The differences between the groups were evaluated using a one-way ANOVA, followed by a Tukey’s HSD test (seven per group). #p < 0.05 compared to the Sham group. *p < 0.05 compared to the Control group.
Declarations
Author contributions
AO: Funding acquisition, Investigation, Project administration, Validation, Visualization, Writing—original draft, Data curation, Writing—review & editing. Takao M and Tadaaki M: Supervision, Validation, Data curation, Writing—review & editing. All authors read and approved the submitted version.
Conflicts of interest
Takao Mori is an employee of LAB Biotech Co., Ltd., which provided funding for this study. He contributed to supervision and validation. The other authors declare that they have no conflicts of interest.
Ethical approval
All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Hokkaido University (protocol No. 23-0077) and were conducted in accordance with relevant institutional guidelines and regulations.
Consent to participate
Not applicable.
Consent to publication
Not applicable.
Availability of data and materials
The sequencing data and all data supporting the findings of this study are available from the corresponding author upon reasonable request.
Funding
This work was supported by JSPS KAKENHI Grant Number JP22K07885 and by LAB biotech Co., Ltd. The funders had no role in study design, data collection, analysis, and preparation of the manuscript.
Open Exploration maintains a neutral stance on jurisdictional claims in published institutional affiliations and maps. All opinions expressed in this article are the personal views of the author(s) and do not represent the stance of the editorial team or the publisher.
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