Exploration of Drug Science

From: Prediction of absolute bioavailability of medicines in adults and children from oral clearance

Table 1. Within fold-error and statistical analysis for the prediction of absolute bioavailability in adults (medicines metabolized in the liver) (n = 33).

Fold-error and statistical analysis
Fold-error	LBF	LPF
0.5–2	33 (100.0%)	32 (97.0%)
0.5–1.5	30 (90.9%)	32 (97.0%)
0.7–1.3	27 (81.8%)	26 (78.8%)
> 2	0 (0.0%)	0 (0.0%)
< 0.5	0 (0.0%)	1 (3.0%)
Bias	3.6	–6.3
RMSE	10.2	11.0
AFE	1.10	0.87
AAFE	1.25	1.15

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LBF: liver blood flow; LPF: liver plasma flow; AFE: average fold error; AAFE: absolute AFE; RMSE: root mean square error. % is of total observations.

Supplementary materials

The supplementary tables for this article are available at: https://www.explorationpub.com/uploads/Article/file/1008160_sup_1.pdf.

Declarations

Author contributions

IM: Conceptualization, Investigation, Data curation, Visualization, Formal analysis, Writing—original draft, Writing—review & editing. The author read and approved the submitted version.

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The author has no conflicts of interest.

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Since this study analyzed secondary data, ethical approval is not required.

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The data and the references are provided in the main text and supplementary files.

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