From:  Alkalinizing salts in ketogenic diet therapies: a narrative review with clinical recommendations for metabolic health and acid-base balance

 Preliminary clinical guidelines for alkalinizing salt supplementation in adults on ketogenic diets: suggested dosages and monitoring parameters.

Alkalinizing saltSuggested dosage rangeFrequencyClinical monitoring parameters
Sodium bicarbonate500–1,000 mg per day1–2 times dailyMonitor for signs of alkalosis, serum sodium levels, blood pressure
Potassium citrate1,000–1,500 mg per day1–2 times dailyMonitor potassium levels, renal function, ECG for arrhythmias
Magnesium citrate750–1,500 mg per day1–2 times dailySerum magnesium levels, renal function, signs of muscle weakness
Calcium carbonate750–1,500 mg per day1–2 times dailyMonitor serum calcium levels, kidney function, signs of hypercalcemia
Bicarbonate-calcium mineral water2,000–3,000 mL per day2–3 times dailyMonitor calcium levels, hydration status, renal function
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These dosages are for adults. The safety of these supplementation regimens for vulnerable populations (elderly, children, individuals with renal impairment) has not been well-established and requires further clinical evaluation. These preliminary guidelines are based on data from the interventional studies summarized in Table 2, previously published ketogenic interventions [55, 56], and the authors’ clinical experience in nutritional management.