 (0.0%)
< 0.5	0 (0.0%)	0 (0.0%)
Bias	15.2	4.7
RMSE	21.1	15.0
AFE	1.32	1.11
AAFE	1.37	1.19

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LBF: liver blood flow; LPF: liver plasma flow; AFE: average fold error; AAFE: absolute AFE; RMSE: root mean square error. % is of total observations.

Supplementary materials

The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1008160_sup_1.pdf.

Declarations

Author contributions

IM: Conceptualization, Investigation, Data curation, Visualization, Formal analysis, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

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The author has no conflicts of interest.

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Since this study analyzed secondary data, ethical approval is not required.

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The data and the references are provided in the main text and supplementary files.

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