Summary of studies evaluating the association between APOA1 gene polymorphisms and the risk of dyslipidemia.
| Authors | Title | Study type | Year | Country | n | MAF | Odds ratio | Conclusions |
|---|---|---|---|---|---|---|---|---|
| Wu et al. [6] | Interactions of Environmental Factors and APOA1-APOC3-APOA4-APOA5 Gene Cluster Gene Polymorphisms with Metabolic Syndrome | Case-control | 2016 | China | 3,441 | 26% | 1.31 (1.14–1.50);p < 0.001 | The polymorphic allele was associated with a higher risk of metabolic syndromes |
| Wang et al. [13] | Interactions of six SNPs in APOA1 gene and types of obesity on low HDL-C disease in Xinjiang pastoral area of China | Case-control | 2017 | China | 1,267 | 17% | 1.34 (1.03–1.74);p = 0.0262 | The polymorphic allele was associated with a higher risk of low HDL-C |
| Feng et al. [14] | Association of APOA1 gene polymorphisms (rs670, rs5069, and rs2070665) with dyslipidemia in the Kazakhs of Xinjiang | Case-control | 2016 | China | 736 | 14% | 1.17 (0.84–1.64); p = 0.3406 | The polymorphic allele was not associated with the risk of dyslipidemia |
| Wang et al. [15] | Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area | Case-control | 2018 | China | 1,433 | 16% | 1.34 (1.06–1.69);p = 0.0141 | The polymorphic allele was associated with a higher risk of dyslipidemia |
| Hosseini-Esfahani et al. [16] | Dietary patterns interact with APOA1/APOC3 polymorphisms to alter the risk of the metabolic syndrome: the Tehran Lipid and Glucose Study | Case-control | 2015 | Iran | 828 | 29% | 1.11 (0.85–1.46);p = 0.4433 | The polymorphic allele was not associated with the risk of metabolic syndromes |
HDL-C: high-density lipoprotein cholesterol; MAF: minor allele frequency.