From:  Pharmacological potential of apigenin: a dietary flavonoid with emerging synergistic interactions in therapeutics

 Apigenin activities, associated molecular pathways, potential drug partners, and reported synergistic roles supported.

ActivityKey pathwaysPotential drug partnersSynergistic role
Anticancer [37]PI3K/Akt, NF-κB, p53Doxorubicin, cisplatin, TRAILEnhances apoptosis, reduces resistance
Anti-inflammatory [38]COX-2, NF-κB, cytokinesNSAIDs, corticosteroidsAmplifies anti-inflammatory effects
Antioxidant [39]Nrf2, ROS modulationChemotherapeuticsReduces oxidative stress-mediated toxicity
Antidiabetic [40]AMPK, GLUT4MetforminImproves insulin sensitivity
Antibacterial [41]Membrane disruption, quorum sensingAntibioticsEnhances drug uptake, reduces resistance