From:  Development and validation of a novel risk assessment model for necrotizing fasciitis in patients with diabetic foot

 General clinical characteristics and baseline data of patients.

IndicatorDF group (703)DNF group (112)P-value
Temperature (°C)36.6 ± 0.637.0 ± 0.9< 0.001
Age (years)66.4 ± 12.261.4 ± 11.3< 0.001
Male (%)464 (66.0)78 (69.6)0.460
BMI (kg/m2)23.6 ± 3.522.9 ± 3.70.054
Diabetes duration (years)10.0 (5.0, 18.0)10.0 (4.0, 15.0)0.136
Diabetic peripheral neuropathy (%)586 (83.4)87 (77.7)0.100
Diabetic retinopathy (%)301 (42.8)49 (43.8)0.701
Diabetic nephropathy (%)354 (50.4)39 (34.8)0.002
Foot skin necrosis (%)172 (24.5)46 (41.1)< 0.001
Wagner classification (%)
2290 (41.2)7 (6.2)-
3243 (34.6)59 (52.7)-
4168 (23.9)45 (40.2)-
52 (0.3)1 (0.9)-
White blood cell (109/L)8.9 ± 4.012.9 ± 6.7< 0.001
Neutrophil (109/L)6.7 ± 3.910.8 ± 6.7< 0.001
Platelet (109/L)225.0 (175.0, 302.0)282.0 (212.5, 345.8)< 0.001
Lymphocyte (109/L)1.4 ± 0.61.3 ± 0.50.013
Monocyte (109/L)0.5 (0.4, 0.7)0.7 (0.5, 0.9)< 0.001
NLR4.2 (2.9, 6.6)8.5 (4.3, 13.0)< 0.001
PLR175.2 (122.7, 243.2)219.4 (168.2, 329.0)< 0.001
LMR2.7 (1.9, 4.0)1.8 (1.2, 2.8)< 0.001
Hemoglobin (g/L)116.2 ± 20.4106.5 ± 22.4< 0.001
HbA1c (%)9.6 ± 2.610.6 ± 2.8< 0.001
hs-CRP > 20 mg/L273 (38.8)87 (77.7)< 0.001
Albumin (g/L)35.9 ± 6.131.6 ± 6.5< 0.001
Na+ (mmol/L)138.3 ± 14.1138.7 ± 5.20.821
Creatinine (mmol/L)82.0 (62.0, 112.5)73.0 (56.0, 109.0)0.142
Fibrinogen (g/L)4.7 (3.7, 6.4)6.6 (4.9, 7.5)< 0.001

Continuous variables are expressed as mean (standard deviation) or median (25th and 75th percentiles), and categorical variables are expressed as percentages (%). BMI: body mass index; DF: diabetic foot; DNF: DF complicated with necrotizing fasciitis; HbA1c: hemoglobin A1c; hs-CRP: hypersensitive C-reactive protein; LMR: lymphocyte-monocyte ratio; NLR: neutrophil-to-lymphocyte ratio; PLR: platelet-lymphocyte ratio.