HG, ÖP, and MM: Conceptualization, Methodology, Data curation, Formal analysis, Investigation, Writing—original draft, Writing—review & editing, Supervision. All authors read and approved the final manuscript.
Conflicts of interest
The authors declare that they have no relevant financial or non-financial interests to disclose.
Ethical approval
This retrospective study was approved by Bakırköy Dr. Sadi Konuk Hospital Ethics Committee (Date: 06.02.2023, Protocol No: 2023/70, Decision No: 2023-03-14) and conducted in accordance with the requirements of the Declaration of Helsinki.
Consent to participate
Informed consent was waived due to the retrospective nature of the study.
Consent to publication
Not applicable.
Availability of data and materials
The datasets analyzed during the current study are available from the corresponding author on reasonable request.
Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
References
Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The Prevalence and Features of the Polycystic Ovary Syndrome in an Unselected Population.J Clin Endocrinol Metab. 2004;89:2745–9. [DOI] [PubMed]
Purwar A, Nagpure S. Insulin Resistance in Polycystic Ovarian Syndrome.Cureus. 2022;14:e30351. [DOI] [PubMed] [PMC]
Zeng X, Xie YJ, Liu YT, Long SL, Mo ZC. Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity.Clin Chim Acta. 2020;502:214–21. [DOI] [PubMed]
Guerrero-Romero F, Simental-Mendía LE, González-Ortiz M, Martínez-Abundis E, Ramos-Zavala MG, Hernández-González SO, et al. The Product of Triglycerides and Glucose, a Simple Measure of Insulin Sensitivity. Comparison with the Euglycemic-Hyperinsulinemic Clamp.J Clin Endocrinol Metab. 2010;95:3347–51. [DOI] [PubMed]
Bilginer MC, Tüfekçi D, Emür Günay Y, Usta O, Coşkun H, Üçüncü O, et al. Evaluation of Insulin Resistance Measurement Methods in Patients with Polycystic Ovary Syndrome.Turk J Diabetes Obes. 2022;6:24–31. [DOI]
Selvi NMK, Nandhini S, Sakthivadivel V, Lokesh S, Srinivasan AR, Sumathi S. Association of Triglyceride–Glucose Index (TyG index) with HbA1c and Insulin Resistance in Type 2 Diabetes Mellitus.Maedica - J Clin Med. 2021;16:375–81. [DOI] [PubMed] [PMC]
Babic N, Valjevac A, Zaciragic A, Avdagic N, Zukic S, Hasic S. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2.Med Arch. 2019;73:163–8. [DOI] [PubMed] [PMC]
Mahdavi-Roshan M, Mozafarihashjin M, Shoaibinobarian N, Ghorbani Z, Salari A, Savarrakhsh A, et al. Evaluating the use of novel atherogenicity indices and insulin resistance surrogate markers in predicting the risk of coronary artery disease: a case‒control investigation with comparison to traditional biomarkers.Lipids Health Dis. 2022;21:126. [DOI] [PubMed] [PMC]
Kaplangoray M, Toprak K, Başanalan F, Palice A, Aydın C, Demirkıran A, et al. Investigação da Relação entre Índice de Triglicerídeos-Glicose e Fluxo Lento Coronariano: Um Estudo Retrospectivo de Caso-Controle.Arq Bras Cardiol. 2023;120:e20220679. [DOI] [PubMed] [PMC]
Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, et al. Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study.Cardiovasc Diabetol. 2019;18:95. [DOI] [PubMed] [PMC]
Ji W, Gao L, Sun P, Jia J, Li J, Wang X, et al. Association of the triglyceride-glucose index and vascular target organ damage in a Beijing community-based population.Front Cardiovasc Med. 2022;9:948402. [DOI] [PubMed] [PMC]
Lu YW, Tsai CT, Chou RH, Tsai YL, Kuo CS, Huang PH, et al. Sex difference in the association of the triglyceride glucose index with obstructive coronary artery disease.Sci Rep. 2023;13:9652. [DOI] [PubMed] [PMC]
Yoon JS, Lee HJ, Jeong HR, Shim YS, Kang MJ, Hwang IT. Triglyceride glucose index is superior biomarker for predicting type 2 diabetes mellitus in children and adolescents.Endocr J. 2022;69:559–65. [DOI] [PubMed]
Prianwari C, Santi Syafril. Relationship Between Triglycerides And Glucose Index (TyG) And Lipid Profile In Patients With Dyslipidemia Treated With Bay Leaf Extract [Syzygium Polyanthum (Wight) Walp].J Endocrinol Trop Med Infect Dis (JETROMI). 2020;2:177–82. [DOI]
Poveda NE, Garcés MF, Darghan AE, Jaimes SAB, Sánchez EP, Díaz-Cruz LA, et al. Triglycerides/Glucose and Triglyceride/High-Density Lipoprotein Cholesterol Indices in Normal and Preeclamptic Pregnancies: A Longitudinal Study.Int J Endocrinol. 2018;2018:8956404. [DOI] [PubMed] [PMC]
Javidan A, Azarboo A, Jalali S, Fallahtafti P, Moayyed S, Ghaemi M, et al. The association between triglyceride-glucose index and polycystic ovary syndrome: a systematic review and meta-analysis across different populations.J Ovarian Res. 2025;18:163. [DOI] [PubMed] [PMC]
Morshed MS, Banu H, Hossan MS, Mahrukh H, Hasanat MA. Association of adiposity indices with insulin resistance among women with polycystic ovary syndrome.Clin Exp Reprod Med. 2025;52:342–7. [DOI] [PubMed] [PMC]
Brito ADM, Hermsdorff HHM, Filgueiras MS, Vieira-Ribeiro SA, Franceschini SDCC, Novaes JF. TAG–glucose (TyG) index in childhood: an estimate of cut-off points and the relation to cardiometabolic risk in 4- to 9-year-old children.Public Health Nutr. 2020;24:2603–10. [DOI] [PubMed] [PMC]
Locateli JC, Lopes WA, Simões CF, de Oliveira GH, Oltramari K, Bim RH, et al. Triglyceride/glucose index is a reliable alternative marker for insulin resistance in South American overweight and obese children and adolescents.J Pediatr Endocrinol Metab. 2019;32:1163–70. [DOI] [PubMed]
Zheng Y, Yin G, Chen F, Lin L, Chen Y. Evaluation of Triglyceride Glucose Index and Homeostasis Model of Insulin Resistance in Patients with Polycystic Ovary Syndrome.Int J Women's Health. 2022;14:1821–9. [DOI] [PubMed] [PMC]
Gawade GC, Wadadekar GS, Padwal MK. Correlation between TyG (Fasting Triglyceride-glucose) Index, TyG BMI Index & Liver Transaminases in Women with Polycystic Ovary Disease Syndrome.Int J Res Rev. 2021;8:193–201. [DOI]
Rhaiem TB, Owczarek AJ, Wójtowicz M, Ciura D, Madej P, Chudek J, et al. The Cut-Off Value for the Triglyceride–Glucose Index (TyG) Discriminating Insulin Resistance Based on the SHBG Level and HOMA-IR Values in Women with Polycystic Ovary Syndrome.Life. 2025;15:691. [DOI] [PubMed] [PMC]
Li X, Luan T, Wei Y, Zhang J, Zhao C, Ling X. The association between triglyceride glucose-body Mass Index and in vitro fertilization outcomes in women with polycystic ovary syndrome: a cohort study.J Ovarian Res. 2024;17:90. [DOI] [PubMed] [PMC]
Yan H, Yang W, Zhou F, Li X, Pan Q, Shen Z, et al. Estrogen Improves Insulin Sensitivity and Suppresses Gluconeogenesis via the Transcription Factor Foxo1.Diabetes. 2018;68:291–304. [DOI] [PubMed] [PMC]
Szymczak-Pajor I, Drzewoski J, Śliwińska A. The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders.Int J Mol Sci. 2020;21:6644. [DOI] [PubMed] [PMC]
Jia Y, Song T, Li Z, Zhou L, Chen S. The Relationship Between Triglyceride Glucose Index and Vitamin D in Type 2 Diabetes Mellitus.Diabetes Metab Syndr Obes: Targets Ther. 2022;15:511–25. [DOI] [PubMed] [PMC]
Mustafa A, Shekhar C. Association between serum 25-hydroxyvitamin-D and Triglycerides-Glucose index among Indian adolescents.BMC Nutr. 2022;8:69. [DOI] [PubMed] [PMC]
Ehrampoush E, Mirzay Razzaz J, Arjmand H, Ghaemi A, Raeisi Shahraki H, Ebrahim Babaei A, et al. The association of vitamin D levels and insulin resistance.Clin Nutr ESPEN. 2021;42:325–32. [DOI] [PubMed]
Teede HJ, Khomami MB, Morman R, Laven JSE, Joham AE, Costello MF, et al. Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process.Lancet. 2026;407:2329–39. [DOI] [PubMed]
