Kruskal-Wallis test of total participants for FEV1, FEV1/FVC, HbA1c, BMI, and age data with and without T2DM for lean, overweight, and obese individuals. Data presented as mean ± standard deviation. *** P < 0.001, **** P < 0.0001 compared with corresponding lean controls with and without T2DM. Δ P < 0.05, ΔΔ P < 0.01, ΔΔΔ P < 0.001, and ΔΔΔΔ P < 0.0001 compared with those without T2DM within the same BMI category. FEV1 forced expiratory volume in one second percentage of predicted; FVC forced vital capacity (L/L%); HbA1c glycated haemoglobin (mmol/mol); BMI, body mass index (kg/m2); COPD: chronic obstructive pulmonary disease; T2DM: type 2 diabetes mellitus
CK and PLM: Conceptualization, Writing—review & editing, Supervision. PS: Conceptualization, Supervision. KC: Data curation. RL: Data curation, Investigation, Formal analysis, Writing—original draft. All authors read and approved the submitted version.
Conflicts of interest
The authors declare that they have no conflicts of interest.
Ethical approval
This research has been conducted using the UK Biobank Resource under application number 48433.
Consent to participate
All UK Biobank participants consented to take part in the UK Biobank project. Approved researchers working under approved projects can access the data for health-related research purposes. Participants were removed from analysis if they later revoked their consent.
Consent to publication
Not applicable.
Availability of data and materials
The data analysed in this study were obtained from UK Biobank. Requests for access to these datasets should be directed to the access management team (AMT), access@ukbiobank.ac.uk.
Funding
CK, PLM, and PS wish to acknowledge funding of a PhD studentship to RL from the Department for the Economy (DfE), Northern Ireland. PS wishes to acknowledge funding of a PhD studentship to KC from the Department for the Economy (DfE), Northern Ireland, and funding support from the Ulster University for the UK Biobank project number 48433. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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