7H9: Middlebrook 7H9-based medium supplemented with glucose/glycerol/BSA/Tween; in 7H9a with glucose/BSA/tyloxapol; in 7H9b with cholesterol/BSA/tyloxapol and in 7H9c with dipalmitoyl phosphatidylcholine/BSA/tyloxapol. Mtb: Mycobacterium tuberculosis; MW: molecular weight; GAST-Fe: glycerol-alanine-salts-Tween-iron; BSA: bovine serum albumin; nd: not determined.
The contributions of the National Institutes of Health (NIH) author(s) were made as part of their official duties as NIH federal employees, are in compliance with agency policy requirements, and are considered Works of the United States Government. However, the findings and conclusions presented in this paper are those of the author(s) and do not necessarily reflect the views of the NIH or the U.S. Department of Health and Human Services.
Acknowledgments
The authors would like to thank the American University and the Midwestern University Offices of Research and Sponsored Programs, as well as the Midwestern University College of Graduate Studies, for their support. MIK would like to thank the following students who participated in synthesizing the library of compounds: Alex Lutz, Marika Cohen, and Jason Corsbie.
Author contributions
MIK: Conceptualization, Funding acquisition, Supervision, Investigation, Visualization, Writing—original draft, Writing—review & editing. KA: Methodology, Formal analysis, Investigation, Visualization, Writing—review & editing. HIMB: Conceptualization, Data curation, Investigation, Visualization, Writing—original draft, Writing—review & editing. BJP: Conceptualization, Supervision, Data curation, Formal analysis, Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that there are no conflicts of interest.
Ethical approval
Not applicable.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
Data available upon request. Requests for accessing the datasets should be directed to mkonak@american.edu.
Funding
This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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5-amino-N-(3-(4-(5-amino-3-(methylthio)-1H-1,2,4-triazole-1-carboxamido)benzyl)phenyl)-3-(methylthio)-1H-1,2,4-triazole-1-carboxamideMW 510.60LogP 2.68
S-(2-chloro-5-fluorophenyl) (2-(trifluoromethyl)phenyl)carbamothioateMW 349.73LogP 5.39
S-[4-(methylsulfanyl)phenyl] (2-nitrophenyl) carbamothioateMW 320.38LogP 4.54
S-(2,5-dichlorophenyl)(2-nitrophenyl) carbamothioateMW 343.18LogP 4.95
S-pyrimidin-2-yl (2-nitrophenyl) carbamothioateMW 276.27LogP 1.96
3-((5-(methylthio)-1,3,4-thiadiazol-2-yl)thio)pyrazine-2-carbonitrileMW 267.34LogP 3.53
MW 137.17LogP –0.64