From:  Behavioral and biochemical evaluation of the neuroprotective role of naringin in streptozotocin‑induced diabetic peripheral neuropathy in rats

 Effect of treatment on lipid profile and proinflammatory cytokines in diabetic rats.

ItemsGroups
NCDCNGN-DGD-Dp-value
TG (mg/dL)75.02 ± 1.4131.17 ± 2.31a69.15 ± 4.42b71.66 ± 5.37bp < 0.01
TC (mg/dL)81.15 ± 4.72125.42 ± 3.88a76.91 ± 3.21b79.77 ± 5.81bp < 0.01
LDL-C (mg/dL)34.62 ± 3.5279.74 ± 2.52a32.71 ± 3.65b35.55 ± 3.67bp < 0.01
HDL-C (mg/dL)38.14 ± 3.4916.32 ± 2.38a40.12 ± 3.71b37.28 ± 2.46bp < 0.01
TNF-α (ng/mL)0.74 ± 0.192.31 ± 0.08a0.76 ± 0.15b1.02 ± 0.14bcp < 0.01
IL-6 (pg/mL)311.4 ± 7.06612.1 ± 27.18a309.2 ± 11.4b357.6 ± 32.2bcp < 0.01

Data are expressed as means ± SEM of 10 rats/group. a Significantly different from the NC group (p < 0.01); b Significantly different from the DC group (p < 0.01); c Significantly different from the NGN-D group (p < 0.05). DC: diabetic control; GD-D: glimepiride-treated diabetic rats; HDL-C: high-density lipoprotein-cholesterol; LDL-C: low-density lipoprotein-cholesterol; NC: normal control; NGN-D: naringin-treated diabetic rats; TC: total cholesterol; TG: triglyceride; TNF-α: tumor necrosis factor-α.