Selected key studies evaluating the association between asthma and OSA.
| Author (Year) (Ref.) | Study design | Population & sample size (N) | OSA diagnostic method | Main visualized & clinical outcomes | Quality & methodological limitations |
|---|---|---|---|---|---|
| Julien et al. (2009) [5] | Case-control | 78 adult patients | Full in-laboratory PSG | Higher prevalence and severity of OSA in severe asthma vs. controls. | High diagnostic accuracy; small sample size; single-center setting. |
| Teodorescu et al. (2010) [7] | Cross-sectional | 472 adult asthma patients | Validated risk questionnaires | OSA risk significantly associated with poor asthma control scores. | High clinical utility; subject to recall bias; lacks objective PSG confirmation. |
| Teodorescu et al. (2015) [4] | Population-based cohort | 547 adult patients (longitudinal) | Serial full PSG over time | Baseline asthma significantly predicts incident OSA development. | Strong longitudinal design; well-controlled for major baseline confounders. |
| Kauppi et al. (2016) [6] | Longitudinal follow-up | 197 asthma patients | Clinical tracking and PSG | Baseline asthma severity correlates with accelerated OSA development. | Excellent real-world data; limited by varying follow-up intervals. |
| Kong et al. (2017) [3] | Systematic review & meta-analysis | 7,675 adult patients | Mixed (PSG and questionnaires) | Confirmed that asthma is associated with a significantly increased risk of OSA. | High statistical power; significant heterogeneity across pooled studies. |
| Lafond et al. (2007) [55] | Interventional trial | 20 comorbid patients | PSG pre- and post-treatment | CPAP therapy significantly improves asthma symptoms and quality of life. | Objective proof of concept; unblinded; lacks a placebo/sham-CPAP control arm. |
OSA: obstructive sleep apnea; PSG: polysomnography; CPAP: continuous positive airway pressure.
During the preparation of this work, the authors used an advanced AI text-generation assistant for structural organization, English language editing, and formatting alignment in response to peer reviewers’ feedback. After utilizing the service, the authors thoroughly reviewed, critically edited, and validated all scientific content, definitions, and medical claims, and take full academic and scientific responsibility for the entire finalized content of the publication.
CL: Conceptualization, Resources, Data curation, Supervision, Validation, Methodology, Writing—original draft, Writing—review & editing. MC: Conceptualization, Resources, Data curation, Methodology, Writing—review & editing. FM: Conceptualization, Resources, Data curation, Methodology, Writing—review & editing. All authors critically reviewed, edited, and approved the final revised version of the manuscript.
Carlo Lombardi, who is the Associate Editor of Exploration of Asthma & Allergy, had no involvement in the decision-making or the review process of this manuscript. The other authors declare no conflicts of interest.
Not applicable. This manuscript is a review article based entirely on previously published literature and public aggregated data. It does not involve any primary research, new clinical trials, or direct experimentation on human participants or animal subjects.
Not applicable. This study does not report on primary data collection derived from individual human subjects, and no primary clinical interventions were performed.
Not applicable. This review contains no individual patient clinical details, identifying case descriptions, or personal media/images requiring specific individual publication consent.
All data generated or analyzed during this review are included within this published article and its accompanying tables. The sources cited and synthesized are fully traceable through the provided bibliography list.
The authors received no specific grant or financial funding from any public, commercial, or non-profit sector sponsor for the research, authorship, or publication of this review article.
© The Author(s) 2026.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.