List of few peptide and drug combinations found helpful in combatting microbial infections

Peptide(s)Combined compound(s)Bacterial specie(s)Testing modelsConcentrationsSynergismReference
CRAMPVancomycinSalmonella enterica serovar TyphimuriumClinical (in-vitro)-Yes[184]
DJK-5 and DJK-6Ciprofloxacin, ceftazidime, tobramycinAcinetobacter baumannii, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosaClinical (in-vitro)0.8 µg/mL of DJK-5 and DJK-6Yes[185]
AMP38ImipenemPseudomonas aeruginosaClinical (in-vitro)62.5 µg/mL of AMP38 plus imipenemYes[186]
HPMACiprofloxacinAcinetobacter baumanniiClinical (in-vitro)25 µM of HPMA, 400 µM of ciprofloxacinYes[187]
LactoferrinCiprofloxacinPorphyromonas gingivalisIn vivo10 μg/mL of ciprofloxacin, 8 mg/mL of lactoferrinYes[188]
NisinPenicillinEnterococcus faecalisClinical (in-vitro)31.25 U/mL of nicin, 0.0625 mg/L of penicillinYes[111]
NisinDHBAStaphylococcus aureusClinical (in-vitro)50 mg/mL of DHBA, 15 mg/mL of nisinYes[189]
hBD-3DNase IHaemophilus influenzaeIn vivo (chinchillas)0.5 g (r)hBD-3/mL, 0.5 g enzyme/mL sBHIYes[190]
KSL-WDispersin BAcinetobacter baumanii, Klebsiella pneumoniae, Staphylococcus aureus, Staphylococcus epidermidisClinical (in-vitro)1 mg/mL of KSL-W, 0.2 mg/mL of dispersin BYes[191]
Temporin 1TbEDTAStaphylococcus epidermidisClinical (in-vitro)2 mg/mL of temporin 1Tb, 50 mM (18.6 mg/mL) of EDTAYes[192]
hBD-2NO, colistin, chloramphenicolPseudomonas aeruginosaClinical (in-vitro)1.5 flux NO, 20 μg/mL AMP, 100 μg/mL antibioticsYes[193]
DD13RNA III-inhibiting peptideStaphylococcus aureus, Staphylococcus epidermidisIn vivo (rat)10 mg/L of DD13, RNA III-inhibiting peptideYes[194]
Citropin 1.1, temporin A, an analog of tachyplesin IColistinPseudomonas aeruginosa, Staphylococcus aureusClinical (in-vitro)32 mg/L of colistin, 1 mg/mL of citropin 1.1, 4 mg/L of temporin AYes[195]
NisinColistin, polymyxin BPseudomonas aeruginosaClinical (in-vitro)100 µM of nisin, 128 or 256 µg/mL of colistin, polymyxin BYes[196]

AMP: antimicrobial peptide; hBD: human beta-defensin; NO: nitric oxide. Adapted with permission from [197], © 2017 the authors (CC BY)