From:  Osteoporosis: definition, diagnosis, and considerations prior to starting treatment

 Common sources of error in DXA [3, 219223].

CategoryCommon errors/issues
Quality control
  • Scanner-related: Ensure proper scanner function, image acquisition, and data analysis

  • Examination-related: Perform regular calibration, phantom scans, and consistent monitoring of control data to detect variability

Indication
  • Requesting DXA in low-risk individuals without clinical justification

  • Failing to screen high-risk patients who could benefit from early osteoporosis or fracture risk detection

Acquisition
  • Demographic data errors: Inaccurate entry of identifiers (sex, age, race)

  • Patient positioning: Misalignment of spine or hip, excessive rotation, or incomplete anatomical coverage

  • Skeletal abnormalities: Scoliosis or vertebral fractures may distort BMD values and require exclusion of affected vertebrae and careful interpretation

  • Artifacts: Metallic objects, clothing components, or retained materials (e.g., barium, implants) can impair image quality and accuracy

Data analysis
  • ROI placement: Incorrect placement may include/exclude bone or soft tissue, altering BMD values

  • Vertebral selection: Degenerated or fractured vertebrae must be excluded; errors compromise accuracy

  • Calibration/software: Poor calibration or processing errors can cause measurement inaccuracies

Interpretation and reporting
  • Misinterpretation of results or inappropriate clinical decisions based on inaccurate data analysis

DXA: dual-energy X-ray absorptiometry; BMD: bone mineral density; ROI: region of interest.