From:  Moderate ischemic mitral regurgitation: novel diagnostic tools and the evolution of treatment approaches

 Comparative table of ischemic mitral regurgitation severity thresholds across key Guidelines.

ParameterACC/AHA
2006 [33]		ACC/AHA
2014 [36]		ACC/AHA
2020 [11]		ESC/EACTS
2012 [37]		ESC/EACTS
2017 [38]		ESC/EACTS
2021 [39]		ESC/EACTS
2025 [10]
EROA, mm2≥ 40≥ 40≥ 40≥ 20≥ 20≥ 20≥ 40 (≥ 30*)
RVol, mL≥ 60≥ 60≥ 60≥ 30≥ 30≥ 30≥ 60 (≥ 45*)
RF, %≥ 50≥ 50≥ 50≥ 50≥ 50≥ 50≥ 50
VC, mm≥ 7≥ 7≥ 7≥ 7≥ 7≥ 7≥ 7
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EROA: effective regurgitant orifice area; RVol: regurgitant volume; RF: regurgitant fraction; VC: vena contracta. *: Clinically significant threshold according to ESC/EACTS 2025.