MBIC and MBEC values of CHX-AgNP against S. aureus and P. aeruginosa reference strains and MDR isolates.
| Microorganism | MBIC CHX/AgNP (μg/mL) | MBEC CHX/AgNP (μg/mL) |
|---|---|---|
| SA ATCC | 10/5 | 2,500/1,125 |
| MRSA | 10/5 | 2,500/1,125 |
| PA ATCC | 40/20 | 10,000/5,000 |
| MDR-PA | 80/40 | 10,000/5,000 |
MBIC: minimum biofilm inhibitory concentration; MBEC: minimum biofilm eradication concentration; CHX: chlorhexidine; AgNP: silver nanoparticles; S. aureus: Staphylococcus aureus; P. aeruginosa: Pseudomonas aeruginosa; MDR: multidrug-resistant; SA ATCC: S. aureus ATCC 29213; MRSA: methicillin-resistant S. aureus; PA ATCC: P. aeruginosa ATCC 27853; MDR-PA: MDR P. aeruginosa.
The authors thank to National Scientific and Technical Research Council (CONICET) for their collaboration in funding Ph.D Scholarships and researchers. We would like to thank the students of the Laboratory of Pharmacological and Toxicological Studies, Faculty of Veterinary Science, La Plata University of La Plata, for their assistance with the experiments.
DB: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing—original draft, Writing—review & editing. AB: Methodology, Writing—review & editing. LGC: Methodology, Writing—review & editing. KJL: Methodology, Writing—review & editing. FA: Methodology, Writing—review & editing. JdF: Methodology, Writing—review & editing. GC: Writing—review & editing, Funding acquisition, Resources. GB: Methodology, Writing—review & editing. AP: Methodology, Writing—review & editing. LM: Conceptualization, Supervision, Writing—review & editing, Data curation, Methodology, Project administration. All authors contributed to the revision and approved the final manuscript.
The authors declare that they have no conflicts of interest.
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The raw data supporting the findings of this study will be made available by the authors, without undue reservation, to any qualified researcher.
The authors declare that financial support was received for the research and authorship of this article. This work was partially financed by the Laboratory of Pharmacological and Toxicological Studies (LEFyT) and the National University of La Plata [UNLP, I+D V323]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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