From:  Aeroallergen sensitization patterns and their impact on lung function in adult asthma from a tertiary care centre in Chhattisgarh, India

 Comparison between atopic and non-atopic asthmatics.

VariablesAtopic asthma
(n = 143)
Non-atopic asthma (n = 62)P-value
Age, years36.6 ± 12.037.7 ± 12.50.54
Male, n (%)97 (67.8)24 (38.7)< 0.001
BMI, kg/m223.9 ± 3.924.6 ± 3.60.26
Allergic rhinitis, n (%)87 (60.8)32 (51.6)0.14
Peripheral blood eosinophils, median (IQR)342 (230–520)300 (207–626)0.58
Eosinophilic asthma,
n (%)
81 (56.6)31 (50.0)0.23
Serum total IgE (IU/ml), median (IQR)542 (266–970)293 (182–578)< 0.001
FVC% predicted74.2 ± 14.469.3 ± 17.40.04
FEV1% predicted57.7 ± 15.655.6 ± 17.00.41
FEV1/FVC%64.3 ± 8.566.8 ± 9.10.06
MMEF% predicted34.7 ± 14.734.8 ± 15.40.96
R5, z-score3.11 ± 2.753.03 ± 2.640.85
R5–19, z-score3.08 ± 3.362.99 ± 3.590.53
X5, z-score–2.63 ± 3.61–3.02 ± 3.990.78
Fres, Hz21.2 ± 6.921.6 ± 7.70.72
AX, cmH2O/L/s24.1 ± 23.927.9 ± 26.50.46
Impaired R5, n (%)94 (65.7)36 (58.1)0.19
Impaired, R5–19, n (%)78 (54.5)32 (51.6)0.41
Impaired X5, n (%)60 (42.0)25 (40.3)0.48
BDR of FEV1, n (%)108 (75.5)49 (79.0)0.36
BDR of FVC, n (%)57 (39.9)29 (46.8)0.22
BDR of R5, n (%)66 (46.2)31 (50.0)0.36
BDR of X5, n (%)55 (38.5)22 (35.5)0.4

AX: integrated area of respiratory reactance between X5 and resonant frequency; BDR: bronchodilator responsiveness; BMI: body mass index; FEV1: forced expiratory volume in 1 s; Fres: resonant frequency; FVC: forced vital capacity; IQR: interquartile range; MMEF: maximal mid-expiratory flow rate; R5: whole-breath respiratory system resistance at 5 Hz; R5–19: difference in whole-breath respiratory resistance between 5 Hz and 19 Hz; X5: whole-breath respiratory system reactance at 5 Hz.