From:  Anakinra for resistant Kawasaki disease in an infant: case report and literature review

 Literature review.

Reference numberStudyYearStudy typeNumber of patientsSexAgeConditionReasonTreatmentOutcomeFollow upMax z score
[30]Sánchez-Manubens et al.2017Case report1Female3 yearsKDResistant2 doses IVIG + glucocorticosteroids + aspirin + anakinra 2 mg/kg OD for 14 daysNo CAA16 weeksNo CAA
[31]Shafferman et al.2014Case report1Female11 weeksKD + MASAneurysms3 doses IVIG + aspirin + glucocorticosteroids + infliximab
Anakinra 3 mg/kg BD for 3 days, then 3 mg/kg TID		Mild dilation RCA8 months11 (giant)
[32]Walser et al.2020Case report1Male3 monthsKD resistantResistant + aneurysms2 doses IVIG + aspirin + etanercept + anakinra 6–8 mg/kg/dayImprovement2 years11 (giant)
[33]Lind-Holst et al.2019Case report1Male12 weeksKD + MASAneurysms2 doses IVIG + aspirin + anakinra 10 mg/kg/dayCAA stable19 months12.68 (giant)
[34]Gambacorta et al.2020Case report1Male9 monthsKD + MASResistant + aneurysms2 doses IVIG + clopidogrelNormalization of CAA1 year11.49 (giant)
[35]Barbara et al.2021Case report1Male12 monthsKD + Salmonella soResistant + aneurysms2 doses IVIG + aspirin + anakinra 8 mg/kg/dayNormalization of CAA19 days3.27 (small)
[36]Guillaume et al.2018Case report1Male18 monthsKDResistant + aneurysms2 doses IVIG + glucocorticosteroids + aspirin + anakinra 6 mg/kg/dayImprovement7 months9.94 (large)
[37]Bossi et al.2022Case report1Male2 monthsRecurrent KDAneurysmsIVIG + corticosteroids + aspirin + anakinra 2 mg/kg/dayNormalization of CAA2 years4.89 (medium)
[38]Blonz et al.2020Case report1Female16 yearsKDResistant + aneurysmsIVIG + heparin + anakinra 100 mg SCImprovement6 monthsAneurysmal dilation 9 mm
[39]Kone-Paut et al.2018Retrospective case series118 male, 3 female4 months–9 yearsKD resistantResistant IVIGIVIG + corticosteroids + aspirin + anakinra 2–6 mg/kg/day1 died, 10 improvedVariableVariable
[40]Kone-Paut et al.2020Prospective open-label study1614 male, 2 female3 months–83 monthsKD resistantResistantVariableImprovement45 daysVariable
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BD: bis die; CAA: coronary artery abnormalities; IVIG: intravenous immunoglobulin; KD: Kawasaki disease; MAS: macrophage activation syndrome; OD: once daily; RCA: right coronary artery; SC: subcutaneous; so: status post; TID: three times daily.