Characteristics of patients
| Characteristics | Baseline | Year 1 | Year 5 | Year 6 | Year 7 | Year 8 | Year 9 | Year 10 |
|---|---|---|---|---|---|---|---|---|
| Patients, n | 74 | 74 | 74 | 41 | 32 | 18 | 11 | 8 |
| Age (year) mean [standard deviation (SD)] | 51.3 (11) | 51.3 (11) | 51.3 (11) | 50.6 (11.1) | 50.5 (10.2) | 50.7 (6.8) | 52.3 (7.3) | 52 (8.5) |
| Female, n (%) | 45 (60.8) | 45 (60.8) | 45 (60.8) | 26 (63.4) | 22 (68.8) | 12 (66.7) | 7 (63.6) | 6 (75) |
| Male, n (%) | 29 (39.2) | 29 (39.2) | 29 (39.2) | 15 (36.6) | 10 (31.3) | 6 (33.3) | 4 (36.4) | 2 (25) |
| Weight (kg), mean (SD) | 76.3 (13.1) | 76.3 (13.1) | 76.3 (13.1) | 77.5 (14.2) | 76.6 (13.5) | 73.7 (11.2) | 75.6 (10.8) | 71.6 (9.9) |
| BMI (kg/m2) | 26.3 | 26.3 | 26.3 | 26.7 | 26.4 | 25.4 | 26 | 25.9 |
| Smoking status, n (%) | ||||||||
| Never, n (%) | 47 (63.5) | 47 (63.5) | 47 (63.5) | 28 (68.3) | 22 (68.8) | 14 (77.8) | 9 (81.8) | 6 (75) |
| Current, n (%) | 5 (6.8) | 5 (6.8) | 5 (6.8) | 3 (7.3) | 3 (9.4) | 0 (0) | 0 (0) | 0 (0) |
| Previous, n (%) | 22 (29.7) | 22 (29.7) | 22 (29.7) | 10 (24.4) | 7 (21.9) | 4 (22.2) | 2 (18.2) | 2 (25) |
| Use of oral corticosteroids (OCSs) | ||||||||
| Patients, n | 44 | 44 | 44 | 26 | 22 | 12 | 7 | 5 |
| OCS (mg), mean (SD) | 20.9 (21.3) | 5 (7.2) | 3.9 (6.3) | 5 (9.1) | 6.5 (12.9) | 4.2 (4.8) | 5.4 (6.3) | 6.5 (5.4) |