From:  Long-term cardiovascular sequelae of COVID-19 in patients with pre-existing heart failure: a systematic review

 Summary of long-term clinical outcomes and key effect modifiers.

OutcomeNo. of studiesTotal patientsPooled estimate (95% CI)Heterogeneity (I2)Key findingsReferences
12-month readmission1812,45028% (24–32%)82%HFrEF > HFpEF (RR = 1.4); comorbidities ↑1.3–1.6×; new HTN HR = 1.57[37, 38, 64, 6872]
≥ 12-month mortality149,81018% (15–22%)79%Vaccination aHR = 0.59; COVID-19 vs. flu ↑1.6–2.1×[7, 16, 67, 68, 71, 7376]
Special populations----Telemonitoring HR = 29.56; racial disparities; persistent fibrosis[61, 77, 78]

Adjusted for relevant confounders as reported in the original studies. Key findings in the last column are derived from subgroup and multivariable analyses reported across the included studies, addressing potential confounding factors. aHR: adjusted hazard ratio; CI: confidence interval; COVID-19: coronavirus disease 2019; HFpEF: heart failure with preserved ejection fraction; HFrEF: heart failure with reduced ejection fraction; HR: hazard ratio; HTN: hypertension; RR: relative risk. ↑: increase.