From:  EKOS failure with INARI salvage in massive pulmonary embolism: a literature review and case report

 Timeline.

Hospitalization orderDayEvents
First hospitalizationDay 1Presented with shortness of breath, palpitations, and syncope. CTA showed a large saddle PE with right heart strain. Started on heparin infusion.
Day 2Underwent catheter-directed thrombolysis (EKOS). Symptoms and tachycardia improved. Transitioned to apixaban.
Day 4Echo showed improving RV function and continued physical therapy.
Day 5Discharged on apixaban (3 months) and home oxygen (2 L/min).
Second hospitalizationDay 1Readmitted the very next day with recurrent syncope. CTA showed a persistent clot burden with right heart strain. Restarted on heparin.
Day 2Echo showed McConnell’s sign. Underwent INARI thrombectomy. Transferred to ICU.
Day 3Marked improvement; tachycardia and dyspnea resolved.
Day 4Stable; cardiology signed off.
Day 5Discharged on apixaban and scheduled for outpatient follow-up.

CTA: computed tomography angiography; EKOS: EkoSonic Endovascular System; PE: pulmonary embolism; RV: right ventricular; ICU: intensive care unit.