Applications of pomegranate in various traditional medicines with clinical correlation.
| Disease | Remedies in traditional medicine | Related studies | Reference(s) |
|---|---|---|---|
| Diseases of the head, neck and throat |
| Wound healing activity: Punica granatum L. flower extract, when applied to skin injuries induced by burns in rats, effectively decreased the wound size and induced fast healing. | Nasiri et al. (2017) [53] |
| Cardiovascular disorders |
| Cardioprotective activity: Punica granatum L. extract reduces inflammatory markers and blood pressure among older adults and promotes healthy aging. | Farhat et al. (2025) [55] |
| Diseases of the eye | Anti-inflammatory activity: Topical application of pomegranate rind extract had significant anti-inflammatory effects on the skin, ameliorating cold sores and herpetic stromal keratitis. | Houston et al. (2017) [56] | |
| Gastro-intestinal disorders |
| Anti-emetic activity: Pomegranate and spearmint syrup have been found effective in NVP. Peel extract of Punica granatum L. exhibited antiemetic activity.Antidiarrheal activity: Punica granatum L. peels showed similar efficacy as loperamide in an in vitro study.Anti-helminthic activity: Extracts of bark and root of Punica granatum L. showed potential anthelmintic activity in an in vitro study. | Abdolhosseini et al. (2017) [57]Ishtiyaq and Abbas (2018) [58]Qnais et al. (2007) [59]Baravkar et al. (2020) [60] |
| Diseases of the reproductive system | Hypo androgenic activity: Pomegranate juice improves insulin resistance, BMI & WC in PCOS.Neuroprotective property: Pomegranate juice helps protect against brain injury in IUGR babies. | Esmaeilinezhad et al. (2019) [61]Ross et al. (2021) [62] | |
| Skin diseases | Hemopoietic activity: Pomegranate juice improved the erythrocytes & mean corpuscular hemoglobin levels.Antioxidant activity: Pomegranate peel extract acts as a potent free radical scavenger in albino rats. | Manthou et al. (2017) [63]Chidambara et al. (2002) [64] | |
| Bleeding disorders |
| Anti-hemorrhagic activity: Punica granatum flower is as effective as tranexamic acid in heavy menstrual bleeding. | Es-Haghee Ashteany et al. (2023) [65]Goshtasebi et al. (2015) [66] |
NVP: nausea vomiting of pregnancy; BMI: body mass index; WC: waist circumference; PCOS: polycystic ovarian syndrome; IUGR: intra-uterine growth retardation.