• 11 results in Exploration of Targeted Anti-tumor Therapy
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    Review
    An introductory review of post-resection chemotherapeutics for primary brain tumors
    The treatment of central nervous system (CNS) tumors is complicated by high rates of recurrence and treatment resistance that contribute to high morbidity and mortality (Nat Rev Neurol. 2022;18:221 [...] Read more.
    Meaghan McGovern ... Brandon Lucke-Wold
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:537–544
    DOI: https://doi.org/10.37349/etat.2023.00150
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    Open Access
    Review
    Glucose metabolism reprogramming promotes immune escape of hepatocellular carcinoma cells
    Hepatocellular carcinoma (HCC) is a complex process that plays an important role in its progression. Abnormal glucose metabolism in HCC cells can meet the nutrients required for the occurrence and d [...] Read more.
    Qiuyue Zhang ... Mengsen Li
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:519–536
    DOI: https://doi.org/10.37349/etat.2023.00149
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    Open Access
    Case Report
    Spontaneous regression of a metastatic carcinoma transmitted by a kidney graft
    Transmission of a malignancy from a donor’s organ to the recipient of the graft is a rare event, though it is a severe complication that can result in a poor outcome. Usually, immunosuppressive th [...] Read more.
    Mikhail V. Kiselevskiy ... Irina Zh. Shubina
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:511–518
    DOI: https://doi.org/10.37349/etat.2023.00148
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    Open Access
    Review
    Increasing differential diagnosis between lipoma and liposarcoma through radiomics: a narrative review
    Soft tissue sarcomas (STSs) are rare, heterogeneous, and very often asymptomatic diseases. Their diagnosis is fundamental, as is the identification of the degree of malignancy, which may be high, me [...] Read more.
    Raffaele Natella ... Antonella Santone
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:498–510
    DOI: https://doi.org/10.37349/etat.2023.00147
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
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    Open Access
    Review
    Type 1 and type 2 cytokine-mediated immune orchestration in the tumour microenvironment and their therapeutic potential
    Cancer remains the second leading cause of death worldwide despite modern breakthroughs in medicine, and novel treatments are urgently needed. The revolutionary success of immune checkpoint inhibito [...] Read more.
    Eric Jou
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:474–497
    DOI: https://doi.org/10.37349/etat.2023.00146
    This article belongs to the special issue Therapeutic Targeting of the Tumor Microenvironment
    Open Access
    Perspective
    Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies
    Immunotherapy strategies targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) are revolutionizing oncology. However,  [...] Read more.
    Ai Tsuji ... Satoru Matsuda
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:460–473
    DOI: https://doi.org/10.37349/etat.2023.00145
    This article belongs to the special issue Cancer Immunotherapy and Tumor Microenvironment
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    Open Access
    Original Article
    Continuous enzyme activity assay for high-throughput classification of histone deacetylase 8 inhibitors
    Aim: Human histone deacetylase 8 (KDAC8) is a well-recognized pharmaceutical target in Cornelia de Lange syndrome and different types of cancer, particularly childhood neuroblastoma. Several clas [...] Read more.
    Markus Schweipert ... Franz-Josef Meyer-Almes
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:447–459
    DOI: https://doi.org/10.37349/etat.2023.00144
    Open Access
    Original Article
    Liquid biopsy: an examination of platelet RNA obtained from head and neck squamous cell carcinoma patients for predictive molecular tumor markers
    Aim: Recently, a tumor cell-platelet interaction was identified in different tumor entities, resulting in a transfer of tumor-derived RNA into platelets, named further “tumor-educated platelets [...] Read more.
    Lisa T. Huber ... Cornelia Brunner
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:422–446
    DOI: https://doi.org/10.37349/etat.2023.00143
    This article belongs to the special issue The Implementation of Liquid Biopsy in Clinical Practice for Different Solid Tumor
    Open Access
    Review
    Artificial intelligence and radiomics in magnetic resonance imaging of rectal cancer: a review
    Rectal cancer (RC) is one of the most common tumours worldwide in both males and females, with significant morbidity and mortality rates, and it accounts for approximately one-third of colorectal ca [...] Read more.
    Giuseppe Di Costanzo ... Enrico Cavaglià
    Published: June 30, 2023 Explor Target Antitumor Ther. 2023;4:406–421
    DOI: https://doi.org/10.37349/etat.2023.00142
    This article belongs to the special issue Artificial Intelligence for Precision Oncology
    Open Access
    Original Article
    Real world outcomes in patients with neuroendocrine tumor receiving peptide receptor radionucleotide therapy
    Aim: 177Lu-Dotatate (Lu-177), a form of peptide receptor radionuclide therapy (PRRT), was approved by Food and Drug Administration (FDA) for the treatment of somatostatin-receptor-positive neur [...] Read more.
    Stijn Hentzen ... Anup Kasi
    Published: June 29, 2023 Explor Target Antitumor Ther. 2023;4:396–405
    DOI: https://doi.org/10.37349/etat.2023.00141
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