Exploration of Drug Science

Table 6. Pharmacokinetic profile of EUB0000226b.

No.	Parameter	Optimal range	Result
1	Size	150–500 g/mol	342.35 g/mol
2	Lipophilicity (consensus)	–0.7 to +5.0	0.09
3	Polarity	20 to 130 Å²	126.65 Å²
4	Water solubility (ESOL)	–6 to 0	–2.48 (soluble)
5	Insaturation	0.25 to 1.0	0.29
6	Flexibility	0 to 9	3
7	Pharmacokinetics	Gastrointestinal (GI) absorption	High
		Blood-brain barrier (BBB) permeant	No
		P-glycoprotein (P-gp) substrate	No
8	Druglikeness	Lipinski	Yes, 0 violations
8	Druglikeness	Bioavailability score	0.55
9	Medicinal chemistry	Synthetic accessibility	4.20
9	Medicinal chemistry	Leadlikeness	Yes

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Declarations

Author contributions

AOM: Conceptualization, Data curation, Formal analysis, Methodology, Resources, Investigation, Writing—original draft. AJA: Formal analysis, Methodology, Investigation, Writing—review & editing. MEA: Resources, Methodology, Investigation, Writing—review & editing. SOI: Visualization, Resources, Writing—review & editing. YOA: Software, Writing—review & editing. All authors read and approved the submitted version.

Conflicts of interest

Authors declare no conflict of interest.

Ethical approval

Not applicable.

Consent to participate

Not applicable.

Consent to publication

Not applicable.

Availability of data and materials

Data generated from this study are available from the corresponding author upon reasonable request.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Copyright

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