From:  Janus-faced role of anti-infective drugs: a revisit through the lens of vascular ageing

 Molecular pathways linking cellular senescence and chronic inflammation in vascular aging.

PathwayRole in senescence & inflammation
NF-κBCentral regulator of SASP transcription and inflammatory gene expression [14, 15]
p53/p21Initiates senescence in response to DNA damage [16]
p16/RbMaintains senescence and suppresses proliferation [17]
NLRP3 inflammasomeActivated by SASP, promotes IL-1β and IL-18 secretion [18]
mTORModulates SASP and autophagy, influencing senescence phenotype [19]
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mTOR: mechanistic target of rapamycin; SASP: senescence-associated secretory phenotype; NF-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NLRP3: NOD-, LRR- and pyrin domain-containing protein 3; Rb: retinoblastoma protein.