Primary mediation analysis: oxytocin → EDE-Q global score → HOMA-IR.
| Path | β | SE | p-value | 95% CI | R2 | |
|---|---|---|---|---|---|---|
| a | Oxytocin → EDE-Q Global | −0.638 | 0.073 | < 0.001 | [−0.836, −0.464] | 0.586 |
| b | EDE-Q Global → HOMA-IR | 0.284 | 0.116 | 0.016 | [0.104, 0.511] | — |
| c | Oxytocin → HOMA-IR (total) | −0.149 | 0.085 | 0.082 | — | 0.445 |
| c′ | Oxytocin → HOMA-IR (direct) | 0.032 | 0.111 | 0.771 | [−0.129, 0.203] | 0.479 |
| ab | Indirect effect via EDE-Q | −0.181 | 0.075 | — | [−0.353, −0.064] | — |
Standardized regression coefficients (β) are presented. All models were adjusted for age and body mass index. Indirect effects were estimated using percentile bootstrap confidence intervals based on 5,000 resamples. EDE-Q: Eating Disorder Examination Questionnaire; HOMA-IR: Homeostatic Model Assessment of Insulin Resistance.
The supplementary materials for this article are available at: https://www.explorationpub.com/uploads/Article/file/1010179_sup_1.pdf.
The authors would like to acknowledge the clinical staff of the Republican Specialized Scientific-Practical Medical Center of Endocrinology for their assistance in data collection and patient management.
SA: Conceptualization, Methodology, Formal analysis, Investigation, Data curation, Visualization, Writing—original draft, Writing—review & editing. ZK: Investigation, Resources, Data curation, Writing—review & editing. AA: Formal analysis, Data curation, Visualization, Writing—review & editing. DK: Investigation, Resources, Data curation, Writing—review & editing. KN: Investigation, Validation, Data curation, Writing—review & editing. AK: Investigation, Data curation, Writing—review & editing. AS: Investigation, Data curation, Writing—review & editing. DU: Investigation, Data curation, Project administration, Writing—review & editing. GN: Methodology, Supervision, Validation, Writing—review & editing. All authors have read and approved the final manuscript.
The authors declare that they have no conflicts of interest.
The study was conducted in accordance with the Declaration of Helsinki (2013 revision) and approved by the Local Bioethics Committee of the Republican Specialized Scientific-Practical Medical Center of Endocrinology (Protocol No. 2/2025, 12 February 2025).
All participants provided written informed consent prior to inclusion in the study.
Not applicable.
The datasets generated and/or analyzed during the current study are not publicly available due to institutional regulations and the presence of potentially identifiable clinical information. Data may be made available from the corresponding author upon reasonable request and with permission of the Institutional Review Board of the Republican Specialized Scientific-Practical Medical Center of Endocrinology.
Not applicable.
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